With its unique algorithmic and pattern-based approach, Diagnosis of Neoplasia in Endometrial Biopsies is an essential practical guide to interpreting endometrial biopsy samples. All potential entities are classified based on the dominant histologic pattern, with each resulting sub-group progressively sub-classified to reach a diagnosis. Decision tree flowcharts facilitate rapid narrowing of the differential diagnosis. Recent advancements are discussed and explained, and strengths and limitations of diagnostic tests are identified in the context of their application to the biopsy sample. Lavishly illustrated throughout, this book serves the practising pathologist as a scope-side assistant for quick reference, up-to-date guidance, and recommendations for ancillary testing. For the resident, this book facilitates quick and comprehensive mastery of the interpretation and diagnosis of endometrial biopsies. The book is packaged with a password, giving the user online access to all the text and images.

This book is devoted to the diagnosis and treatment of male breast pathology. It provides a comprehensive overview of current strategies for the diagnosis of breast malignancies in men, with a focus on imaging modalities. Ultrasound of male breast abnormalities is discussed in particular depth, but the roles of other imaging techniques, genetic tests, and interventional diagnostic modalities are also carefully covered. Special attention is paid to differential diagnosis of malignant and benign lesions, and the most important benign breast diseases are described and illustrated with high-quality images. A special chapter analyzes treatment strategy in men with breast malignancies and principles of follow-up after breast surgery. Individual chapters are also devoted to the diagnosis of recurrent cancer and cancer metastases. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons.

This concise overview of the fundamental concepts of cancer biology is ideal for those with little or no background in the field. A summary of global cancer patterns introduces students to the general principles of how cancers arise and the risk factors involved. By focusing on fundamental examples of the signalling pathways within cells, the functional effects of DNA damage are explained. Later chapters then build on this foundation to provide a comprehensive summary of the major signalling pathways that affect tumour development. Current therapeutic strategies are reviewed, along with a discussion of methods for tumour detection and biomarker identification. Finally, the impact of whole genome sequencing is discussed, bringing students up to date with key recent developments in the field. From basic principles to insights into cutting-edge research, this book will enable the reader to move into the cancer field with confidence.

This book focuses on the preoperative diagnosis of early-stage gastric cancer, presenting various cases and their diagnoses using Endoscopic Submucosal Dissection (ESD), a new technique for dissecting early-stage gastric cancer. The first chapter presents different cases with precise explanations and observations, thus providing basic knowledge of invasion depth diagnosis, diagnostic coverage, and qualitative diagnosis. The second part of this book further expands on these topics with more examples and current practices before concluding with an in-depth look at the application in difficult-to-treat cases, complete with a vast range of figures and detailed diagnoses. Edited and authored by pioneering researchers in the field, Preoperative Diagnosis of Gastric Cancer is designed as a textbook for clinicians and professionals in the fields of endoscopy and gastroenterology.

The past decade has witnessed tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma as well as in understanding of the underlying molecular pathogenesis. Optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors. Even more importantly, molecular targeted approaches have been shown to be effective in the treatment of distinct lymphoma subtypes. Against this background, clinical management of especially the rare lymphomas remains a challenge for the general oncologist. This book provides a comprehensive overview of current treatment strategies in these rare lymphoma subtypes. Experts in the field from around the world describe the histomorphology in a clinically relevant manner, consider the role of risk factors in detail, and discuss the spectrum of therapeutic approaches. Special emphasis is placed on the translation of molecular science into clinical care, and a disease-specific algorithm is proposed for each entity. This book will prove an excellent resource for both experienced and inexperienced practitioners.

This ready reference discusses different methods for statistically analyzing and validating data created with high-throughput methods. As opposed to other titles, this book focusses on systems approaches, meaning that no single gene or protein forms the basis of the analysis but rather a more or less complex biological network. From a methodological point of view, the well balanced contributions describe a variety of modern supervised and unsupervised statistical methods applied to various large-scale datasets from genomics and genetics experiments. Furthermore, since the availability of sufficient computer power in recent years has shifted attention from parametric to nonparametric methods, the methods presented here make use of such computer-intensive approaches as Bootstrap, Markov Chain Monte Carlo or general resampling methods. Finally, due to the large amount of information available in public databases, a chapter on Bayesian methods is included, which also provides a systematic means to integrate this information. A welcome guide for mathematicians and the medical and basic research communities.

