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Depending on their mechanism of action, the cytotoxic and targeted drugs and radiotherapy employed in oncologic treatment may cause complications and toxicities in many organ systems, with variable radiologic presentations. This comprehensive and excellently illustrated book covers the basics of therapy-induced complications and toxicities in oncologic patients, identifies their consequences for all the major organs, and describes the imaging of these impacts by means of the various radiologic modalities. By familiarizing radiologists with the most frequent and prominent toxicities that are recognizable on radiologic imaging following tumor therapy, it will facilitate identification of their early manifestations and permit differential diagnosis based on relevant findings.
Lung cancer is the leading cause of mortality worldwide, with a low survival rate. Carcinogenesis generally requires a constellation of entwined steps, involving both innate cellular and environmental factors. This book shares the updated knowledge on the origin and development of cancer through genotypic changes which upset the physiological balance between cell proliferation, differentiation, growth control, and apoptosis. The emphasis is put on the role of microRNA proteins involved in the cellular processes above outlined. Cognitive changes, related to dysregulated cellular mechanisms in cancer cells, as yet unchartered area of research, also are tackled. A better understanding of the molecular and cellular biology of lung cancer is the key source of breakthroughs in the diagnosis and prognosis, and finding more effective therapies that target specific mutations. The book provides a source of current facts and trends in clinical research and practice. It will be of interest to clinicians, researchers, and other medical professionals.
This book identifies key treatment challenges and unique care considerations in patients with head and neck cancers, providing a comprehensive guide to patient management that illustrates the critical importance of a multidisciplinary approach in achieving optimal oncological, functional, and survival outcomes. It covers all relevant specialties, including dental and oral medicine, medical oncology, radiation oncology, surgical oncology, and reconstructive surgery. It highlights the vital role played by ancillary head and neck cancer services, such as speech and swallowing therapy, occupational and physical therapy, and nutritional therapy in offering essential physical and psychological support from the time of diagnosis onward. The closing chapters address post-treatment issues, including those relating to survivorship, surveillance, and end-of-life care. Multidisciplinary care is perhaps even more important for patients with head and neck cancers than for other cancer patients, and in addressing all its aspects this book is invaluable for a wide range of practitioners.
Clear cell carcinoma (CCC) of the ovary with its unique clinical and biological features has attracted great attention, and calls for the publication of a specialized book on the subject. This is the first atlas that has narrowed its focus to CCC. Revealed here are the typical and variable histological features of CCC and related tumors. Hundreds of high-quality photographs help the reader to recognize the pathological features and clinical manifestations of CCC and to formulate diagnoses confidently and accurately. Data are based on the international central pathological review of the JGOG/GCIG3017 clinical trial in which experts around the world participated. Using a virtual slide system, interesting and significant features of CCC were discovered in the review of 652 cases. This book provides the newest information on the categorization and classification of CCC: growth patterns (papillary, tubocystic, solid, and adenofibromatous), cell types (classical hobnail and clear cell, eosinophilic, oxyphilic, and oncocytic), stromal changes (hyalinized, necrotic, hemorrhagic, lymphocytic infiltrative, luteinized, and psammomatous calcification), presence of endometriosis and atypical endometriosis, and borderline/atypical proliferative tumors. The Atlas of Clear Cell Carcinoma of the Ovary is an invaluable diagnostic resource for pathologists and gynecologic oncologists.
Colorectal Cancer: Diagnosis and Clinical Management provides colorectal surgeons, gastroenterologists and oncologists with an authoritative, practical guide to best practice in the diagnosis and clinical management of colorectal cancer. Covering all forms of treatment including surgery, chemotherapy and radiotherapy, it examines the various new and emerging therapies, new strategies for screening and prevention, as well as the latest guidance on the most challenging and controversial aspects of managing colorectal cancer. The authors present important information on: * Controversies in adjuvant chemotherapy * Long versus short course radiotherapy * Minimally invasive surgery and robotics * Radical colonic resection Each chapter contains key points, tips and tricks and clinical case studies to aid rapid browsing and knowledge of the basic principles, while self-assessment questions allow readers to test their clinical knowledge. With leading international surgeons, gastroenterologists and oncologists combining to offer their considerable wealth of expertise and knowledge, Colorectal Cancer is a well-balanced, indispensable resource for all those involved in colorectal cancer management.
