Separation processes in biotechnology are of increasing industrial importance since they entail the major costs of bioprocessing especially when high purity is required. Chromatography and membranes are two of the most important technologies used for direct treatment of fermentation broths as well as for high resolution steps in product purification. The theoretical foundations of chromatographic and membrane processes are well understood for the case of small molecules. Nevertheless there is a need to adapt and further develop that knowledge to the processing of large biological molecules. This is being achieved with the contribution of other areas like molecular biology and materials science. The objective of this NATO Advanced Study Institute is to present an updated treatment of the fundamentals of chromatographic and membrane processes with special relevance in bioprocessing.This volume collects the lectures presented at this Institute. The lectures are arranged in five chapters. Chapter I deals with chromatographic processes covering topics like equilibrium, kinetics and contacting devices. Membrane processes and some applications in biotechnology are treated in chapter 2. Chapter 3 is devoted to affinity chromatographic and membrane processes. Chapter 4 considers the current developments on chromatographic supports and membranes both from the constitutive materials and form points of view. Scale-up, optimization and reaction/separation integration are the topics covered in chapter 5. We are very grateful to all lecturers and participants that made possible this Institute. Financial support from NATO Scientific Affairs Division, INIC, JNICT, FLAD, University of Ac;ores and DRT Ac;ores is gratefully acknowledged.

Sheet and film processes include coating, papermaking, metal rolling, and polymer film extrusion. Products produced by these processes include paper, bumper stickers, plastic bags, windshield safety glass, and sheet metal. The total capitalization of industries that rely on these processes is well over $ 500 billion worldwide. These processes are notorious for being difficult to control. The goal of this book is to present the theoretical background and practical techniques for the identification and control of sheet and film processes. It is explained why many existing industrial control systems perform poorly for sheet and film processes. Identification and control algorithms are described and illustrated which provide consistent and reliable product quality. These algorithms include an experimental design technique that ensures that informative data are collected during input-output experimentation, model identification techniques that produce a process model and an estimate of its accuracy, and control techniques that take into account actuator constraints as well as robustness to model uncertainties. The algorithms covered in this book are truly the state of the art. Variations on some of the algorithms have been implemented on industrial sheet and film processes. Other algorithms are in various stages of implementation. All of the algorithms have been applied to realistic simulation models constructed from industrial plant data; many of these studies are included in this book.

This book presents new approaches to constructing fuzzy models for model-based control. Simulated examples and real-world applications from chemical and process engineering illustrate the main methods and techniques. Supporting MATLAB and Simulink files create a computational platform for exploration of the concepts and algorithms.

Japanese semiconductor firms are well known for obtaining dynamics in a short period of time and achieving even global leadership. A significant portion of their success are attributable to cooperative interfirm relations and the development of intermediate organizational structure based on long-term relationship between firms. The purpose of this book is to explain how interfirm relations contributed to their dynamics during the golden age of the semiconductor industry. Meanwhile this book clarifies the real source of dynamics in interfirm relations and how the firms have interacted. The author concludes that the competitive-cum-cooperative (CCC) interfirm interaction are observed. Quantitative and qualitative findings show that firms enjoy not only flexible cooperation based synergy effects, but also dynamics market-like effects by creating competition among partners through CCC interaction.

Polymers continue to play an ever increasing role in the modern world. In fact it is quite inconceivable to most people that we could ever have existed of the increased volume and variety of materials without them. As a result currently available, and the diversity of their application, characterisation has become an essential requirement of industrial and academic laboratories in volved with polymeric materials. On the one hand requirements may come from polymer specialists involved in the design and synthesis of new materials who require a detailed understanding of the relationship between the precise molecular architecture and the properties of the polymer in order to improve its capabilities and range of applications. On the other hand, many analysts who are not polymer specialists are faced with the problems of analysing and testing a wide range of polymeric materials for quality control or material specification purposes. We hope this book will be a useful reference for all scientists and techno or industrial laboratories, logists involved with polymers, whether in academic and irrespective of their scientific discipline. We have attempted to include in one volume all of the most important techniques. Obviously it is not possible to do this in any great depth but we have encouraged the use of specific examples to illustrate the range of possibilities. In addition numerous references are given to more detailed texts on specific subjects, to direct the reader where appropriate. The book is divided into II chapters."

