The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation methods to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer researchers can uncover a series of new discoveries and biological insights.

The First Cancer Systems Biology Book Designed for Computational and Experimental Biologists
Unusual in its dualistic approach, Cancer Systems Biology discusses the recent progress in the understanding of cancer systems biology at a time when more and more researchers and pharmaceutical companies are looking into a systems biology approach to find drugs that can effectively be used to treat cancer patients.

Includes Contributions from more than 30 International Experts
Part I introduces basic concepts and theories of systems biology and their applications in cancer research, including case studies of current efforts in cancer systems biology. Part II discusses basic cancer biology and cutting-edge topics of cancer research for computational biologists. In contains an overview of genomics, cell signaling, and tumorigenesis, in addition to hot topics like molecular mechanisms of cancer metastasis and the molecular relationships between solid tumors, their microenvironments, and tumor blood vessels. Rounding out the book's solid coverage, Part III explores a variety of computational tools and public data resources that are useful for studying cancer problems at a systems level.

Cancer systems biology is still in its infancy as a field of study, but it is fast becoming indispensable in the battle to defeat cancer and develop successful new treatments. Cancer Systems Biology marks an important step toward reaching that goal.

The inspiring story that touched people all over the world, The Council of Dads is the life-changing portrait of a group of friends who offer wisdom, humor, and guidance for how to live our lives with meaning and joy. Faced with one of life's greatest challenges, New York Times bestselling author Bruce Feiler reached out to six men who helped shape him and asked each one for a piece of advice for his daughters: how to live, how to travel, how to question, how to dream.

Feiler gathered their life lessons, along with a few of his own--"Always Learn to Juggle on the Side of a Hill," "Hug the Monster," "Take a Walk with a Turtle"--into a heartwarming, deeply enriching book that has inspired readers everywhere to start their own Councils of Moms or Dads. Full of warmth and wisdom, The Council of Dads is a singular story that offers lessons for us all--helping us draw closer to our friends, be more resourceful as parents, and celebrate what's important in our lives.

Originally published in 1997 Evolutionary Change addresses the somatic mechanism of change. Although astounding advances in molecular biology have opened up new engineering possibilities to shape our future in terms of "improving" the human species as well as eradicating all kinds of pathological characteristics of biological development, these possibilities pose potentially serious dangers. They arise primarily from the local nature of changes that are introduced and the impact of the environment on the overall development of the biological system. The book explores the biological mechanisms of change in their entirety - as they fit into the general dynamics of biological systems - and demonstrates the pitfalls of tackling change from a narrow perspective, using cancer as an example of certain pathological manifestations of these mechanisms of change.

At no time in U.S. history has there been a more effective challenge to medical expertise and authority than that mounted by the contemporary Laetrile movement. The efficacy of Laetrile has been debated for over twenty-five years, but despite vigorous opposition from the medical community, support for the purported cancer treatment continues to gro

This book covers the basic experimental models in glioblastoma research. It starts with a description in the first two chapters of general clinical, neuroimaging and genetic data about glioblastoma (WHO grade IV glioma), which is the most frequent and the most malignant primary tumour in adults. Despite the complex treatment which includes neurosurgery, radiotherapy and chemotherapy, survival of the patients usually is between 9 and 12 months. Moreover, the surgery is not able to cure the disease due to the specific infiltrative growth pattern of glioblastoma. Therefore, laboratory research is essential in order to find new molecular and cellular therapies for this lethal disease. After shortly reviewing the modern hypothesis regarding the origin of glioblastoma in the third chapter, namely the cancer stem cells hypothesis, the author describes step-by-step in the following chapters (Chapters 4-8) the most important in vitro and in vivo models of research in glioblastoma. Chapter 4 is dedicated to the first and the essential step in any research project on glioblastoma: how to obtain good quality glioblastoma samples, how to prepare the samples and how to store the samples long-term for subsequent research. Open surgery and the image-guided stereotactic technique are also described in this chapter. After obtaining the tumour samples, the next step is to initiate the primary cells cultures. These in vitro techniques (either serum conditioning cell cultures and tumour stem cells cultures) will be discussed in detail in Chapters 5 and 6. Usually the new molecules with antitumor activity are tested in vitro on both primary glioblastoma cells cultures but also on glioblastoma cells lines in order to obtain a better standardised results. The next chapter, Chapter 7 is dedicated to in vivo techniques, which are required for testing the anti-tumoural effect of the new molecules before starting with the clinical trials. The author describes in detail the techniques of stereotactic intracranial inoculation of glioblastoma cells (either glioblastoma cell lines or glioblastoma-derived tumour stem cells) and the main growth patterns of the intracranial glioblastoma xenografts obtained using these techniques. Another technique very useful for exploring in real time the migratory glioblastoma cells is the organotypic brain slice cultures which is described in the last chapter of the book.

