"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
Provides information on cancer researchOutstanding and original reviewsSuitable for researchers and students

Volume 542 of "Methods in Enzymology" continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.
Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization scienceProvides theoretical overview on metabolic alterations of cancer cells, and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo

This book provides patients and their physicians (especially "non-oncologist" health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient's own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today's daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors' expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.

"Molecular Diagnostics andTreatment of Pancreatic Cancer "describes the different emerging applications of systems biology and howit is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are alsohighlighted.

Addressing this important area, "Molecular Diagnostics and Treatment of Pancreatic Cancer" provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design.
Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scalesCoverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas - helping researchers in pancreatic cancer drug discoverySummarizes many relevant computational and clinical references from fast-evolving literatureComprehensive glossary helps newer readers understand technical terms and specialized nomenclature"

Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, "Cancer Theranostics" reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment.

"Cancer Theranostics" describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives.
Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapyFully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

This book is a comprehensive guide to the assessment and management of adults with thyroid disorders in daily clinical practice. All important aspects and disorders are considered. Relevant information on basic anatomy, embryology, immunology, and physiology is included to provide a better basis for understanding the development of disease and its diagnosis and treatment. Currently available biochemical tests and other specific diagnostic tools are also considered in detail. The various common thyroid disorders are then discussed in a series of individual chapters that focus on etiology, pathophysiology, symptomatology, diagnosis, and treatment. Numerous high-quality illustrations and concise fact boxes are included. The authors are all experts with wide experience in three disciplines and a long-standing interest in thyroid disease.

"Cancer Genomics" addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions," examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment.
Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics.Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including: Genetic approaches for personal oncologyTargeting epigenetic dysregulation and protein interaction networksVaccines and antibodies in cancer immunotherapyTumor heterogeneity and chemotherapy resistanceTumor associated macrophages in anticancer treatment

Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences

Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviewsseries, which features reviews published in "Cell Press" primary research and "Trends" reviews journals.
Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics
Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy
Features reviews on basic science advances translated into drug discovery and therapeutic approaches
Includes articles originally published in "Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine," and "Trends in Pharmacological Sciences""

Cell Press Reviews: Stem Cells to Model and Treat Disease informs, inspires, and connects stem cell researchers and clinicians at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publication offers a broad view of some of the most compelling topics in stem cell research including: Safety and efficacy of stem cell treatmentsStem-cell-based organ regenerationIntegrating stem cells into personalized drug discoveryUsing pluripotent stem cells for treating neurological diseaseEngineering hematopoietic stem cells for innovative therapies

Contributions come from leading voices in the field, including: - Shinya Yamanaka, Recipient of the 2012 Nobel Prize for Physiology or Medicine, Recipient of the 2012 Millennium Technology Prize, Professor and Director of the Center for iPS Cell Research and Application at Kyoto University, Senior Investigator at the Gladstone Institute of Cardiovascular Disease, L.K. Whittier Foundation Investigator in Stem Cell Biology and Professor at the University of California, San Francisco - George Q. Daley, Samuel E. Lux IV Professor of Hematology/Oncology at Harvard Medical School and Director for the Stem Cell Transplantation Program at Boston Children s Hospital - Irving Weissman, Member of National Academy of Sciences, Virgina & D.K Ludwig Professor for Clinical Investigation in Cancer Research, and Director for Institute of Stem Cell Biology and Regenerative Medicine at Stanford University of Medicine

Cell Press Reviews: Stem Cells to Model and Treat Disease is part of the Cell Press Reviewsseries, which features reviews published in "Cell Press" primary research and "Trends" reviews journals.
Provides timely overviews on a wide range of stem cell applications
Offers insight from experts on the key opportunities and challenges facing the field
Features reviews on genetic, cellular, and molecular aspects of stem-cell-based applications
Includes articles originally published in "Cell, Cell Stem Cell, Neuron, Trends in Molecular Medicine," and "Trends in Biotechnology
""