A comprehensive and up to date survey of the science and technology of polymeric dispersions. The book discusses the kinetics and mechanisms of polymerization in dispersed media, examines the processes controlling particle morphology, presents both off-line and on-line methods for the characterization of polymer colloids, considers reactor engineering and control, and covers a wide variety of applications, such as latex paint formulations, encapsulation of inorganic particles, reactive latexes, adhesives, paper coating, and biomedical and pharmaceutical applications. Audience: A valuable resource for scientists and engineers, academic and industrial, who are involved in the manufacture or application of polymeric dispersions.

Chemical pretreatment of nuclear wastes refers to the sequence of separations processes used to partition such wastes into a small volume of high-level waste for deep geologic disposal and a larger volume of low-level waste for disposal in a near-surface facility. Pretreatment of nuclear wastes now stored at several U. S. Department of Energy sites ranges from simple solid-liquid separations to more complex chemical steps, such as dissolution of sludges and removal of selected radionuclides, e. g. , 90Sr, 99Tc, 137CS, and TRU (transuranium) elements. The driving force for development of chemical pretreatment processes for nuclear wastes is the economic advantage of waste minimization as reflected in lower costs for near-surface disposal compared to the high cost of disposing of wastes in a deep geologic repository. This latter theme is expertly and authoritatively discussed in the introductory paper by J. and L. Bell. Seven papers in this volume describe several separations processes developed or being developed to pretreat the large volume of nuclear wastes stored at the US DOE Hanford and Savannah River sites. These papers include descriptions of the type and amount of important nuclear wastes stored at the Hanford and Savannah River sites as well as presently envisioned strategies for their treatment and final disposal. A paper by Strachan et al. discusses chemical and radiolytic mechanisms for the formation and release of potentially explosive hydrogen gas in Tank 241-SY-101 at the Hanford site.

This introductory book is for newcomers to the field of desalting. As a result of the development of arid regions, and also in the wake of intensive use of water in urban areas all over the world, fresh water is frequently not available in the quantities desired. In the last 20 years, great strides have been made in the development of the science and technology of water desalting. Statesmen, economists, scientists, and engineers must often make decisions relating to this field. Quite often such decisions involve the disposition of considerable amounts of energy and investment funds. It is hoped that this book will provide newcomers with sufficient background to appreciate the fundamentals involved, to understand the jargon of the "insiders," to guide them to the rich original multidisciplinary literature of this field, and to facilitate the first stages of further reading. Conversion of salt water into fresh water requires useful energy, i. e. , energy that could otherwise be used for mechanical or electrical work. Therefore, the problem of water desalting is intimately linked to power supply. A second, equally important factor in the economic balance is the availability and cost of equipment. The production of energy-efficient and reliable desalting plants requires considerable engi neering skill and usually a variety offairly sophisticated control devices.

Natural gas, an abundant natural energy and chemical resource, is underutilized. Its inherent high energy content is compromised by its volatility. Storage and transportation problems abound for liquified natural gas. Several of the drawbacks of the utilization of natural gas, particularly its high volatility, could be offset by development of an economical and efficient process for coupling and/or further homologation of its principal component, methane. Alternatively, other conversion strategies such as partial oxidation to methanol and syngas, to oxygenates or conversion to such products via the intermediacy of chlorides should also be considered. Given the energy-intensive regimes necessary for the likely activation of methane, it was inevitable that researchers would tum to the use of heterogeneous catalysts. Heterogeneous catalysis is now a relatively mature discipline with numerous and diverse reactions being explored alongside informative studies on surface characterization, mechanism, and theory. Relationships to important related areas such as homogeneous catalysis, organometallic chemistry, and inorganic chemistry have become firmly established within this discipline. The field of methane and alkane activation is now over ten years old. The first decade of investigation produced results plagued by low yields and low-moderate conversions with well-articulated mechanistic limitations. As we begin the second decade of inquiry, novel strategies have brought increasing yields and conversions to such products as ethane, ethylene, methanol, and formaldehyde. These new approaches utilize separation of products via membranes or adsorbents. Moreover, additional mechanistic insight has been forthcoming from theoretical and computational examination as well as experimental investigation.

