Eyelid tumors are commonly encountered by oculoplastic as well as plastic surgeons. The challenge of managing these cases lies not only in performing the surgery in a precise manner in small area, but also in ensuring a visually-appealing cosmetic outcome. This is an innovative and concise portable handbook that guides the surgeons on how to approach and manage these cases in a step-by- step manner. Each chapter of this practical guidebook has outstanding illustrations drawn in full color clearly showing each incision line, flap management, suture placement and its technique, and the expected cosmetic outcome. When a lid tumor is excised, there is a tissue defect that needs to be corrected. Ophthalmologists and plastic surgeons will find this work an excellent reference material to solve the jigsaw puzzle of tissue defects in and around the periorbital region. Importantly, they can quickly refer to the images just before starting a procedure. The author has first explained the anatomical aspects and anesthetic techniques for eyelid surgery, followed by review of the benign and malignant tumors, finally describing the flap creation and reconstruction techniques that are currently used in various lid tumors in an organized fashion.

Get quick access to the most important information surrounding cancer and oncology nursing care with Mosby's Oncology Nursing Advisor, 2nd Edition. Covering everything from the various types of cancer and cancer treatment options to patient education and nursing best-practices, this indispensable nursing guide is like getting seven books in one! Plus, its user-friendly layout and straightforward coverage make it ideal for use in any clinical setting. With 17 new chapters, updated evidence-based content throughout, and proven patient teaching handouts, this new edition offers the authoritative guidance you need to provide the best possible oncology nursing care. Detailed descriptions of over 50 major cancer types provide essential information on incidence, etiology and risk factors, signs and symptoms, diagnostic workup, histology, staging, treatment, prognosis, and prevention. Coverage of cancer management principles outlines a wide range of treatment and pharmacologic modalities, including surgery, chemotherapy, radiation therapy, hormonal therapy, immunotherapy, and complementary and alternative therapies. Symptom management guidelines offer in-depth coverage of pathophysiology, signs and symptoms, assessment tools, lab and diagnostic tests, differential diagnoses, interventions, patient education, follow up care, and resources for over 30 common symptoms associated with cancer and cancer treatments. Essential information on many oncologic emergencies and emergent issues prepares readers to respond quickly to structural, metabolic, and hematologic emergencies. Section on palliative care and end-of-life issues offers helpful guidelines for dealing with topics related to survivorship, palliative care, the final hours of the cancer patient, and loss, grief, and bereavement. NEW! Updated evidence-based content reflects the latest national and international quality standards regarding various cancer types, major drug and non-drug treatments, treatment protocols, and approaches to symptom management. NEW! Nursing Practice Considerations section incorporates information on communication, cultural considerations, ethical considerations, safe and quality care, evidence-based practice, patient navigation, and patient education. NEW! 17 new chapters cover topics including myelofibrosis, neuroendocrine cancers, tumor treating fields, oral adherence, clinical trials, epistaxis, hypersensitivity reactions, hypertension, hyperglycemia, nail changes, ocular and visual changes, rashes, survivorship, quality and safety, evidence-based practice, nurse navigation, and patient education. NEW! Expanded content on patient education keeps readers on top of best practices in this critical area. NEW! High-quality electronic patient teaching handouts are evidence-based and have been vetted by practicing nurses.

Benign breast diseases constitute a heterogeneous group of lesions. In this book, common benign lesions are summarized and their relationship to developing subsequent breast cancer is emphasized. The majority of lesions occurring in the breast are benign. As we know, the most common breast malignancy is in women; however, benign lesions of the breast are far more frequent than malignant ones. The majority of the information that we have available in the literature about the nonmalignant breast diseases is fragmented in texts and innumerable articles. The information provided in this book throughout its fourteen chapters is very complete with regard to the diagnosis of and indications for the treatment of these diseases. Over the last decade, there have been dramatic advances in the imaging techniques employed for the detection and diagnosis of breast cancer, which now include conventional or antilog mastography; digital ultrasound mammography, and magnetic resonance. The most frequent pathologies of the breast, as observed by those of us devoted to Oncology, are of the benign type. However, this is not so for non-specialist physicians and for the women who suffer from these and for whom they are a true cause for alarm. Therefore, it is very important for physicians who are not specialists in cancer to know the signs and symptoms of each of these benign breast diseases in order for them to be able to emit a diagnostic impression and to suggest treatment. Groups of medical specialists with experience in benign diseases of the breast from different institutions in Mexico have been invited to describe the differential diagnosis of benign breast lesions versus breast cancer.