Kidney cancer is the 10th most common cancer in Europe with overall mortality rates increasing until the late 1980s and early 1990s and thereafter, stabilised. Until recently, renal cell carcinoma (RCC) was thought to represent a monomorphic disease; however, modern genetic characterisation has demonstrated different subtypes with specific cell types and molecular metabolism. Imaging diagnostic methods are basic for staging and for new treatment strategies. Moreover, tumour biopsy has been reintroduced in the diagnostic armamentarium, mainly in patients with small masses but also when disseminated tumours need to be treated with new target therapies. Although TNM stage, Fuhrman grade and Eastern Oncology Group (ECOG) performance status are the most recognised prognostic factor in RCC, active research continues to determine new prognostic factors to classify different risks for death from RCC. Laparoscopy has gained widespread popularity because of a less morbidity and a faster post-operative convalescence. Partial laparoscopic nephrectomy is a demanding operation that can be made depending on the experience of the surgeon, the size or location of the tumour in the kidney. New robotic approaches are being introduced for nephron sparing surgery. Conversely, cardiac bypass can be necessary for resection of tumours with thrombus extending into the inferior vena cava above the level of hepatic veins. With the advent of modern ablative energies (cryotherapy or radiofrequency) for renal tumours in selected patients with percutaneous or laparoscopic techniques, it is now possible to achieve long cancer specific survival with decreased morbidity. A need for standardisation of follow-up after surgery with lifelong protocols has been recognised in last years. Finally, angiogenesis inhibitors have demonstrated a high probability of disease control in patients with metastatic renal carcinomas. Their indication as adjuvant in local advanced tumours as well as the role of nephrectomy in patients with metastatic disease is being evaluated in current clinical trials.

Chemotherapy and radiotherapy for cancer can have devastating side effects on the skin of a patient. This innovative guide for both dermatologists and oncologists gives a good introduction both to therapy regimes and to dermatological management for medical professionals treating their patients.

Mistletoe is a parasitic evergreen plant that lives on trees such apple and elm. Modern complementary therapies for cancer increasingly make use of mistletoe preparations. However, because mistletoe grows on many different trees, the properties of the plant vary according to the host tree. For the first time, this book presents an important reference for practitioners on the characteristics of each type of mistletoe, and what kind of cancers they are best suited to treat. Thirteen host trees are described, covering all aspects from mythology and botany to homeopathy and flower essences. The author then pulls the various characteristics together to provide a unique guide to which patients might benefit most from the different types of mistletoe. The results will be useful not only in treating cancer but also in prevention. The book includes specific case-studies as well as notes on supplementary therapies using metals.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition. Integrates basic science into individual cancer chapters for more efficient reference Features quarterly updates that include late-breaking developments in oncology such as new drugs and clinical trials, as well as new case studies and interactive algorithms Offers balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist Provides updated content on immunotherapy and genetics throughout Includes important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues Now available in a convenient single volume, or a seven-multivolume option for portability and ease of use Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

A practical and up-to-date guide to pacemaker technology and its clinical implementation As the field of cardiology continues to advance and expand, so too does the technology and expertise behind today's electrophysiological devices. Cardiac Pacing, Defibrillation and Resynchronization has been assembled by international specialists to give all those caring for patients with heart disorders a clear and informative guide to the pacemakers and clinical methods of today. Now in its fourth edition, this essential resource: Explains different methods of pacemaker implementation in a straightforward and easy-to-follow manner Explores the most common challenges faced by working clinicians Features more than 750 illustrative graphics Contains data on the efficacy and long-term outcomes of different device models Covers new technology and clinical trial data Written for cardiologists, cardiac pacing caregivers, and those preparing to take their electrophysiology board examinations, Cardiac Pacing, Defibrillation and Resynchronization offers a complete exploration of electrophysical devices and their vital role in modern-day cardiology.