Proceedings of the European Membrane Society XVI Annual Summer School on Integration of Membrane Processes into Bioconversions, held August 22-27, 1999, in Veszprem, Hungary. The purpose of this book is to give an overview of the current situation of membrane separation processes in the field of bioengineering and also to describe how their joint application possibilities can be used in both laboratory and industrial scale applications. In commercial applications, focus is centered on the fields of food industry, chemical/fine chemical industry, and environmental protection. Most of the European experts in the interdisciplinary fields of membrane processes and bioconversions have contributed to the chapters in this work, making it the most up-to-date volume currently available.

The first NATO Advanced Study Institute on Olefin Metathesis and Polymerization Catalysts was held on September 10-22, 1989 in Akcay, Turkey. Based on the fundamental research of RRSchrock, RGrubbs and K.B.Wagener in the field of ring opening metathesis polymerization (ROMP), acyclic diene metathesis (ADMET) and alkyne polymerization, these areas gained growing interest within the last years. Therefore the second NATO-ASI held on metathesis reactions was on Ring Opening Metathesis Po lymerization of Olefins and Polymerization of Alkynes on September 3-16, 1995 in Akcay, Turkey. The course joined inorganic, organic and polymer chemists to exchange their knowledge in this field. This volume contains the main and short lectures held in Akcay. To include ADMET reactions better into the title of this volume we changed it into: Metathesis Polymerization of Olefins and Alkyne Polymerization. This volume is addressed to research scientists, but also to those who start to work in the area of olefin metathesis and alkyne polymerization. The topics of the course were: mechanism of ROMP reactions/ new catalysts for ROMP/ new products by ROMP/ new catalysts for ADMET/ new products by ADMETI degradation of polymer by metathesis reactions/ alkyne polymerization and metathesis/ industrial application of metathesis reactions. The Advanced Study Institute was generously sponsored by the Scientific Affairs Division of NATO and the editor gratefully acknowledges this sponsorship. We also thank the Members of the Local Organizing Committee for their engagement on a successful NATO-AS ."

This book consists of papers prepared for and presented at a NATO sponsored Advanced Study Institute which was held in Montechoro, Portugal during the period 16-27 April, 1990. This Institute was attended by approximately ninety delegates from fifteen countries and followed from a related Institute held in Vimeiro, Portugal in 1987 (see the book entitled "Instrumentation for Combustion and Flow in Engines", edited by D. F. G. Dur~o, J. H. Whitelaw and P. O. Witzel. The purposes of the first Institute related closely to instrumentation for use in gas-turbine combustors and the cylinders of internal-combustion engines. These topics were also addressed in the second Institute, though in a manner which was wider ranging and chosen to demonstrate and explain the development and application of measurement methods to combusting flows in general. The papers contained in this boo~ were selected to provide the reader with a comprehensive and up-to-date view of the variety of experimental techniques available to measure in combusting flows. Included are discussions of their range and applicability, potential accuracy and ease of use. Thus, the first paper provides a brief overview and the second an indication of those aspects of combustion which should influence the choice of flow property to be measured and the technique to be used.

Advanced composite materials have been a major research focus for the past forty years. As a reinforcement for conventional materials including glass, ceramics and polymers, carbon has proved to be the most successful. Carbon gives these materials flexibility so that they may be produced in bulk form with a wide variety of properties. Whereas carbon/carbon composites are the most effective materials in extreme temperature conditions. Application ranges from brakes to missile nose cones. Carbon Reinforcements and Carbon/Carbon Composites gives the present state on this subject in comprehensive form, as well as projections for other "High Tech" materials and their application.

In this new textbook on physical chemistry, fundamentals are introduced simply yet in more depth than is common. Topics are arranged in a progressive pattern, with simpler theory early and more complicated theory later. General principles are induced from key experimental results. Some mathematical background is supplied where it would be helpful. Each chapter includes worked-out examples and numerous references. Extensive problems, review, and discussion questions are included for each chapter. More detail than is common is devoted to the nature of work and heat and how they differ. Introductory Caratheodory theory and the standard integrating factor for dGrev are carefully developed. The fundamental role played by uncertainty and symmetry in quantum mechanics is emphasized. In chemical kinetics, various methods for determined rate laws are presented. The key mechanisms are detailed. Considerable statistical mechanics and reaction rate theory are then surveyed. Professor Duffey has given us a most readable, easily followed text in physical chemistry.