This manual presents a large collection of clinical cases in oncology with accompanying whole-body FDG PET-CT scans. The aim is to promote an integrated approach to the use of PET-CT, and detailed attention is therefore paid to the clinical history and diagnostic question. A central aspect of every clinical case described in this manual is the guidance on the clinical report, which is the official tool for communicating with both the referring physician and the person undergoing the diagnostic test; for this reason it needs to be clear, understandable, and written in shared language. The advice regarding report preparation is strongly supported by informative PET, CT, and PET-CT fused images of each disease. The book is broadly structured according to anatomic region, and a wide range of common diseases likely to be imaged using PET-CT is covered. This book will be of value to all those training or working in the field of oncology who wish to ensure that they are best placed to contextualize, interpret, and report the findings obtained with PET-CT, which can have such a dramatic impact on prognosis, therapeutic choice, and quality of life.

Infections must be thought as one of the most important, if not the most important, risk factors for cancer development in humans. Approximately 15-20% of all cases of cancer around the world are caused by viruses. The
establishment of a causal relationship between the presence of specific infective agents and certain types of human cancer represents a key step in the development of novel therapeutic and preventive strategies.
In this book, Professor zur Hausen (Nobel Prize in Physiology/Medicine 2008) provides a thorough and comprehensive overview on carcinogenic infective agents -- viruses, bacteria, parasites and protozoons -- as well as their corresponding transforming capacities and mechanisms. The result is an invaluable and instructive reference for all oncologists, microbiologists and molecular biologists working in the area of infections and cancer.
The author was among the first scientists to reveal the cervical cancer-inducing mechanisms of human papilloma viruses and isolated HPV16 and HPV18, and, as early as 1976, published the hypothesis that wart viruses
play a role in the development of this type of cancer.

Image-Guided Prostate Cancer Treatments is a comprehensive reference and practical guide on the technology and application of ultrasound and MRI in the male pelvis, with special attention to the prostate. The book is organized into three main sections, the first of which is devoted to general aspects of imaging and image-guided treatments.The second section provides a systematic overview of the application of ultrasound and MRI to the diagnosis and treatment of diseases of the lower urinary tract. Performance of the ultrasound and MRI studies is explained, and the normal and abnormal pathological anatomy is reviewed. Correlation with the ultrasound in the same plane is provided to assist in understanding the MRI sequences. Biopsy and interventional procedures, ultrasound-MRI fusion techniques, and image-guided therapies, including focused ultrasound, photodynamic therapy, microwave and laser ablation, are all fully covered. The third section focuses on securing treatment effectiveness and the use of follow-up imaging to ensure therapeutic success and detect tumor recurrence at an early stage, which is vital given that prompt focal treatment of recurrence is very successful. Here, particular attention is paid to the role of Doppler ultrasound and DCE-MRI technologies. This book, containing a wealth of high-quality illustrations based on high-end equipment, will acquaint beginners with the basics of prostate ultrasound and MRI, while more advanced practitioners will learn new skills, means of avoiding pitfalls, and ways of effectively relating the imaging and image-guided treatments to the clinical situation. The information provided will permit a tailored approach in dealing with specific pathologic issues."

Germ cell tumors are relatively rare compared with other malignancies, and compilations of knowledge that encompass the entire spectrum of the disease are lacking. This textbook, written by the foremost authorities in the field, rectifies the situation by discussing in depth a broad range of topics, including biology, epidemiology, pathology, treatment, and late effects. Bearing in mind that germ cell tumors are most prevalent in the adolescent and young adult age group, causes of disease and treatment approaches in pediatric and adult patients are compared and contrasted. By spanning the entire life course, from prenatal origins of disease through to treatment in adults and late effects of treatment, the editors have produced a book that will be of interest to both pediatric and adult oncologists.