The diagnostic and therapeutic achievements in radiopharmaceuticals and nuclear medicine instrumentation - PET, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT - are the result of the interdisciplinary research efforts of cell-biologists, chemists, pharmacologists, physicists, computer-scientists, engineers, nuclear medicine physicians, and oncologists. The clinical implications of these achievements have made nuclear medicine indispensable in the management of cancer. This superbly illustrated text on modern nuclear medicine applications in the diagnosis and treatment of cancer describes the state of the art and the current position of nuclear medicine in the light of these recent developments. It is intended as a valuable update also for non-nuclear medicine specialists working in oncology. Nuclear medicine as part of molecular imaging and therapy has changed radically in the last decade. The growing importance and clinical impact of these changes in the near future has impelled the internationallyrenowned editors and contributors to put them on record in "Advances in Nuclear Oncology,"

This book provides a first comprehensive summary of the basic principles, instrumentation, methods, and clinical applications of three-dimensional dosimetry in modern radiation therapy treatment. The presentation reflects the major growth in the field as a result of the widespread use of more sophisticated radiotherapy approaches such as intensity-modulated radiation therapy and proton therapy, which require new 3D dosimetric techniques to determine very accurately the dose distribution. It is intended as an essential guide for those involved in the design and implementation of new treatment technology and its application in advanced radiation therapy, and will enable these readers to select the most suitable equipment and methods for their application. Chapters include numerical data, examples, and case studies.

Brachytherapy has become the modality of choice for several cancer localizations, minimizing the possibility of unacceptable risks for healthy tissues and providing a more cost-effective and convenient treatment for patients. Written by leading experts in the physics, development, and implementation of brachytherapy, The Physics of Modern Brachytherapy for Oncology discusses the subject in detail, covering its definition, the basic physics of radiation interaction with matter, radionuclides, sources and source production, calibration and dosimetry protocols as well as experimental dosimetry methods appropriate for practical use. Logically organized, the book begins with basic information, including quantities and units, followed by fundamental atomic and nuclear physics. It also provides the historical background of brachytherapy physics. The next several chapters discuss the radionuclides used in brachytherapy, reflecting upon past (radium), present (iridium or cobalt), and future (ytterbium) methods. The book proceeds to examine source calibration and dosimetry protocols for dose rate calculation while the final chapters explore more recent processes, including Monte Carlo-aided, experimental, and gel dosimetry. The appendices provide useful tables of isotopes, unit conversions and physical constants, brachytherapy sources, TG-43 and TG-43 U1 data tables, and dose rate tables. Detailing the physics behind brachytherapy treatment, The Physics of Modern Brachytherapy for Oncology is essential reading for researchers, practicing radiation oncologists, and medical physicists who want to keep abreast of the developments in this changing field as well as for postgraduate students in medical physics.

Chemotherapy and radiotherapy for cancer can have devastating side effects on the skin of a patient. This innovative guide for both dermatologists and oncologists gives a good introduction both to therapy regimes and to dermatological management for medical professionals treating their patients.

Now in its second edition, this bestselling title has been extensively revised and expanded to include new topics on: obesity and breast cancer induction of anti-hormone and anti-growth factor resistance in breast cancer clinical implications of testosterone and breast cancer insulin-like growth factors discussions on the biological, genetic, and molecular pathways linked to the development and progression of breast cancer analyses on the latest therapeutic strategies, prognostic and predictive factors, and prevention strategies Examining new developments, Breast Cancer: Prognosis, Treatment, and Prevention, Second Edition also covers: the mechanism involved in carcinogenesis the relationship among a fetus, pregnancy, and breast cancer recent developments in endocrine treatment the relationship among hormone replacement therapy, cytotoxic therapy, and other non-hormonal approaches for the treatment of metastases management of locally advanced breast cancer, and the importance of BRCA-1 and BRCA-2 in hereditary breast cancer With new topics and updated chapters, this new edition keeps both oncologists and radiologists abreast of the current trends and advancements in the prognosis, treatment, and prevention of breast cancer.

An in-depth exploration of Benzene Carcinogenicity including source, measurement, analysis, and clinical conclusions.

This book represents the most current, comprehensive, and authoritative study of integrins on the market today. It provides an overview of the diverse biological functions of integrins, including: The structure and functions of integrin cytoplasmic domains, the role of b2 integrins in leukocyte adhesion, the role of platelet membrane fibrinogen receptor glycoprotein IIb-IIIa (aIIbb3) in thrombosis and hemostasis, the functions of aV integrin family, the role of integrins in signal transduction, the role of integrins in carcinoma cells, the role of integrins in internalization of microbial pathogens through the binding of Yersinia pseudotuberculosis invasin protein, the role of integrins in the skin, the integrin function in early vertebrate development using amphibian embryos. Key selling features: the structure and functions of integrin cytoplasmic domains the role of b2 integrins in leukocyte adhesion the role of platelet membrane fibrinogen receptor glycoprotein IIb-IIIa (aIIbb3) in thrombosis and hemostasis the functions of aV integrin family the role of integrins in signal transduction

Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this
source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

