In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy. Randomized Phase II Cancer Clinical Trials explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm phase II trials and many phase II cancer clinical trials still use single-arm designs. The book then presents methods for randomized phase II trials and describes statistical methods for both single-arm and randomized phase II trials. Although the text focuses on phase II cancer clinical trials, the statistical methods covered can also be used (with minor modifications) in phase II trials for other diseases and in phase III cancer clinical trials. Suitable for cancer clinicians and biostatisticians, this book shows how randomized phase II trials with a prospective control resolve the shortcomings of traditional single-arm phase II trials. It provides readers with numerous statistical design and analysis methods for randomized phase II trials in oncology.

Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers - such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy.

Highly Commended, BMA Medical Book Awards 2013 Oncology research and practice in lung cancer continues to develop rapidly. This latest edition of an acclaimed reference briefs the oncology community with a review of the recent literature, emphasizing the most significant therapeutic advances. The expert contributions of Lung Cancer Therapy Annual 7 offer an update of the impact that this information will have on the day-to-day management of the lung cancer patient. New to the seventh edition are four new chapters on the treatment of non-small cell lung cancer (NSCLC) and a new chapter on thymoma. Additional topics include: Oncogenic driver mutations First line therapy of advanced non-small cell lung cancer without activating EGFR mutation Second line therapy of non-small cell lung cancer Adjunct and neoadjunct therapy of non-small cell lung cancer Advances in surgery of lung cancer; advances in radiotherapy of lung cancer Mesothelioma Thymic tumors

First Published in 2017. Routledge is an imprint of Taylor & Francis, an Informa company.

A Diagnostic Atlas of Tumors of the Upper Aero-Digestive Tract brings readers up to date on the correct identification and diagnosis of malignancies of the larynx, pharynx, and esophagus. The atlas provides broad-based coverage of these anatomical areas and highlights the different pathologies physicians may encounter. Key features of this illustrated guide include: A thorough exploration of the entire upper aero-digestive tract and its pathologies Recent advances in flexible endoscopy, which makes visualization, identification, biopsy, and treatment of conditions of the upper aero-digestive tract easier and possible under local anesthesia in an outpatient setting More than 170 high-quality images Accompanying video clips of the technology available online Accessible and concise, the book is suitable for a range of readers, including: Oncologists, Otolaryngologists, Gastroenterologists, Respiratory and ENT physicians, Maxillo-facial, thoracic, and upper gastrointestinal surgeons, medical students, nurses, and medical trainees. Provides a practical overview that details the advantages and pitfalls in transnasal laryngoesophagoscopy Includes analysis and current treatment of both benign and malignant cancers of the nasopharynx, nose/sinuses, oral cavity, oropharynx, larynx, hypopharynx, trachea, esophagus, and thyroid Contains illustrated case examples Covers the challenges of this diagnostic approach and the techniques that minimize patients' discomfort Details the choice of treatment and the options and limitations

The field of thermal therapy has been growing tenaciously in the last few decades. The application of heat to living tissues, from mild hyperthermia to high-temperature thermal ablation, has produced a host of well-documented genetic, cellular, and physiological responses that are being researched intensely for medical applications, particularly for treatment of solid cancerous tumors using image guidance. The controlled application of thermal energy to living tissues has proven a great challenge, requiring expertise from multiple disciplines, thereby leading to the development of many sophisticated pre-clinical and clinical devices and treatment techniques. Physics of Thermal Therapy: Fundamentals and Clinical Applications captures the breadth and depth of this highly multidisciplinary field.

Focusing on applications in cancer treatment, this book covers basic principles, practical aspects, and clinical applications of thermal therapy. An overview of the fundamentals shows how use of controlled heat in medicine and biology involves electromagnetics, acoustics, thermodynamics, heat transfer, and imaging sciences. The book discusses challenges in the use of thermal energy on living tissues and explores the genetic, cellular, and physiological responses that can be employed in the fight against cancer from the physics and engineering perspectives. It also highlights recent advances, including the treatment of solid tumors using image-guided thermal therapy, microbubbles, nanoparticles, and other cutting-edge techniques.

