This practical guide summarizes the principles of working with dying patients and their families as influenced by the commoner world religions and secular philosophies. It also outlines the main legal requirements to be followed by those who care for the dying following the death of the patient. The first part of the book provides a reflective introduction to the general influences of world religions on matters to do with dying, death and grief. It considers the sometimes conflicting relationships between ethics, religion, culture and personal philosophies and how these differences impact on individual cases of dying, death and loss. The second part describes the general customs and beliefs of the major religions that are encountered in hospitals, hospices, care homes and home care settings. It also includes discussion of non-religious spirituality, humanism, agnosticism and atheism. The final part outlines key socio-legal aspects of death across the UK. Death, Religion and Law provides key knowledge, discussion and reflection for dealing with the diversity of the everyday care of dying and death in different religious, secular and cultural contexts. It is an important reference for practitioners working with dying patients, their families and the bereaved.

In this issue of Thoracic Surgery Clinics, Guest Editor Farid Shamji brings considerable expertise to the topic of Lung Cancer in this second issue covering this topic. Top experts in the field cover key topics such as biological treatments, improving anesthesia safety in pulmonary resection for lung cancer, history of surgical instruments in thoracic surgery, The Hemithorax - the empty chest syndrome, and more. Provides in-depth, clinical reviews on lung cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 16 relevant, practice-oriented topics including Assessment of Operability and Resectability in Lung Cancer; Complications of chest wall resection in conjunction with pulmonary resection; Sepsis in the postpneumonectomy space: pathogenesis, recognition and management; Neuroendocrine cancers of the lung: natural history, pathological classification, biological behaviour and treatment; and more.

Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics provides a review of the basic anatomy, physiology, biochemistry and pathology of the eye with a focus drug therapy, drug delivery and use of therapeutic medical miniature devices. An understanding of the pharmacological actions of drugs acting on the eye requires the student and health care practitioner to learn additional principles in basic and clinical sciences that are unique to this organ. As a sensory organ, the eye is relatively inaccessible to the systemic circulation due to the blood-vitreous, blood-aqueous and blood-retinal barriers. Consequently, the administration of drugs for therapeutic effects in the eye necessitates an understanding of physico-chemical properties of the molecules and pharmacokinetic principles involved in the access to its site of action via topical, intracameral and intravitreal administration. This book includes information on the general principles of pharmacokinetics and pharmacodynamics of drugs as it pertains to the eye and in combating ocular disorders and diseases. Using a disease-themed approach, the book discusses basic and clinical pharmacological principles involved in the therapy of these diseases including the ocular side effect of systemically-administered drugs, drugs used in ophthalmic surgery and miscellaneous agents, the therapeutic utility of biologics, drug conjugates, combination products, gene and cellular therapy are also covered. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics is useful as a primary and secondary source of reference for up-to-date information about the pharmacological mechanisms of action, pharmacokinetics, side effects, drug-drug interactions and therapeutic indications of drugs for pharmacologists, pharmaceutical scientists, students in the health care disciplines (nursing, pharmacy, optometry, medical), and practitioners in optometry and ophthalmology.

In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications. Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.

The best and most concise single source for state-of-the-art diagnosis and treatment of lung cancer -newly revised, updated, and expanded.Lung cancer has long been the number-one cause of death from cancer every year and the third most frequently diagnosed after breast and prostate cancers. In 2010, about 15% of all cancer diagnoses and 30% of all cancer deaths were due to lung cancer. Needless to say, there is a great need for more rapid advancements in diagnosis and treatment of this devastating disease.

Here is the comprehensively revised, updated, and expanded edition of the well-established, evidence-based reference book that deals with the most recent advances in lung cancer prevention, screening, diagnosis, research, and treatment for the clinician. Edited and authored by leading authorities in the field, this Fourth Edition of the highly regarded" Lung Cancer" is better than ever -featuring nine new chapters along with seven re-formatted ones that are nearly brand new in content and approach. It covers Smoking Prevention and Cessation; Molecular Profiling; Somatic Genome Alterations in Human Lung Cancers; Management of Multi-Focal Bronchioloalveolar Carcinoma (BAC); Primary Tracheal Tumors; Predictive Tumor Biomarkers for EGFR Inhibitors; Non-Small Cell and Small-Cell Lung Carcinoma; and more.

