HPV is a growing epidemic in head and neck cancer and specialists working with these diseases are provided information on shifting trends in HPV in head and neck cancers along with challenges and controversies in treating this disease. With this virus related cancer, there is a different approach to managing this patient population. Novel therapeutic treatments are actively being developed for this type of head and neck cancer. Topics include: Epidemioloygy of HPV-head and neck cancer; Clinical detection of HPV; Clinical evaluation and disease patterns of HPV-related head and neck cancers; Impact of HPV-related head and neck cancer in clinical trials; Molecular biology of HPV and head and neck cancer and targeted therapies; Transoral robotic surgery: new surgical techniques for oropharyngeal cancers; Economic impact of HPV-related cancers; Rehabilitation needs of oropharyngeal cancer patients; Psychosocial care needs of HPV-head and neck cancer patients; and a Multi-disciplinary approach to head and neck cancers.

Management of the Patient at High Risk for Breast Cancer provides a state-of-the art review of patients who are at high risk for breast cancer, how to identify them, the tools available for risk assessment and quantification and indications for genetic counseling and testing. The book summarizes the high risk breast imaging options, including newest techniques and schedules. Pathologic evaluation of high risk lesions are featured as well as the management issues surrounding these lesions. The volume also covers the management of concomitant cancer risk and screening strategies. A concise, yet comprehensive overview of the current status of the topic, Management of the Patient at High Risk for Breast Cancer serves as a useful resource for physicians and researchers dealing with and interested in patients at high risk for breast cancer.

Topics include: Neoplastic Meningitis and Epidural Metastases: Evaluation and Management; Management of Brain Metastases: Surgery, Radiation, or Both?; Meningiomas/Nerve Sheath Tumors/Pituitary Tumors: Diagnosis and Treatment; Medulloblastoma/Primitive Neuroectodermal Tumor and Germ Cell Tumors: The Uncommon but Potentially Curable Primary Brain Tumors; Primary CNS Lymphoma: Overview of Current Treatment Strategies; Anaplastic Gliomas: Radiation, Chemotherapy, or Both?; Low Grade Gliomas: When and How to Treat?; Glioblastoma Multiforme: Overview of Current Treatment and Future Perspectives.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Guidance molecules in Cancer and cancer angiogenesis" and contains outstanding and original reviews.
Provides invaluable information on the exciting and fast-moving field of cancer research. This volumelooks at "Guidance molecules in Cancer and cancer angiogenesis."Outstanding and original reviews"

This issue of the Obstetrics and Gynecology Clinics provides an update in Gynecologic Oncology.? Vulvar/Vaginal, cervical, uterine, and ovarian cancer are all covered, along with early detection and screening, and genetics and hereditary risk.? There is also an article on trends in cancer care in North America, which discusses cancer care and cost and sustainability as well as practice evloution.

In this issue of Surgical Oncology Clinics of North America, Guest Editor Clifford Ko, MD has assembled the top experts concerning Outcomes Research in Oncology.? Topics in this issue will include: Currently Available Quality Initiatives in Surgical Oncology; Variation in Mortality After High Risk Cancer Surgery: Failure to Rescue; Readmission as a Quality Measure Following High Risk Cancer Surgery; Randomized Controlled Trials in Surgical Oncology: Where Do We Stand?; Lymph Node Staging in GI Malignancies; Racial and Socioeconomic Disparities in Cancer Care; Patient Safety in Surgical Oncology: Perspective from the Operating Room; Value Based Health Care: A Surgical Oncologist Perspective; Monitoring the Delivery of Cancer Care: Commission on Cancer and National Cancer Data Base; Prediction Tools in Surgical Oncology; Collaboration With the Community Cancer Center: Benefit for All; and Evaluating the Appropriateness of Cancer Care in the United States.

This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development.

Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology.

The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.

The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.