This book includes real-time photographical recording and panoramic summary of 105 cases with oral mucosal diseases along with their diagnosis and management. This book reflects the characteristic clinical manifestations through images of each case presented. In addition to the medical history, examination, diagnosis, pathology and management of each case, a comprehensive commentary is introduced in the end of each chapter with an emphasis on the normative clinical train of thoughts and guidelines.

Gastric cancer is one of the leading causes of malignancy-related deaths world-wide with differences in incidence and treatment patterns geographically. There is extensive ongoing research for a better understanding of the cancer pathology and finding newer treatments. Advancements in basic science research are being translated for improving gastric cancer patient care. This book discusses an extensive array of different topics on gastric cancer in which strides of improvement have been achieved. The contributors of each specialised chapter of the book are leaders in their field and have been recognised for their work globally. This book aims to bring the readers up to date about all aspects of gastric cancer - from basic science research about animal models of gastric cancer, to pathophysiology, staging systems, different adjuvant therapies and surgical treatment options for gastric cancer. The newer treatment options of endoscopic mucosal resections and bursectomy are described in detail. The current statuses, debates and ongoing controversies in addition to the advancements on different aspects of gastric cancer research are discussed. The book is an invaluable resource of information on all aspects of gastric cancer with the latest advancements.

Leiomyosarcomas (LMS) are soft tissue tumours derived from smooth muscles cells, often in the uterus, retroperitoneum, skin, vessels, and bone. They are one of the most common types of sarcoma. Most leiomyosarcomas are sporadic, but may develop in the setting of genetic syndomes such as hereditary retinoblastoma and L-Fraumeni syndrome. Leiomyosarcomas may also be a result of radiation exposure; however, radiation-induced sarcomas are typically undifferentiated, fibrosarcomas or malignant peripheral nerve sheath tumors. Like other sarcomas, prognosis is worse with higher grade tumours. Although chemotherapy and radiation are sometimes used as adjuvant therapy, the mainstay of therapy, and the only chance for cure, is surgery. The management of LMS is especially complex when the tumour involves major blood vessels. This book discusses the diagnosis and treatments most effectively used for Leiomyosarcomas. It also provides insight on the specific areas that LMS is found and how it affects that area.

Informal caregivers - family members, friends, and other loved ones - are an essential, uncompensated and significantly burdened extension of the healthcare team. Rapid advances in cancer care, including new drugs and immunotherapies and more sophisticated diagnostic tools, have markedly improved the ability to medically extend lives and enhance survival. As patients are living longer, with today's shorter hospital stays and shift towards increased outpatient care, however, the demands placed on all caregivers and their needs have substantially increased. Cancer Caregivers reveals the field of Psycho-Oncology's exploration of the depth of complexities of caregiving experiences and identifies the vast expanses left to be understood. This text describes the characteristics and experiences of cancer caregivers based on their life stage, relationship to the patient, and ethnic group membership, as well as patients' disease and treatment type. It highlights the significant progress in research focused on the development and dissemination of psychosocial interventions for cancer caregivers, and includes in-depth case studies to illustrate their delivery and application. The text also explores the provision of support to caregivers in the community and the legal and ethical concerns faced by caregivers throughout the caregiving process. Cancer Caregivers offers both fundamental and practical information and is the essential resource for all healthcare professionals who work with patients and families facing cancer.