This Fourth Edition of "Lung Cancer" Provides the very latest research in the identification of biomarkers to predict a high risk for developing lung cancer - vital for implementing screening, diagnosis, and prevention strategiesPresents the newest lung cancer staging system, as well as updated and cutting-edge surgical and radiation therapy techniques that make local tumor control more effective and less invasive while sparing normal tissuesDiscusses combined modality therapy and new chemotherapeutic agents which are yielding higher response rates and improved survival when used in the adjuvant setting or concurrent with highly sophisticated radiation or proton treatmentOffers novel and emergent approaches to preventative, diagnostic, and therapeutic modalities with an emphasis on the best evidence available from the latest studies and clinical trials

With almost half of the revised and updated content being brand new, "Lung Cancer," Fourth Edition, is an important and vital resource for all medical professionals and students involved in the care and treatment of those struck with this catastrophic illness.

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.

This authoritative work, now in its fourth edition, presents state of the art knowledge on all key aspects of cancer prevention. In addition to detailed summaries on preventive strategies for specific cancers, readers will find current knowledge on a range of relevant scientific topics including the benefits of cancer prevention, the importance of diet and physical activity, innate and adaptive immune responses to cancer, hereditary risks, cancer health disparities, and the preventive role of telemedicine. In this new edition of the book, the coverage has been expanded to include additional disease sites and to provide up-to-date information across the range of disciplines in the field of cancer prevention and control. Written as a collaborative work by internationally recognized leaders in the field, Fundamentals of Cancer Prevention is an essential reference guide and tool for oncologists, primary care physicians, the research community, and students with an interest in reducing the burden of cancer through the implementation of effective preventive strategies.

Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models.

"..it is increasingly clear that cancer is also a disease of inertia. In this book, a broadly multidisciplinary group presents the evidence and provides the recommendations. ... The antidote to diseases of inertia is movement - let's move!" John Potter, M.D.,Ph.D., from the Foreword The American Cancer Society estimates that a third of all cancer deaths could be prevented through avoidance of obesity and the rejection of sedentary lifestyles. The World Health Organization also supports this claim. Additionally, these and other organizations now recognize the role that activity can play in improving the quality of life for cancer patients. Cancer Prevention and Management through Exercise and Weight Control provides us with the support necessary to make a call to action. Itbrings together the contributions of world-class researchers to lay out the evidence and a plan of attack for coping with this crisis. The text begins by focusing on the research methods used in assessing the complex associations between activity, energy balance, and risk and prognosis. In comprehensive literature reviews, the authors consider the role of physical activity in the incidence of individual cancers, then explore the mechanisms that might explain this connection. They continue with a look at the relation between weight and cancer incidence, including a consideration of genetics. Research is also provided linking physical activity and weight control to a cancer patient's quality of life and prognosis. The work concludes with ideas on how a plan of action might be implemented at the individual, clinical, and public health levels. It also provides guidance on incorporating exercise and diet recommendations into clinical oncology practice.

