This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors. Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric low-grade gliomas, meningiomas and spinal cord tumors. Expert oncologists, neurosurgeons, physicians, research scientists and pathologists from around the world have contributed to this extensive publication. Their chapters highlight practical experience and provide exceptional insight into the nature of cancer. The authors cover topics ranging from the use of molecular criteria in diagnosis and targeting of medicine, through evidence-based approaches, to in-depth discussion of long-term follow-up after surgery. This handbook, as earlier volumes in the series, will appeal to professionals involved in the treatment of cancer, as well as to researchers. The series crosses subjects of diagnosis, drug development, therapy and its assessment and prognosis of tumors of the central nervous system, cancer recurrence and resistance to chemotherapy.

The expanded guide to cardiac mapping The effective diagnosis and treatment of heart disease may vitally depend upon accurate and detailed cardiac mapping. However, in an era of rapid technological advancement, medical professionals can encounter difficulties maintaining an up-to-date knowledge of current methods. This fifth edition of the much-admired Cardiac Mapping is, therefore, essential, offering a level of cutting-edge insight that is unmatched in its scope and depth. Featuring contributions from a global team of electrophysiologists, the book builds upon previous editions comprehensive explanations of the mapping, imaging, and ablation of the heart. Nearly 100 chapters provide fascinating accounts of topics ranging from the mapping of supraventricular and ventriculararrhythmias, to compelling extrapolations of how the field might develop in the years to come. In this text, readers will find: Full coverage of all aspects of cardiac mapping, and imaging Explorations of mapping in experimental models of arrhythmias Examples of new catheter-based techniques Access to a companion website featuring additional content and illustrative video clips Cardiac Mapping is an indispensable resource for scientists, clinical electrophysiologists, cardiologists, and all physicians who care for patients with cardiac arrhythmias.

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new "drugs" will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently "nanomaterials" have been said to "show promise" but none of these promises have so far been "reduced" to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug-carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile.

This international primer on psycho-oncology spans settings of care as well as regional boundaries. Designed to be easy to read, with informaton clearly displayed in concise tables and boxes accompanied by clinical vignettes, the book provides clear, practical guidance on all aspects of the psychological care of patients with cancer. Both trainees and practitioners will find it useful in the clinic as well as a resource for continued professional development.

This is a rare compilation of clinically focused chapters on the practice of oncology in more than 25 countries and areas around the world that experience ongoing or intensifying ethnic, religious, and nationalistic conflict. Each chapter is written by an internationally respected local physician or nurse. Topics include the relationship between local culture and the local practice of mainstream modern medicine, critical clinical issues faced by local physicians, and options for when and how to incorporate palliative care. The book ends with chapters on the United States' current initiatives on promoting cancer care training in these regions, and another on clinical concepts for Western clinicians undertaking oncology practice in emerging countries. The audience includes oncologists around the world: those practicing medicine in similarly extreme circumstances; Western oncologists organizing or preparing for medical missions; and Western oncologists who wish to learn from the experiences of oncologists who practice under radically different conditions.

This book is the first of its kind in bringing together biodiversity, chemical ecology, phytochemistry and cancer therapy. The highlight of the book is an exhaustive compilation of scientific data on biodiversity of medicinal plants, biodiversity and metagenomics, chemical ecology of medicinal plants, chemical ecology of marine organisms, natural products from terrestrial microbial organisms with activity towards cancer cells, marine organisms, ethnopharmacology and phytotherapy, contribution of African flora in world fight against cancer, natural products derived from terrestrial plants with activity towards cancer cells and established anticancer drugs from natural origin.The book discusses the state-of-the-art of each topic to serve as reference resource tools for graduate students as well as scientists and scholars in pharmaceutical sciences, pharmacology, organic chemistry and biochemistry, pharmacognosy, phytochemistry, ethnomedicine and ethnopharmacology, complementary and alternative medicine, medical and public health sciences and others. It includes cutting-edge developments in anticancer discovery from both medicinal plants and organisms.