This book presents a general introduction to and review of HIV-associated hematological malignancies, with a special focus on practical management issues. Each of the relevant malignancies is addressed individually, with an overview of treatment approaches, assessment of evidence regarding their efficacy, and discussion of therapeutic controversies. In addition, careful consideration is paid to issues in molecular and clinical pathology, epidemiological aspects, symptomatology, diagnosis, and risk factors. Separate chapters are devoted to autologous and allogeneic stem cell transplantation and to chemotherapy and interactions with antiretroviral agents. Many of the chapters are written by experts who have been instrumental in shifting the balance for people living with HIV and blood cancers. While two decades ago this diagnosis represented a death sentence, advances in treatment have transformed these cancers into often curable conditions. Nevertheless, optimal treatment of hematological malignancies remains a challenge, particularly in patients with severe immunosuppression. This book will be an invaluable source of information for all practitioners in the fields of clinical hematology and medical oncology and HIV medicine.
This volume provides resources, ideas, and bench manuals for the study of breast cancer. This book is divided into five sections: methods used in clinical laboratory for diagnosis (Detection of Molecular Markers of Breast Cancer); methods used in both clinical and research laboratories for testing genetic alterations (Genetic Detection of Breast Cancer) and (Isolation of Breast Cancer Cells); methods used to study the behavior of breast cancer cells (In Vitro Experimental Assays for Breast Cancer); and methods used for mimicking human breast cancer in a living organism (In Vivo Experimental Models for Breast Cancer). Breast Cancer: Methods and Protocols also explores several recently developed techniques for the study of breast cancer progression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Breast Cancer: Methods and Protocols, is a valuable handbook for both graduate and advanced undergraduate students of biological sciences, as well as scientists, technicians, and physicians working in the academic, hospital, or pharmaceutical industry aimed at studying or diagnosing breast cancer.
Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented.
Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of benign and malignant lesions of lymph node, spleen, and extranodal lymphomas. Outstanding images make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Unsurpassed visual coverage with carefully annotated gross and microscopic pathology, stains, ancillary tests, and detailed medical illustrations that provide clinically and diagnostically important information on typical and variant disease features Designed to help the reader identify crucial elements of each diagnosis, along with associated differential diagnoses and pitfalls, to more quickly resolve problems during routine signout of cases Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index Thoroughly updated content throughout, reflecting the 2016 revision of the WHO classification of lymphoid neoplasms, the latest nomenclature of diseases, and a current review of the literature of each disease New coverage of classification of B-cell lymphomas, subtypes of diffuse large B-cell lymphoma, and gray zone lymphoma; classification of T-cell lymphomas, recent genomic discoveries, and their effect in classification; and an updated review of provisional entities such as breast implant-associated anaplastic large cell lymphoma, cutaneous lymphomas, and lymphomas derived of cytotoxic lymphocytes Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
This classic text offers a comprehensive, yet concise and manageable overview of oncology nursing. This edition expands on the previous edition by pulling out the symptom management subjects into their own unit. Also includes over 400 multiple-choice review questions for each chapter case study to promote effective content review as well as OCN and AOCN certification preparation. Comprehensive yet concise overview of oncology nursing Consistent format in disease chapters for quick access and understanding of key information Review questions with answers and rationales at the end of each chapter New chapter on Functional Status and its effect on patient outcomes New chapter on Ethical Considerations for the oncology nurse New chapters on Skin Integrity, Oral Mucositis, Bone Marrow Suppression New chapter on Palliative Care offers information regarding providing physical and emotional comfort to dying patients and their families New chapters on Patient Education and Family Caregiving for information on assisting families that provide needed health services and support outside of the healthcare setting New Symptom Management unit with new chapters on Dyspnea, Sleep Disturbance, Nausea, and Hot Flashes Case studies at the end of each chapter correspond with chapter content and review questions with rationales
This volume brings together the work of experts from clinical and basic sciences specialties and addresses some of the controversial issues and advances in the management of oral cancer. Improving the outcome for the oral cancer patient will require dedicated work from many disciplines working together as multidisciplinary units. The book is meant for medical students, residents and consultants in various disciplines, including otolaryngology, head and neck surgery, neurosurgery, plastic surgery, maxillofacial surgery and oncology.
This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation. Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians -- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.
The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. * Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce * Fully revised with new material and an evidence-based, teach-by-example approach * Provides insight on real-world decision making in the clinical setting * Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview * Extensively illustrated in full color throughout, including heat maps to show gene expression
Current Toxicology Series Series Editors Diana Anderson Tno Bibra
International Ltd, Surrey, UK Michael D Waters Consultant, Chapel
Hill, NC, USA Timothy C Marrs Department of Health, London, UK Food
Borne Carcinogens Heterocyclic Amines Edited by Minako Nagao, Tokyo
University of Agriculture, Japan Takashi Sugimura, National Cancer
Center, Japan Food Borne Carcinogens provides a comprehensive
review of the genotoxic and carcinogenic activities of heterocyclic
amines (HCAs) found in cooked foods. This unique and timely
publication describes the latest research and offers an insight
into new developments. Key topics covered include:
Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own "kind" or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.
