With increasing emphasis on the early diagnosis and management of urologic tumours, it is imperative that the practising urologist comprehend the relevance of the morphology for the clinical diagnostic and therapy. Moreover, the clinician should be fully informed of the importance of modern morphological methods for the diagnosis and management of urological tumours. Not only is this highly illustrated text a necessary adjunct in the attending urologist's armamentarium, it will also satisfy the needs of residents in pathology or even of pathologists, who are not daily faced with urological tumours. The structure of the chapters follows a uniform schema: short introduction with the definition of the tumour/ tumours, clinical history epidemiology, aetiology, gross morphology, microscopy, tumour genetics, importance of ancillary methods for the diagnosis, differential diagnosis, principles of grading and staging, morphological prognostic factors, and clinical course. The tables showcase the latest WHO histological classification of the tumours of the single organs, the integral (or complete) form of the latest TNM staging version, and the principles of the international accepted grading systems (kidney, bladder, prostate, penis ). A short chapter is devoted to handling procedures for surgical specimens and biopsies by clinicians.

Prognostic and Predictive Factors in Gynecologic Oncology takes a fresh look at a critical aspect of cancer treatment planning. An international team of authors reviews the traditional prognostic and predictive factors such as tumor grade, histologic subtype, and grade and then goes a step further to review the growing number of molecular discoveries that have increasing clinical significance. The book is organized into comprehensive sections on ovarian, endometrial and cervical cancer and includes up to date reviews, newly discovered molecular pathways, genetic markers, molecular imaging techniques, and their relevance to clinical medicine.

Prognostic and Predictive Factors in Gynecologic Oncology is illustrated with over 100 figures and is essential reading for oncologists, translational and basic scientists, as well as fellows, residents and students with a special interest in gynecologic oncology.

Over the past decade interventional radiology techniques have replaced surgical and clinically guided diagnostic procedures such that the vast majority of patients have a non surgical diagnosis of a breast problem. Interventional Ultrasound of the Breast, written by a collection of well-established and respected authors from the UKa (TM)s leading cancer centres, is an invaluable reference for all medical and clinical oncologists, breast surgeons and radiologists.

"Textbook of Lung Cancer, 2nd edition, " published in association with the European Society of Medical Oncology, is a comprehensive and multidisciplinary text, which examines all aspects of this disease, with contributions from a multinational team of authors on etiology, epidemiology, molecular biology, pathology, smoking, detection and management, clinical features, staging and prognostic factors, surgery, radiotherapy and chemotherapy. It provides essential information and guidance for specialist trainees in oncology, and for the many physicians and specialists involved in the field of lung cancer.

Primary bile duct cancers are rare and generally aggressive entities. Historically, this disease was managed exclusively with surgical therapy with few long-term survivors. However, with improvements in chemotherapeutics, targeted therapy, interventional radiology techniques and development of alternative surgical approaches, treatment has moved to the utilization of a multidisciplinary care team employing multimodality treatments which has finally led to improvement in outcomes. In this book, Chapter One examines symptoms and the current state of medical and surgical management of bile duct cancer, while Chapter Two discusses the clinical aspects of care of extrahepatic biliary cancers with an emphasis on diagnosis and management. Chapter Three assesses the risk of bile duct cancer among beneficiaries of The Health Insurance Society of Printing Industry (HISPI) using diagnosis-procedure-combination (DPC) data in comparison with general population. Chapter Four concludes with a summary of results for chemotherapy and targeted therapies.

The last few years have seen major advances in all aspects of the understanding and treatment of kidney cancer, particularly the commonest variant clear cell carcinoma of the kidney. This book brings the reader up to date with these developments, covering aetiology, epidemiology, pathogenesis, prognostic factors, presentation, interventional radiology, minimally invasive surgery, surgery for locally advanced tumours and for metasatic disease, adjuvant medical therapies, therapies for advanced disease, radiotherapy and palliation of symptoms. Each chapter is written by acknowledged experts in the field. The reader gains an excellent idea of the state of the art in the treatment of kidney cancer in an accessible format.