Due to the increasing number of digital mammograms and the advent of new kinds of three-dimensional x-ray and other forms of medical imaging, mammography is undergoing a dramatic change. To meet their responsibilities, medical physicists must constantly renew their knowledge of advances in medical imaging or radiation therapy, and must be prepared to function at the intersection of these two fields. Physics of Mammographic Imaging gives an overview on the current role and future potential of new alternatives to mammography in the context of clinical need, complementary approaches, and ongoing research.

This book provides comprehensive coverage on the fundamentals of image formation, image interpretation, analysis, and modeling. It discusses the use of mammographic imaging in the detection, diagnosis, treatment planning, and monitoring of breast cancer. Expert authors give a balanced summary of core topics such as digital mammography, contrast-enhanced mammography, stereomammography, breast tomosynthesis, and breast CT. The book highlights the use of mammographic imaging with complementary breast imaging modalities such as ultrasound, MRI, and nuclear medicine techniques. It discusses critical issues such as computer-aided diagnosis, perception, and quality assurance.

This is an exciting time in the development of medical imaging, with many new technologies poised to make a substantial impact on breast cancer care. This book will help researchers and students get up to speed on crucial developments and contribute to future advances in the field.

The Royal Marsden is the world's first hospital dedicated to cancer diagnosis, treatment, research and education - a centre of excellence with an international reputation for ground-breaking research and pioneering the very latest in cancer treatments and technologies, as well as specialising in cancer diagnosis and education. This companion volume to the internationally successful The Royal Marsden Manual of Clinical Nursing Procedures is designed to support practitioners who work specifically with oncology patients by providing detailed evidence-based procedures and rationale, and problem-solving guidance on all aspects of oncology nursing. The Royal Marsden Manual of Cancer Nursing Procedures: Is organized and structured to represent the needs of the patient along their care pathway Provides the latest evidence underpinning all procedures Includes information on haematological procedures; pain assessment and management; wound care; oncological emergencies; and end-of-life care Gives detailed guidelines on supporting patients living with cancer with practical information on such things as benefits, exercise and nutrition. The Royal Marsden Manual of Cancer Nursing Procedures is an invaluable, definitive resource for all those involved in the provision of cancer care and support to patients and their families.

"There used to be limited therapeutic options for women who developed metastatic breast cancer. However, recent development with novel systemic drugs and palliative surgical techniques, together with advances in diagnostic imaging, have given new hope for these patients and made the treatment of these patients considerably more challenging. One convenient source bringing together the various relevant aspects is long overdue. This handbook covers treatment for both the cancer and the complications that can arise from treatment itself"--Provided by publisher.

Peritoneal malignancy is a rapidly growing field within surgical oncology. National and International treatment programmes and training curricula are being established worldwide to co-ordinate treatment and management of these challenging clinical problems. A large body of evidence now exists, but the practical implications of this evidence base remain unclear. The Peritoneal Malignancy Institute in Basingstoke, the largest centre in the world, is at the forefront of new developments and techniques. This manual combines the experience of the PMI with the latest evidence to provide a practice-oriented guide to the successful set up and running of a peritoneal malignancy unit.

Please visit www.cancerstaging.org for information about content updates and staging forms. The AJCC Cancer Staging Manual is used by physicians and health care professionals throughout the world to facilitate the uniform description and reporting of neoplastic diseases. Proper classification and staging of cancer is essential for the physician to assign proper treatment, evaluate results of management and clinical trials, and to serve as the standard for local, regional and international reporting on cancer incidence and outcome. Significantly expanded and developed by international disease site expert panels, the Eighth Edition AJCC Cancer Staging Manual brings together all the currently available knowledge on staging of cancer at various anatomic sites. In this edition, evidence-based TNM staging is supplemented, as appropriate, by selected molecular markers and newly acquired insights into the molecular underpinnings of cancer. This edition features 12 entirely new staging systems, a wide range of changed or new staging definitions, and a refined emphasis on a personalized-medicine approach. To enhance the print and electronic usability of the cancer staging forms, they are now available exclusively for access and downloading at www.cancerstaging.org. The Eighth Edition AJCC Cancer Staging Manual remains the gold standard reference for oncologists, surgeons, pathologists, radiologists, cancer registrars and medical professionals world-wide to ensure that all those caring for cancer patients are fully versed in the language of cancer staging.