Since its first publication more than 35 years ago, Enzinger and Weiss's Soft Tissue Tumors has established itself as the most comprehensive and authoritative reference available on soft tissue pathology. The 7th Edition from Drs. John R. Goldblum, Andrew L. Folpe, and Sharon W. Weiss, continues this tradition with detailed, well-written, logically organized coverage of the full spectrum of these often difficult and challenging tumors. It offers clear guidance to practicing and trainee pathologists on diagnosis of tumors by microscopy, immunohistochemistry, and molecular genetics, as well as a significant amount of clinically significant information of interest to the clinicians who most frequently see these diseases - dermatologists, orthopaedists, and oncologists. Offers practical information on differential diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures, helping you accurately diagnose and confidently sign out pathology reports on even the most challenging cases. Provides unsurpassed scope and depth in this complex area with microscopic findings correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, for a comprehensive and integrated approach to evaluation and diagnosis. Incorporates new knowledge on recently identified entities, next-generation sequencing (NGS), molecular diagnostic techniques, and immunohistochemical and genetic features of soft tissue tumors, providing up-to-date diagnostic and prognostic information that will inform day-to-day therapeutic decisions. Features nearly 2,000 high-quality images that clearly capture the clinical, macroscopic and microscopic features of benign and malignant conditions, helping you relate these characteristics to their specific classifications. Utilizes a logical, well-structured format including summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity, enabling you to navigate the text quickly, improve turnaround time when diagnosing a specimen, and clearly report on the prognosis and therapeutic management options. Includes abundant algorithms, tables, and graphs to facilitate rapid decision making. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

"Renal Disease in Cancer Patients" is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment.

With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, "Renal Disease in Cancer Patients" presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more.
Covers clinical description, diagnostics, management, and treatment throughout along with genetics, animal models, and pathology in specific chaptersSummarizes all renal diseases unique to cancer patients in a single referenceProvides a resource for oncologists and nephrologists, as well as general internal and family medicine practitioners, and physicians in training"

Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of "Gene Therapy of Cancer" provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive.

Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies.

In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response.
Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategiesCovers the breadth of gene therapy approaches including immunotherapeutic, drug resistance, oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers AEG-1/MTDH/Lyric implicated in multiple human cancers.
Provides information on cancer researchOutstanding and original reviewsSuitable for researchers and students

2013 Reprint of 1939 Edition. Full facsimile of the original edition, not reproduced with Optical Recognition Software. Georges Lakhovsky (1869-1942) was a Russian engineer, scientist, author and inventor. His controversial medical treatment invention, the Multiple Wave Oscillator, is described as having been used by him in the treatment of cancer. Lakhovsky published books and articles that claimed and attempted to demonstrate that living cells emit and receive electromagnetic radiations at their own high frequencies. In 1939 he published "The Secret of Life: Electricity, Radiation and Your Body" in which he claimed and attempted to demonstrate that good or bad health was determined by the relative health of these cellular oscillations, and bacteria, cancers, and other pathogens corrupted them, causing interference with these oscillations. Numerous depictions pictured in the book supposedly have Lakhovsky in a Paris, France hospital conducting clinical research treating cancer patients with before, during, and after photographs.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

First published in 1943, "Vitamins and Hormones" is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, "Vitamins and Hormones" continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hormones and breast cancer.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

The Understanding Breast Cancer chart presents an overview of the symptoms, types and stages of breast cancer in women. The anatomy of the breast is shown, including the lymph nodes. The breast self exam is covered, showing types of movement. Text and graphics describe treatment options.

This fully updated edition provides the most recent advances in cancer cell signaling knowledge combined with some discussion of the current challenges and prospects in cancer therapy. Beginning with an important section on cancer resistance, the main obstacle to effective cancer therapy, the book continues with chapters exploring state-of-the-art methods in epigenetic control of cancer, metastasis promotion, as well as a variety of new technologies in the study of cancer. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Cancer Cell Signaling: Methods and Protocols, Third Edition serves as an ideal guide to researchers seeking to overcome the challenges in the vital field of cancer cell signaling.

