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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General

Multifunctional Nanoprobes - From Design Validation to Biomedical Applications (Hardcover, 1st ed. 2018): Yanlan Liu Multifunctional Nanoprobes - From Design Validation to Biomedical Applications (Hardcover, 1st ed. 2018)
Yanlan Liu
R1,525 Discovery Miles 15 250 Ships in 10 - 15 working days

This thesis mainly focuses on the design and synthesis of novel multifunctional nanoprobes, investigating their feasibility for applications involving sensing, molecular imaging, and the simultaneous diagnosis and therapy of cancer. Above all, it discusses the development of innovative nanomaterials to address the issues limiting the effectiveness of currently available nanoprobes such as the synthesis shortcoming and poor performance in sensing, imaging and therapeutic applications. One of the strengths of this thesis is its integration of knowledge from chemistry, materials science and biomedicine. Further, it presents the theoretical fundamentals in the design of nanoprobes, which can offer guidance for future studies on the development of novel multifunctional nanomaterials with significantly enhanced performance.

Molecular and Cellular Biology Prostate Cancer - Symposium Proceedings (Hardcover, New): James P. Karr, Etc Molecular and Cellular Biology Prostate Cancer - Symposium Proceedings (Hardcover, New)
James P. Karr, Etc
R2,620 Discovery Miles 26 200 Ships in 12 - 19 working days

I. Intracellular Communications.- Tissue Specificity and Cell Death are Associated with Specific Alterations in Nuclear Matrix Proteins.- Mechanism of Growth Regulation in Androgen Responsive Cells.- The Impact of Androgen, Extracellular Matrix, and Stroma upon Proliferation and Differentiation of Benign and Malignant Prostate Epithelial Cells.- Therapeutic Approaches to Activating Programmed Cell Death of Androgen-Independent Prostatic Cancer Cells.- Cell Motility and Structural Harmonics in Prostate Cancer.- Panel Discussion.- II. Growth Factors - 1.- Studies of the Endocrine and Paracrine Effect of Tumor Produced Factors in Human Genitourinary Cancers.- Fibroblast Growth Factor: Implications in the Etiology of Benign Prostatic Hyperplasia.- Fibroblast-Mediated Human Epithelial Tumor Growth and Hormonal Responsiveness In Vivo.- Polyamine Requirement of Prostate Cancer Cell Proliferation.- Heparin-Binding (Fibroblast) Growth Factor/Receptor Gene Expression in the Prostate.- Characterization and Partial Purification of a Non - Heparin-Binding Prostate Growth Factor From Cancerous Human Prostate.- Panel Discussion.- Growth Factors - 2.- Transforming Growth Factor a: A Potential Autocrine Growth Regulator in Prostatic Carcinoma.- Prostatic Growth Factors (PrGFs) - From the Identification of Probasin to the Role of PrGFs.- Urogenital Sinus Derived Growth Inhibitory Factor.- Growth Factor Antagonists in Prostate Cancer: Suramin and Cytotoxic Polyamines as Potential Therapy.- Transforming Growth Factors in Human Prostate Cancer.- Gene Products as the Motivating Force in the Prostate Cell's Response to Androgens.- Panel Discussion.- III. Steroid Receptors.- Molecular Biology of Prostate - Specific Antigen.- Structure and Expression of the Androgen Receptor in Normal Tissues and in Prostate Carcinoma Cell Lines.- Structural Analysis and Gene Expression of TR2 Receptor and TR3 Receptor.- cDNA Cloning, Antibody Production and Immunohistochemical Localization of the Androgen Receptor.- New Approaches to Studies on the Androgen Receptor.- Specific Receptors for Vitamin D3 in Human Prostatic Carcinoma Cells.- Panel Discussion.- IV. Poster Presentations.- Role of Androgens and Extracellular Matrix in the Growth and Differentiation of Benign and Malignant Prostatic Epithelial Cells.- Tissue Specificity and Cell Death Are Associated with Specific Alterations in Nuclear Matrix Proteins.- ElTect of Transformation on Rat Prostatic Fibroblasts: Alterations In Extracellular Matrix and Cytoskeleton Gene Expression with Retention of Androgen Responsiveness and Androgen Receptor Expression.- A Potential Role for the MDR-1 Gene in the Development of Androgen-Independent Tumors.- Relevance of Low Androgen Levels and Adrenal Androgens in the Growth of Transplantable Human Prostatic Carcinomas.- Growth-Stimulating Effect of Growth Factor(s) from Androgen Independent Tumor Cells (CS 2-Cell) on Androgen Responsive Tumor Cells.- The Cellular Form of Human Prostatic Acid Phosphatase May Function as a Phosphotyrosyl Protein Phosphatase in Cells.- Expression of Prostate Antigen in LNCaP Cells in Culture.- Allelic Expression of the Mouse Ren-1 Genes in the Anterior Prostate (Coagulating Gland).- V. Dna Structure and Gene Expression.- Genomic Alterations in Prostatic Cancer.- Regulation of Gene Expression in the Prostate.- Androgen Regulation of HBGF I-(aFGF) and Characterization of the Androgen-Receptor mRNA in the Human Prostate Carcinoma Ceil Une - LNCaP/A-dep.- DNA Methylation, Differentiation and Cancer.- Evidence for tbe Involement of Genetic Differences and Mesenchymal Factors in the Progression of Oncogene - Induced Prostate Cancer in Reconstituted Mouse Prostate.- Differential Hybridization Analysis as a Tool to Study Prostatic Cancer Metastasis.- Molecular Biology of Androgen Acceptors in Prostatic Cancer Cells.- Panel Discussion.- Panel Discussion.- Panel Discussion.- Panel Discussion.- Panel Discussion.- Contributors.