This issue of Surgical Oncology Clinics of North America, Guest Edited by Neal Wilkinson, MD, is devoted to the Management of Gastric Cancer.? Articles in this issue will focus on Epidemiology; Genetics and Prophylactic Surgery; Endoscopic Diagnosis & Staging; Gastric Stromal Tumors (GIST); Management of Early Stage Gastric Cancer; Endoscopic Mucosal Resection (EMR); Tailored Lymphadenectomy; Laparoscopic Resection Gastric Cancer - Western Experience; Gastric Cancer - Eastern Experience; Update of Gastric Cancer Clinical Trials; Preoperative and Postoperative Chemotherapy for Gastric Cancer; and Phase I and II Clinical Trials.

This book aims to bring together clinical information on the biology, diagnosis, therapy and management of patients with inflammatory breast cancer. Authored by experts from the Instituto Nacional de Cancerologia in Mexico, this book will provide the reader with the state-of-the art treatment of this rare but pernicious disease.

The book is the first one published exclusively on the field of nutritional epidemiology of breast cancer. It summarizes the currently existing knowledge, with an updated and comprehensive international bibliography (~ 1.000 references). The authors also performed a review on the epidemiological studies on nutrition and breast cancer carried out in Uruguay between 1994 and 2011, which allowed exploring and identifying the main risk and protective factors for the disease in this high-risk country. Epidemiologists, Nutritionists, Public Health managers and breast specialists -from the prevention to the treatment fields - will find in this book a unique source of technical information, which will contribute in expanding their knowledge and view of the disease.

This volume will describe both growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine, on their own or in combination, in cancer. It will coherently review the pathophysiological aspects of the mucin glycoproteins in malignancies and provide an updated account of the status of bromelain and N-acetylcysteine in cancer therapy. The volume will develop the idea of using these two drugs as a combination formulation for mucin-depleting effects.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
113th volume of Advances in Cancer ResearchExpert authorsChapters on topics including microRNA regulatory network, multifaceted oncoprotein tax, and underlying chromosomal translocations

Topics in this issue?include: Targeting IGF-1R; Tyrosine Kinase Inhibitors in Lung Cancer; Targeting mTOR; Targeting Hedgehog; Mitotic Inhibitors; Topoisomerase I Inhibitors; and New Strategies and Drugs Inhibiting Folate Pathways.

The aim of this issue is to provide the thoracic surgeon with information about the staging and treatment of cancer to the mediastinal lymph nodes. The issue includes articles on the anatomy and physiology of the lymph nodes, imaging of the lymph nodes, and various techniques for diagnosing and dissecting the lymph nodes, including video-assisted mediastinoscopic lymphadenectomy and transcervical extended mediastinal lymphadenectomy.

Natural History of Vestibular Schwannomas (includes histology, epidemiology); Clinical and Diagnostic Evaluation (includes cost effectiveness of imaging vs audiometry); Neurophysiological Correlates: Preoperative, Intraoperative and Postoperative - Facial nerve, Auditory function, Vestibular; Neurofibromatosis Type 2 and Genetics; Art of Management Decision Making: From Intuition to Evidence Based Medicine (includes analysis of various decision making strategies); Radiation Therapy and Radiosurgery: Indications, Techniques and Results (CK, GK, LINAC,etc...); Management of Radiation/Radiosurgical Complications and Failures; Retrosigmoid Approach: Indications, Techniques and Results; Translabyrinthine Approach: Indications, Techniques and Results; Middle Fossa Approach: Indications, Techniques and Results; Endoscopic Approach: Indications, Techniques and Results; Management of Surgical Complications and Failures; Chemotherapy: Present and Future (new trials of Avastin and similar drugs); Habilitation of Auditory and Vestibular Dysfunction (Baha, vestibular rehab, etc.); Habilitation of Facial Nerve Dysfunction (neural grafts, muscle transfers, etc...); Support Groups and Patient Resources (Acoustic Neuroma Association, Neurofibromatosis Society)

Topics in this issue?include: Why does my patient have leukocytosis?; Why Is My Patient Neutropenic?; Does My Patient with a Serum Monoclonal Spike have Multiple Myeloma?; DVT and Pulmonary Embolism; Why Does My Patient Have Lymphadenopathy/Splenomegaly?; and Why Does My Patient have Thrombocytopenia?

