Do you manage patients with gastrointestinal cancer? Do you need a rapid reference handbook to guide you through your diagnosis and management options? If so, then Handbook of Gastrointestinal Cancer is the book for you, providing clear, practical guidance to the diagnosis and clinical management of all forms of GI cancer, in a highly accessible format. Perfect for GI/Oncology trainees and junior gastroenterologists/oncologists and designed for point-of-care consultation, each chapter is structured in a uniform way and contains a variety of handy text features to help the reader such as case histories, key practice points, key weblinks and potential pitfalls The authors emphasize the best clinical assessment and management methods of patients and dedicate an entire chapter to each cancer, from esophageal to lower GI, and from biliary to pancreatic cancer. This attractive new book features: * Comprehensive yet quick and easy display of key points * Case studies to illustrate cardinal lessons or dilemmas * A fully integrated GI/oncologic approach * An outstanding and international editor and author team of great experience * Illustrations of key clinical or investigative features Handbook of Gastrointestinal Cancer answers all your clinical needs and is a must-have tool on the ward for all trainee and junior gastroenterologists and oncologists. "Handbook of GI Cancer ...does an excellent job of indicating which clinical recommendations are solidly evidence-based, and highlighting those that would benefit from further research." Monica M. Bertagnolli, MD, Chief, Division of Surgical Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, USA "Handbook of Gastrointestinal Cancer is a comprehensive text that should be on the bookshelf of every physician and surgeon who deals with GI malignancies. The editors, who are internationally renowned, have assembled an all-star cast of contributing authors from around the world. The inclusion of key points and case studies, and the use of an evidence-based approach, make this a stand-out reference." Mark K. Ferguson, MD,Professor, Department of Surgery and The Cancer Research Center, The University of Chicago Medicine & Biological Sciences, Chicago, USA

This book aims to provide the reader with a complete understanding of the development of oral cancer by explaining the role of a wide variety of implicated risk factors and identifying their gene targets and key regulators. Some of the discussed risk factors are well known, including smoking, alcohol, betel quid chewing, and oncoviruses such as high-risk human papillomaviruses and Epstein-Barr virus; however, careful attention is also paid to less widely recognized factors, such as Qat chewing and yerba Mate consumption. The book concludes by describing and evaluating the most important strategies currently available for the prevention of oral carcinogenesis in humans. In presenting the most up-todate research and knowledge on these topics, this book will serve as a valuable source of up-to-date information for oncologists, cancer scientists, and medical students.

The breast cancer guide every woman needs for herself, her best friend, and her sister-a warm, practical, relatable handbook, that dispels the terror, taking you step-by-step through the process, from diagnosis to post-treatment. When Andrea Hutton was diagnosed with breast cancer, she wanted to know everything. She voraciously read books, articles, and websites and talked to everyone she knew. But nothing prepared her for what the surgery, chemotherapy, and radiation would feel like. Were there tricks that could ease her pain and discomfort? What was "fatigue" and how would it affect her? At what exact moment would her hair fall out and how? Hutton wanted what she could not find: a clear how-to guide for the cancer girl she had become. Bald Is Better with Earrings is Hutton's answer for women diagnosed with breast cancer: a straightforward handbook, leavened with humor and inspiration, to shepherd them though the experience. Warm and down-to-earth, Hutton explains what to expect and walks you through this intense and emotional process: tests, surgery, chemo, losing your hair and shaving your head, being bald, radiation treatments. Hutton offers a wealth of invaluable advice-from tricks for surviving chemo, to treating your skin during radiation, to keeping track of meds-and includes a practical list of tips for each stage of the process at the end of every chapter. Compassionate, friendly, and shaped by Hutton's first-hand knowledge, Bald Is Better with Earrings is the comprehensive, essential companion for anyone dealing with breast cancer.