The Retinoblastoma Protein (Hardcover, 1st ed. 2018): Pedro G. Santiago-Cardona The Retinoblastoma Protein (Hardcover, 1st ed. 2018)
Pedro G. Santiago-Cardona
R3,594 Discovery Miles 35 940 Ships in 12 - 19 working days

This volume covers the mechanisms of pRb inactivation detailing repressive mechanisms commonly associated to cancer, and representative of the experimentally relevant tests used in the establishment of cancer diagnosis and prognosis. Chapters contain protocols and in-depth discussions for commonly used experimental approaches to assess the status and function of components of the pRb pathway, including pRb itself, in cell lines and biological samples.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Retinoblastoma Protein aims to serve as a guide to assist molecular cancer biologists in their search for understanding of the molecular functions of this preeminent tumor suppressor.

Advances in Cancer Research, Volume 121 (Hardcover): Kenneth D. Tew, Paul B. Fisher Advances in Cancer Research, Volume 121 (Hardcover)
Kenneth D. Tew, Paul B. Fisher
R3,943 Discovery Miles 39 430 Ships in 12 - 19 working days

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
Provides information on cancer researchOutstanding and original reviewsSuitable for researchers and students

Thyroid Cancer and Other Thyroid Disorders, An Issue of Endocrinology and Metabolism Clinics of North America, Volume 43-2... Thyroid Cancer and Other Thyroid Disorders, An Issue of Endocrinology and Metabolism Clinics of North America, Volume 43-2 (Hardcover)
Kenneth D. Burman
R1,783 Discovery Miles 17 830 Ships in 12 - 19 working days

Managing and treating patients with thyroid issues accounts for about 30% of an endocrinologist's practice. The issue will be divided into two parts: thyroid cancer and other major disorders. Articles will cover new information on TSH and radioiodine therapy to treat thyroid cancer, as well as best practices for managing hypothyroidism, Graves disease and thyroiditis.