This book provides a comprehensive visual review of pathologic disease variations of the five main types of gynecologic cancers: ovarian, endometrial, cervical, vaginal, and vulvar. Through the use of cross-sectional imaging modalities, including computed tomography, magnetic resonance imaging, ultrasound, and positron emission tomography, it depicts normal anatomy as well as common gynecological tumors. For each type of cancer, aspects such as primary staging, recurrence patterns, and findings from different yet complementary imaging modalities are explored. Atlas of Gynecologic Oncology Imaging presents a coherent perspective of the roles of standard and cutting-edge imaging techniques in gynecologic oncology via a multidisciplinary approach to cancer care. Featuring over 600 images, this book is a valuable resource for diagnostic radiologists, radiation oncologists, and gynecologists.

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

Exploring a technology that is significantly impacting the noninvasive evaluation of the physiology and anatomy of tumors, as well as the diagnosis of infectious processes and cardiac diseases, this source presents recent advances and clinical applications of sequential, single session single-photon emission computed tomography and computed tomography imaging. This source is written by pioneers in hybrid imaging and offers authoritative sections on state-of-the-art breakthroughs in sentinel lymph node identification, cardiac imaging, and the study and treatment of a variety of disorders including lymphoma, thyroid and parathyroid tumors, neuroendocrine tumors, prostatic cancer, and bone metastases.

Bladder cancer is the fifth most common cancer of American men and the eighth most common cancer of American women, with sixty thousand new cases of the disease diagnosed each year in the US alone. Disease prevalence is high in western nations due to the predominance of the chronic relapsing form of cancer that occurs in these countries (USA prevalence estimated to be 600,000; NCI-SEER database), and this single fact makes bladder cancer one of the most expensive cancers to treat. expertise of an international community of experts in the area. All aspects of disease biology, diagnosis and treatment are addressed. Appropriate for scholars and students of medicine at all levels, it promises to become a key text in the field.

Written by over 250 of the world's leading urologists and uro-oncologists from the USA, Canada, UK, Austria, Belgium, Finland, France, Germany, Ireland, Italy, the Netherlands and Singapore, who tackle prostate cancer on a daily basis, this comprehensive and fully up-to-date illustrated text reference covers the etiology, pathophysiology, diagnosis, management and treatment of early and advanced prostate cancer. advanced non-surgical procedures, Prostate Cancer: Principles and Practice focuses on the following key areas: * the pathology and etiology of prostate cancer assessing the prostate, whether qualified or in training.

Although a wealth of information can be found scattered throughout periodicals and research papers, tracking down the most effective treatment for a heterogeneous syndrome such as cachexia can be problematic. Edited by experts in the field, with contributions from a multidisciplinary panel, Pharmacotherapy of Cachexia is the first book devoted solely to the treatment of cachexia with a focus on pharmacotherapeutic aspects. The book discusses the various aspects of the syndrome and compares and contrasts its diverse treatment options. It explores the topic from a theoretical and practical perspective and provides an overview of currently available and future treatment. The first half of the book includes coverage of pathophysiology, associated diseases, and general therapeutic aspects. The subsequent sections devoted to pharmacotherapy cover drugs in clinical use, drugs in research and development, and the final section focuses on potential future advancements. Numerous internationally recognized specialists have contributed chapters on the various aspects of cachexia to this book. Their critical evaluation of pathophysiological mechanisms, clinical features, and therapeutic options make it a valuable source of information on all aspects of this serious and life-threatening condition. Expert editorial guidance ensures minimal repetition of information and uniform presentation. Addressing the multiple disease processes associated with cachexia in an organized and useful way, the book is a comprehensive reference for the management of this recalcitrant and hard-to-treat syndrome.

The rapid rate of development in the fields of prevention, early detection and management for colorectal cancer means that the successful first edition of this accessible guide has needed to be updated and revised throughout. Primary care physicians and specialists alike will continue to find this an indispensable synopsis of the issues and options.