This issue of Hematology/Oncology Clinics, guest edited by Dr. Glenn J. Hanna, will focus on Head and Neck Cancer. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. This issue addresses the evaluation and management of the complex head and neck cancer patient with articles focused on unique epidemiology and therapeutic principles by subsite of disease. Additional information relevant to rare head and neck malignancies is included. The issue further focuses on the evolving applications of minimally invasive surgery in oropharynx cancer and the role of immunotherapy in the management of advanced disease. Topics include: Radiologic Evaluation of the Head and Neck Cancer Patient, Robotic and Endoscopic Approaches to Head and Neck Surgery, Cancer of the Oral Cavity and Lip, Cancer of the Oropharynx and the Association with Human Papillomavirus, Cancer of the Larynx and Hypopharynx, Cancer of the Nasal Cavity and Paranasal Sinuses, Cancer of the Nasopharynx and the Association with Epstein-Barr Virus, Salivary Glands Cancers, Thyroid and Parathyroid Cancers, Cutaneous Malignancies of the Head and Neck, Managing Recurrent and Metastatic Head and Neck Cancer, and Immunotherapy for Head and Neck Cancer. Provides in-depth, clinical reviews on head and neck cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Diagnosis and Treatment of Gastrointestinal Cancers, guest editors Drs. Marta Davila and Raquel E. Davila bring their considerable expertise to the topic of Diagnosis and Treatment of Gastrointestinal Cancers. The early detection, diagnosis, and accurate staging of GI cancers, along with enhanced imaging techniques, new therapies, and a greater understanding of GI tumors at the molecular level, has revolutionized the approach to GI cancer patients in recent years. In this issue, distinguished authors recognized internationally as leading authorities in the field provide an exhaustive review of the latest topics in GI cancer. Contains 13 practice-oriented topics including management of Barrett's esophagus and early esophageal adenocarcinoma; familial pancreatic cancer; colorectal cancer: screening and early detection; the microbiome in gastrointestinal cancers; and more. Provides in-depth clinical reviews on diagnosis and treatment of gastrointestinal cancers, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Radiologic Clinics, guest editor Dr. Hillary W. Garner brings her considerable expertise to the topic of Imaging of Bone and Soft Tissue Tumors and Mimickers. Top experts provide timely articles on the imaging findings and other relevant clinical information of frequently encountered benign and malignant tumors of bone and soft tissue, in addition to separate reviews on common and potentially confusing tumor mimics. In addition, orthopaedic oncologists have contributed valuable perspectives on how they incorporate imaging information into their patient care plans. Contains 11 relevant, practice-oriented topics including bone tumors: what the oncology team wants to know; bone tumors: imaging features of common and rare benign entities; bone tumors: common mimickers; soft tissue tumors: what the oncology team wants to know; soft tissue tumors: common mimickers; bone and soft tissue tumors: horizons in radiomics and artificial intelligence; and more. Provides in-depth clinical reviews on imaging of bone and soft tissue tumors and mimickers, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This popular textbook provides a clear and comprehensive introduction to the principles and practice of clinical oncology. Ideal for medical undergraduates, clinicians and other health professionals who want to increase their understanding of the challenges of managing patients with cancer, the book enables readers to learn and then test themselves on all aspects of cancer medicine, from epidemiology, aetiology, pathogenesis and presentation, through to diagnosis, staging, management and prognosis.

Mindfulness-based Cognitive Therapy for Cancer presents an eight-week course for MBCT which has been tried and tested over ten years of clinical use, and is targeted specifically for people with cancer. * There is growing evidence of mindfulness as a successful and cost-effective intervention for reducing the negative psychological impact of cancer and treatment * Draws upon the author s experience of working with people with cancer, and her own recent experience of using mindfulness with cancer diagnosis and treatment * Stories from cancer patients illustrate the learning and key themes of the course * Includes new short practices and group processes developed by the author

This book provides essential insights into the various pathogeneses, diagnoses and therapies for patients with gastric cancer. Special attention is given to trending topics: endoscopic diagnosis, cancer screening and eradication of H. pylori as prevention of the disease. A dedicated section focuses on risk classification and cancer screening/diagnosis, and is intended for practical use in clinical doctors' day-to-day management of patients. Since cancer screening and prevention is currently only practiced in Japan, this book is intended to disseminate new findings and serve as a point of departure for further research. Abundant color illustrations of the enhanced endoscopic imaging are also included, making it a valuable resource for GI medical doctors, medical students and those seeking detailed information on H. pylori.