This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.

This textbook is intended as a comprehensive reference that will provide easy-to-follow and well-organized guidance on the management of lip cancer, from diagnosis to treatment and reconstruction. After discussion of anatomy and premalignant conditions, detailed attention is paid to squamous cell carcinoma of the lip. Surgical management is explained, and the roles of radiation therapy and chemotherapy, discussed. Reconstruction techniques following ablative surgery are then described in depth, with reference to defect size and complexity. In addition, the potential complications of treatment and reconstruction are presented, with advice on their management. The closing chapter considers other malignant lesions of the lip. The informative text is complemented by high-quality illustrations and clinical and radiographic material. The contributors all have extensive experience and in-depth knowledge of the topics they address. "

Oncogenic transcription factors are an increasingly important target for anticancer therapies. Inhibiting these transcription factors could allow tumour cells to be "reprogrammed", leading to apoptosis or differentiation from the malignant phenotype. As the use of kinase inhibitors is gradually declining, transcription factor inhibition is the next hot topic for oncology research and merits much attention. This book highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors. It also presents the evidence that this important protein class can be modulated in a number of ways to develop novel classes of therapeutic agents. The broad range of aspects covered by the book is noteworthy and renders it enormously valuable. This title serves as a unique reference book for postgraduates, academic researchers and practitioners working in the fields of biochemistry, biotechnology, cell and molecular biology and bio-inorganic chemistry.

This extensively illustrated book aims to systematize the selection of treatment options in patients with parotid tumors that extend beyond the borders of the parotid tissue and therefore present particular problems for the surgeon. Reconstruction of the postoperative defect is especially difficult in such cases because of the complexity and density of the anatomical structures in the lateral region of the head and neck and also the general condition of most patients, who tend to be elderly and to have accompanying disorders. The difficulty in the management of extended parotid tumors is increased by the need to sacrifice the facial nerve, even if only partially. The book provides clear criteria to assist in the choice of treatment, from the simplest options involving use of local flaps to the most sophisticated ones. It will assist the surgeon in ensuring that the patient achieves the best possible quality of life, no matter what the patient's age or the associated comorbidities.

A magnificent, beautifully written biography of cancer -- from its first documented appearances thousands of years ago through the epic battles to cure, control and conquer it, to a radical new understanding of its essence.

In The Emperor of All Maladies, Siddhartha Mukherjee, doctor, researcher and award-winning science writer, examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years.

The story of cancer is a story of human ingenuity, resilience and perseverance, but also of hubris, arrogance and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out 'war against cancer'. Mukherjee recounts centuries of discoveries, setbacks, victories and deaths, told through the eyes of predecessors and peers, training their wits against an infinitely resourceful adversary.

From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteeth-century recipient of primitive radiation and chemotherapy and Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through toxic, bruising, and draining regimes to survive and to increase the store of human knowledge.

Riveting and magesterial, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments and a brilliant new perspective on the way doctors, scientists, philosophers and lay people have observed and understood the human body for millennia.

Computer-Assisted Surgery (CAS) is a new tool for performing complex procedures in a predictable and safe way. This book is designed to serve as a comprehensive review of Computer-Assisted Surgery, covering the current status of both research and applications. CAS includes Virtual Preoperative Planning (VPP) and Intraoperative Virtual Navigation (IVN), which are a set of technologies used to measure oncological margins in 3-Dimensions (3D), to locate small intraosseous tumors and apply controlled resections preserving anatomical structures. During VPP, patient acquired multimodal images are processed and an interactive virtual scenario is created. This can then be used as a platform to measure oncological distances and preplan osteotomies in safe areas. IVN is a procedure which allows the execution of the VPP with a mean error of less than 3mm. For the student, medical doctors, research and development scientists or new researchers, the protocols are central to the performance of Computer-Assisted technologies.

The first edition of "Living Downstream"--an exquisite blend of precise science and engaging narrative--set a new standard for scientific writing. Poet, biologist, and cancer survivor, Steingraber uses all three kinds of experience to investigate the links between cancer and environmental toxins.

