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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General

Mechanisms of Molecular Carcinogenesis - Volume 2 (Hardcover, 1st ed. 2017): Johannes Haybaeck Mechanisms of Molecular Carcinogenesis - Volume 2 (Hardcover, 1st ed. 2017)
Johannes Haybaeck
R5,491 Discovery Miles 54 910 Ships in 12 - 17 working days

Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects. This second volume complements the first by presenting and concisely explaining the carcinogenesis of various tumor entities such as non-melanoma skin cancers, bone and soft tissue tumors, pancreatic cancers, hepatocellular cancer and neuroendocrine tumors. As in volume one, each chapter illuminates the similarities and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic strategies. The focus of volume two lies on the presentation of modern molecular biological techniques for diagnosis, as well as strategies for biomarker identification and validation. Furthermore, it discusses potential therapeutic targets and individualized treatment strategies, offering a valuable resource for all basic scientists and medical researchers interested in translational cancer research.

Mechanisms of Molecular Carcinogenesis - Volume 1 (Hardcover, 1st ed. 2017): Johannes Haybaeck Mechanisms of Molecular Carcinogenesis - Volume 1 (Hardcover, 1st ed. 2017)
Johannes Haybaeck
R5,378 Discovery Miles 53 780 Ships in 12 - 17 working days

Divided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects. This 1st Volume presents tumor entities of the ocular system, the thyroid organ, the oesophagus, gliomas, non-glial brain tumors, head and neck as well as lung cancer. In addition it also discusses in-depth potential novel molecular players and the role of stem cells as well as the endocannabinoid system in carcinogenesis, it furthermore explains tumor metabolism components and signaling pathways. Each of the chapters discusses potential therapeutic strategies and novel drug targets. The book addresses basic scientists and medical researchers interested in translational cancer research.

Current Applications for Overcoming Resistance to Targeted Therapies (Book, 1st ed. 2019): Myron R. Szewczuk, Bessi Qorri,... Current Applications for Overcoming Resistance to Targeted Therapies (Book, 1st ed. 2019)
Myron R. Szewczuk, Bessi Qorri, Manpreet Sambi
R2,923 Discovery Miles 29 230 Ships in 10 - 15 working days

Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.

Notch Signaling - Immunity and Cancer (Hardcover, 1st ed. 2017): Koji Yasutomo Notch Signaling - Immunity and Cancer (Hardcover, 1st ed. 2017)
Koji Yasutomo
R2,886 Discovery Miles 28 860 Ships in 10 - 15 working days

This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry.

Cancer in Sub-Saharan Africa - Current Practice and Future (Hardcover, 1st ed. 2017): Olufunso Adebola Adedeji Cancer in Sub-Saharan Africa - Current Practice and Future (Hardcover, 1st ed. 2017)
Olufunso Adebola Adedeji
R2,959 R2,060 Discovery Miles 20 600 Save R899 (30%) Ships in 12 - 17 working days

This book discusses the current state of cancer pathway as it is relevant to sub-Saharan Africa and highlights differences in epidemiology and the underlying problems with management. It outlines the current practice and opinions in all forms of cancer, also highlighting future prospects. Starting by providing background information on the epidemiology and genomic variations, the book then goes on to look at Infection-related cancers and continues to prostate GI, breast cancer and ovarian and cervical cancer. The last part of the book focuses on delivery of affordable and accessible care. Palliative services and primary and transnational research, as well as clinical trials are also discussed. Written by a team of authors based in the UK, Nigeria, South Africa and the US. this book offers an overview of the current state and challenges of cancer care in sub-Saharan Africa, and it would be valuable to policy makers, researchers, funding organisations, and can be an adjunct to standard text books for students, residents and established doctors.

Adult T-cell Leukemia/Lymphoma (Hardcover, 1st ed. 2017): Toshiki Watanabe, Takuya Fukushima Adult T-cell Leukemia/Lymphoma (Hardcover, 1st ed. 2017)
Toshiki Watanabe, Takuya Fukushima
R4,923 Discovery Miles 49 230 Ships in 10 - 15 working days

This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.

