"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Elsevier now offers a series of derivative works based on the acclaimed "Meyler s Side Effect of Drugs, 15th Edition." These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician.
There has been significant progress in the development of targeted therapy drugs that act specifically on certain cancers, and that minimize damage to normal cells. Oncologists and cancer researchers will rely on this volume to determine effective drug treatments.
* The only drug guide that includes clinical case studies and expert analysis
* "UNIQUE " Features not only anticancer drugs, but also all other drugs that act upon related organ systems affected by cancer
* Most complete cross referencing of drug-drug interactions available
* Latest content from the most highly regarded compilation of drug side effects: "Side Effects of Drugs Annual" serial"

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including liposome-based chemotherapy and immunotherapy, human polyomaviruses, the role of micro RNAs in CLL, and cancer and cholesterol.

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including nitric oxide-induced apoptosis in tumor cells, detection of minimal residual disease, immunity to oncogenetic human papillomavirus, and modeling prostate cancer in the mouse.

The treatment of cancer in young women and men is increasingly turning from focusing purely on survival to a recognition of the long-term effects of treatment on subsequent quality of life. In this regard, fertility is a very high priority for patients. This is the first book to explain the latest techniques in fertility preservation. Chapters cover fertility preservation in both women and men, management of cancer in pregnancy, egg donation and surrogacy, hormone replacement options, counselling and ethical issues. A multidisciplinary team of over 60 specialists were involved in this work, with contributions from leading obstetricians, medical oncologists, gynaecological oncologists, urologists and fertility specialists. The book is formally supported by the Association of Cancer Physicians (ACP). This highly patient-centred, readable text will be of value to a wide range of clinicians and physicians, and doctors in training, in their daily work.

The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including tumor dormancy, micro RNA, tumor angiogenesis, cancer in mouse models, liposome based chemo and autoimmunotherapy, signaling in angiogenesis, targeted cancer therapy, and regulatory t-cells.

* A highly illustrated guide and reference for haematologists, oncologists and clinical scientists * Guiding investigation, differential diagnosis, prognosis and treatment options Meeting the needs of haematologists, oncologists and clinical scientists for an up-to-date reference, this handbook provides a visual presentation of lymphoproliferative disorders, lymphoid leukaemias and plasma cell neoplasms. Each malignancy is surveyed based on molecular and cellular changes, including histochemistry, cytochemistry and relevant radiographs. Pertinent clinical information relating to clinical presentation, differential diagnosis and prognostic indicators are concisely outlined, using numerous graphics and citing key references in the field.

A clear, concise, and essential guide providing key information about cancer survivors and their needs-and how those needs can best be met. Excellent Care for Cancer Survivors: A Guide to Fully Meet Their Needs in Medical Offices and in the Community is edited by the director of the Lance Armstrong Cancer Survivorship Program at the Dana Farber Cancer Institute and comprised of articles by experts from that prestigious institution, from the Harvard Medical School, and other leading cancer programs. Its goal is simple: to assure that the millions of cancer survivors in the United States get the help they need to live life to its fullest. This timely work, enriched by conversations with cancer survivors themselves, explains the array of challenges that may affect survivors, from physical needs to psychological, spiritual, sexual, and financial issues. Topics such as nutrition and exercise are also addressed, as are risk assessment, rehabilitation, and possible cognitive dysfunction after chemotherapy. A final section explains the nuts and bolts of starting a professional cancer survivorship program, from staffing to fundraising, exploring what can and is being done to help cancer survivors in different settings achieve optimal health and quality of life. Conversations with cancer survivors explaining the physical and psychological challenges/obstacles they face A listing of current cancer survivorship programs across the United States

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal.
The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.
* Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer
* Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination
* Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

As the likely first responder in an emergency, you need quick access to essential information on the potential complications of many different cancer types and treatments. The new edition of this trusted resource provides up-to-date information on the pathophysiology, complications, risks, treatment approaches, prognosis, assessment findings, and nursing and medical interventions for a wide range of cancers. It also offers valuable information to help you fulfill your role as care coordinator and patient advocate, including client education guidelines, discharge procedures, and strategies for helping the client and family deal with the impact of the disease's progression. A consistent format throughout helps you quickly find the information you need, no matter what the topic. This indispensable reference is written and reviewed by both oncology and acute care nurses, ensuring accuracy, currency, and clinical relevance. Coverage of each cancer includes pathophysiologic mechanisms, epidemiology and etiology, risk profile, prognosis, professional assessment criteria (PAC), nursing care and treatment, evidence-based practice update, patient teaching, nursing diagnoses or DSM-IV, evaluation and desired outcomes, and discharge planning with follow-up care, where needed. The latest prognosis statistics give you a realistic picture of the survival possibilities for your patients so you can provide the most appropriate nursing care and patient education. Multiple-choice review questions with answers and rationales at the end of each chapter help reinforce your understanding of key concepts and prepare you for certification examinations. Special boxes highlight pediatric-specific care considerations for working with children. Six new chapters - Biliary and Pancreatic Obstruction, Depression and Cognitive Dysfunction, Dyspnea and Airway Obstruction, GI Obstruction, Heart Failure, and Spiritual Distress - keep you up to date with the latest advances in oncology nursing. Evidence-based rationales in the nursing interventions help you apply the latest research findings to actual practice. Each chapter includes a new section on pathophysiology to help you understand the physiologic processes associated with each oncologic complication.

The "Advances in Cancer Research" series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including RUNX Genes in Development and Cancer; The RNA Continent; The c-myc Promoter; Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond; and Dendritic Cells in Cancer Immunotherapy.