This issue of the Urologic Clinics provides a timely update on Renal Cancer and the evolving treatment standards in urology.? Articles include Contemporary Imaging of the Renal Mass, Surgical Approach to Multifocal Renal Cancers, and Systemic Therapy Prior to Surgery.? Effects of the various existing surgical approaches on long-term renal function is also discussed, along with a review of the current trends in surgical management of renal cancers with specific attention to utilization of laparoscopic approach, partial nephrectomy, ablative technologies and observation.

This issue serves as a comprehensive review and update in the management of the geriatric cancer patient. Topics covered include: Cancer and Aging, Comprehensive Geriatric Assessment, Breast Cancer in the Elderly, Solid Tumors in the Elderly, Radiation Therapy with the Elderly, Liquid Tumors in the Elderly, Nursing and Palliation of Elderly Cancer Patients, Ethics and Religion in Care of the Elderly, and Surgery in the Elderly.

This book collates past and current research on one of the most promising emerging modalities for breast cancer detection. Readers will discover how, as a standalone technology or in conjunction with another modality, microwave imaging has the potential to provide reliable, safe and comfortable breast exams at low cost. Current breast imaging modalities include X- ray, Ultrasound, Magnetic Resonance Imaging, and Positron Emission Tomography. Each of these methods suffers from limitations, including poor sensitivity or specificity, high cost, patient discomfort, and exposure to potentially harmful ionising radiation. Microwave breast imaging is based on a contrast in the dielectric properties of breast tissue that exists at microwave frequencies. The book begins by considering the anatomy and dielectric properties of the breast, contrasting historical and recent studies. Next, radar-based breast imaging algorithms are discussed, encompassing both early-stage artefact removal, and data independent and adaptive beamforming algorithms. In a similar fashion, microwave tomographic reconstruction algorithms are reviewed in the following chapter, introducing the reader to both the fundamental and more advanced algorithms. Apart from imaging, the book also reviews research efforts in extracting clinically useful information from the Radar Target Signature of breast tumours, which is used to classify tumours as either benign or malignant. Finally, the book concludes by describing the current state of the art in terms of prototype microwave breast imaging systems, with a particular emphasis on those which have progressed to the clinical evaluation stage. This work is motivated by the fact that breast cancer is one of the leading causes of death amongst women in Europe and the US, and the second most common cancer in the world today. Such an important area of research will appeal to many scholars and practitioners.p>

Various aspects, including diagnosis, therapy, and prognosis, of two brain tumors (meningioma and schwannoma) , of brain tumors are discussed in this volume. Insights on the understanding of molecular pathways involved in brain tumor biology are explained. For example, the role of E-cadherin gene instability, carbonic anhydrase 11, urokinase plasminogen activator, and Wnt signaling is discussed in detail. Such information will lead to the development of effective aniicancer drugs. The role of molecular genetics and epigenetic mechanisms in schwannomas is explained. Also, is explained the role of cyclin D1 in vestibular schwannoma. The determination of subtypes of meningiomas using perfusion magnetic resonance imaging is explained. Diagnosis of incidentally discovered meningioma and cystic papillary meningioma is also included. Diagnosis of facial nerve schwannoma, vestibular schwannoma, and intermediate nerve schwannoma is explained. Treatments for atypical meningioma, oncocytic meneingioma, intracranial meningioma, and cavernous are presented. Therapeutic methods such as neurosurgery, Gamma knife radiosurgery, and adjuvant radiation for this cancer are included. Large number of other treatments, including radiosurgery, retrosigmoidal craniotomy, and immunotherapy, for vestibular schwannoma patients are detailed.

This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy.

The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained.