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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
Foundations of Colorectal Cancer provides a holistic and
comprehensive dive into colorectal cancer, discussing the
contributions of each discipline that studies it, allowing its
understanding from the most demographic and ethical facts, to the
treatment process, its varieties and genetic background. Written by
experts in diverse areas such as cancer research, oncology,
genetics, biochemistry, psychology, social sciences, bioinformatics
and palliative care, the book brings real-world experiences to help
readers with any challenge they may face when dealing with patients
or during their research workflow. The content is split into nine
sections: Clinical manifestations and disease detection, covering
primary and secondary prevention, and the role of primary care;
Diagnosis and staging, discussing endoscopy, colonoscopy, molecular
pathology, and anatomopathological diagnosis; Treatment, including
endoscopic, surgical, radiological, and postoperative approaches;
Molecular and biological mechanisms, with the role of intestinal
microbiota, stem cells and signaling pathways; New diagnostic
methods, encompassing biomarkers and bioinformatics tools for
research; Biobanks, with an overview of their regulations and
importance in the research; Epidemiological studies, focusing on
incidence and mortality globally and by regions; Hereditary
colorectal cancer, differentiating nonpolyposis and polyposis
types; and Addressing the consequences of colorectal cancer,
covering psychological effects, nutrition and ethical issues.
Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to
Bedside, Third Edition comprehensively investigates key discoveries
in the field of bone biology. New aspects of bone cancer biology
are treated in new chapters covering exosomes, autophagy, and
metabolism. These have led to the development of entirely new areas
for investigation, such as therapies which combine surgery and
biological approaches. The Third Edition expands on the original
overview of bone cancer development (physiology and
pathophysiology), with 40% new material. Each chapter has been
written by internationally recognized specialists on the bone
cancer microenvironment, bone metastases, osteoclast biology in
bone cancer, proteomics, bone niche, circulating tumor cells, and
clinical trials. Given the global prevalence of breast and prostate
cancers, knowledge of bone biology has become essential for
everyone within the medical and cancer research communities. Bone
Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside
continues to offer the only translational reference to cover all
aspects of primary bone cancer and bone metastases. This revision
opens the door to myeloma with two short chapters dedicated to this
bone-associated disease.
This book discusses the role of genetic polymorphism in
susceptibility to cancers. The book explores the understanding of
differences between the genetic polymorphisms and mutations.It
reviews the mechanisms underlying the effect of polymorphism in
genes encoding proteins that play an essential role in metabolism,
signal transduction, cell cycle, and DNA repair mechanisms.
Further, it investigates various techniques that are used for
analyzing the genetic polymorphisms. The book contains many
chapters which summarize the importance of genetic information
obtained from polymorphism-based pharmaco-genetic tests to predict
better drug response and life-threatening adverse reactions to
chemotherapeutic agents, help in understanding of the impact of
SNPs on gene function, and gives overview of the different SNP
databases for examination. This book, therefore, serves as an
essential guidebook for independent researchers as well as
institutions working in this specialised field.
Currently, intensive effort is being directed toward the
identification of molecular targets that can provide approaches to
the development of novel therapeutic strategies in cancer
management. This book focuses on metastasis-associated genes,
metastasis promoter and suppressor genes, which relate specifically
to behavioral alterations of cancer cells in epithelial mesenchymal
transition, cancer stem cell maintenance and propagation, and to
the acquisition of invasive and metastasis faculty. The function of
these genes has implications for cell cycle regulation and cell
proliferation and so constitute an essential element in cancer
growth and dissemination. The emphasis in this book is on how
appropriate these genes are as molecular targets and how
practicable are the constituents of their signal transduction
systems as potential candidates and how accessible they are to
targeted therapy. Written in a straightforward and clear style with
background information supporting the new research, this book will
be useful for students and researchers in cancer therapies.
Identifies molecular targets and their accessibility for
therapeutic interventionProvides information on biological features
of tumor development and dissemination Background information
provided for each topic
Overcoming Drug Resistance in Gynecologic Cancers provides
up-to-date information related to important gynecologic cancers and
focuses on mechanisms of drug resistance, genetics, signaling,
immunology, health disparities, nanotechnology, economic
considerations and financial impacts. The book covers not only drug
resistance but also important means to reverse resistance both in
the laboratory and clinic. The book discusses topics such as
lifestyle, nutrition and risk of gynecologic cancers, the financial
impact of drug resistance, chemosensitizing agents and targeted
therapies in cervical, endometrial and ovarian cancer,
immunotherapy to overcome drug resistance, and genetic
polymorphisms in gynecologic cancers. Additionally, it discusses
ethnic and racial health disparity perspectives and future
developments in chemosensitizing activities to reverse drug
resistance in gynecologic cancers. It is a valuable resource for
cancer researchers, oncologists, clinicians and other biomedical
field members who are interested in new approaches to improve
chemotherapy outcome in patients with gynecologic cancers.
Advanced Drug Delivery Systems in the Management of Cancer
discusses recent developments in nanomedicine and nano-based drug
delivery systems used in the treatment of cancers affecting the
blood, lungs, brain, and kidneys. The research presented in this
book includes international collaborations in the area of novel
drug delivery for the treatment of cancer. Cancer therapy remains
one of the greatest challenges in modern medicine, as successful
treatment requires the elimination of malignant cells that are
closely related to normal cells within the body. Advanced drug
delivery systems are carriers for a wide range of pharmacotherapies
used in many applications, including cancer treatment. The use of
such carrier systems in cancer treatment is growing rapidly as they
help overcome the limitations associated with conventional drug
delivery systems. Some of the conventional limitations that these
advanced drug delivery systems help overcome include nonspecific
targeting, systemic toxicity, poor oral bioavailability, reduced
efficacy, and low therapeutic index. This book begins with a brief
introduction to cancer biology. This is followed by an overview of
the current landscape in pharmacotherapy for the cancer management.
The need for advanced drug delivery systems in oncology and cancer
treatment is established, and the systems that can be used for
several specific cancers are discussed. Several chapters of the
book are devoted to discussing the latest technologies and advances
in nanotechnology. These include practical solutions on how to
design a more effective nanocarrier for the drugs used in cancer
therapeutics. Each chapter is written with the goal of informing
readers about the latest advancements in drug delivery system
technologies while reinforcing understanding through various
detailed tables, figures, and illustrations. Advanced Drug Delivery
Systems in the Management of Cancer is a valuable resource for
anyone working in the fields of cancer biology and drug delivery,
whether in academia, research, or industry. The book will be
especially useful for researchers in drug formulation and drug
delivery as well as for biological and translational researchers
working in the field of cancer.
This book highlights both conventional and nanomaterials-based
biosensors for the detection of cervical cancers. It describes
developments in the selective and sensitive electrochemical
biosensors based on DNA for the early diagnosis of cervical cancer.
Further, this book covers other nano-biosensing systems such as
nano-thermometry-based sensing platforms, mechanical sensing
platforms encompassing piezoelectric-based sensors, electrochemical
impedance spectroscopy based on PEGylated arginine functionalized
magnetic nanoparticles, and field-effect transistor-based platforms
for the early detection of cervical cancer. Also, it presents
conventional platforms such as vibrational spectroscopy and
polymerase chain reaction techniques for the diagnosis of cervical
cancer. Finally, it reviews currently available biomarkers for the
early diagnosis of cervical cancer and presents strategies for
developing novel biomarkers based on cellular and molecular
approaches. As such, this book is a comprehensive resource for
researchers and clinicians working in cervical cancer diagnostics.
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