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: Challenges and Opportunities in Translation is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: Challenges and Opportunities in Translation: * Critically analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential * Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy * Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer * Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Single best answers to 500+ questions covering all of the key exam topics Perfect preparation and practice for the medical oncology SCE and a valuable tool for the FRCR (Oncology) and ESMO exams Produced in partnership with the Association of Cancer Physicians (ACP) Written by senior trainees and consultants and verified by experienced medical oncology consultants in the style of the specialty certificate exam, this collection of 500 single best answers offers an ideal preparation for success. The aim of 500 SBAs for the Medical Oncology Specialty Certificate Exam is to provide an important evidence-based resource for trainees and non-trainees in preparation for the SCE in Medical Oncology. The practice questions enable learners to assess their own knowledge and identify gaps for further learning. Single-best answer (SBA) questions are accompanied with a description of the answer that highlights important trial data, NICE/other national guidelines and resources. The question number and layout closely mirrors that of the SCE blueprint. Topics covered follow the blueprint of the exam closely, and include: Scientific basis of malignancy, Systemic anti-cancer therapy, Acute oncology, Supportive therapies and palliative care, Breast cancer, Upper GI cancer, Colorectal and anal cancer, Lung and thoracic cancer, Gynaecological cancers, Urological and germ cell cancers, Haematological cancers, Skin cancer, Sarcoma. Less common cancers (Head and neck, CNS cancers, Endocrine), Carcinoma of unknown primary, Professional skills and ethics. Make this book the last thing you use before you take the exam.

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research.

Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts:

• Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents.
• Phase II trials Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs.
• Phase III trials Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials.
• Exploratory and high-dimensional data analyses All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added.

Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Image-Guided Radiation Therapy presents key image-guided radiation treatment (IGRT) technologies for external beam radiotherapy. The book explores the decades-long technological developments that have occurred in the realm of image-guided conformal, customized radiation treatment.

Expert authors, all of whom have actively participated in the development or implementation of IGRT, imaging, and enabling technologies, share their first-hand experiences on the science, clinical uses, and impact of these technologies. They describe kilovoltage and megavoltage imaging as well as radiological, ultrasound, and optical technologies for determining and validating target and patient positioning. The book examines how anatomical and biological imaging using CT and PET has contributed to the understanding of target volume boundaries and biological behavior. It also explores such innovations as 4D PET/CT and digital tomosynthesis.

Advancing patient care, this book focuses on a wealth of hybrid IGRT technologies and devices for coupled imaging and treatment inside the radiation treatment room. It thoroughly covers the modalities, software tools, and imaging treatment geometries that constitute IGRT.

A key resource for all genetic counselors and other healthcare providers, this comprehensive reference has been completely updated and reorganized for its fourth edition Inherited genetic mutations contribute significantly to the onset of some cancers. Over 50 hereditary cancer predisposition genes have been identified by researchers, such as the BRCA1 and BRCA2 genes which are associated with breast and ovarian cancers. Testing for these genes can be a powerful tool in assessing individual cancer risk and creating robust medical plans, but this can also be a complex process, with personal and familial factors carrying real emotional weight. As such, genetic counseling for patients and their families before and during the process of genetic testing can be critical. Counseling about Cancer: Strategies for Genetic Counseling is the only comprehensive resource available for clinicians and cancer genetic counselors who want to understand and apply these dimensions of patient care. This updated and reorganized edition provides detailed information designed to be incorporated in a variety of clinical and health-care contexts. Updated with the latest guidance and research, it promises to continue as the indispensable guide to this challenging subject. Readers of the fourth edition of Counseling about Cancer will also find: New chapters analyzing pediatric cancer syndromes, genetic testing technology, and more Increased focus on gynecological cancer syndromes and related genes Detailed case studies to reinforce themes of each chapter Counseling about Cancer is a useful reference for genetic counselors and other healthcare providers looking to familiarize themselves with best practices of patient counseling and care.

