"Read this important book to learn how cancer is an environmental, metabolic disease with many small causes that stack up-and what you can do to prevent or even reverse it."-Dave Asprey, New York Times bestselling author of The Bulletproof Diet The Optimal Terrain Ten Protocol to Reboot Cellular Health! The Metabolic Approach to Cancer offers an innovative, metabolic-focused nutrition protocol that works. Naturopathic, integrative oncologist and cancer survivor Dr. Nasha Winters and nutrition therapist Jess Higgins Kelley have identified the ten key elements of a person's "terrain" (think of it as a topographical map of our body) that are crucial to preventing and managing cancer. Each of the terrain ten elements-including epigenetics, the microbiome, the immune system, toxin exposures, and blood sugar balance-is illuminated as it relates to the cancer process, then given a heavily researched and tested, non-toxic and metabolic, focused nutrition prescription. The ketogenic diet-which relies on the body's production of ketones as fuel-is the centerpiece of The Metabolic Approach to Cancer. Further, Winters and Kelley explain how to harness the anticancer potential of phytonutrients abundant in low-glycemic plant and animal foods to address the 10 hallmarks of cancer-an approach Western medicine does with drug-based therapies. The optimized, genetically-tuned diet shuns: Grains Legumes Sugar Genetically modified foods Pesticides Synthetic ingredients The optimized, genetically-tuned diet emphasizes: Whole, wild foods Local Organic Ferments Heirloom Low-glycemic Other components of their approach include harm-reductive herbal therapies like mistletoe (considered the original immunotherapy and common in European cancer care centers) and cannabinoids (which shrink tumors and increase quality of life, yet are illegal in more than half of the United States). Through addressing the ten root causes of cancer and approaching the disease from a nutrition-focused standpoint, we can slow cancer's endemic spread and live optimized lives. "The Metabolic Approach to Cancer is a powerhouse of detailed information on how to prevent, manage, and treat cancer. . . . It is written in an intimate conversation style that comes from decades of deep personal experience, research, and genuine passion."-Travis Christofferson, author of Tripping over the Truth

Cancer risk prediction models provide an important approach to assess risk and susceptibility by identifying individuals at high risk, facilitating the design and planning of clinical chemoprevention trials, and allowing the evaluation of interventions. Conventional breast cancer risk model includes the cumulative estrogen exposure data such as age, age at menarche and menopause, age at first live birth, and use of HRT in risk calculation, since estrogens are the main risk factor for mammary carcinogenesis. The most widely known and commonly used model for breast cancer risk assessment is the Gail model, which focuses primarily on non-genetic risk factors, with limited information on family history. The first chapter of this book examines breast cancer risk assessment models. The following chapters discuss the association between obesity and breast cancer development; current and future standards for treatment of breast cancer and long term care of patients; and mastectomies and voluntarism.

Written by leading American practitioners, the Oxford American Handbooks of Medicine each offer a pocket-sized overview of an entire specialty, featuring instant access to guidance on the conditions that are most likely to be encountered. Precise and prescriptive, the handbooks offer up-to-date advice on examination, investigations, common procedures, and in-patient care. These books will be invaluable resources for residents and students, as well as a useful reference for practitioners.
The essential reference for medical students, residents, and clinical oncologists seeking a current, portable resource on the delivery of sophisticated cancer care. Chapters focus on the immediate information needs in clinical decision making including treatment choices. Algorithms, best practice guidelines, highlight tables, and targeted lists of landmark references enhance concise text. The Handbook covers solid tumors and hematologic malignancies plus cancer biology, genetics, prevention and screening, cancer staging, complications, and supportive care.

Why choose the Oxford American Handbook of Oncology?
The design....
The Handbook uses a unique flexicover design that's durable and practical. Compact, light, and fits in your pocket Also has quick reference tabs, four-color presentation, and bookmark ribbons to help provide fast answers.
The interior layout....
The Handbook is a quick reference in a small, innovative package. With one to two topics per page, it provides easy access and the emergency sections are in red to stand out. Icons throughout aid quick reference.
The information....
The Handbook succinctly covers all the essential topics in a one or two-page spread format with colored headings that break up the text and provide a logical structure for readers of all levels. Common clinical questions are answered clearly and extensively.
The history....
Oxford University Press is known around the world for excellence, tradition, and innovation. These handbooks are among the best selling in the world.
The price....
You get an extremely useful tool at a great value