Breast Cancer, An Issue of Surgical Oncology Clinics of North America, Volume 23-3 (Hardcover): Lisa Newman Breast Cancer, An Issue of Surgical Oncology Clinics of North America, Volume 23-3 (Hardcover)
Lisa Newman
R1,770 Discovery Miles 17 700 Ships in 12 - 19 working days

This issue of Surgical Oncology Clinics of North America is devoted to "Breast Cancer" and is edited by Lisa Newman, MD, of the University of Michigan.? Expert authors in this issue review this topic in articles such as: Applications for Breast MRI; Lobular Neoplasia; Epidemiology of Breast Cancer; Percutaneous Ablation of Breast Tumors; Triple Negative Breast Cancer and the Basal Breast Cancer Subtype; Molecular Profiling of Breast Cancer; Surgical Leadership and Standardization of Multidisciplinary Breast Cancer Care; Neoadjuvant/Primary Systemic Therapy for Breast Cancer; Management of the Clinically Node-Negative Axilla in Patients with Primary and Locally-Recurrent Breast Cancer; Management of the Axilla in Patients with Node-Positive Breast Cancer; Prophylactic Bilateral Mastectomy and Contralateral Prophylactic Mastectomy; Advances in Reconstruction of Mastectomy and Lumpectomy Defects; Nipple-Sparing Mastectomy; and Breast Cancer Disparities.

Cancer Genomics and Proteomics - Methods and Protocols (Hardcover, 2nd ed. 2014): Narendra Wajapeyee Cancer Genomics and Proteomics - Methods and Protocols (Hardcover, 2nd ed. 2014)
Narendra Wajapeyee
R4,590 R3,733 Discovery Miles 37 330 Save R857 (19%) Ships in 12 - 19 working days

Cancer Genomics and Proteomics: Methods and Protocols, Second Edition includes methods for the analyses of cancer genome and proteome that have illuminated us about the changes in cancer cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Genomics and Proteomics: Methods and Protocols, Second Edition seeks to aid scientists in the further study into various aspects of tumor initiation and progression.

Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism, Volume 542 (Hardcover): Lorenzo Galluzzi, Guido... Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism, Volume 542 (Hardcover)
Lorenzo Galluzzi, Guido Kroemer
R4,600 Discovery Miles 46 000 Ships in 12 - 19 working days

Volume 542 of "Methods in Enzymology" continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.
Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization scienceProvides theoretical overview on metabolic alterations of cancer cells, and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo

Handbook of Long Term Care of The Childhood Cancer Survivor (Hardcover, 1st ed. 2015): Grace A. Mucci, Lilibeth R. Torno Handbook of Long Term Care of The Childhood Cancer Survivor (Hardcover, 1st ed. 2015)
Grace A. Mucci, Lilibeth R. Torno
R6,475 Discovery Miles 64 750 Ships in 10 - 15 working days

This authoritative reference examines in depth the myriad challenges facing pediatric cancer survivors and proposes a robust framework for structured follow-up of these patients through adulthood. Approaches to long-term follow-up include both established models of care and targeted models of lifelong surveillance of late effects by bodily systems and neurological outcomes. Sections devoted to quality of life and re-entry after treatment focus on key concerns such as health risk behaviors, school and career issues, psychological challenges, and care disparities. And a robust resources section adds extra usefulness to the expert coverage. Among the Handbook's topics: * Developmental considerations in the transition from child and adolescent to adult survivorship. * Long-term follow-up roadmaps by disease and treatment. * Neuropsychological effects of pediatric brain tumors and associated treatment. * Building resiliency in childhood cancer survivors: a clinician's perspective. * School issues and educational strategies for survivors of childhood cancer. * Educating and preparing the childhood cancer survivor for long-term care: a curriculum model for cancer centers. A work of rare scope, scholarship, and clinical acumen, the Handbook of Long-Term Care of the Childhood Cancer Survivor is a rewarding, practice-building resource essential to a wide range of healing professionals, including primary care physicians, pediatricians, oncologists, nurses, psychologists, neuropsychologists, child psychologists, and licensed therapists.

