Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: From Research to Clinical Practice: Analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

The nanosciences are a rapidly expanding field of research with a wide applicability to all areas of health. They encompass a variety of technologies ranging from particles to networks and nanostructures. This book focuses on the application of nanomedicine and nanotechnology to cancer. It covers an introduction to nanocarriers, nanorods, nanoprobes nanoplatforms, nanorings, nanotubes nanowires, nano-sensor arrays and a variety of methodological techniques. This is done within the framework of numerous cancer types. Contributors are all leading experts and are carrying out ground breaking work. The book is essential reading for oncologists, research scientists, doctors, health care professionals, pathologists, biologists, biochemists, chemists and physicists as well as those interested in disease and nanosciences or cancer in general.

Tumors and Cancers: Skin - Soft Tissue - Bone - Urogenitals provides succinct reviews of neoplastic growths disrupting normal functions of affected structures. Each chapter presents a state of the art summary of tumor/cancer of a particular type in relation to its biology, epidemiology, disease mechanisms, clinical signs, diagnosis, treatment and prognosis.

Molecular Genetics of Cancer, Second Edition provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to tumorigenesis. The book is therefore a valuable source of reference for clinicians and genetic counsellors as well as researchers.

This book represents the most current, comprehensive, and authoritative study of integrins on the market today. It provides an overview of the diverse biological functions of integrins, including: The structure and functions of integrin cytoplasmic domains, the role of b2 integrins in leukocyte adhesion, the role of platelet membrane fibrinogen receptor glycoprotein IIb-IIIa (aIIbb3) in thrombosis and hemostasis, the functions of aV integrin family, the role of integrins in signal transduction, the role of integrins in carcinoma cells, the role of integrins in internalization of microbial pathogens through the binding of Yersinia pseudotuberculosis invasin protein, the role of integrins in the skin, the integrin function in early vertebrate development using amphibian embryos.

Tumors and cancers are insidious diseases characterized by an abnormal growth of cells that extend beyond their usual boundaries and disrupt the normal functions of affected organs. Forming the first of the four volumes devoted to tumors and cancers, this volume focuses on the central and peripheral nervous systems. Each chapter presents a state of the art summary of tumor/cancer of a particular type in relation to its definition, biology, epidemiology, disease mechanism/pathogenesis, clinical signs, diagnosis, treatment and prognosis.

An in-depth exploration of Benzene Carcinogenicity including source, measurement, analysis, and clinical conclusions.

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.

Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome. This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient's clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.

Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of current cancer therapies. Up to date, clearly organized, and thorough-sure to become a standard in the field! Providing comprehensive treatment on radiolabeled antibody therapy, Radioimmunotherapy of Cancer -reviews dosimetric principles and clinical dosimetry of radioimmunotherapy in the targeting and delivery of radiation -describes tumor architectures and outlines novel constructs for radionuclide delivery -analyzes a variety of improved targeting approaches, including pretargeting contextual analysis of extracorporeal techniques in radioimmunotherapy -details studies from the radiotherapy of lymphoma, solid tumors, and ovarian cancer and the targeted radiotherapy of neuroblastoma and squamous head and neck cancer -and much more! With contributions from nearly 50 international experts and containing over 1300 literature references, drawings, photographs, tables, and equations, Radioimmunotherapy of Cancer is an invaluable and indispensable reference for physicians in nuclear medicine and medical physicists; oncologists, radiologists, radiochemists, and radiopharmacists; immunologists, pulmonologists, and cancer researchers; pharmacologists and drug delivery pharmaceutical chemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

This comprehensive publication on biological actions of hydrazines includes all the available published material and chronological descriptions of the literature. The uniformly applied principle of evaluations separates each hydrazine chemical and divides according to species. This monograph presents data on carcinogenic activity of hydrazines in animals.

Using his now familiar image of a garden and a personal, plain English style, renowned breast cancer specialist Professor John Boyages MD, PhD, walks you slowly through the stress and confusion of diagnosis, treatment, and life after DCIS of the breast. Your whole life stops after a diagnosis of DCIS. The condition is extremely confusing. Treatment advice varies and there is a danger of both undertreatment and overtreatment. One doctor recommends a lumpectomy and radiation and another recommends a mastectomy. One tells you it's a cancer and the other tells you it's not cancer. In"DCIS of the Breast: Taking Control," John Boyages provides you with all the information you, your family, and your friends need to take control, understand what DCIS is, and how to best treat this condition. Learn how to identify the twenty control points, and about the important decisions you must make to navigate the medical maze and take control if DCIS or cancer returns.

This book summarizes the etiology, presentation, and treatment of the complex symptoms, infections, and opportunistic cancers of people living with HIV/AIDS. Presents therapies that strike a balance between controlling and eliminating cancer and minimizing the damage to the immune system. Illustrates points with clear and easily read figures, tables, and flow charts! Written to survey the magnitude of the impact HIV and AIDS have had on public health and oncology, AIDS-Related Cancers and Their Treatment -identifies types of cancer and gives evidence for their associations with immunosuppression -compares and contrasts AIDS-related cancer with non-HIV malignancies -investigates the pathogenesis of malignancy in HIV/AIDS patients -provides guidelines for recognizing possible symptoms and making accurate diagnoses -supplies algorithms for evaluating and staging patients at presentation -outlines potential problems and obstacles in caring for AIDS-related cancer patients -suggests optimal therapeutic approaches for the care of patients with AIDS and cancer -discusses prognostic factors in response to therapy and survival statistics -describes preliminary experience with emerging therapies and projects new approaches -advises how to enroll patients to participate in clinical trials of new therapies -considers the psychological impact on patients and their need for counseling and support -reviews access-to-care issues in AIDS and the community burden of this epidemic -provides information sources for both AIDS patients and their physicians -and more With contributions from nearly 25 clinicians and citing more than 1200 references to support and elaborate on text material, AIDS-RelatedCancers and Their Treatment is a crucial reference for oncologists, immunologists, infectious disease specialists, hematologists, internists, microbiologists, virologists, epidemiologists, molecular and cell biologists, pathologists, and medical students in these disciplines.