Modern brachytherapy is one of the most important oncological treatment modalities requiring an integrated approach that utilizes new technologies, advanced clinical imaging facilities, and a thorough understanding of the radiobiological effects on different tissues, the principles of physics, dosimetry techniques and protocols, and clinical expertise. A complete overview of the field, Comprehensive Brachytherapy: Physical and Clinical Aspects is a landmark publication, presenting a detailed account of the underlying physics, design, and implementation of the techniques, along with practical guidance for practitioners. Bridging the gap between research and application, this single source brings together the technological basis, radiation dosimetry, quality assurance, and fundamentals of brachytherapy. In addition, it presents discussion of the most recent clinical practice in brachytherapy including prostate, gynecology, breast, and other clinical treatment sites. Along with exploring new clinical protocols, it discusses major advances in imaging, robotics, dosimetry, Monte Carlo-based dose calculation, and optimization.

Written by internationally known experts in the field, Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy examines one of the fastest-developing subspecialties within radiation oncology. These procedures deliver large doses of radiation in one to five sessions to a precisely determined target. Often these techniques have proven to be as or more effective than traditional radiation therapy techniques, while at the same time being cost-efficient and convenient for the patient. These techniques, however, require careful planning, specialized equipment, and well-trained staff. This volume provides a cutting-edge look at the biological and technical underpinnings of SRS and SBRT techniques. It includes a history of the development of SRS and SBRT; clinical applications of the techniques; dedicated devices for delivering precisely shaped, high doses of radiation; use of in-room imaging for treatment planning and treatment guidance; immobilization techniques for accurate targeting; and future developments that will continue to evolve and refine existing techniques. A valuable introduction to those just learning about these specialized techniques, and an ideal reference for those who are already implementing them, this book covers a wide variety of topics, with clear discussions of each aspect of the technology employed.

Based on a Tumor Immunology Symposium held in Pittsburgh, this work provides comprehensive coverage of the most important aspects of tumor immunology. It reveals novel approaches to the immunotherapy of cancer and presents complex issues in an accessible manner.

Translated by:
Heather Goodare

Chinese herbal medicine (CHM), which is becoming recognized worldwide for remarkable anticancer, anticarcinogenic, and immuno-regulative properties Many new scientific results, such as the latest discoveries in cancer inhibitors, new inhibitors from structural modification, and recent explorations in the mechanisms of CHMs during lab examinations and clinical trials The first book to specifically highlight the development of cancer inhibitors derived from a selection of Chinese medicinal herbs Information on new drug design and new therapy design to improve cancer treatment and prevention

Biomathematical Problems in Optimization of Cancer Radiotherapy provides insight into the role of cell population heterogeneity in the optimal control of fractionated irradiation of tumors. The book emphasizes the mathematical modeling aspect of the problem and presents the state of the art in the stochastic description of irradiated cell survival. Some of the results are of general theoretical interest and can be applied to other areas of optimal control methodology. Detailed explanations of all mathematical statements are provided throughout the text. The book is excellent for biomathematicians, radiotherapists, oncologists, health physicists, and other researchers and students interested in the topic.

Cancer is extremely common and in many situations a truly frightening disease, but the psychological aspects and effects have frequently been ignored. Patrice Guex reviews current thinking on the subject of possible psychosomatic causes of cancer, on the emotional or psychological reactions that it provokes, and on the medical treatment available. Illustrated with 11 case histories, this work aims to deal with the reactions of cancer patients to their illness, and the ways in which they can be helped in the hospital setting, at the same time having regard for their human dignity. In the context of a multidisciplinary approach that takes account of medical treatments as well as psychological interventions, the author suggests better ways of communicating in order to provide a therapeutic partnership between carer and client. Every aspect of cancer care, including pain relief, psycho-pharmology and complementary medicine, is considered, paying special attention to the needs of terminal patients and their carers.