From its inception in 1983, ESPRIT (the European Strategic Programme for Research and Development in Information Technology) has aimed at improving the competitiveness of European industry and providing it with the technology needed for the 1990s. Esprit Project 623, on which most of the work presented in this book is based, was one of the key projects in the ESPRIT area, Computer Integrated Manufacturing (CIM). From its beginnings in 1985, it brought together a team of researchers from industry, research institutes and universities to explore and develop a critical stream of advanced manufacturing technology that would be timely and mature for industrial exploitation in a five year time frame. The synergy of cross border collaboration between technology users and vendors has led to results ranging from new and improved products to training courses given at universities. The subject of Esprit Project 623 was the integration of robots into manufacturing environments. Robots are a vital element in flexible automation and can contribute substantially to manufacturing efficiency. The project had two main themes, off-line programming and robot system planning. Off-line programming enlarges the application area of robots and opens up new possibilities in domains such as laser cutting, and other hazardous operations. Reported benefits obtained from off-line program ming include: - significant cost reductions because re-programming eliminates robot down-time; - faster production cycles, in some cases time-savings of up to 85% are reported; - the optimal engineering of products with improved quality."

CONJUGATED POLYMERS: THE IMTERPLAY BETWEEN SYNTHESIS, 1 STRUCTURE, AND PROPERTIES C. B. GORMAN and R. H. GRUBBS 1. Introduction 2 2. Structural Features of Conjuqated. Polyaers 3 3. Polymer Synthesis: Basic Methods 4 3. 1 Step-Growth Polymerization 5 3. 2 Chain-Growth Polymerization 6 3. 3 Rinq-Openinq Polymerization 8 4. Direct Synthetic Methods 8 4. 1 Electrochemical Synthesis 9 4. 2 Synthesis by Step-Growth Polymerization 11 4. 2. 1 Polyaniline (PAN) 11 4. 2. 2 Poly(Phenylene Sulfide) 12 4. 2. 3 Poly thiophene and its Derivatives 13 4. 2. 4 Other 5-membered Heterocyclic 16 Derivatives 4. 2. 5 Polyparaphenylene (PPP) 17 4. 2. 6 Polysilanes 18 4. 2. 7 Polymers of Phthalocyanines 19 4. 2. 8 Other Conjugated Metal Coordination 20 Polymers 4. 2. 9 Ladder Polymers 21 4. 3 The Unusual Topochemical Polymerization to 23 form Polydiacetylenes 4. 4 Chain-Growth Polymerizations 24 4. 4. 1 Polyacetylene via Ziegler-Natta 24 Polymerization 4. 4. 2 Ring-Opening Metathesis Polymerization 26 Routes to Polyacetylenes 5. Polymers fro. precursors 27 5. 1 Polyparaphenylene (PPP) 27 5. 2 Poly(Phenylene Vinylene) (PPV) and Other 28 Vinylene Polymers 5. 3 Precursors to Polyacetylene 29 6. Extentions of these Methods in the Synthesis of 31 *saall-Bandqap* Pplymers 7. Conjuqated. Polymer Matrices 33 8. Conclusions and Caveats 35 Acknowled. qements 36 References 36 vi TABLE OF CONTENTS PROPERTIES OF HIGHLY CONDUCTIHG POLYACETYLEHE 49 Th. SCHIMMEL, D. GLASER, M. SCHWOERER AND H. NAARMANN 1. Introduction 50 2. SBIlpie Synthesis, lIorphology and Properties 52 2.