The updated science in this exciting new edition strengthens the case for banning poisons now pervasive in our air, our food, and our bodies. Because synthetic chemicals linked to cancer come mostly from petroleum and coal, Steingraber shows that investing in green energy also helps prevent cancer. Saving the planet becomes a matter of saving ourselves and an issue of human rights. A documentary film based on the book will coincide with publication.

Now in its second edition, Gynecologic Oncology Handbook: An Evidence-Based Clinical Guide has been thoroughly updated to include the latest advances in surgical techniques, chemotherapy protocols, AJCC 8th Edition staging criteria, and much more. This current edition contains illustrations that reinforce key concepts, algorithms for diagnostic techniques, and tables to guide you in optimal disease management. The handbook covers the spectrum of gynecologic oncology from seminal studies to guide the oncologist, to the essential workup for the Obstetrician/Gynecologist and related clinician. This handbook can be carried by the practitioner on the ward or in the clinic. It includes necessary details on gynecologic cancer screening and treatment regimens for preinvasive disease, to staging and management of all the gynecologic cancers such as cervical cancer, ovarian cancer, uterine cancer, vulvar cancer, vaginal cancer, and gestational trophoblastic disease. It highlights evidence-based best practices for managing these cancers, hereditary cancer syndromes, for surgical care, and for all adjuvant therapies including chemotherapy, radiation therapy, targeted therapies, and immunotherapies. Detailed sections on survivorship care, palliative care, as well as managing reproductive function and other comorbid medical conditions make this a `one-stop shop' for navigating all clinical aspects and effects of gynecologic cancer. Featuring new and important clinical study references, medical comorbidity algorithms, directed gynecologic cancer workups and treatments, numerous tables and easy-to-reference illustrations, the Gynecologic Oncology Handbook, Second Edition is the ultimate quick reference for the clinical management of all gynecologic malignancies and related conditions. Key Features: Covers all fundamentals of gynecologic oncology including workup, staging, surgical management, chemotherapy and radiation therapy treatment, comorbidity diagnosis and management, and background study data Provides Gynecologic Oncology Referral Parameters, Performance Status Scales, Adverse Event Grading, RECIST evaluation criteria, chemotherapy protocols, statistics, and other useful formulas. Includes clinical study references, medical comorbidity algorithms, directed workups, and treatment guidelines

Cancer is one of the most exciting specialties in medicine. This book aspires to convey the authors enthusiasm for oncology and this new edition of Oncology Lecture Notes is a must for students and trainees. There has been a revolution in the practice of oncology. The changes are due to amazing advances in basic science, and the development of new drugs and successful immunisation programmes that have followed. Cancer death rates have fallen and this is in part due to radical new treatments, effective screening programmes, and also, as a result of popular movements for change in patient care, and decreased exposure to carcinogens. Completely revised and updated, this new edition of Oncology Lecture Notes describes advances in molecular biology research and highlights the importance of patient perspectives in cancer care. The text includes many new figures and tables, an update of molecular biology and highlights new treatments. With learning objectives and key point summaries in each chapter, Oncology Lecture Notes is an ideal introduction to the biological basis and principles of treatment in oncology. Includes a companion website at www.lecturenoteseries.com/oncology featuring cases and self-assessment MCQs

This book provides a comprehensive and up-to-date overview of current polypectomy techniques and describes new perspectives in the field. A wide variety of topics are covered, including classification of colon polyps, established polypectomy techniques and related controversies, advanced endoscopic resection, endoscopic submucosal dissection, the use of submucosal injection solutions, management of complications, management of anticoagulant and antiplatelet medications, and post-polypectomy endoscopic surveillance. Information is also provided on a novel risk calculation score for adenoma recurrence after polypectomy, developed by the editors of the book and their colleagues. In acquainting readers with the state of the art in the field, Colon Polypectomy will serve as a valuable reference and practical tool for all who perform the procedure, which is of ever-increasing importance given the recent success of colon cancer screening campaigns in leading to earlier detection of colon polyps.