A brand-new edition of the bestselling guide to hematologic malignancies. An international team of contributors come together to present all clinically relevant aspects of leukemias, lymphomas, and myelomas. Using clear terminology, the book discusses salient features, diagnostic procedures, prognosis, and treatments for these cancers. Following on the successful steps of the first edition, this Second Edition covers: various types of leukemias, lymphomas, and myelomas utilizing stem cell transplantation side-effects of various treatments future prospects for leukemia, lymphoma, and myeloma targeted therapies and history of the cancers information and support sources for patients

This authoritative work, now in its fourth edition, presents state of the art knowledge on all key aspects of cancer prevention. In addition to detailed summaries on preventive strategies for specific cancers, readers will find current knowledge on a range of relevant scientific topics including the benefits of cancer prevention, the importance of diet and physical activity, innate and adaptive immune responses to cancer, hereditary risks, cancer health disparities, and the preventive role of telemedicine. In this new edition of the book, the coverage has been expanded to include additional disease sites and to provide up-to-date information across the range of disciplines in the field of cancer prevention and control. Written as a collaborative work by internationally recognized leaders in the field, Fundamentals of Cancer Prevention is an essential reference guide and tool for oncologists, primary care physicians, the research community, and students with an interest in reducing the burden of cancer through the implementation of effective preventive strategies.

This work includes a foreword by Elizabeth Rogerson. Head of Education and Development, International Virtual Nursing School Head, Distance Learning Centre (Nursing and Palliative Care), University of Dundee. It considers all the patient's symptoms and all the information available to us, then assesses the symptoms, signs and information given, using this to choose the appropriate remedies for the problem, and extra information will be offered where available and appropriate. This easy to use, evidence-based guide offers practical resources for every day use. Well laid out, with a simple alphabetical format, "Care of the Cancer Patient" covers the management of common problems, contains basic explanations of pathophysiology and relevant pharmacology, and includes vital guidance on new treatments and scientific papers. It is ideal for non-specialist doctors, nurses, carers and other health professionals who look after patients with cancer-related symptoms. 'This book recognises the complexity inherent in the cancer journey and places a spotlight on the human face of health care management, specifically on the ability to provide careful, individualised and sensitive management of symptom control that aims to make a difference to the patient's quality of life. It is written in a manner that is acceptable to professionals, patients and carers alike. This book adopts a unique approach to symptom management in palliative care, inviting the practitioner to consider the possible causes of the symptom, and then assess the patient with these in mind. Paying attention to the pathophysiology of the symptom and respecting the individual needs of the patient, one is guided to make a logical choice of treatment by thinking about the pharmacological actions of the available drugs. This is a book to be on the desk ready for quick reference, not stored on a shelf in a library.' - Elizabeth Rogerson, in the Foreword.

Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including: Human T-cell leukemia virus type 1 (HTLV-1) Hepatitis C virus (HCV) Epstein-Barr virus (EBV) Human papilloma virus (HPV) Human herpes virus 8 (HHV-8)/Kaposi's sarcoma-associated herpes virus (KSHV) Human immunodeficiency virus (HIV/AIDS) Oncolytic viruses This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies.

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.

"Keto for Cancer brings clarity to this emerging science and makes implementation of this information straightforward and uncomplicated."-David Perlmutter, New York Times bestselling author "This book addresses every question or concern that cancer patients might have in using a ketogenic metabolic strategy for managing their cancer."-Thomas Seyfried ,PhD THE comprehensive guide for patients and practitioners from a foremost authority in the emerging field of metabolic therapies for cancer. Although evidence supporting the benefits of ketogenic diet therapies continues to mount, there is little to guide those who wish to adopt this diet as a metabolic therapy for cancer. Keto for Cancer fills this need. Nutritionist Miriam Kalamian has written the book to lay out comprehensive guidelines that specifically address the many challenges associated with cancer, and particularly the deep nutritional overhaul involved with the ketogenic diet. Kalamian, a leading voice in the keto movement, is driven by passion from her own experience in using the ketogenic diet for her young son. Her book addresses the nuts and bolts of adopting the diet, from deciding whether keto is the right choice to developing a personal plan for smoothly navigating the keto lifestyle. It is invaluable for both beginners and seasoned users of the ketogenic diet, as well as for health-care professionals who need a toolkit to implement this targeted metabolic therapy. The book guides readers to a deeper understanding of the therapeutic potential of the ketogenic diet-which extends well beyond simply starving cancer-emphasizing the powerful impact the diet has on the metabolism of cancer cells. Nutritional nuances and meal templates and tracking tools are explored in sections such as: Fasting Protocols Know What's in the Foods You Eat Preparing Keto Meals Put Your Plan Into Action Kalamian also discusses important issues such as self-advocacy empowering readers by offering tips on how to critically examine cancer-care options and then incorporate what resonates into a truly personalized treatment plan.