Disability is part of human life and most of us will, at some time during our lifetime, experience an impairment or difficulty in our functioning, either by disease or in our old age. Once upon a time, disability in a person resulted in many kinds of disadvantages and shunning from society as a whole, but in our time society has changed attitudes toward this part of our population. The idea today is to transform a disability into an ability and to support and help this population in any way possible via treatment, interventions or new technology to make a better quality of life and an optimal functioning, despite the disability or chronic disease. Chronic disease for example is a long lasting condition that can be somehow controlled, but not cured. This lifespan approach to chronic diseases was the topic of the Gerry Schwartz and Heather Reisman 4th International Conference on Pediatric Chronic Diseases, Disability and Human Development held in Jerusalem, Israel during January 21-23, 2015 and in this book you will find the abstracts from the conference.

This authoritative reference compiles the latest studies on the epidemiology, diagnosis, and treatment of uterine cancer and offers an extensive review of the molecular pathogenesis of endometrial and uterine disorders-analyzing patterns of disease presentation as population demographics change and considering the challenges this will place on future healthcare procedures.

Drawing on the real-world experience of leading experts in oncological medicine, this reference serves as an invaluable source of guidance for anyone specializing in the care of acutely ill cancer patients-providing quick reference to effective techniques, therapies, and approaches for surgical, medical, pediatric, pain, and general oncology issues.

"Keto for Cancer brings clarity to this emerging science and makes implementation of this information straightforward and uncomplicated."-David Perlmutter, New York Times bestselling author "This book addresses every question or concern that cancer patients might have in using a ketogenic metabolic strategy for managing their cancer."-Thomas Seyfried ,PhD THE comprehensive guide for patients and practitioners from a foremost authority in the emerging field of metabolic therapies for cancer. Although evidence supporting the benefits of ketogenic diet therapies continues to mount, there is little to guide those who wish to adopt this diet as a metabolic therapy for cancer. Keto for Cancer fills this need. Nutritionist Miriam Kalamian has written the book to lay out comprehensive guidelines that specifically address the many challenges associated with cancer, and particularly the deep nutritional overhaul involved with the ketogenic diet. Kalamian, a leading voice in the keto movement, is driven by passion from her own experience in using the ketogenic diet for her young son. Her book addresses the nuts and bolts of adopting the diet, from deciding whether keto is the right choice to developing a personal plan for smoothly navigating the keto lifestyle. It is invaluable for both beginners and seasoned users of the ketogenic diet, as well as for health-care professionals who need a toolkit to implement this targeted metabolic therapy. The book guides readers to a deeper understanding of the therapeutic potential of the ketogenic diet-which extends well beyond simply starving cancer-emphasizing the powerful impact the diet has on the metabolism of cancer cells. Nutritional nuances and meal templates and tracking tools are explored in sections such as: Fasting Protocols Know What's in the Foods You Eat Preparing Keto Meals Put Your Plan Into Action Kalamian also discusses important issues such as self-advocacy empowering readers by offering tips on how to critically examine cancer-care options and then incorporate what resonates into a truly personalized treatment plan.

This compact, illustrated handbook is a concise but comprehensive resource that introduces medical students, general medical practitioners and gynecologists to the significance of the human papillomaviruses in the etiology of cervical cancer. All chapters are fully referenced and written by experts in the field. The content review virus structure, the epidemiology of HPV, the latest advances in HPV vaccination, and new markers for cervical disease.

.,"it is increasingly clear that cancer is also a disease of inertia. In this book, a broadly multidisciplinary group presents the evidence and provides the recommendations. ... The antidote to diseases of inertia is movement - let's move!"

"John Potter, M.D., Ph.D., from the Foreword"

The American Cancer Society estimates that a third of all cancer deaths could be prevented through avoidance of obesity and the rejection of sedentary lifestyles. The World Health Organization also supports this claim. Additionally, these and other organizations now recognize the role that activity can play in improving the quality of life for cancer patients.

Cancer Prevention and Management through Exercise and Weight Control provides us with the support necessary to make a "call to action," Itbrings together the contributions of world-class researchers to lay out the evidence and a plan of attack for coping with this crisis. The text begins by focusing on the research methods used in assessing the complex associations between activity, energy balance, and risk and prognosis. In comprehensive literature reviews, the authors consider the role of physical activity in the incidence of individual cancers, then explore the mechanisms that might explain this connection. They continue with a look at the relation between weight and cancer incidence, including a consideration of genetics.