The Cancer Degradome - Proteases and Cancer Biology (Hardcover, 2009 ed.): Dylan Edwards, Gunilla Hoyer-Hansen, Francesco... The Cancer Degradome - Proteases and Cancer Biology (Hardcover, 2009 ed.)
Dylan Edwards, Gunilla Hoyer-Hansen, Francesco Blasi, B.F. Sloane
R5,810 Discovery Miles 58 100 Ships in 10 - 15 working days

Proteolysis is essential for life. From the breakdown of proteins in food for biosynthesis, through to antigen processing in the immune system, the blood cl- ting cascade, and the hormone-regulated remodelling of female reproductive tissues in adult mammals - proteolysis governs functionality, homeostasis, and fate at the levels of the cell and the entire organism. For the cancer cell, intracellular prote- ysis carried out by caspases and the proteasome must be enlisted and controlled to allow it to escape apoptosis. Functioning on the cancer cell surface or in the extracellular milieu, secreted proteases (primarily metalloproteinases, serine p- teases, and cathepsins) determine the interactions of cells with their environments. Once considered simply as promoting tumour cell invasion through tissue barriers, proteolysis is now known to be integral to many aspects of cancer biology, including angiogenesis, regulation of the bioavailability of growth factors, cellular adhesion, cytokine/chemokine signalling, in?ammatory cell recruitment, and the mobilization of normal cells from their tissue compartments to act as accomplices in metastasis. The last decade has witnessed a revolution in our thinking concerning the role of extracellular proteolysis in cancer biology: this is the primary focus of this book.

Omics Applications for Systems Biology (Hardcover, 1st ed. 2018): Wan Mohd Aizat, Hoe-Han Goh, Syarul Nataqain Baharum Omics Applications for Systems Biology (Hardcover, 1st ed. 2018)
Wan Mohd Aizat, Hoe-Han Goh, Syarul Nataqain Baharum
R4,576 Discovery Miles 45 760 Ships in 12 - 19 working days

This book explains omics at the most basic level, including how this new concept can be properly utilized in molecular and systems biology research. Most reviews and books on this topic have mainly focused on the technicalities and complexity of each omics' platform, impeding readers to wholly understand its fundamentals and applications. This book tackles such gap and will be most beneficial to novice in this area, university students and even researchers. Basic workflow and practical guidance in each omics are also described, such that scientists can properly design their experimentation effectively. Furthermore, how each omics platform has been conducted in our institute (INBIOSIS) is also detailed, a comprehensive example on this topic to further enhance readers' understanding. The contributors of each chapter have utilized the platforms in various manner within their own research and beyond. The contributors have also been interactively integrated and combined these different omics approaches in their research, being able to systematically write each chapter with the conscious knowledge of other inter-relating topics of omics. The potential readers and audience of this book can come from undergraduate and postgraduate students who wish to extend their comprehension in the topics of molecular biology and big data analysis using omics platforms. Furthermore, researchers and scientists whom may have expertise in basic molecular biology can extend their experimentation using the omics technologies and workflow outlined in this book, benefiting their research in the long run.

Clinical Management of Brain Tumor (Hardcover): Michael Jones Clinical Management of Brain Tumor (Hardcover)
Michael Jones
R2,524 Discovery Miles 25 240 Ships in 12 - 19 working days
Tumor Microenvironment - Extracellular Matrix Components - Part A (Hardcover, 1st ed. 2020): Alexander Birbrair Tumor Microenvironment - Extracellular Matrix Components - Part A (Hardcover, 1st ed. 2020)
Alexander Birbrair
R4,379 Discovery Miles 43 790 Ships in 10 - 15 working days