The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. * Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce * Fully revised with new material and an evidence-based, teach-by-example approach * Provides insight on real-world decision making in the clinical setting * Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview * Extensively illustrated in full color throughout, including heat maps to show gene expression

DNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array data are key to performing the assay and utilizing the data correctly. The most difficult challenge has been the lack of a powerful method to analyze the data for all genes (more than 30,000 genes) simultaneously and to use the microarray data in a decision-making process. In this book, the authors describe DNA microarray technology and data analysis by pointing out current advantages and disadvantages of the technique and available analytical methods. Crucially, new ideas and analytical methods based on the authors' own experience in DNA microarray study and analysis are introduced. It is believed that this new way of interpreting and analyzing microarray data will bring us closer to success in decision-making using the information obtained through the DNA microarray technology.

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states.Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments - endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

Nearly half of all Americans will be diagnosed with an invasive cancerOCoan all-too ordinary aspect of daily life. Through a powerful combination of cultural analysis and memoir, this stunningly original book explores why cancer remains so confounding, despite the billions of dollars spent in the search for a cure. Amidst furious debates over its causes and treatments, scientists generate reams of dataOCoinformation that ultimately obscures as much as it clarifies. Award-winning anthropologist S. Lochlann Jain deftly unscrambles the high stakes of the resulting confusion. Expertly reading across a range of material that includes history, oncology, law, economics, and literature, Jain explains how a national culture that simultaneously aims to deny, profit from, and cure cancer entraps us in a state of paradoxOCoone that makes the world of cancer virtually impossible to navigate for doctors, patients, caretakers, and policy makers alike. This chronicle, burning with urgency and substance leavened with brio and wit, offers a lucid guide to understanding and navigating the quicksand of uncertainty at the heart of cancer. "Malignant" vitally shifts the terms of an epic battle we have been losing for decades: the war on cancer.

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. * New contributors reflecting broader international authorship and even greater expertise * Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations * Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date * Now produced in full color for enhanced clarity * Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent * Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible

Skin lymphomas are relatively rare but potentially fatal They can easily be misdiagnosed as benign skin diseases. Dermatologists and pathologists need to have a good understanding of the clinical presentations and the pathological correlates of this challenging disease to ensure the correct diagnosis and most appropriate treatment is provided. Skin Lymphoma: The Illustrated Guide is a full-color illustrated text and atlas that combines pathology with clinical features and treatment. Jam-packed with pictures that illustrate key diagnostic points and supplemented by teaching cases to highlight effective decision making. It includes all newly identified entities and provides pointers on how to differentiate these. In addition, it also covers all inflammatory conditions that may simulate skin lymphomas (cutaneous pseudolymphomas). Skin Lymphoma: The Illustrated Guide provides * Clinical and pathological guidance on diagnosis of skin lymphomas * Clear illustrations to aid visual recognition * Nomenclature according to WHO/EORTC classifications * Cases to enhance the scope for teaching and learning This fully refreshed fourth edition continues to provide the clinical excellence that has helped a generation of dermatologists and dermatopathologists to effectively diagnose skin lymphoma.

Over 50 years, children with cancer changed from being symbols of hopelessness and the failure of modern medicine, to representing the triumph of science, fund raising, and personal heroism. Yet before 1940, children with cancer were largely invisible, to the medical professions and to the public at large. This book, written for historians and medical professionals interested in the history of child health, examines these transitions in visibility, image and expectation, and the impact of these changes on self-identity for patient and physician.

This book provides state of the art knowledge on a broad range of clinical issues in pancreatic cancer, covering topics from screening and pathophysiology to surgical treatments. In particular, the focus is on current controversies and on evidence-based surgical techniques. Further aspects considered include the management of precancerous lesions, diagnostic methods, perioperative care and nonsurgical treatment. The description of surgical methods is supported by many helpful illustrations and important technical issues are carefully addressed. Determination of resectability and extent of surgery is also discussed. Based on recent developments in surgical techniques, some surgeons are performing more and more radical operations. It is essential, however, that surgical strategy is based on the best available evidence and surgeons will find that this book offers valuable help in achieving this aim. In addition, it will be a great asset in clinical practice for all who are involved or interested in the management of pancreatic cancer.