FRANCIS W. HOLM 7102 Meadow Lane, Chevy Chase, MD 20815 The North Atlantic Treaty Organization (NATO) sponsored an Advanced Research Workshop (ARW) in Prague, Czech Republic, on 1-2 July 1996, to collect and study information on mobile alternative and supplemental demilitarization technologies and to report these fmdings. The mobile, or transportable, technologies identified for assessment at the workshop are alternatives to incineration technology for destruction of munitions, chemical warfare agent, and associated materials and debris. Although the discussion focused on the treatment of metal parts and explosive or energetic material, requirements for decontamination of other materials were discussed. The mobile alternative technologies are grouped into three categories based on process bulk operating temperature: low (0-200 C), medium (200-600 C), and high (600- 3,500 C). Reaction types considered include hydrolysis, biodegradation, electrochemical oxidation, gas-phase high-temperature reduction, stearn reforming, gasification, sulfur reactions, solvated electron chemistry, sodium reactions, supercritical water oxidation, wet air oxidation, and plasma torch technology. These categories represent a broad spectrum of processes, some of which have been studied only in the laboratory and some of which are in commercial use for destruction of hazardous and toxic wastes. Some technologies have been developed and used for specific commercial applications; however, in all cases, research, development, test, and evaluation (RDT &E) is necessary to assure that each technology application is effective for destroying chemical warfare materiel.

This volume contains the papers presented at the Third European Symposium on electrochemical engineering "Electrochemical Engineering and Energy," held on March 23- 25, 1994 in Nancy, France. This meeting was organised by the Laboratoire des Sciences du Genie Chimique, CNRS, and the Centre de Perfectionnement des Industries Chimiques, in conjunction with the Groupe Fran ais de Genie des Procectes, the Society of Chemical Industry, Dechema, and the European Federation of Chemical Engineeling. The organisers would like to thank the members of the Scientific Committee for the careful selection and refereeing of the papers. We are grateful to all contributors for the thorough preparation of their manuscripts. Thanks are due to the International Society of Electrochemistry, District Urbain de Nancy, Region Lorraine, Electticite de France, Institut National Poly technique de Lorraine, and CNRS for their support. The meeting was devoted to the role of electrochemical engineeting and its relationship to the general issue of energy. The twenty-four papers contained here represent new research results and the potential technological developments in a variety of impOltant and relevant areas of the field. The remaining three papers are expert reviews in areas of current technological concern where electrochemical engineering can clearly be seen to have major relevance to energy policy and environmental protection.

Modern computer-based control systems are able to collect a large amount of information, display it to operators and store it in databases but the interpretation of the data and the subsequent decision making relies mainly on operators with little computer support. This book introduces developments in automatic analysis and interpretation of process-operational data both in real-time and over the operational history, and describes new concepts and methodologies for developing intelligent, state space-based systems for process monitoring, control and diagnosis. The book brings together new methods and algorithms from process monitoring and control, data mining and knowledge discovery, artificial intelligence, pattern recognition, and causal relationship discovery, as well as signal processing. It also provides a framework for integrating plant operators and supervisors into the design of process monitoring and control systems.

With the development in the 1960s of ultrahigh vacuum equipment and techniques and electron, X-ray, and ion beam techniques to determine the structure and composition of interfaces, activities in the field of surface science grew nearly exponentially. Today surface science impacts all major fields of study from physical to biological sciences, from physics to chemistry, and all engineering disciplines. The materials and phenomena characterized by surface science range from se- conductors, where the impact of surface science has been critical to progress, to metals and ceramics, where selected contributions have been important, to bio- terials, where contributions are just beginning to impact the field, to textiles, where the impact has been marginal. With such a range of fields and applications, questions about sample selection, preparation, treatment, and handling are difficult to cover completely in one review article or one chapter. Therefore, the editors of this book have assembled a range of experts with experience in the major fields impacted by surface characterization. It is the only book which treats the subject of sample handling, preparation, and treatment for surface characterization. It is full of tricks, cautions, and handy tips to make the laboratory scientist's life easier. With respect to organization of the book, the topics range from discussion of vacuum to discussion of biological, organic, elemental or compound samples, to samples prepared ex situ or in situ to the vacuum, to deposition ofthin films. Generic considerations of sample preparation are also given.