A bracing account that challenges current medical thinking. This book makes urgently clear that winning the war on cancer will not be accomplished by physicians, scientists, pharmaceutical corporations, epidemiologists and geneticists, nor by the thousands employed in governmental agencies and universities at home and abroad. It will be won by people who understand the connection between the loss of personal health and the unchecked boundaries of worldwide pollution.

This compact, illustrated handbook is a concise but comprehensive resource that introduces medical students, general medical practitioners and gynecologists to the significance of the human papillomaviruses in the etiology of cervical cancer. All chapters are fully referenced and written by experts in the field and review virus structure, the epidemiology of HPV, the latest advances in HPV vaccination, and new markers for cervical disease.

Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin's lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

Despite a decline in developed countries, cancer has consistently maintained its status as one of the top killers since time immemorial. Exploring cancer management and treatment at the molecular level, Biology of Oral Cancer: Key Apoptotic Regulators presents a key molecular event-apoptosis-in relation to genesis and progression of oral cancer. The book uses oral cancers as the specific means to demonstrate the use of apoptotic regulators for controlling cancers. The book comprehensively deals with the different aspects of oral cancer. The authors discuss strategies to leverage apoptotic regulatory mechanisms for better management along with state-of-the-art medical options available for management and treatment. Using an informal writing style that makes the information accessible to a wider audience, each chapter begins with a prologue followed by detailed discussion and concludes with a glimpse into future approaches and challenges. The book examines detection techniques that leverage molecular events associated with oral carcinogenesis to effectively detect oral cancer. A thorough examination of the internal (genetics) and external (carcinogens, radiation, and smoking) factors that cause cancer, the book provides an enhanced understanding of why oral cancer has consistently ranked among the top ten causes of cancer-related mortalities worldwide. It furthers the effective identification of the causal factors and their modulation that can restore cells' normal state and be used to develop increasingly effective modalities.

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

Brief Cognitive Behavior Therapy for Cancer Patients is a practical, clinical guide that allows for the integration of techniques from multiple newer CBT models, organized around a clear conceptual foundation and case conceptualization. The book targets those cognitive, emotional, and behavioral processes that research suggests are instrumental in the maintenance of human psychological suffering. Author Scott Temple also draws on newer models that build on strengths and resilience and brings clinical work to life through vivid case examples, worksheets, and case conceptualization forms. Detailed vignettes show clinicians how to create a case conceptualization as a guide to treatment, as well as how to integrate Beckian and newer CBT techniques.

A Guide to Cancer: Origins and Revelations unfolds the complex and fascinating topic of cancer in two ways: firstly, no specialist knowledge is assumed on the part of the reader, and secondly, despite the serious nature of the topics, the book aims to stimulate interest, provoke thought, and paradoxically entertain. It takes an array of complex topics and breaks them down in clear, concise terms, so that anyone with a basic knowledge of science can understand. The book is aimed at the general public as well as students of biological subjects, first and second year university students, and researchers in the nascent field of cancer genomics.

A Guide to Cancer: Origins and Revelations unfolds the complex and fascinating topic of cancer in two ways: firstly, no specialist knowledge is assumed on the part of the reader, and secondly, despite the serious nature of the topics, the book aims to stimulate interest, provoke thought, and paradoxically entertain. It takes an array of complex topics and breaks them down in clear, concise terms, so that anyone with a basic knowledge of science can understand. The book is aimed at the general public as well as students of biological subjects, first and second year university students, and researchers in the nascent field of cancer genomics.

For more than 30 years, the majority of researchers has assumed quiescence to be the default state of all cells and so have provided cells in culture with 'growth factors' to stimulate them to proliferate. During this time, many putative growth factors have been identified and ever more complex mechanisms through which they could interact and stimulate cells have been proposed. However, quiescence as the default state does not make evolutionary sense and many sets of data do not support this hypothesis. In The Society of Cells, an alternative explanation for these results is proposed by applying the premise that the default state must be proliferation, with multiplication being a 'built in' property of all forms of life. The authors begin by reviewing the concepts and theories that guide research on the control of cell proliferation and cancer, and asking the question 'what is the nature of the default state of all cells - quiescence or proliferation?'. Later chapters concern cancer, where control of cell proliferation and the tissue organisation are defective. Despite decades of work and financial support to explore the somatic mutation theory of carcinogenesis, we appear no nearer to explaining how cancer arises. This requires researchers to take stock and consider new hypotheses and alternative approaches to the study of control of cell proliferation, and cancer in particular. The Society of Cells is intended to encourage such a revaluation and proposes the adoption of new premises to explore these important subjects.

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Neonatal hematology is a fast-growing field, and the majority of sick neonates will develop hematological problems. This is an essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values. Chapters have been thoroughly revised according to the latest advances in the field for this updated third edition. Topics discussed include erythrocyte disorders, platelet disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Coverage of oncological issues has been expanded to two separate chapters on leukemia and solid tumors, making information more easily accessible. Approaches to identifying the cause of anemia in a neonate are explained, with detailed algorithms provided to aid clinicians in practice. Covering an important hematologic niche with an ever increasing amount of specialized knowledge, this book is a valuable resource for hematologists, neonatologists and pediatricians.