This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book: describes the effects of retinoids on squamous differentiation in normal, pre-malignant, and malignant epithelial tissues; addresses the mechanisms by which cultured keratinocytes respond to retinoids; considers the antitumor activity of combination therapy with retinoids and cytokines; reviews the toxicity profiles of the vitamin A molecule and the synthetically derived retinoid compounds and their effects on humans; examines the use of retinoids in the prevention of basal cell carcinoma and squamous cell carcinoma (SCC) and in the therapy of advanced SCC; and summarizes data on the potential of retinoids to prevent epithelial cancer, to act as adjuvants to current therapies in early stages of the disease and to aid in the management of both solid tumours and hematologic malignancies.;A guide for the many disciplines involved in the preclinical studies and direct care of cancer patients, this book serves as useful reading for clinical, surgical and radiation oncologists; clinical immunologists; dermatologists; obstetricians/gynaecologists; haematologists; otolaryngologists; internists; nutritionists; and pulmonary-disease specialists.

Exercise and Disease reviews the role of exercise and physical fitness in the prevention or causation of cancer. Relevant mechanistic studies, particularly immunomodulation, are emphasized. The book also interprets effects of long-term exercise on immune functions and data that shows how exercise influences disease resistance. On the other hand, exercise may be involved in immune mediated motion injuries. Finally, exercise plays a potential role in cancer therapy. The book will be useful to researchers interested in the most recent developments and their interpretations.

Bone Marrow Processing and Purging: A Practical Guide provides an up-to-date practical guide to the major ex vivo procedures associated with bone marrow transplantation. Previously, this information was communicated primarily by word of mouth; now experts in the field present detailed descriptions and evaluations of methods for marrow harvesting, evaluation (including tumor infiltration, flow cytometric analysis, and colony assays), comparative methods for automated nucleated cell separation and enumeration, tumor cell purging, T cell depletion, stem cell selection, gene transfer, and cytopreservation. Special sections address quality control and FDA regulations.
The book provides a unique information source intended for clinicians, researchers, technical staff, transplant nurses, and medical students involved in this rapidly expanding area of medicine.

Updated to reflect changes in the field since publication of the first edition in 1979. Provides a detailed review of the methodology available for assessing the diagnosis and prognosis of cancer patients including data on the application of tumor marker assays and other immunodiagnostic procedures

Cholangiocarcinoma is a devastating illness with poor long-term survival. The diagnosis and treatment of cholangocarcinoma is becoming increasingly important, particularly with the increasing incidence of hepatocellular carcinoma, another primary liver tumour. Since the diagnosis, treatment, and prognosis of the two similar malignancies vary tremendously, a thorough understanding of cholangiocarcinoma is vital for any practitioner dealing with this patient population. The diagnosis and treatment of patients with this disease requires input from nearly every specialist in cancer care: pathologists, diagnostic radiologists, hepatologists, endoscopists, surgical oncologists, medical oncologists, radiation oncologists, and interventional radiologists, who all play a very active role in the management of this disease process. The intent of this book is to provide an overview of the entire disease process, from the diagnosis through imaging and pathology, to the clinical care of patients pre- and post-treatment, to primary oncologic interventions.

Based on the National Academy of Sciences approach to quantitative risk assessment. Emphasizes how an accurate assessment of cancer risk must draw on a wide range of disciplines, such as biology, chemistry, physics, engineering, and the social sciences. Provides tables of Poisson confidence limit fa

Up-to-Date Details on Using Ultrasound Imaging to Help Diagnose Various Diseases Due to improvements in image quality and the reduced cost of advanced features, ultrasound imaging is playing a greater role in the diagnosis and image-guided intervention of a wide range of diseases. Ultrasound Imaging and Therapy highlights the latest advances in using ultrasound imaging in image-guided interventions and ultrasound-based therapy. The book presents current and emerging techniques, identifies trends in the use of ultrasound imaging, and addresses technical and computational problems that need to be solved. The book is organized into three sections. The first section covers advances in technology, including transducers (2-D, 3-D, and 4-D), beamformers, 3-D imaging systems, and blood velocity estimation systems. The second section focuses on diagnostic applications, such as elastography, quantitative techniques for therapy monitoring and diagnostic imaging, and ultrasound tomography. The final section explains the use of ultrasound in image-guided interventions for image-guided biopsy and brain imaging.

This volume presents the most complicated and powerful cancer biotherapies developed. It provides an overview of human immune system function and the mechanisms by which adoptive cellular immunotherapies (ACI) harnesses the activity. The volume provides a vision on the developments in ACI.