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components - Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists' focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Early Detection of Prostate Cancer, An Issue of Urologic Clinics, Volume 41-2 (Hardcover): Stacy Loeb Early Detection of Prostate Cancer, An Issue of Urologic Clinics, Volume 41-2 (Hardcover)
Stacy Loeb
R1,763 Discovery Miles 17 630 Ships in 12 - 19 working days

PSA screening remains highly controversial due to several important disadvantages. More PSA is produced with prostatic enlargement and in other benign conditions such as urinary tract infections. False positive tests can then lead to unnecessary diagnostic workup with invasive prostate biopsy. Another major problem with screening programs in general is overdiagnosis of cancers that would not have caused harm during the patient's lifetime. For example, many prostate cancers have a relatively indolent behavior so may not require diagnosis or treatment in a patient with limited life expectancy. All forms of prostate cancer treatment have potential urinary and sexual side effects, so reducing overdiagnosis and overtreatment are critical public health issues. Because screening has many proven benefits but also significant harms, there are widely disparate guidelines on prostate cancer screening from major organizations worldwide. This issue of the Urologic Clinics will provide insights into the many different prostate cancer guidelines and related policy issues.

Molecular Diagnostics and Treatment of Pancreatic Cancer - Systems and Network Biology Approaches (Hardcover): Asfar Azmi Molecular Diagnostics and Treatment of Pancreatic Cancer - Systems and Network Biology Approaches (Hardcover)
Asfar Azmi
R1,957 Discovery Miles 19 570 Ships in 12 - 19 working days

"Molecular Diagnostics andTreatment of Pancreatic Cancer "describes the different emerging applications of systems biology and howit is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are alsohighlighted.

Addressing this important area, "Molecular Diagnostics and Treatment of Pancreatic Cancer" provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design.
Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scalesCoverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas - helping researchers in pancreatic cancer drug discoverySummarizes many relevant computational and clinical references from fast-evolving literatureComprehensive glossary helps newer readers understand technical terms and specialized nomenclature"

Targeting Notch in Cancer - From the Fruit Fly to the Clinic (Hardcover, 1st ed. 2018): Lucio Miele, Spyros Artavanis-Tsakonas Targeting Notch in Cancer - From the Fruit Fly to the Clinic (Hardcover, 1st ed. 2018)
Lucio Miele, Spyros Artavanis-Tsakonas
R4,409 Discovery Miles 44 090 Ships in 10 - 15 working days

The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected

Human T-Lymphotropic Viruses - Methods and Protocols (Hardcover, 1st ed. 2017): Claudio Casoli Human T-Lymphotropic Viruses - Methods and Protocols (Hardcover, 1st ed. 2017)
Claudio Casoli
R4,658 Discovery Miles 46 580 Ships in 12 - 19 working days

While HIV-1 continues to be well-researched, this detailed volume draws attention to other members of the Retrovirus family, namely the Human T-lymphotropic Viruses (HTLVs), featuring the most updated technical information about HTLV determination and the methods to investigate their interaction with the host immune system and interfering pathogens. The contents include essential aspects of epidemiology and virus transmission, novel and robust methodologies for studying the effects of trans-activating regulatory HTLVs' proteins, the latest techniques for genotyping and gene expression analysis, as well as cellular phenotype and dynamics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Human T-Lymphotropic Viruses: Methods and Protocols serves as an ideal guide to an area of study that is very much worthy of further research.

Adenomatous Polyps of the Colon - Pathobiological and Clinical Features (Hardcover, New): Robert Lev Adenomatous Polyps of the Colon - Pathobiological and Clinical Features (Hardcover, New)
Robert Lev; Foreword by B.C. Morson
R2,567 Discovery Miles 25 670 Ships in 10 - 15 working days