Over the last decade, immuno-oncology has witnessed an astonishing pace of discovery and innovation translating into unprecedented successes in the clinical setting, arguably representing one of the most profound and transforming revolution in the history of cancer therapy. This book provides a concise and accurate outline of the main developments in major tumor types including melanoma, lung, breast, brain and renal cell cancers. In addition, transversal chapters that describe the commonalities of some of the therapeutic strategies are provided to cover topics like immune checkpoint biology, T cell engineering or rational combination therapies. Each chapter has been authored by senior key opinion leaders in their respective fields to provide the most up-to-date view on cancer immuno-oncology. To reflect on the key translational aspect of immuno-oncology, all chapters are making explicit connections between basic science discoveries and the resulting translational therapeutic strategies. Immuno-Oncology will be an invaluable source of information for scientists interested in the translation of basic immunology into the clinical practice, as well as for clinician interested in deepening their knowledge of current and upcoming immune strategies in the fight against cancers.

The term 'carcinoid' entered medical literature over 100 years ago to describe a peculiar intestinal epithelial neoplasm. Since then, a large body of literature has expanded the concept of carcinoid, later replaced by the term 'NeuroEndocrine Tumor' (NET), defining a wide spectrum of peculiar tumors, potentially affecting all organs and tissues, originating from neuroendocrine cells, sharing, but, at the same time, keeping, pathognomonic pathological, radiological and clinical features. This book provides an authoritative overview of the epidemiological, clinical, genetic, molecular and pathological characteristics of NETs and highlights the most relevant controversial issues in the classification, diagnosis and therapy. Furthermore the new frontiers in the field of medical therapies are presented, through a multidisciplinary and translational approach. Considering the fact that NETs have been recently demonstrated less rare as considered so far, 'Neuroendocrine Tumors: A Multidisciplinary Approach' is a must read for endocrinologists, gastroenterologists, endocrine surgeons, as well as pathologists, nuclear medicine physicians and radiologists focused on NET.

This book aims to educate nurses and advanced practice providers (APP's) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP's are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP's with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

This book provides readers with a thorough review on cervical cancer, treatment guidelines and emerging therapies available for the disease. It reviews the epidemiology clinical features, diagnosis, and medical management of cervical cancer. Given the increasing need for preventive strategies, treatment optimization with collaborative and integrative work, this book improves the actual and integral knowledge in this neoplasm. Given the high prevalence of this disease in Latin America, this is an important text for clinicians in this region. This book outlines the state of the art in cervical cancer treatments and is an indispensable companion for oncologists, gynecologists, surgeons and medical students.

This book provides an up-to-date overview on the epidemiology, clinical presentation, and imaging characteristics of sacral tumors, discusses the available treatment options, and reports the published outcomes. The diagnostic roles of conventional radiology, CT, and MRI are thoroughly described and imaging appearances are compared with the histologic features. The coverage of therapeutic approaches includes chemotherapy, radiotherapy, radiosurgery, and surgery (partial or total sacrectomy and spinopelvic reconstruction). Special attention is paid to the specific anatomic constraints that make tumors in this region of the spine more difficult to manage effectively than those in the extremities and the mobile portions of the spine. All components of the sacrum can give rise to benign or malignant tumors, which pose significant diagnostic and therapeutic challenges. Although these tumors are often diagnosed at an advanced stage, good clinical outcomes may be achieved if an aggressive multidisciplinary approach is used. This book will be of value for a range of practitioners; it will assist in prompt diagnosis and help to overcome lack of familiarity with the required treatment strategies.

EMPOWER YOURSELF! No one with lung cancer needs to be alone in their fight against this disease. 100 Questions & Answers About Lung Cancer, Third Edition, guides patients and their families through diagnosis, treatment and survivorship. Providing both the doctor's and patient's point of view, this book is a complete guide to understanding treatment options, post-treatment quality of life, sources of support, and much more. Through 100 Questions & Answers About Lung Cancer, Third Edition, expert authors use their experiences with patients to provide support and hope to the tens of thousands of people coping with lung cancer.

Psycho-Oncology is a comprehensive handbook that provides best practice models for the management of psychological, cognitive, and social outcomes of adults living with cancer and their families. Chapters cover a wide range of topics including screening tools and interventions, psychiatric emergencies and disorders, physical symptom management, communication issues, and issues specific to common cancer sites. A resource section is appended to provide information on national services and programs. This book features contributions from experts designed to help clinicians review, anticipate and respond to emotional issues that often arise in the context of treating cancer patients. Numerous cross-references and succinct tables and figures make this concise reference easy to use. Psycho-Oncology is an ideal resource for helping oncologists and nurses recognize when it may be best to refer patients to their mental health colleagues and for those who are establishing or adding psychosocial components to existing clinics.