This comprehensive textbook on the echocardiographic assessment of pediatric and congenital heart disease has been updated for a second edition with an emphasis on new technologies. This highly-illustrated full-color reference contains over 1200 figures, and offers over 600 video clips on a companion website. * Fully updated, with new chapters on the assessment of the post-Fontan procedure patient and on pregnancy and heart disease * Each lesion chapter includes new section highlighting the key elements of the echocardiogram(s) * Written by experts from the leading centers around the world, with numerous new authors * Revision emphasizes new technologies and quality of images * Comprehensive content contains overview of ultrasound physics, discussion of laboratory set-up, protocol for a standard pediatric echocardiogram and quantitative methods of echocardiographic evaluation, including assessment of diastolic function * Also includes special techniques and topics including 3D echocardiography, intraoperative echocardiography, and fetal echocardiography

First published in 1991. Routledge is an imprint of Taylor & Francis, an informa company.

Gynaecological oncology is very much a part of the MRCOG curriculum and while one might not expect a recently qualified MRCOG candidate to be able to perform radical surgery or manage the acute complications of non-surgical therapies, one would expect a solid basic knowledge and understanding of the sub-discipline. Its aim is to provide the basic core knowledge to achieve the first step in gaining expertise. Many will wish to develop their skills further and some may go on to provide a sub-specialist service. The book has been written by a local team whose members have had almost 15 years' experience in training gynaecological cancer specialists and being trained. In addition, the authors all currently work in an environment where the network model is well advanced and the value of cross-network multidisciplinary working is well accepted Blurb to first ed.].

Clinical Problems in Oncology: A Practical Guide to Management is an easy-to-use, compact reference guide packed with essential practical information on how to manage oncological emergencies as well as the side effects and complications of cancer and its treatment. The main objective is for the book to become a go-to reference guide for UK-based oncology registrars (fellows in the USA) and house officers seeking information on how to manage and deal with oncological problems at the point of care, on the wards as well as in outpatient clinics. However, the book is prepared in such a way that it will be of use to other medical professionals in the UK or Europe who encounter oncology patients in the course of their work. The book covers the most common scenarios encountered in the day-to-day management of both clinical and medical oncology patients and collates useful information that is currently scattered around in various different places. For example, if a patient was admitted neutropenic with abdominal pain, vomiting and diarrhoea then the doctor may wish to access the following resources: Guidelines on when to use GCSFPharmacy details regarding the toxicities associated with their chemotherapy (i.e. does their chemotherapy regime often cause diarrhoea?)Details on how to grade toxicityA review article on the management of chemotherapy-induced diarrhoeaPharmacy monographs on the correct prescribing of electrolyte replacementPalliative care guidance on how to switch oral opiates to IV opiates or how to start a syringe driverIt is often difficult to find this kind of specific, practical information in a timely manner, even using the Internet Clinical Problems in Oncology collates all of this information and puts it at the practitioner's fingertips, making heavy use of bullet points, tables and flowcharts in order to assist users in finding the information they need quickly. While not replacing local cancer treatment guidelines, this exciting new book provides a truly useful starting point for the management of oncology patients.

Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis, and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine, and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology, and pharmacy.

This SpringerBrief gives the latest research on the role of miRNAs in breast cancer metastasis. MicroRNAs (miRNAs) are recently described small endogenous noncoding RNAs implicated in the posttranscriptional control of gene expression. These tiny molecules are involved in developmental, physiologic phenomenon as well as pathologic processes including cancers. In fact, miRNAs have emerged as critical regulators of cancer progression, invasion and metastasis. This is mainly because a single miRNA can affect several downstream genes and signaling pathways with oncogenic or tumor suppressor actions depending on the target genes affected. Due to this multimodal downstream signaling effects, these small endogenous molecules hold great promise in metastasis prevention and treatment. Modulating the activity of miRNAs can provide opportunities for novel cancer interventions. Targeting miRNAs could become a novel prognostic and therapeutic strategy to prevent the future development of metastasis. Thus, miRNAs could also serve as a potential targets for anti-metastatic therapy. The book explores how the expression of miRNAs in the primary tumor could be silenced using antagomirs (chemically modified anti-miRNA oligonucleotides), which could prevent the development of metastasis; whereas once metastasis develops then it could be treated with miRNA mimics for inducing its expression for the treatment. Therefore, development of miRNA-based prophylactic therapies could serve as precision and personalized medicine against future development of metastasis of breast and other cancers."