Developed by the American Cancer Society this new textbook designed for a wide range of learners and practitioners comprehensively addresses all aspects of cancer diagnosis and treatment taking a balanced, authoritative and, -where possible- evidence-based stance. Edited by leading clinicians in the field and a stellar contributor list from the US and Europe, this book is written in an easy to understand style by multidisciplinary teams of medical oncologists, radiation oncologists and other specialists, reflecting day-to-day decision-making and clinical practice. Input from pathologists, surgeons, radiologists, and other specialists is included wherever relevant and comprehensive treatment guidelines are provided by expert contributors where there is no standard recognized treatment. This book is an ideal resource for anyone seeking a comprehensive understanding of the field of oncology, with an emphasis on prevention and early detection.

This book presents the state of the art in high-flow nasal cannula (HFNC), an oxygen therapy technique that has recently proven to be a very promising approach to supporting respiratory function in several medical fields.In the opening part of the book, readers will learn the differences between high-flow and low-flow techniques and gain an overview of HFNC's technical aspects and physiological effects. The book subsequently describes the pathophysiological mechanisms involved in different respiratory diseases, analyzing how this technique positively impacts patients' respiratory status. The authors highlight clinical applications of HFNC, both in adults and in children, in various clinical settings - e.g. intensive care and semi-intensive care unit, emergencies, rehabilitation etc. - and present tips, tricks and pitfalls, as well as up-to-date reports on technical issues. The book is intended for pneumologists, intensivists, anesthesiologists, ED doctors, rehabilitation therapists, internists and oncologists, as well as fellows and nurses in these fields.

Lead Compounds from Medicinal Plants for the Treatment of Cancer is the first volume in the series, Pharmaceutical Leads from Medicinal Plants. The plant species described in this reference have been carefully selected based on pharmacological evidence and represent today s most promising sources of natural products for the discovery of anti-cancer drugs. Containing references to primary source material, over a hundred botanical illustrations, a table of chemical structures and much more, this book is an essential starting point for cancer researchers and those involved in anti-cancer drug discovery helping you identify the best novel lead molecules for further anti-cancer drug development.
Provides a compilation of hundreds of medicinal plants from Europe, Asia, North and South America and Africa that contain prominent lead candidates for anti-cancer drug discoveryContains primary source references and hundreds of the most relevant citations from the current literature for additional researchOffers cancer researchers and pharmaceutical scientists valuable tools such as chemical structures and promising pharmacological data to help them select the novel lead compounds that will best aid drug discovery. "

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Applications of viruses for cancer therapy." With outstanding and original reviews, this volume covers topics such as Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes, esign of improved oncolytic adenoviruses, and Adenovirus-based immunotherapies for cancer.
Provides invaluable information on the exciting and fast-moving field of cancer researchThis thematic volume looks at "Applications of viruses for cancer therapy"Outstanding and original reviews

Over the past decade, PET-CT has achieved great success owing to its ability to simultaneously image structure and function, and show how the two are related. More recently, PET-MRI has also been developed, and it represents an exciting novel option that promises to have applications in oncology as well as neurology. The first part of this book discusses the basics of these dual-modality techniques, including the scanners themselves, radiotracers, scan performance, quantitation, and scan interpretation. As a result, the reader will learn how to perform the techniques to maximum benefit. The second part of the book then presents in detail the PET-CT and PET-MRI findings in cancers of the different body systems. The final two chapters address the use of PET/CT in radiotherapy planning and examine areas of controversy. The authors are world-renowned experts from North America, Europe, and Australia, and the lucid text is complemented by numerous high-quality illustrations.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Guidance molecules in Cancer and cancer angiogenesis" and contains outstanding and original reviews.
Provides invaluable information on the exciting and fast-moving field of cancer research. This volumelooks at "Guidance molecules in Cancer and cancer angiogenesis."Outstanding and original reviews"

Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.