Integrative health pioneer offers her groundbreaking approach to treating (and preventing) cancer, based on 6 Revolutionary Findings, with a practical program and strategies. When it comes to cancer, conventional doctors are trained to treat their patients exclusively with surgery, radiation, and chemotherapy. These methods are grueling on the whole body--and they don't treat beyond the tumor or the cancer itself. The focus is on the disease, not the whole person--and because of this, the outcomes in conventional medicine can be bleak. But it doesn't have to be this way. Dr. Leigh Erin Connealy has developed a whole-person approach to treating cancer--and these treatments have helped thousands of patients through her Cancer Center for Healing. In The Cancer Revolution, Dr. Connealy shows you how to get to the root causes of cancer and the practical steps you can take to get back on the path to healing--from balancing your body's chemistry with nutritional supplements, following a healthy food plan, detoxifying your body and home, exercising regularly, getting deep restful sleep every night, practicing stress reduction techniques, and putting together a supportive healing team. Chemotherapy and radiation have their place in treatment, but in many cases, they are simply not enough, because cancer isn't caused by one thing, but by many different factors. All of these causes must be addressed, not just the tumor. The Cancer Revolution will equip you to make impactful, achievable lifestyle choices that fight the root of the disease, and that offer hope for recovery and a cancer-free life.

The entire span of a woman's reproductive years and beyond is the scope of this volume, which presents research covering events from first menstruation through the post-menopausal years. Special care has been taken to balance basic research and clinical information.

The volume comprises chapters on first menstruation, hypothalamic amenorrhea, implantation and recurrent abortion, XX metabolic syndrome, endometriosis, menopause, osteoporosis, minimally invasive surgery, assisted reproduction, ultrasound imaging in obstetrics, estrogen receptor modulators, and urogynecology. Papers on fertility drugs and gynecologic cancer, contraception today, prenatal genetic diagnosis, cloning and stem cells, transdermal hormone therapy, and estrogen and brain function will also be included.

Authors from the International Federation of Gynecology and Obstetrics will address issues such as, Is there an optimal rate for cesarean section? and fistulas in Africa, as well as perinatal mortality in Europe.

This volume is the latest proceedings of a series of meetings that has been held in Athens for over a decade, and the participants are internationally known authorities in their fields.

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An extensive reference work, Textbook of Melanoma presents the latest information on the causes, diagnosis, and treatment of this increasingly common type of cancer. It distinguishes itself by its scholarship, its comprehensive treatment of all aspects of the disease, its accessibility, and especially its focus. The breadth and depth of the coverage is reflected by the wide range of international authors, all experts in their respective fields, profiling everything from prevention strategies to gene therapy. The result is a comprehensive review of current knowledge, a guide to what is currently regarded as best clinical practice, and a preview of future developments.

Clinical Oncology and Error Reduction fills a gap - the lack of a single volume on medical error in the vast field of cancer care - that has existed since a 1999 Institute of Medicine's report introduced the term 'medical error' as a topic for doctors and patients alike. The volume, edited by Antonella Surbone, M.D., a clinical oncologist and Michael Rowe, Ph.D., a medical sociologist, includes chapters written by experts on the topic including physicians, nurses, patients, and advocates, and covers a wide range of topics essential to an understanding of the unique character, challenges, and needed responses to the risk, incidence, and aftermath of medical error in the diagnosis, treatment, and aftermath of treatment for cancer. Clinical Oncology and Error Reduction will serve as the standard for framing the discussion of error in the field for oncologists, epidemiologists, nurses, healthcare administrators, researchers, and scholars. An indispensable handbook for all clinical oncologists, their staff, nurses, and oncology residents and fellows, this book: Contains practical information for immediate clinical application Covers topics such as patient safety, error prevention, quality improvement, errors disclosure and apology, and the impact of errors on patients and doctors Each chapter contains special "take home" points that highlight issues of particular clinical relevance and application Prepared by an expert, multidisciplinary, international team of physicians, nurses, researchers, hospital administrators, bioethicists, patients and patient advocates Dr. Surbone shared with ASCO Connection her insights about patient safety and medical errors and offered a glimpse into the history that led to this new book: https://connection.asco.org/magazine/features/opening-dialogue-about-medical-errors