Normal Colon.- A. Anatomic Considerations.- B. Histology.- Pathology.- A. General Prevalence and Anatomic Distribution.- B. Gross Appearance.- Multiplicity.- Size.- C. Microscopic Features.- Tubular versus Villous Adenomas.- Degree of Dysplasia.- Problems in Grading Dysplasia.- Carcinoma in a Polyp.- Morphometric Studies.- D. Differential Diagnosis.- Hyperplastic (Metaplastic) Polyps.- Mixed Hyperplastic-Adenomatous Polyps.- Juvenile Polyps.- Hamartomatous Polyps.- Polypoid Carcinoma.- Nonepithelial Polyps.- E. The Diminutive Polyp.- F. Other Characteristics of Polyps.- Kinetics.- Electron Microscopy.- Histochemistry.- Markers.- Tissue Culture.- DNA Content.- Doubling Time.- Regression of Polyps.- G. Histogenesis of Polyps.- Adenomatous Polyposes.- A. Familial Polyposis Coli and Gardner's Syndrome.- B. Other Adenomatous Polyposis Syndromes.- C. The Genetics of Adenoma Transmission.- Malignant Potential of Adenomatous Polyps.- A. Association of Polyps and Carcinomas.- Risk Factors for Carcinomas among Polyp-Bearers.- Natural History of Polyps; Metachronous Carcinomas.- Peak Incidences of Adenomatous Polyps and Colorectal Carcinomas.- Metachronous Carcinomas in Subjects with Synchronous Polyps and Carcinomas.- Prevalence of Polyps in Subjects with Colorectal Carcinomas.- Opposing Views.- B. Histological Evidence of Malignant Transformation.- C. Adenomatous Remnants in Carcinomas.- D. Epidemiological Evidence and Etiological Factors.- Sex and Age.- Relationship of Polyps and Colorectal Carcinomas.- Dietary and Other Factors.- Etiology.- E. Findings in Experimental Animals.- Observations.- Genesis of Tumors.- Interpretation of Findings and Relevance to Humans.- F. Alternate Hypotheses of Carcinogenesis.- The Flat Mucosa.- Other Routes.- Nonadenomatous Polyps.- Inflammatory Bowel Disease.- Miscellaneous.- The Field Effect.- Hereditary Nonpolyposis Colorectal Cancer.- G. Conclusions.- Evidence of Malignant Potential of Adenomatous Polyps.- Significance of Malignant Potential of Adenomatous Polyps.- The Problem of the Metachronous Carcinoma.- Detection and Management.- A. Screening, Diagnostic, and Surveillance Techniques.- Principles of Screening.- The At-Risk Population to Be Screened.- Digital Examination of the Rectum.- Stool Blood Tests.- Barium Enema (BE).- Endoscopy.- Proctosigmoidoscopy.- Colonoscopy.- Sensitivity.- Comparisons with Barium Enema.- Effectiveness of Screening.- B. The Malignant Polyp.- The Problem.- Frequency.- Risk Factors for Malignancy in a Polyp.- Size.- Multiplicity.- Villous Component.- Degree of Dysplasia.- Effects of Study Design and Polyp Processing Technique.- Statistical Analysis.- Adverse Outcomes.- Level of Submucosal Invasion by Carcinoma.- Postpolypectomy Therapy.- C. Endoscopic Polypectomy.- How Polyps Are Detected.- Rationale for Detection and Eradication of Polyps.- Manpower and Cost Considerations.- Therapy of Diminutive Polyps.- Polypectomy Technique.- D. Postpolypectomy Surveillance Recommendations.- Recurrent Polyps.- Risk Factors for New Polyps.- Surveillance Schedules.- Effectiveness and Cost of Surveillance.- E. The National Polyp Study.- F. Polyp Registries.- Conclusions.- Glossary and Abbreviations.

Cancer Theranostics (Hardcover): Xiaoyuan Chen, Stephen Wong Cancer Theranostics (Hardcover)
Xiaoyuan Chen, Stephen Wong
R3,862 Discovery Miles 38 620 Ships in 12 - 19 working days

Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, "Cancer Theranostics" reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment.