This book serves to educate and train primary care clinicians to provide high quality care to patients across the cancer care continuum. This guide is divided into six main chapters that follow the trajectory of cancer care: prevention, screening, diagnosis, treatment, survivorship care, and palliative/end-of-life care. Its succinct style, bullet points, tables and figures allow busy clinicians to both develop an overview of the core competencies involved in cancer care and quickly refer to the text in the process of caring for patients. Written by primary care physicians with expertise in cancer care, each chapter covers current recommendations and includes key points for select populations, considerations for the role of team based care, and resources for further learning. This is an ideal resource for primary care clinicians caring for patients along the cancer care continuum.

The microenvironment in which a tumor originates plays a critical role in its initiation and progression. "Tumor Microenvironment" reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. "Tumor Microenvironment" also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.

This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.

In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee.

With an emphasis on multidisciplinary collaboration and decision-making, this practical resource reflects the extraordinary advances in the treatment of prostate cancer during the past five years. Approximately thirty international, leading-edge investigators describe the most current evidence-based approaches to prostate cancer treatment. The book provides a comprehensive view of the entire spectrum of prostate cancer management from initial screening through novel and experimental treatments that have the potential for a major impact on practice.The book first reviews fundamental issues including epidemiology, screening, risk reduction, diagnosis and pathologic characterization, staging, and imaging. This includes strategies for improving the accuracy of PSA screening and an update on controversies surrounding the ISUP Modified Gleason Score. The book covers novel molecular and genotype profiling in prostate cancer, including morphometric and systems pathology. Detailed information is provided on radiographic imaging for diagnosis and staging. The treatment sections of the book correspond to the staging of disease. The treatment of localized disease addresses the range of multidisciplinary management options including a discussion of prostate cancer's impact on the quality of life.A detailed review of multimodal therapies (medical, surgical, and radiologic) addresses the treatment of localized advanced disease, and coverage of advanced metastatic prostate cancer reviews current management options including a range of promising novel and experimental agents. The book also discusses counseling the high-risk patient. Several chapters incorporate models of care delivery, patient navigation for multidisciplinary care, genomic and risk assessment, and comparative effects of research in treatment decision-making. The book is designed as a management text for all health care professionals who provide care for prostate cancer patients as well as patients, families, and advocates. Extensive references offer opportunities for additional study.Key Features:Delineates a practical, concise approach to multidisciplinary management of prostate cancerProvides a wide range of perspectives and expertiseWritten and edited by an international, multidisciplinary team of prostate cancer specialistsFocuses on such key issues as special populations, screening controversies, patient counseling, and quality of lifeIncludes discussion of important emerging topics such as gene profiling and targeting therapies and comparative effectiveness data

This book provides clinicians with clear guidance on treatment decision-making in patients with rare kidney cancers. After a brief review on epidemiology, pathology, and biology, each chapter focuses on the multidisciplinary management of a particular tumor subtype using the full range of available cancer therapy modalities, including surgery, radiotherapy, chemotherapy, targeted therapies, and immunotherapy. Emerging therapies and future directions in the management of each cancer subtype are also discussed. The chapters are all written by multidisciplinary teams of international experts comprising at least a urologist, a medical oncologist, and a pathologist. Rare kidney cancers represent 15% of renal cell carcinomas. In comparison with clear cell renal cell carcinomas, little is known about the biology of such cancers, and few trials have reported on the efficacy of targeted therapies in the metastatic setting. Optimal management thus poses significant challenges and often requires a multidisciplinary team. This book will be an ideal reference guide for all clinicians involved in the care of patients with these orphan tumors.

This book introduces and explains various facets of the cancer systems biology in microscopic scale. This book is organized into three parts. After an introduction of cancer biology, the authors describe the modeling algorithms and their applicability limitations. Then, in part two, microscopic scale modeling of cancer will be covered, followed by the modeling of the networks dealing with cell proliferation, cell survival, angiogenesis, migration and metastasis. At the end, the modeling of EGFR signaling in lung cancer is discussed as a case study and then two normal and cancerous EGFR signaling models are compared.