Cancers are on the rise across the world. Except for viral-based cancers, overall cancers are diseases that may be preventable. This book looks at the many levels of determined, probable, and possible causation for several common cancers. These causes include realities found in culture, anthropology, sociology, politics, the environment, agriculture and food, beliefs, and the modern lifestyle. These realities are filtered through the perennial science of Chinese medicine - an ecological system of knowing and understanding the human body as it relates to the world around us.The book covers lung, colorectal, breast, prostate, and virally-caused cancers. It interweaves conventional medical knowledge of these cancers with modern realities of everyday life we all live, and with Chinese medicine interpretations and strategies for treating probable pre-cancerous conditions. This makes it a book that is useful for the practitioner of Chinese medicine. It is also useful for the patient suffering a cancer diagnosis in terms of survivorship and for other medical practitioners who wish to understand how integrated care for cancerous diseases and conditions may relate to Chinese medicine and prevention.The final chapters of the book are dedicated to finding answers for a cure for cancer through making connections between how we live, what we believe, the environment we are creating based on those beliefs, and the social and political mechanisms we now have in place that keep us from change and, therefore, from the cure for cancer.

Cancers are on the rise across the world. Except for viral-based cancers, overall cancers are diseases that may be preventable. This book looks at the many levels of determined, probable, and possible causation for several common cancers. These causes include realities found in culture, anthropology, sociology, politics, the environment, agriculture and food, beliefs, and the modern lifestyle. These realities are filtered through the perennial science of Chinese medicine - an ecological system of knowing and understanding the human body as it relates to the world around us.The book covers lung, colorectal, breast, prostate, and virally-caused cancers. It interweaves conventional medical knowledge of these cancers with modern realities of everyday life we all live, and with Chinese medicine interpretations and strategies for treating probable pre-cancerous conditions. This makes it a book that is useful for the practitioner of Chinese medicine. It is also useful for the patient suffering a cancer diagnosis in terms of survivorship and for other medical practitioners who wish to understand how integrated care for cancerous diseases and conditions may relate to Chinese medicine and prevention.The final chapters of the book are dedicated to finding answers for a cure for cancer through making connections between how we live, what we believe, the environment we are creating based on those beliefs, and the social and political mechanisms we now have in place that keep us from change and, therefore, from the cure for cancer.

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. * Introduces cutting-edge bench to bedside and back breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer * Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine * Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

This is the first of four volumes that together offer an authoritative, in-depth reference guide covering all aspects of the management of oral cancer from a multidisciplinary perspective and on the basis of a strong scientific foundation. This volume, on tumor biology, epidemiology, etiology, emerging role of cancer stem cells and prevention of oral cancer, opens by discussing oral carcinogenesis in general and the role of particular carcinogens and human papillomavirus. Global epidemiology and changes in disease prevalence are then addressed. Up-to-date information is provided on emerging cancer biomarkers, and the biologic basis of personalized therapy is explained. Histopathological features of malignant and premalignant neoplasms and their relevance to management are described. Further chapters focus on the current status of chemoprevention, the management of oral submucous fibrosis, and the value of various diagnostic adjuncts. The volume concludes by critically evaluating the efficacy of oral screening methods. Volume 1: Biology, Epidemiology, Etiology, and Prevention Volume 2: Diagnosis and Management Volume 3: Oral and Maxillofacial Reconstructive Surgery Volume 4: Rehabilitation and Supportive Care

This book describes the principles around which cancer research and clinical trials can be developed. Additionally, by describing the particularities of planning and implementing cancer research in developing countries, this book provides valuable practical information for researchers in resource-rich countries who contemplate cooperating with scientists from limited-resource countries in performing research.Written and edited by leaders in the field who work in these developing countries, Cancer Research and Clinical Trials in Developing Countries: A Practical Guide will appeal to a wide range of researchers, students, and physicians who are engaging in cancer research and clinical trials. It focuses on methodology and statistics while structured around the needs of cancer research. It provides valuable information regarding international collaboration, funding mechanisms as well as publishing and dissemination of research findings.

This book is a pocket guide to the science and practice of PET/CT imaging of esophageal and gastric malignancies. The scientific principles of PET/CT, the radiopharmaceuticals used in this context, the role of PET/CT, the characteristic PET/CT findings, and limitations and pitfalls are all clearly described. In addition, information is provided on epidemiology, clinical presentation, diagnosis, staging, pathology, management, and radiological imaging. The book is published within the Springer series Clinicians' Guides to Hybrid Imaging, which is aimed at referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. Compiled under the auspices of the British Nuclear Medicine Society, the series is the joint work of many colleagues and professionals worldwide who share a common vision and purpose in promoting and supporting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions.