This book covers novel strategies and state of the art approaches for automated non-invasive systems for early prostate cancer diagnosis. Prostate cancer is the most frequently diagnosed malignancy after skin cancer and the second leading cause of cancer related male deaths in the USA after lung cancer. However, early detection of prostate cancer increases chances of patients' survival. Generally, The CAD systems analyze the prostate images in three steps: (i) prostate segmentation; (ii) Prostate description or feature extraction; and (iii) classification of the prostate status. Explores all of the latest research and developments in state-of-the art imaging of the prostate from world class experts. Contains a comprehensive overview of 2D/3D Shape Modeling for MRI data. Presents a detailed examination of automated segmentation of the prostate in 3D imaging. Examines Computer-Aided-Diagnosis through automated techniques. There will be extensive references at the end of each chapter to enhance further study.

Inflammation and Oral Cancer: From Bench to Bedside discusses all aspects surrounding the relationship between inflammation and oral cancer, from basic science to the translational research that helps in the optimization of clinical management strategies. The book discusses topics such as chronic inflammation and cancer in oral cavity, the role of HPV in oral inflammation and cancer, rodent models of oral cancer, and epigenetics in oral inflammation and cancer. This is a valuable resource for cancer researchers, oncologists and members of biomedical field who are interested in learning more about the diverse aspects of inflammation and oral cancer. Inflammation in oral mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it can have fundamental clinical consequences, the principal of which can be premalignant lesions throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for oral cancer - therefore it is very important to understand these interactions in detail.

An innovative, three-dimensional x-ray imaging technique that enhances projection radiography by adding depth resolution, Tomosynthesis Imaging explores tomosynthesis, an emerging limited-angle tomographic imaging technology that is being considered for use in a range of clinical applications, and is currently being used for breast cancer screening and diagnosis. While conventional mammography has been very successful in reducing breast cancer mortality, it is not perfect. A major limitation of mammography is that the recorded image represents the superposition of complex three-dimensional structures in the breast onto a two-dimensional plane, making detection and diagnosis of breast cancer challenging. Tomosynthesis produces quasi-three-dimensional images that can significantly enhance the visualization of important diagnostic features. This book highlights the flexibility of tomosynthesis systems for new clinical applications, and provides a detailed discussion of the tomosynthesis acquisition process and the impact of physical factors. It explores such topics as acquisition parameters, system components, modeling, image reconstruction algorithms, and system evaluation. Provides in-depth coverage of system design considerations, as well as image reconstruction strategies Describes the current state of clinical applications of tomosynthesis, including imaging of the breast and chest, as well as its use in radiotherapy Illustrates the merits of tomosynthesis imaging and its potential clinical applications in imaging of the breast and chest, as well as for radiation therapy Divided into five sections, this text delves into the history and development of tomosynthesis. It introduces tomosynthesis imaging, discusses imaging system design considerations, and reviews image reconstruction algorithms that have been developed for tomosynthesis. It also describes system evaluation methodologies, emphasizes current clinical applications, and examines the future direction for tomosynthesis.

Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies discusses the current understanding of breast cancer tumor microenvironment components, their role in tumorigenicity and the development of therapeutic resistance, along with updates on recent advances.

This book provides an overview of the key developments in both acute lymphocytic leukemia and acute myeloid leukemia with a comprehensive guide to the epidemiology, pathogenesis, etiology, clinical manifestations, classification, diagnosis, and staging as well as the most recent developments in the therapeutic landscape for acute leukemia. The Handbook of Acute Leukemia offers readers a key resource into the future outlook for patients with leukemia and is edited and authored by internationally renowned experts in the field. Leukemia is cancer of the white blood cells and acute leukemia means the condition progresses rapidly and aggressively, requiring immediate treatment. Acute leukemia is classified according to the type of white blood cells that are affected: either lymphocytes and myeloid cells.