The prospect of entering treatment is overwhelming for anyone facing a diagnosis of cancer. While patients have access to a vast amount of medical information online, this advice is often unreliable or confusing. In Living with Cancer, Drs. Vicki A. Jackson and David P. Ryan have crafted the first step-by-step guide aimed at helping people with this life-defining disease grasp what's happening to them while coping physically and emotionally with cancer treatment. An empathetic resource full of relatable patient stories, this book teaches patients and caregivers how to ask the right questions to get the best possible care-beginning at the moment of diagnosis. Drs. Jackson and Ryan explain how to work with a team of doctors and nurse practitioners to minimize symptoms and side effects while living as fully as possible in the face of cancer. They relay important information about understanding prognosis, and they translate what doctors mean when they describe tests, treatments, and medical procedures. Finally, they discuss hospice care and answer questions about continuing treatment and managing the final phase of life. Based on new research and a groundbreaking program in which patients are treated with palliative care-along with the best cancer care-during the course of their illness, this honest and caring book provides the right advice to use at the right time throughout a journey with cancer. It allows a person with cancer to concentrate on living the best life possible, despite an uncertain future. Patients at every stage will find Living with Cancer a comprehensive, thoughtful, and accessible guide for navigating the illness and its treatment.

Bringing together more than a decade of dedicated investigation and clinical work, this unique textbook is a unified, comprehensive source for oncofertility research and medical practice that is both authoritative and up-to-date. It will serve as the primary oncofertility reference for the various medical disciplines that must be coordinated to provide care for young cancer patients. Moreover, it contains case studies that are prismatic for new entrants into the field. The book is organized around the major themes of the discipline and includes current research, clinical practice, emerging technologies and didactic questions and is divided into six thematic sections: Fertility implications in both oncologic and non-oncologic settings Options for fertility preservation, both male and female Care of the oncofertility patient, including contraception and pregnancy considerations Oncofertility in clinical practice, from setting up a new program to genetic counseling and communication Ethical and legal considerations Advances in the basic science of oncofertility In each chapter, bulleted key learning points and review study questions bookend the text. Six additional sections, comprised exclusively of clinical case studies illustrating the management of both oncologic and non-oncologic conditions, add to the pedagogical value of the text. Timely and utilizing the best current evidence, Textbook of Oncofertility Research and Practice: A Multidisciplinary Approach will be an invaluable resource for students, residents, fellows and professionals in reproductive endocrinology, pediatric endocrinology, adult and pediatric oncology, adult and pediatric urology, breast surgery, radiation oncology and allied professions where iatrogenic treatments or genetic conditions result in infertility.

This open access book focuses on diagnostic and interventional imaging of the chest, breast, heart, and vessels. It consists of a remarkable collection of contributions authored by internationally respected experts, featuring the most recent diagnostic developments and technological advances with a highly didactical approach. The chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As such, it presents a comprehensive review of current knowledge on imaging of the heart and chest, as well as thoracic interventions and a selection of "hot topics". The book is intended for radiologists, however, it is also of interest to clinicians in oncology, cardiology, and pulmonology.

Written by internationally renowned experts, the 3rd edition of this six volume textbook provides detailed practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. Supplying the reader with state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible, this book is divided into six volumes: Basic Principles, Eyelid and Conjunctival Tumors, Orbital Tumors, Uveal Tumors, Retinal Tumors, and Retinoblastoma. The information presented enables readers to provide effective patient care using the latest knowledge on ophthalmic oncology and to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Clinical Ophthalmic Oncology's clinically focused and user-friendly format allows for rapid retrieval of information in daily practice and is written for residents, fellows, and any physician involved in the care of patients with ocular or orbital malignancies. Additionally, this edition adds several hundred new images to improve comprehension of procedures and techniques. This volume describes the classification, differential diagnosis, and imaging of retinoblastoma and discusses the most suitable treatment options for different tumor types.

Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. In this volume guidance is provided on diagnosis and therapy for retinal tumors including vitreoretinal lymphoma and paraneoplastic disorders.