Tumors often start out as a benign growth, but gradually progress toward the malignant stage over a relatively long period of time. Tumor progression results from accumulated genetic mutations and inheritable epigenetic modifications that enable clonal evolution and selection of new clonal populations of tumor cells with aggressive characteristics including metastasis and therapy resistance. Increasing amounts of experimental evidence suggests that tumor microenvironment play a significant role in directing clonal evolution and determining clonal cell fate, which eventually leads to emergence of malignant tumor cell clones. Hypoxia is the most commonly observed feature of tumor microenvironment. Tumor hypoxia is significantly associated with malignant progression and predicts poor patient outcomes. This book provides detailed and up-to-date treaties on the role of hypoxia as a major driving force in tumor microenvironment to elicit cellular adaptation and clonal selection via genetic mutations and epigenetic modifications, to facilitate cancer stem cell maintenance, to enhance metastasis, to augment therapy resistance, and to evade immune surveillance.

What men with prostate cancer really want-the guarantee of a long, healthy life with their prostate cancer definitively behind them-is not available. There is no crystal ball that can forecast the certain, good outcome that every man hopes for, not even for those who will ultimately get the result they want. In Managing Prostate Cancer, Dr. Andrew Roth teaches strategies for how to live better with the questions and decisions that arise from prostate cancer. A psychiatrist who has specialized in helping people to cope with these challenges for over twenty years, Dr. Roth provides clear and understandable advice for patients, their loved ones, and healthcare givers. With his guidance, men and their families will learn how to manage the psychological stressors of a new cancer diagnosis. Dr. Roth shows men how to navigate what feel like impossible treatment choices, and to handle the emotional ups and downs of active surveillance and anxiety about prostate-specific antigen (PSA) tests. Patients will also learn mechanisms for accepting and adapting to the consequences of their cancer treatment, which may include the physical complications of urinary, erectile, or bowel dysfunction, fatigue, and hot flashes, as well as the demoralizing recurrence of disease after treatment. Dr. Roth clearly addresses issues that are not easily discussed yet can bring significant suffering. Men receive valuable tips on how to manage the impact of the cancer and its treatment on their social, sexual, and intimate relationships and behaviors. Finally, Dr. Roth provides gentle, wise guidance for men with advanced prostate cancer about becoming realistic yet invaluable role models for children, grandchildren, and friends. Dr. Roth shows men and their families how to face the end of life with improved self-esteem and sense of worth. The book will also assist oncology teams to address complex issues of coping and to communicate more constructively with their patients.

Cancer imposes daunting effects on the nervous system Brain cancer is one of the most devastating diagnoses a physician can deliver. Cancer of the nervous system can take many different forms. Treatment is specific to the type of malignancy, its location in the nervous system and, increasingly, its molecular characteristics. The challenges manifest further when management choices need to be made, and multidisciplinary approaches are required. Additional complexities arise in children, where the developing neurological system requires more sensitive treatment. Neuro-oncology unmasks the complexities to provide a straightforward guide to cancers of the nervous system. Following a general approach to diagnosis and treatment, the clinical aspects of specific cancer types in adults and children are explained in practical terms. A final section considers the effect of system cancer on the nervous system and the side effects of treatment. Clinical in approach, practical in execution, Neuro-oncology will help you diagnose and manage your patients more effectively. Neurology in Practice Series Editors Robert A Gross , MD, PhD, Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA Jonathan W Mink, MD, PhD, Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA The Neurology in Practice series provides clinical 'in the office' or 'at the bedside' guides to effective patient care for neurologists. The tone is practical, not academic, with authors offering guidance on what might be done and what should be avoided. The books are informed by evidence-based practice and feature: * Algorithms and guidelines where they are appropriate *'Tips and Tricks' boxes hints on improving outcomes *'Caution' warning boxes hints on avoiding complications *'Science Revisited' quick reminder of the basic science principles * Summaries of key evidence and suggestions for further reading