This volume comprises the proceedings of the First International Rehovot Conference on Modem Agriculture and the Environment, held at the Rehovot Campus of the Faculty of Agriculture, the Hebrew University of Jerusalem, Israel, 2-6 October 1994. The conference, first in a series intended to be convened in Rehovot at 4-5 year intervals to address various aspects of the interaction of agriculture and the environment, was initiated, organised and carried out under the auspices of the Faculty of Agriculture, the leading academic institution in agricultural and environmental studies in Israel. It featured four keynote addresses, 39 invited lectures, 40 submitted papers, and 62 posters. Of these, 51 articles, written by 122 contributing authors from 14 countries, were selected by the editors to be presented in this book. All through the twentieth century, and especially ever since the advent of the Green Revolution, modem agriCUlture has been striving to feed and clothe the ever increasing multitudes of the human species through improved technology, relying heavily on tremendous inputs of fertilisers, pesticides, and various other agrochemicals. Undoubtedly, this has been a great blessing to mankind, and enormous strides have indeed been made in the never-ending struggle against starvation, but these have been achieved at a very steep price of increased environmental deterioration. In fact, modem agriculture has become one of the major factors contributing to the degradation of the world's fragile biosphere.

Over the past decades, although stochastic system control has been studied intensively within the field of control engineering, all the modelling and control strategies developed so far have concentrated on the performance of one or two output properties of the system. such as minimum variance control and mean value control. The general assumption used in the formulation of modelling and control strategies is that the distribution of the random signals involved is Gaussian. In this book, a set of new approaches for the control of the output probability density function of stochastic dynamic systems (those subjected to any bounded random inputs), has been developed. In this context, the purpose of control system design becomes the selection of a control signal that makes the shape of the system outputs p.d.f. as close as possible to a given distribution. The book contains material on the subjects of: - Control of single-input single-output and multiple-input multiple-output stochastic systems; - Stable adaptive control of stochastic distributions; - Model reference adaptive control; - Control of nonlinear dynamic stochastic systems; - Condition monitoring of bounded stochastic distributions; - Control algorithm design; - Singular stochastic systems. A new representation of dynamic stochastic systems is produced by using B-spline functions to descripe the output p.d.f. Advances in Industrial Control aims to report and encourage the transfer of technology in control engineering. The rapid development of control technology has an impact on all areas of the control discipline. The series offers an opportunity for researchers to present an extended exposition of new work in all aspects of industrial control.

This book presents a design-driven investigation into smart materials developed by chemists, physicists, materials and chemical engineers, and applied by designers to consumer products. Introducing a class of smart materials, that change colors, the book presents their characteristics, advantages, potentialities and difficulties of applications of this to help understanding what they are, how they work, how they are applied. The books also present a number of case studies: products, projects, concepts and experiments using smart materials, thus mapping out new design territories for these innovative materials. These case studies involve different fields of design, including product, interior, fashion and communication design. Within the context of rising sustainable and human-centered design agendas, the series will demonstrate the role and influence of these new materials and technologies on design, and discuss how they can implement and redefine our objects and spaces to encourage more resilient environments.

Electroactive polymers have been the object of increasing academic and industrial interest and in the past ten to fifteen years substantial progress has been achieved in the development and the characterization of this important new class of conducting materials. These materials are usually classified in two large groups, according to the mode of their electric transport. One group includes polymers having transport almost exclusively of the ionic type and they are often called 'polymer electrolytes' or, in a broader way, 'polymer ionics'. The other group includes polymeric materials where the transport mechanism is mainly electronic in nature and which are commonly termed 'conducting polymers'. Ionically conducting polymers or polymer ionics may be typically described as polar macromolecular solids in which one or more of a wide range of salts has been dissolved. The most classic example is the combina tion of poly(ethylene oxide), PEO, and lithium salts, LiX. These PEO-LiX polymer ionics were first described and proposed for applications just over ten years ago. The practical relevance of these new materials was im mediately recognized and in the course of a few years the field expanded tremendously with the involvement of many academic and industrial lab oratories. Following this diversified research activity, the ionic transport mechanism in polymer ionics was soon established and this has led to the development of new host polymers of various types, new salts and advanced polymer architectures which have enabled room temperature conductivity to be raised by several orders of magnitude."

This unique book is the only recent summary presenting a comprehensive, up-to-date and detailed treatment of relay feedback theory, the use of relay feedback for process identification and the use of identified models for general control design in a single volume.