"Cancer Theranostics" describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives.
Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapyFully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

Chronic Lymphocytic Leukemia (Hardcover): Matthew Griffin Chronic Lymphocytic Leukemia (Hardcover)
Matthew Griffin
R2,522 Discovery Miles 25 220 Ships in 12 - 19 working days
Cancer - Oxidative Stress and Dietary Antioxidants (Hardcover): Victor R. Preedy Cancer - Oxidative Stress and Dietary Antioxidants (Hardcover)
Victor R. Preedy
R2,518 Discovery Miles 25 180 Ships in 12 - 19 working days

"Cancer: Oxidative Stress and Dietary Antioxidants" bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this.

Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.
Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teamsNutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods

Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease, An Issue of Hematology/Oncology Clinics, Volume 28-2... Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease, An Issue of Hematology/Oncology Clinics, Volume 28-2 (Hardcover)
Elliot Vichinsky
R1,772 Discovery Miles 17 720 Ships in 12 - 19 working days

This issue of Hematology/Oncology Clinics, guest edited by Dr. Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses on pathophysiology of hemoglobinopathies, therapeutic targets, and new approaches to correcting ineffective erythropoiesis and iron dysregulation. Articles in this issue include Polymerization and red cell membrane changes; Overview on reperfusion injury in the pathophysiology of SCD; Regulation of ineffective erythropoiesis in iron metabolism; Altering oxygen affinity; Cellular adhesion and the endothelium; Arginine therapy; Role of the hemostatic system on SCD pathophysiology and potential therapeutics; Adenosine signaling and novel therapies; New approaches to correcting ineffective erythropoiesis and iron dysregulation; New approaches to correcting ineffective erythropoiesis and iron dysregulation; Fetal hemoglobin induction; Gene therapy for hemoglobinopathies; and Oxidative injury and the role of antioxidant therapy.

Multimodality Management of Borderline Resectable Pancreatic Cancer (Hardcover, 1st ed. 2016): Matthew H.G. Katz, Syed A. Ahmad Multimodality Management of Borderline Resectable Pancreatic Cancer (Hardcover, 1st ed. 2016)
Matthew H.G. Katz, Syed A. Ahmad
R4,069 R3,787 Discovery Miles 37 870 Save R282 (7%) Ships in 12 - 19 working days

This volume provides the most comprehensive coverage of clinical management of borderline resectable pancreatic cancer available. Authored by leaders in the field, the book focuses on current clinical management of this disease stage, the importance of multimodality treatment algorithms, and an interdisciplinary approach to care. Surgical chapters are well-illustrated to provide surgeons and surgical trainees with important technical pearls. Clinical trials and trial design are also discussed. Multimodality Management of Borderline Resectable Pancreatic Cancer is a valuable resource for gastroenterologists, medical oncologists, radiation oncologists, surgical oncologists, general surgeons, and trainees interested in the treatment of pancreatic cancer.

The Molecular Basis of Cancer (Hardcover, 4th edition): John Mendelsohn, Peter M. Howley, Mark A. Israel, Joe W. Gray, Craig B.... The Molecular Basis of Cancer (Hardcover, 4th edition)
John Mendelsohn, Peter M. Howley, Mark A. Israel, Joe W. Gray, Craig B. Thompson
R4,655 R4,263 Discovery Miles 42 630 Save R392 (8%) Ships in 12 - 19 working days

2015 BMA Medical Book Awards Highly Commended in Oncology Category! The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. Access the entire text and illustrations online, fully searchable, at Expert Consult.

Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173 (Hardcover, 1st ed. 2017): Bernd Nilius, Pieter De Tombe, Thomas... Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173 (Hardcover, 1st ed. 2017)
Bernd Nilius, Pieter De Tombe, Thomas Gudermann, Reinhard Jahn, Roland Lill, …
R3,587 Discovery Miles 35 870 Ships in 10 - 15 working days

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

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Jennifer Chan, Matthew Kulke Hardcover R1,799 Discovery Miles 17 990
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