This valuable self-help book for people affected by cancer, their loved ones and friends focuses on self-care when life hurts. It explores the impact of cancer and explains why the usual ways of coping may leave people stuck. The first book of its kind to focus on the scientifically based Acceptance and Commitment Therapy (ACT) approach, it helps people to find ways to cope with painful thoughts and feelings, and to rebuild a meaningful life despite the cancer. With an emphasis on value-based living the book illustrates skills such as mindfulness and the development of acceptance to help people affected by cancer to participate in a fuller life and gain a greater sense of well-being. It combines evidence-based practice with the experiences of people who are living with cancer in the form of numerous quotations throughout, as well as paper and pencil 'thought' exercises. Living Your Life with Cancer through Acceptance and Commitment Therapy helps people affected by cancer to feel more able to sit with the uncertainty of their future, show themselves kindness and compassion and to learn to be true to themselves, no matter what the cancer throws at them. It is also important reading for psychological therapists working in oncology.

Mistletoe is a parasitic evergreen plant that lives on trees such apple and elm. Modern complementary therapies for cancer increasingly make use of mistletoe preparations. However, because mistletoe grows on many different trees, the properties of the plant vary according to the host tree. For the first time, this book presents an important reference for practitioners on the characteristics of each type of mistletoe, and what kind of cancers they are best suited to treat. Thirteen host trees are described, covering all aspects from mythology and botany to homeopathy and flower essences. The author then pulls the various characteristics together to provide a unique guide to which patients might benefit most from the different types of mistletoe. The results will be useful not only in treating cancer but also in prevention. The book includes specific case-studies as well as notes on supplementary therapies using metals.

Cancer is one of the most exciting specialties in medicine. This book aspires to convey the authors enthusiasm for oncology and this new edition of Oncology Lecture Notes is a must for students and trainees. There has been a revolution in the practice of oncology. The changes are due to amazing advances in basic science, and the development of new drugs and successful immunisation programmes that have followed. Cancer death rates have fallen and this is in part due to radical new treatments, effective screening programmes, and also, as a result of popular movements for change in patient care, and decreased exposure to carcinogens. Completely revised and updated, this new edition of Oncology Lecture Notes describes advances in molecular biology research and highlights the importance of patient perspectives in cancer care. The text includes many new figures and tables, an update of molecular biology and highlights new treatments. With learning objectives and key point summaries in each chapter, Oncology Lecture Notes is an ideal introduction to the biological basis and principles of treatment in oncology. Includes a companion website at www.lecturenoteseries.com/oncology featuring cases and self-assessment MCQs

"Read this important book to learn how cancer is an environmental, metabolic disease with many small causes that stack up-and what you can do to prevent or even reverse it."-Dave Asprey, New York Times bestselling author of The Bulletproof Diet The Optimal Terrain Ten Protocol to Reboot Cellular Health! The Metabolic Approach to Cancer offers an innovative, metabolic-focused nutrition protocol that works. Naturopathic, integrative oncologist and cancer survivor Dr. Nasha Winters and nutrition therapist Jess Higgins Kelley have identified the ten key elements of a person's "terrain" (think of it as a topographical map of our body) that are crucial to preventing and managing cancer. Each of the terrain ten elements-including epigenetics, the microbiome, the immune system, toxin exposures, and blood sugar balance-is illuminated as it relates to the cancer process, then given a heavily researched and tested, non-toxic and metabolic, focused nutrition prescription. The ketogenic diet-which relies on the body's production of ketones as fuel-is the centerpiece of The Metabolic Approach to Cancer. Further, Winters and Kelley explain how to harness the anticancer potential of phytonutrients abundant in low-glycemic plant and animal foods to address the 10 hallmarks of cancer-an approach Western medicine does with drug-based therapies. The optimized, genetically-tuned diet shuns: Grains Legumes Sugar Genetically modified foods Pesticides Synthetic ingredients The optimized, genetically-tuned diet emphasizes: Whole, wild foods Local Organic Ferments Heirloom Low-glycemic Other components of their approach include harm-reductive herbal therapies like mistletoe (considered the original immunotherapy and common in European cancer care centers) and cannabinoids (which shrink tumors and increase quality of life, yet are illegal in more than half of the United States). Through addressing the ten root causes of cancer and approaching the disease from a nutrition-focused standpoint, we can slow cancer's endemic spread and live optimized lives. "The Metabolic Approach to Cancer is a powerhouse of detailed information on how to prevent, manage, and treat cancer. . . . It is written in an intimate conversation style that comes from decades of deep personal experience, research, and genuine passion."-Travis Christofferson, author of Tripping over the Truth