The guide to effective practice management of precancerous lesions in cervix and lower genital tract.

This third edition contains in-depth examination of the different modalities that contribute to the safe and scientific management of precancerous lesions in the female genital tract. One of the most important is colposcopy which provides an accurate and effective route to their identification.

Professor Albert Singer is internationally recognized as a master of colposcopy. His training courses throughout the world are in high demand. In this edition, he has teamed with fellow expert Ashfaq Khan to present a very accessible, authoritative and highly illustrated guide to the power of colposcopy.

Practical pictorial guidance to recognizing potentially cancerous abnormalities in the cervix, vagina, and vulva is framed by internationally agreed disease classifications. Consensus guidelines from the US and Europe provide a rigorous platform for management advice. The latest information on HPV, the role of biomarkers, and new methods in diagnosis and treatment are all featured.

Cervical and Lower Genital Tract Precancer is the ideal companion for anyone wishing to incorporate safe and scientific methods of diagnosis and treatment into their clinical practice.

Written by a naturopathic physician specializing in complementary cancer care, Breast Cancer: Thriving Through Treatment to Recovery provides solutions for maintaining health and improving quality of life during conventional cancer treatment. With diet, exercise, and mental health plans tailored to treatment protocol and cancer type, this valuable guide offers safe and effective tools and practices to support patients through every phase and protocol. Organized into six easy chapters, the book summarizes the effects of chemotherapy, surgery, radiation, and hormone therapy; catalogs potential side effects; and includes recipes, exercise programs, and mental health therapy suggestions based on symptoms and predictable side effect risks to build strength, promote healing, and improve outcomes. This essential resource will help breast cancer patients reduce short- and long-term effects during and after treatment and includes: Scientifically-proven practices to support physical and emotional health using nutrition, exercise, and mind-body therapies Concise explanation of how specific cancer therapies work and their effects on the immune system Exercises to build strength with an array of low- to high-impact cardiovascular and weight-bearing exercises Quick and delicious recipes designed to include daily protein, fiber, and carbohydrate needs for patients in recovery Psychological health and well-being promoted therapies that address patient concerns

This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.

This is the first comprehensive clinical reference on cancer emergencies. It is edited and written by world-renowned experts in emergency medicine and oncology and covers the diagnosis and management of the full range of emergencies caused directly by cancer or by its treatment. It shows how the entire spectrum of clinical medicine is brought to bear in the care of cancer patients in the unique setting of the emergency department (ED), from health promotion and prevention, to treatment and palliative care. Recognizing the multiple, overlapping contexts in which emergency care of cancer patients occurs, the book addresses clinically crucial interdisciplinary topics such as the ethics of ED cancer care, the interface with palliative social work, substance abuse, and more. Finally, perspective on care system and social forces that shape ED cancer care, such as cancer care disparities and care models, and on how ED cancer care is delivered outside of the United States, frame the book as a whole. Against the backdrop of rising numbers of cancer patients and survivors as the United States population ages and a forecast shortage of oncologists, this book is designed to serve as the authoritative, single-source clinical reference on cancer emergencies. The intended audience includes emergency physicians, oncologists, internists, family physicians, emergency nurses, nurse practitioners, physician assistants, policy makers as well as pre- and postgraduate trainees.

With more than fifty years' experience as a cancer physician, Dr Philip A. Salem believes that knowledge alone is not enough when battling the disease. Patients need love, care, hope, compassion and time to talk about their fears, anxieties and concerns. This book, written with passion and precision, is intended to empower patients, helping them to receive the best possible care. Expertly taking patients through each part of the treatment process, starting with diagnosis - and supplemented throughout with insightful patient stories - Defeating Cancer will give strength to anyone affected by the condition.

Managing urologic cancer by preserving, as opposed to removing, affected tissue, is rapidly becoming the favoured choice for urologists and oncologists. Discover all available options and how to achieve the best possible patient management with this expert guide to the area. The editor, Mark Schoenberg, is an internationally-renown expert in this exciting new area and has recruited an outstanding team featuring some of the leading urologists/oncologists in North America and Europe to assist him.