Research has demonstrated that children with cancer and their parents regards procedure-related pain as one of the most difficult parts of having cancer, and their distress continues years after the completion of anti-cancer treatment. This is a practical 'how to' book that will provide readers with the knowledge, skills, structure and techniques to help young patients and their families to cope with painful medical procedures. The author has gathered together over 10 years experience in clinical pediatric oncology and palliative care to provide a concise overview of procedure-related pain. The book describes the pharmacological and psychological methods of pain relief and how they may be combined, along with the difficulties that may be encountered in their implementation. It also encourages better integration between research work and clinical practice. This is an essential guide for all healthcare professionals working with young people in palliative care or oncology, or those working with children undergoing painful treatments for other conditions such as those with diabetes or those undergoing dialysis.

This monograph explains the considerable impact that monoclonal antibodies and molecular probes have had on the diagnosis of tumor types and sub-types. It explains how radiolabelled monoclonal antibodies have also been used as imaging agents to try to improve the oncologist's ability to define residual tumor deposits after combination chemo/radiotherapy. Finally, the childhood malignancies that still have a poor prognosis are presented, and new novel ways of therapy are explained.

When Eric Wendel was diagnosed with acute lymphoblastic leukemia in 1966, the survival rate was 10 percent. Today, it is 90 percent. Even as politicians call for a "Cancer Moonshot," this accomplishment remains a pinnacle in cancer research. The author's daughter, then a medical student at Georgetown Medical School, told her father about this amazing success story. Tim Wendel soon discovered that many of the doctors at the forefront of this effort cared for his brother at Roswell Park in Buffalo, New York. Wendel went in search of this extraordinary group, interviewing Lucius Sinks, James Holland, Donald Pinkel, and others in the field. If there were a Mount Rushmore for cancer research, they would be on it. Despite being ostracized by their medical peers, these doctors developed modern-day chemotherapy practices and invented the blood centrifuge machine, helping thousands of children live longer lives. Part family memoir and part medical narrative, Cancer Crossings explores how the Wendel family found the courage to move ahead with their lives. They learned to sail on Lake Ontario, cruising across miles of open water together, even as the campaign against cancer changed their lives forever.

This book describes the identification and characterization of genetic loci that determine susceptibility to liver, mammary, or skin carcinogenesis in rodents. It focuses on protein kinases and phospholipases, and stress-related signal transduction.

An innovative contemporary history that blends insights from a variety of disciplines to highlight how a storied African cancer institute has shaped lives and identities in postcolonial Uganda. Over the past decade, an increasingly visible crisis of cancer in Uganda has made local and international headlines. Based on transcontinental research and public engagement with the Uganda Cancer Institute that began in 2010, Africanizing Oncology frames the cancer hospital as a microcosm of the Ugandan state, as a space where one can trace the lived experiences of Ugandans in the twentieth century. Ongoing ethnographic fieldwork, patient records, oral histories, private papers from US oncologists, American National Cancer Institute records, British colonial office reports, and even the architecture of the institute itself show how Ugandans understood and continue to shape ideas about national identity, political violence, epidemics, and economic life. Africanizing Oncology describes the political, social, technological, and biomedical dimensions of how Ugandans created, sustained, and transformed this institute over the past half century. With insights from science and technology studies and contemporary African history, Marissa Mika's work joins a new wave of contemporary histories of the political, technological, moral, and intellectual aspirations and actions of Africans after independence. It contributes to a growing body of work on chronic disease and situates the contemporary urgency of the mounting cancer crisis on the continent in a longer history of global cancer research and care. With its creative integration of African studies, science and technology studies, and medical anthropology, Africanizing Oncology speaks to multiple scholarly communities.

Scientific advances have led to the recognition that many chronic diseases such as cancer may be preventable. In this volume, 36 contributions test cancer prevention hypotheses, attempt to interpret their results, and provide a guide to the background, rationale, and selection of cancer prevention agents, as well as the design, im>plementation, and evaluation of cancer prevention studies. It will offer assistance to many in the conduct of investigations and will be of interest to all in the in>terpretation of research results in the scientific literature.

Prominent specialists champion the view that contemporary management of breast, or any, cancer requires the partnership of physicians, nurses, social workers, and all others whose special training and talents should be integrated for treating the whole patient. Here is the book that sets forth the rationale for this nationwide emerging concept and the means for accomplishing it.
Dealing with total care of the whole patient, this new classic text is written by and for surgeons, radiation oncologists, medical oncologist, pathologists, radiologists, nurses, social workers, and others involved with the care and management of the patient with breast cancer.