Unusual Cases in Peritoneal Surface Malignancies (Hardcover, 1st ed. 2017): Emel Canbay Unusual Cases in Peritoneal Surface Malignancies (Hardcover, 1st ed. 2017)
Emel Canbay
R2,863 R1,964 Discovery Miles 19 640 Save R899 (31%) Ships in 12 - 17 working days

This book has been designed to provide the full description of the comprehensive management of peritoneal surface malignancies which have originated from different primaries, such as breast cancer, small bowel cancers and imatinib resistant GISTosis and sarcomas and pseudomyxoma. The book provides the most up-to-date information on current approaches such as cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Given the increasing evidence that the patients who may benefit from this treatment modality avoid potential lethal course of these diseases, the book explores the application of these approaches to a number of types of malignancy. The first chapters explore Benign Multicystic Mesothelioma and Pseudomyxoma Peritonei arising from unusual primaries. Among other explored topics are peritoneal metastases from serous papillary uterine carcinoma, sarcoma and from unusual origins. This book is valuable for surgical oncologists who deal with the management of peritoneal surface malignancies.

Immunotherapy of Hepatocellular Carcinoma (Hardcover, 1st ed. 2017): Tim F. Greten Immunotherapy of Hepatocellular Carcinoma (Hardcover, 1st ed. 2017)
Tim F. Greten
R5,172 Discovery Miles 51 720 Ships in 10 - 15 working days

In this book we provide insights into liver - cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical "inflammation-induced" cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Juvenile Angiofibroma (Hardcover, 1st ed. 2017): Siba P. Dubey, Bernhard Schick Juvenile Angiofibroma (Hardcover, 1st ed. 2017)
Siba P. Dubey, Bernhard Schick
R4,488 R3,715 Discovery Miles 37 150 Save R773 (17%) Ships in 12 - 17 working days

This book provides a comprehensive up-to-date review of juvenile angiofibroma, with contributions from all relevant specialties. Starting with a brief introduction to the history, etiology and relevant anatomy, the book goes on to discuss the pathology, clinical features and treatment of this disease in depth, concluding with a summary of current controversies. Juvenile Angiofibroma is aimed at a global audience of otolaryngologists, endoscopists, head and neck surgeons, maxillofacial surgeons, pathologists, radiologists and geneticists.

Current Concepts in Endometrial Cancer (Hardcover, 1st ed. 2017): Ranu Patni Current Concepts in Endometrial Cancer (Hardcover, 1st ed. 2017)
Ranu Patni
R3,191 Discovery Miles 31 910 Ships in 12 - 17 working days

This book comprehensively covers endometrial carcinoma, a type of gynecological cancer that is often overlooked but of great interest. Although the incidence of the disease is rapidly increasing, both per se and as part of familial cancer syndromes, there is a great deal of controversy regarding its diagnosis, evaluation and management. This book underlines the significance of endometrial carcinoma, highlights key prevention measures, charts its evaluation, and addresses the stage-by-stage management of this malignancy, with particular attention to the role of minimally invasive surgery. Further, it includes a chapter on future perspectives including robotics, targeted therapies and other developments in the offing. Overall, the book provides a comprehensive guide to endometrial cancer, which if approached properly, can have an excellent prognosis, thus saving many lives and/or achieving substantially improved quality of life.>

Gonadal Tissue Cryopreservation in Fertility Preservation (Hardcover, 1st ed. 2016): Nao Suzuki, Jacques Donnez Gonadal Tissue Cryopreservation in Fertility Preservation (Hardcover, 1st ed. 2016)
Nao Suzuki, Jacques Donnez
R4,384 R3,586 Discovery Miles 35 860 Save R798 (18%) Ships in 12 - 17 working days

This book is a practical guide to the cryopreservation and transplantation of oocytes, embryos, and ovarian and testicular tissue for fertility preservation. Illustrated with a wealth of figures and photos, it provides updated techniques for clinicians, technicians, and researchers. This book also gives insights into in vitro activation (IVA), in vitro growing (IVG), and in vitro maturation (IVM), with both basic research and future directions. These techniques combined with cryopreservation will improve the chances of reproduction. Cryopreservation is essential to protect fertility in cancer patients who undergo treatment with radioiodine or chemotherapy, which may cause damage to their reproductive organs, and also for primary ovarian insufficiency patients. The book also includes a chapter on the risk of the presence of malignant cells in ovarian tissue. Both editors are pioneering researchers in this field.

Cancer and Chronic Conditions - Addressing the Problem of Multimorbidity in Cancer Patients and Survivors (Hardcover, 1st ed.... Cancer and Chronic Conditions - Addressing the Problem of Multimorbidity in Cancer Patients and Survivors (Hardcover, 1st ed. 2016)
Bogda Koczwara
R6,228 Discovery Miles 62 280 Ships in 10 - 15 working days

This book addresses the growing problem of multimorbidity in cancer patients and survivors with the focus on how to best integrate the effective cancer care with the care of multiple chronic conditions. As cancer is more prevalent in older individuals, many patients with cancer also suffer from other chronic conditions that impact on the uptake, tolerance and outcomes of cancer treatment and their long term mortality and morbidity. In addition, cancer and its treatment increase the risk of future chronic conditions. Readers will examine the prevalence and predictors of chronic conditions in cancer, impact of chronic conditions on screening and treatment, evidence for preventative strategies that address both cancer and chronic conditions, emerging management and care integration strategies and directions for management of multimorbidity in special cancer populations - the very young, the very old and those at the end of life. Authored by clinicians and researchers from diverse expertise including epidemiology, sociology, hematology, medical oncology, palliative care, pharmacy and representing Australia, New Zealand, US, Canada and the Netherlands, the book brings an international perspective to a problem that affects all cancer settings. The book is going to be of interest to diverse professionals interested in cancer control including epidemiologists, public health researchers, policy makers as well as clinicians dealing with cancer patients within specialist cancer and non-cancer and primary care settings.

Oncologic Imaging: Urology (Hardcover, 1st ed. 2017): Seung Hyup Kim, Jeong Yeon Cho Oncologic Imaging: Urology (Hardcover, 1st ed. 2017)
Seung Hyup Kim, Jeong Yeon Cho
R3,798 Discovery Miles 37 980 Ships in 12 - 17 working days

This book is designed as a reference and working guide for practitioners who deal with patients with neoplastic diseases of the urinary tract and male genitalia, including tumors of the kidney, ureter and urinary bladder, prostate, testis, adrenal gland, and retroperitoneum. Each chapter describes and illustrates key imaging findings relevant to the characterization, differential diagnosis, and staging of lesions. Pattern recognition is facilitated through the use of schematic drawings, and imaging findings on post-treatment follow-up also form an important component of the book. Brief core descriptions of related multidisciplinary fields, such as nuclear medicine, pathology, urologic surgery, and radiation oncology are included whenever relevant.

Bio-Psycho-Social Obstetrics and Gynecology - A Competency-Oriented Approach (Paperback, 1st ed. 2017): K. Marieke Paarlberg,... Bio-Psycho-Social Obstetrics and Gynecology - A Competency-Oriented Approach (Paperback, 1st ed. 2017)
K. Marieke Paarlberg, Harry B. M. Van De Wiel
R5,677 Discovery Miles 56 770 Ships in 12 - 17 working days

This book will assist the reader by providing individually tailored, high-quality bio-psycho-social care to patients with a wide range of problems within the fields of obstetrics, gynaecology, fertility, oncology, and sexology. Each chapter addresses a particular theme, issue, or situation in a problem-oriented and case-based manner that emphasizes the differences between routine and bio-psycho-social care. Relevant facts and figures are presented, advice is provided regarding the medical, psychological, and caring process, and contextual aspects are discussed. The book offers practical tips and actions within the bio-psycho-social approach, and highlights important do's and don'ts. To avoid a strict somatic thinking pattern, the importance of communication, multidisciplinary collaboration, and creation of a working alliance with the patient is emphasized. The book follows a consistent format, designed to meet the needs of challenged clinicians.

Surgical Pathology of Hepatobiliary Tumors (Hardcover, 1st ed. 2017): Wen-Ming Cong Surgical Pathology of Hepatobiliary Tumors (Hardcover, 1st ed. 2017)
Wen-Ming Cong
R4,870 Discovery Miles 48 700 Ships in 10 - 15 working days

This book focuses on the pathological diagnosis of primary hepatic and bile duct tumors, and introduces the "Three Types and Six Sub-types" classification of hepatobiliary tumors. With more than 600 figures, including photographs and microscopy images, it highlights morphology, immunology and molecular pathology and their correlations with hepatic surgery and hepatic oncology. The book reviews the pathobiological characteristics of hepatic tumors and reveals the latest developments in this field. It is a valuable reference resource for hepatologists, pathologists and researchers.

Childhood Acute Lymphoblastic Leukemia (Hardcover, 1st ed. 2017): Ajay Vora Childhood Acute Lymphoblastic Leukemia (Hardcover, 1st ed. 2017)
Ajay Vora
R4,582 Discovery Miles 45 820 Ships in 12 - 17 working days

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Functional Urologic Surgery in Neurogenic and Oncologic Diseases - Role of Advanced Minimally Invasive Surgery (Hardcover, 1st... Functional Urologic Surgery in Neurogenic and Oncologic Diseases - Role of Advanced Minimally Invasive Surgery (Hardcover, 1st ed. 2016)
Antonio Carbone, Giovanni Palleschi, Antonio Luigi Pastore, Aurel Messas
R3,846 R2,038 Discovery Miles 20 380 Save R1,808 (47%) Ships in 12 - 17 working days

This book offers a comprehensive guide to state-of-the-art techniques in functional urologic surgery that minimize functional damage to the urinary tract and are of particular value in patients with oncologic or neurogenic diseases. It describes the main minimally invasive surgical techniques currently available step by step, while also offering guidance on indications and how to select appropriate surgical devices to achieve specific oncological and functional outcomes. Further, the book presents data from relevant case series, documenting the favorable functional and oncologic results achieved with these techniques and devices as well as the low associated morbidity and positive impacts on quality of life. Lastly, it offers advice on preoperative assessment and postoperative care, and presents specific diagnostic algorithms of value in daily clinical practice. The contributing authors represent an international mix of respected experts carefully selected for their knowledge of the topics discussed.

Breast Cancer Prevention and Treatment (Paperback, 1st ed. 2016): Lida A. Mina, Anna Maria Storniolo, Hal Douglas Kipfer, Cindy... Breast Cancer Prevention and Treatment (Paperback, 1st ed. 2016)
Lida A. Mina, Anna Maria Storniolo, Hal Douglas Kipfer, Cindy Hunter, Kandice K. Ludwig
R1,846 Discovery Miles 18 460 Ships in 10 - 15 working days

Uniquely designed for oncologists and general practitioners, this book offers clinicians comprehensive guidelines when dealing with women at high risk for breast cancer. Written by experts in the field on the cutting edge of this research, the following questions will be answered for the reader by the end of the book: * Who is at elevated risk for breast cancer? * Who should be genetically screened? * When and how often should we obtain imaging? * What type of imaging is adequate? * What medications are available for prevention? * When is surgical intervention appropriate? * What lifestyle changes should be implemented to prevent this disaster? With one in eight women likely to contract breast cancer in her lifetime, the significance of identifying and managing the high-risk patient is evident. Breakthroughs in the identification of genes associated with breast carcinoma, particularly BRCA1 and 2, as well as other risk factors, influence not only how patients are screened, but also how they are treated. Breast Cancer Prevention and Treatment provides a guided approach to prevention of breast cancer in women at elevated risk for this malignancy.

Systems Biology of Tumor Microenvironment - Quantitative Modeling and Simulations (Hardcover, 1st ed. 2016): Katarzyna A.... Systems Biology of Tumor Microenvironment - Quantitative Modeling and Simulations (Hardcover, 1st ed. 2016)
Katarzyna A. Rejniak
R5,477 Discovery Miles 54 770 Ships in 12 - 17 working days

This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.

Cancer and Cardiovascular Disease - A Concise Clinical Atlas (Hardcover, 1st ed. 2018): Syed Wamique Yusuf, Jose Banchs Cancer and Cardiovascular Disease - A Concise Clinical Atlas (Hardcover, 1st ed. 2018)
Syed Wamique Yusuf, Jose Banchs
R5,223 Discovery Miles 52 230 Ships in 10 - 15 working days

The atlas provides a clear, concise, yet comprehensive review of common cardiovascular diseases occurring in patients with cancer. Cancer and cardiovascular disease are the two most common conditions worldwide. In clinical practice we frequently encounter patients who have established cardiovascular disease and subsequently develop cancer or are survivors of cancer with subsequent cardiovascular complications related to chemotherapy and or radiation. Most of the chapters are case based, followed by images and a discussion on current (evidence based, wherever available) investigations and treatment outline.