The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume.

This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.

This book will assist the reader by providing individually tailored, high-quality bio-psycho-social care to patients with a wide range of problems within the fields of obstetrics, gynaecology, fertility, oncology, and sexology. Each chapter addresses a particular theme, issue, or situation in a problem-oriented and case-based manner that emphasizes the differences between routine and bio-psycho-social care. Relevant facts and figures are presented, advice is provided regarding the medical, psychological, and caring process, and contextual aspects are discussed. The book offers practical tips and actions within the bio-psycho-social approach, and highlights important do's and don'ts. To avoid a strict somatic thinking pattern, the importance of communication, multidisciplinary collaboration, and creation of a working alliance with the patient is emphasized. The book follows a consistent format, designed to meet the needs of challenged clinicians.

The first comprehensive and most recent overview of the topic, this ready reference and handbook reviews current knowledge of TAAs, their subclasses, and pinpoints their application areas in medicine. In addition, it emphasizes target identification procedures, the need for an accurate and thorough analysis of the function of TAAs, and the validation of those in clinical settings. The whole is rounded off with an overview of currently approved therapeutic antibodies.
The result is a must-have for biologists and oncologists in science, clinics and industry.

This volume reviews disparities in cancer genetics, etiology, treatment and survivorship that are associated with differences in energy balance and how those differences and disparities may be affected by geography, socioeconomic status, ethnicity, biology, behavior and others. State-of-the-art strategies are outlined to alter these problems at the individual, community and policy levels. The book provides a comprehensive assessment of the multiple contributions of disparities in energy balance and how they affect cancer. this volume should constitute a valuable resource to disparity focused investigators at all levels and serves an important guide to professionals that deal with these issues, especially those who determine and implement policy."

Understanding Liver Cancer is a concise and up-to-date review, which discusses diagnosis, management, patient care, current and emerging therapies, and useful resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of liver cancer as well as a summary of current therapies will benefit from this succinct text."

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year. Of these cases, approximately 15-25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor outcomes. However, in the past decade, survival rates of patients with HER-positive breast cancer have significantly improved due to increased screening, HER2 testing, and breakthrough HER2-targeted drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer provides oncologists, primary care physicians, trainees and other healthcare providers with a concise, accessible, and up-to-date survey of the field, including a review of our current understanding of the biology of the HER2 pathway and the rationale for targeting it in early-stage and advanced breast cancer, an overview of HER2-testing, and evidence-based discussions of available HER2-targeted regimens in the adjuvant and metastatic settings.

A Quick Guide to Cancer Epidemiology is an ideal addition to Springer Briefs in Cancer Research. The Brief provides core concepts in cancer epidemiology and also gives a snapshot of the epidemiology of seventeen human cancers. The Brief aims to provide-with quantitative focus-estimates of the global burden of neoplasms, of recent and likely future trends, distribution, causes and strategies for prevention for major groups of cancers. Finally, the Brief will give an overview of severals factors that cause cancer including dietary factors, tobacco smoking, obesity and alcohol consumption.

This book provides hands-on information on how to manage pregnant cancer patients in clinical practice. In this context a multidisciplinary perspective is essential, and contributions are accordingly presented from experts in surgical management, medical oncology, radiotherapy, pharmacokinetics, obstetric care, psychological care, neonatal and pediatric care. In addition a series of chapters focused on management in particular disease settings are presented, including breast cancer, melanoma, cervical cancer, ovarian tumors, lymphoma, leukemia, and thoracic cancers. The book reflects the major progress that has been achieved in the care of pregnant cancer patients in the recent years as important data have become available on patient management, and fetal safety in addition to valuable preclinical research on the impact of pregnancy on pharmacokinetics of anti-cancer agents. Edited and authored by worldwide leaders in the field, it will serve as a valuable resource not only for oncologists but also for obstetricians, gynecologists, neonatologists, and pediatricians caring for pregnant cancer patients and their newborns.