Research is also provided linking physical activity and weight control to a cancer patient's quality of life and prognosis. The work concludes with ideas on how a plan of action might be implemented at the individual, clinical, and public health levels. It also provides guidance on incorporating exercise and dietrecommendations into clinical oncology practice.

Integrative Oncology is a comprehensive, evidence-based approach to cancer care that addresses all individuals involved in the process, and can include the use of complementary and alternative medicine (CAM) therapies alongside conventional modalities such as chemotherapy, surgery and radiation therapy. The number of integrative care programs is increasing worldwide and this book forms a foundation text for all who want to learn more about this growing field. Bringing together some of the most progressive and important thinking in the area, key features of the book include: - insightful descriptions of models of integrative care, and of the perspectives and practices of alternative systems of healing - discussions of the transformational experience that the cancer care process may bring for physicians and patients - clear summaries of research, business, clinical and legal considerations - reviews of the contributions of CAM therapies to preventive, supportive, antineoplastic, palliative and end-of-life care - comprehensive references regarding the research evidence-base. generous perspective on integrative care, an outstanding overview of the exciting clinical opportunities these techniques can offer, and a guide to the new territories that all oncologists and CAM practitioners need to explore and understand.

Young medical oncologists, who may often find themselves faced by major complications caused by cancer or by cancer treatment, will welcome this handbook as a highly useful tool to develop their knowledge and skills in the area.

Initiated by the European Society for Medical Oncology's (ESMO) Young Medical Oncologists Working Group, this succinct text has been written by a distinguished team of young medical oncologists and senior figures in the field, and is designed to provide oncologists with a secure practical grounding in the correct courses of action to follow in an emergency.

The key topics covered include:

* cardiovascular complications

* neurological complications

* renal and urologic complications

* metabolic complications

* respiratory complications

* gastro-intestinal complications

* hematologic complications

* cancer pain.

In the area of urologic oncology, laparoscopic techniques were met with a 'let's wait and see attitude.' Only recently have outcome data exceeding 5 years become available, thus solidifying the place of laparoscopy in treating genitourinary malignancy. Laparoscopic radical nephrectomy was the first urologic laparoscopic procedure for cancer to significantly decrease the side effects of open surgery while giving equivalent or improved disease specific outcomes. Scepticism about cancer control and difficulty in learning the procedure delayed the dissemination of these techniques to the patient and limited laparoscopic teaching to a few academic laparoscopic centers of excellence. The purpose of this beautifully illustrated surgical text is to share the experience gained by experts of urologic laparoscopy in teaching techniques found to be effective and reproducible. Robert Moore and Jay Bishoff firmly believe that Minimally Invasive Uro-oncologic Techniques will propagate the educational waves started by innovative, courageous surgeons who questioned long-standing, deeply rooted beliefs about surgical norms in order to decrease patient morbidity.

This invaluable reference surveys current practices and emerging breakthroughs in the screening, identification, diagnosis, and treatment of uterine and endometrial malignancies. The book analyzes various signs and symptoms, risk factors, therapeutic options, and ongoing clinical research, as well as the prevention, pathology, and surgical management of early and advanced stages of disease. With contributions from leading authorities on gynecologic cancers, this guide covers recent advances in the molecular phenotyping of endometrial cancer and considers risk factors for endometrial cancer and examines screening methodologies including pelvic ultrasound and endometrial sampling.

Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Contents:
1. Introduction 2. Ultrasound Principles and Anatomy of the Prostate 3. Effect of Radiology on Prostate Histopathology and Assessment of Residual Cancer 4. What Should You Ask Your Pathologist When Contemplating Minimally Invasive Therapy 5. Detailed Mapping of Prostate Carcinoma Foci: Implications for Prostate Brachytherapy 6. Treatment Decisions: Surgery vs. Brachtherapy a Urologist's Perspective 7. Treatment Decisions: a Patient's Perspective on Prostate Brachytherapy 8. Principles of Prostate Brachytherapy Isotope Decisions 9. Use of Artificial Neural Networks in the Clinical Staging of Prostate Cancer: Implications for Prostate Brachytherapy 10. What Do Whole Mount Radical Prostatectomy Specimens Teach Us About Extracapsular Disease. Implications for Prostate Brachytherapy 11. Can Permanent Implants Address Extracapsular Disease, Can Extraprostatic Extension be Treated by Prostate Brachytherapy? An Analysis Based on Postimplant Dosimetry 12. Evaluating the Role of Neoadjuvant Deprivation for Patients Undergoing Prostate Brachytherapy 13. Impact of Hormonal Therapy on Pubic Arch Interference 14. Pre Implantation Urologic Considerations 15. Selection of Equipment for Prostate Brachytherapy 16. Advances Beyond Biplanar Ultrasound for Permanent Prostate Implants 17. What to Look for When Choosing Treatment Planning Software for Prostate Brachytherapy 18. A Comprehensive Review of Prostate Cancer Brachytherapy: Defining an Optimal Technique 19. Planning an Implant: Preplanning Versus Intraoperative Planning 20. Point Kernels and Superposition Methods for Scatter Dose Calculations in Brachytherapy 21. Treatment Planning for High Dose-rate Prostate Brachytherapy 22. High Dose-rate Afterloading Iridium-192 Prostate Brachytherapy 23. Use of Conformal High-dose Rate Brachytherapy for Management of Patients with Prostate Cancer: Optimizing Dose Escalation 24. The Role of High Dose Rate Prostate Brachytherapy in the Management of Prostate Cancer, Treatment Planning and Results from Memorial Sloan-Kettering Cancer Center 25. Modified Uniform Seed Loading for Prostate Brachytherapy: Rationale, Design and Evaluation 26. Treatment Planning and the Seattle Prostate Institute Approach to Treatment Planning for Permanent Implants. 27. Surgical Tips: Improving Ultrasound Imaging During Interstitial Implant 28. Intraoperative Technique 29. Intraoperative Technique Using Pd-103 30. Intraoperative Technique with Biplane Ultrasound and Fluoroscopic Guidance for Optimal Seed Placement 31. Performing a Prostate Implant Under Local Anaesthesia 32. A Prospective Multi-center Study of Transperineal Prostatic Block for Transurethral Needle Ablation (TUNA) of the Prostate 33. Improvement of Transperineal Implant Dosimetry by Intraoperative Cystoscopic Confirmation of Prostate Anatomy Nursing Management of Prostate Brachytherapy Patients 34. Management of Patients Receiving Transperineal Palladium-103 Prostate Implants 35. Prevention of Perineal Hematoma Using the Perineal Pressure Application Device (PPAD) After Prostate Brachytherapy 36. The Role of a Needle Manipulator/ruler in 1125/Pd 103 Preloaded Needle Implants of the Prostate 37. Defining a Quality Prostate Implant 38. Options for a Suboptimal Permanent Prostate Implant 39. Long-term Results. Radiation Oncologist's Perspective 40. Biochemical Outcome After Radical Prostatectomy, External Beam Radiotherapy or 125I Prostate Brachytherapy for Low and Intermediate Risk Prostate Cancer Patients 41. Acute and Chronic Toxicity After IMRT/HDR for Patients S/P TURP, Large Glands, High IPS Scores: Patient Selection, OR Technique, Treatment Planning, Inpatient Management, Catheter Movement and QOL Assessment Long-term Results. A Urologist's Perspective 42. The Intermediate Risk Disease Patient: Is There an Advantage for External Beam Radiotherapy and Implant? 43. Experimental Evaluation of the Rtog Recommendation for Permanent Prostate Brachytherapy Implants 53. Dosimetric Analysis of Urinary Morbidity Following Prostate Brachytherapy (125i vs. 103pd) Combined with External Beam Radiation Therapy 54. Lessons from the Learning Curve Erectile Function Following Prostate Brachytherapy 55. Rectal Complications after Permanent Seed Implants Sexual Dysfunction after Permanent Implant 56. Management of Voiding Dysfunction Following Implantation 57. Transient Elevation of Serum Prostate