Management of Extended Parotid Tumors (Hardcover, 1st ed. 2016): Victor-Vlad Costan Management of Extended Parotid Tumors (Hardcover, 1st ed. 2016)
Victor-Vlad Costan
R4,265 R3,779 Discovery Miles 37 790 Save R486 (11%) Ships in 12 - 17 working days

This extensively illustrated book aims to systematize the selection of treatment options in patients with parotid tumors that extend beyond the borders of the parotid tissue and therefore present particular problems for the surgeon. Reconstruction of the postoperative defect is especially difficult in such cases because of the complexity and density of the anatomical structures in the lateral region of the head and neck and also the general condition of most patients, who tend to be elderly and to have accompanying disorders. The difficulty in the management of extended parotid tumors is increased by the need to sacrifice the facial nerve, even if only partially. The book provides clear criteria to assist in the choice of treatment, from the simplest options involving use of local flaps to the most sophisticated ones. It will assist the surgeon in ensuring that the patient achieves the best possible quality of life, no matter what the patient's age or the associated comorbidities.

HIV-associated Hematological Malignancies (Hardcover, 1st ed. 2016): Marcus Hentrich, Stefan K. Barta HIV-associated Hematological Malignancies (Hardcover, 1st ed. 2016)
Marcus Hentrich, Stefan K. Barta
R3,928 Discovery Miles 39 280 Ships in 10 - 15 working days

This book presents a general introduction to and review of HIV-associated hematological malignancies, with a special focus on practical management issues. Each of the relevant malignancies is addressed individually, with an overview of treatment approaches, assessment of evidence regarding their efficacy, and discussion of therapeutic controversies. In addition, careful consideration is paid to issues in molecular and clinical pathology, epidemiological aspects, symptomatology, diagnosis, and risk factors. Separate chapters are devoted to autologous and allogeneic stem cell transplantation and to chemotherapy and interactions with antiretroviral agents. Many of the chapters are written by experts who have been instrumental in shifting the balance for people living with HIV and blood cancers. While two decades ago this diagnosis represented a death sentence, advances in treatment have transformed these cancers into often curable conditions. Nevertheless, optimal treatment of hematological malignancies remains a challenge, particularly in patients with severe immunosuppression. This book will be an invaluable source of information for all practitioners in the fields of clinical hematology and medical oncology and HIV medicine.

How to Starve Cancer - ...and Then Kill It with Ferroptosis (Paperback, 2nd ed.): Jane McLelland How to Starve Cancer - ...and Then Kill It with Ferroptosis (Paperback, 2nd ed.)
Jane McLelland
R619 Discovery Miles 6 190 Ships in 12 - 17 working days
Diagnosis and Management of Craniopharyngiomas - Key Current Topics (Hardcover, 1st ed. 2016): Andrea Lania, Anna Spada,... Diagnosis and Management of Craniopharyngiomas - Key Current Topics (Hardcover, 1st ed. 2016)
Andrea Lania, Anna Spada, Giovanni Lasio
R2,613 R2,015 Discovery Miles 20 150 Save R598 (23%) Ships in 12 - 17 working days

This book provides up-to-date coverage of the most relevant topics in the diagnosis and management of craniopharyngiomas. After introductory discussion of natural history and clinical presentation, individual chapters are devoted to pathological and molecular aspects, use of diagnostic imaging techniques, the surgical approach to craniopharyngiomas, radiotherapy and radiosurgery, and associated endocrine disturbances. A particular feature of the book is the detailed attention devoted to the metabolic consequences of the disease and related treatments, including obesity and electrolyte disturbances, and to cognitive alterations. This book will be of value to oncologists, neurosurgeons, and endocrinologists by assisting in diagnostic workup, delivery of appropriate treatment, and management of the serious metabolic and endocrine consequences.

Targeting Oral Cancer (Hardcover, 1st ed. 2016): Andrew Fribley Targeting Oral Cancer (Hardcover, 1st ed. 2016)
Andrew Fribley
R4,305 R3,831 Discovery Miles 38 310 Save R474 (11%) Ships in 12 - 17 working days

This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.

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