Hepato-Pancreato-Biliary (HPB) surgery is now firmly established within the repertoire of modern general surgery. This new edition has been completely rewritten by world-leading surgeons to reflect the considerable advances made in the surgical management of HPB disorders since the highly successful first edition. This new edition includes: An in depth coverage of benign and malignant disorders of the liver, pancreas, and bile ducts and gallbladder A comprehensive section on anatomy, imaging, and surgical technique Over 20 new chapters, including a complete account of pediatric HPB disorders Illustrated with almost 300 high-resolution images, many in full-color Surgical Management of Hepatobiliary and Pancreatic Disorders, Second Edition, comprehensively covers the full spectrum of common HPB diseases and associated surgical techniques to assist not only the general surgeon in regular practice, but also surgical trainees and those in related specialties of oncology, radiology, gastroenterology, and anesthesia.

A brand-new edition of the bestselling guide to hematologic malignancies. An international team of contributors come together to present all clinically relevant aspects of leukemias, lymphomas, and myelomas. Using clear terminology, the book discusses salient features, diagnostic procedures, prognosis, and treatments for these cancers. Following on the successful steps of the first edition, this Second Edition covers: various types of leukemias, lymphomas, and myelomas utilizing stem cell transplantation side-effects of various treatments future prospects for leukemia, lymphoma, and myeloma targeted therapies and history of the cancers information and support sources for patients

Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complications such as paraneoplastic disorders and neoplastic plexopathy. Highlights include: The pathophysiology and molecular biology of cancer and the metastatic phenotype Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses Metabolic and nutritional disorders CNS infections Neurological complications of immunotherapy and bone marrow transplants Additional chapters review problems related to each specific tumor type, such as breast, lung, and colorectal, as well as gynecological cancer, genitourinary cancer, and malignant melanoma. The book also discusses neurological complications related to treatments such as radiation and chemotherapy. Bringing clinical trial knowledge from the bench to the bedside, this volume is an essential reference for the practicing oncologist and neurologist.

There has been tremendous progress in cancer diagnosis and treatment methodologies, and this book focuses on major cancers of the cervix, breast, endometrium, and the associated reproductive system affecting women. It focuses on specific diagnostic techniques and treatment strategies including computational tools, Nanomedicine, and the use of Machine Learning (ML), Artificial Intelligence (AI), Big Data, and other latest techniques, including the evolution of these treatments over the years. Oncologists, cancer scientists, and professionals will find using the content on cutting-edge interventions by experts in their field, significantly improving earlier diagnosis and treatment options. Key Features: * Helps to improve quality of life after treatment as the focus of healthcare is shifting from curative methods to primary prevention of diseases, screening methods and early detection and treatment. * Appeals to clinicians and residents interested in exploring cutting-edge technology for early diagnoses and treatment of women associated cancers. * Features a chapter on the Clinician's perspective on advanced diagnostic and treatment methods.

Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of data across scales, and the prediction of tumor progression and treatment outcome (in silico oncology). Drawing on an interdisciplinary group of distinguished international experts, Multiscale Cancer Modeling discusses the scientific and technical expertise necessary to conduct innovative cancer modeling research across scales. It presents contributions from some of the top in silico modeling groups in the United States and Europe. The ultimate goal of multiscale modeling and simulation approaches is their use in clinical practice, such as supporting patient-specific treatment optimization. This volume covers state-of-the-art methods of multiscale cancer modeling and addresses the field's potential as well as future challenges. It encourages collaborations among researchers in various disciplines to achieve breakthroughs in cancer modeling.