This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.
"Manual of Cancer Treatment Recovery" presents the first comprehensive program to guide the recovery from cancer and its treatment. The "Manual" helps you, other practitioners, and your staff members plan early intervention and promote healing right from the start, before distressing symptoms begin. "Manual of Cancer Treatment Recovery" teaches how to guide patients and families in setting up a simple plan that minimizes treatment's unwanted effects, how to coordinate with other clinicians involved in the patient's management; and how to develop a directed survivorship program in your practice. Divided into three sections, the book covers what everyone needs to know about survivorship, how to implement effective and enduring care, and how to work with patients utilizing The LEARN System (Living, Education, Activity, Rest, Nutrition) that Dr. Fleishman developed.
"Manual" also includes easy-to-use forms that patients may complete even before the initial consultation and post-treatment survivorship care plans for primary care providers.
Whether used independently or in conjunction with Dr. Fleishmanis patient-focused companion book "Learn to Live Through Cancer," the "Manual of Cancer Treatment Recovery" enables the oncology care team to anticipate patient and family needs even before they arise.
The "Manual" will help you to:
Developed by the American Cancer Society this new textbook designed for a wide range of learners and practitioners is a comprehensive reference covering the diagnosis of cancer, and a range of related issues that are key to a multidisciplinary approach to cancer and critical to cancer control and may be used in conjunction with the book, The American Cancer Society's Oncology in Practice: Clinical Management. Edited by leading clinicians in the field and a stellar contributor list from the US and Europe, this book is written in an easy to understand style by multidisciplinary teams of medical oncologists, radiation oncologists and other specialists, reflecting day-to-day decision-making and clinical practice. Input from pathologists, surgeons, radiologists, and other specialists is included wherever relevant and comprehensive treatment guidelines are provided by expert contributors where there is no standard recognized treatment. This book is an ideal resource for anyone seeking a deeper understanding of cancer prevention, screening, and follow-up, which are central to the ACS's worldwide mission on cancer control.
Cancer research has progressed enormously in recent years. This review volume will address recent findings in the area of T-cell therapy for cancer, including use of tumour infiltrating lymphocytes (TILs) as a therapy for melanoma, choice of target antigens, advances in engineered receptors, methods of gene transfer to T cells, review of cell processing methods and clinical trial design. Written by leadings scientists in the field, this up-to-date review on cancer research will be an important reference source to the researchers and healthcare professionals in the field.dari LOndon
This book presents an Asian perspective on how the treatment of colorectal cancer can be optimized and standardized in ways that take into account technological advances and the trend towards individually tailored therapy. Readers will find careful, well-illustrated descriptions of the standard surgical techniques for rectal cancer and colon cancer that have contributed to recent improvements in 5-year survival rates in the Asia-Pacific region, where the incidence of colorectal cancer has been rising alarmingly due to lifestyle changes. The vital role now being played by minimally invasive laparoscopic and robotic options receives detailed scrutiny. Extent and timing of surgery, patient safety, risk of complications, and unresolved issues are all discussed. Furthermore, the use of surgery within the context of multimodal management including chemotherapy and radiotherapy is explained and an integrated approach for stage IV and recurrent disease is described. The book will serve as a valuable reference for young surgeons who are in training, experienced practitioners who want to enhance their knowledge and skills, and all others who wish to learn about this field.
Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.
Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies. The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section. With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter. This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.
Mindfulness: A Kindly Approach to Being with Cancer offers people with cancer a means to bring mindfulness and kindliness into their lives, to help them cope with the challenge of a life-threatening illness. * Adapts Mindfulness-Based Cognitive Therapy (MBCT), an approach with a strong evidence base for people with recurrent depression, for the needs and challenges of people with cancer * Presents the standard 8-week course of MBCT for cancer in a flexible format that is designed to suit each reader s own particular timescale, context and situation * Based on more than 15 years of program development and clinical application by the author, and the work and experience of mindfulness teachers in other cancer centres around the world * Provides specific practices and approaches tailored to support the different phases of a cancer experience from diagnosis and treatment to living with uncertainty and managing life with cancer * Features five extended stories from people personally affected by cancer who have used mindfulness-based practices to support them in their own experience of illness, life and treatment
In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy. Click here to listen to Dr Kratz's Expert Commentary as he discusses where the field of drug delivery in oncology has made advances in the last ten years, and which therapeutic approaches may have promise for the next generations of anti-tumor agents, including nucleic acid and antibody-based approaches.
This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful.
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