SITC's Guide to Managing Immunotherapy Toxicity is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part One contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with Anti-CTLA4 agents, Anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part Two is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part Two concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of `financial toxicity 'on patients and caregivers. With chapters written by world recognized oncology leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Includes access to the fully searchable downloadable eBook

This is the second of four volumes that together offer an authoritative, in-depth reference guide covering all aspects of the management of oral cancer from a multidisciplinary perspective and on the basis of a strong scientific foundation. This volume addresses a range of management issues in oral cancer, from imaging and staging through to the roles of radiation therapy and chemotherapy. Principles of ablative surgery are explained, and neck dissection and sentinel lymph node biopsy techniques, described. Detailed consideration is also given to the management of complications, salvage surgery and re-radiation, the biologic basis of treatment failure, and emerging approaches to overcome treatment resistance. The inclusion of resource-stratified guidelines will meet the needs of practitioners in different geographic regions with varying resources. Overview on all volumes: Volume 1: Biology, Epidemiology, Etiology, and PreventionVolume 2: Diagnosis and Management Volume 3: Oral and Maxillofacial Reconstructive Surgery Volume 4: Rehabilitation and Supportive Care

This volume investigates the links between the incidence of diet-related cancers and dietary patterns within Europe. It presents current understanding of the major cancers thought to be caused by diet alongside detailed data on regional variations in dietary composition, and collates these sets of information to illustrate associations between foods and nutrients and the risk of cancer at specific sites. There is particular discussion of the role of fat, meat, fibre, cereals and fresh vegetables. The importance of the "Mediterranean diet", and regional variance in this diet within Europe, is examined. Japanese and US dietary evidence is also considered. This book highlights the debate on cancer and diet, and points the way ahead for important new research.

This book provides essential insights into the various pathogeneses, diagnoses and therapies for patients with gastric cancer. Special attention is given to trending topics: endoscopic diagnosis, cancer screening and eradication of H. pylori as prevention of the disease. A dedicated section focuses on risk classification and cancer screening/diagnosis, and is intended for practical use in clinical doctors' day-to-day management of patients. Since cancer screening and prevention is currently only practiced in Japan, this book is intended to disseminate new findings and serve as a point of departure for further research. Abundant color illustrations of the enhanced endoscopic imaging are also included, making it a valuable resource for GI medical doctors, medical students and those seeking detailed information on H. pylori.

Biomathematical Problems in Optimization of Cancer Radiotherapy provides insight into the role of cell population heterogeneity in the optimal control of fractionated irradiation of tumors. The book emphasizes the mathematical modeling aspect of the problem and presents the state of the art in the stochastic description of irradiated cell survival. Some of the results are of general theoretical interest and can be applied to other areas of optimal control methodology. Detailed explanations of all mathematical statements are provided throughout the text. The book is excellent for biomathematicians, radiotherapists, oncologists, health physicists, and other researchers and students interested in the topic.

Significantly expanded, expertly and beautifully illustrated, The AJCC Cancer Staging Atlas, 2nd Edition, offers more than 600 illustrations created exclusively for this new edition and is fully updated to reflect the concepts discussed in the 7th Edition of both the AJCC Cancer Staging Manual and its companion Handbook. This Atlas illustrates the TNM classifications of all cancer sites and types included in the 7th Edition of the Manual and visually conceptualizes the TNM classifications and stage groupings. Specifically designed for simplicity and precision, the drawings have been verified through multi-disciplinary review to ensure accuracy and relevancy for clinical use. Every illustration provides detailed anatomic depictions to clarify critical structures and to allow the reader to instantly visualize the progressive extent of malignant disease. In addition, nodal maps are included for each site, appropriate labeling has been incorporated to identify significant anatomic structures, and each illustration is accompanied by an explanatory legend. The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.

The goal of this volume is to comprehensively cover a highly readable, updated and extended, overview on our present knowledge of positive and negative effects of UV-exposure, with a focus on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of the second edition of this book to summarize essential up-to-date information for every clinician or scientist interested in how to balance between positive and negative effects of UV-exposure to minimize the risks of developing vitamin D deficiency and skin cancer.