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Designed for the busy practitioner, "Cancer" provides succinct coverage of the assessment and treatment of a multitude of rehabilitation issues as they uniquely affect cancer patients. Broken into four sections with 66 alphabetically arranged topics, this go-to reference addresses the key concerns in cancer rehabilitation ranging from basic principles, exercise, and therapy interventions to acupuncture, massage, and end-of-life care. Primary conditions covered include bone marrow transplant, brain disease and tumors, hematologic cancer, metastatic bone disease, neurofibromatosis, and spinal cord compression. The largest section of the book is devoted to the myriad disease or treatment-related symptoms and medical issues endemic in the cancer population such as pain, anemia, anorexia, cognitive dysfunction, chemotherapy-related problems and radiation effects, lymphedema, fatigue, malnutrition, sleep disorders, spasticity, and much more.
Every entry is standardized for quick look-up in the office or clinic, and features description, etiology, risk factors, clinical features, natural history, diagnosis, red flags, treatment, prognosis, helpful hints and suggested readings.
All Rehabilitation Medicine Quick Reference titles provide: Consistent Approach and Organization-at-a-glance outline format allows readers to find the facts they need instantly Concise Coverage--of must-know information broken down into easy-to-locate topics Fast Answers to Clinical Questions--diagnostic and management criteria for problems commonly encountered in daily practice Hands-on Practical Guidance--for all types of interventions and therapies Multi-Specialty Perspective--ensures issues of relevance to all rehabilitation team members are addressed
Nanotechnology has emerged as a key technology which has opened new vistas to find effective therapies for cancer. Nanomaterials are particularly promising candidates for early diagnosis of cancer cells. Several classes of nanomaterials, including dendritic and supramolecular polymers, carbon nanotubes, graphene and metal nanoparticles, have shown tremendous ability to recognize and destroy cancer cells in vivo. In this book, some of these novel systems and their potential applications in cancer therapy are reviewed. (Imprint: Nova Biomedical)
This is the first book to be devoted exclusively to rare tumors in children and adolescents, and its aim is to provide up-to-date information on their diagnosis and clinical management. The opening section of the book addresses general issues including epidemiology, risk factors/etiology, biology and genetics, prevention, early detection, and screening. It also discusses solutions to assist in the management of rare tumors, such as international networking and internet platforms, thus providing the reader with access to the developing clinical network for rare tumors in children. In the second section, specific malignancies are described, with practical guidance on diagnostic workup, multimodal therapy, survival outcome, follow-up, and adverse effects. These chapters are organized by site according to the clinician's approach to the patient. Each chapter includes an introduction to the differential diagnostic assessment of tumors at the site in question, encompassing both frequent and rare tumor types. This approach should enable the clinician to take rare entities into account during the diagnostic assessment, so that the initial diagnostic steps are performed optimally. Each chapter goes on to provide detailed therapeutic guidelines for specific rare tumors. The authors are a multidisciplinary group of specialists who have dedicated themselves to this group of tumors. This well- illustrated book will prove an invaluable source of information for all pediatricians and oncologists faced with the often difficult task of diagnosing and treating rare tumors in the pediatric age group.
I have been exiled from my body. I was ejected at a very young age and I got lost. Playwright, author and activist Eve Ensler has devoted her life to the female body - how to talk about it, how to protect and value it. Yet she spent many years disassociated from her own - a disconnection brought on by her father's sexual abuse and her mother's remoteness. While working in the Congo, Ensler is shattered to encounter the horrific rape and violence inflicted on the women there. Soon after, she is diagnosed with uterine cancer, and through months of treatment she is forced to become first and foremost a body - pricked, punctured, cut, scanned. It is then that all distance is erased. As she connects her own illness to the devastation of the earth, her life force to the resilience of humanity, she is finally, fully - and gratefully - joined to the body of the world.
This book presents a unified approach to studying the stability of both elliptic Cauchy problems and selected inverse problems. Based on elementary Carleman inequalities, it establishes three-ball inequalities, which are the key to deriving logarithmic stability estimates for elliptic Cauchy problems and are also useful in proving stability estimates for certain elliptic inverse problems. The book presents three inverse problems, the first of which consists in determining the surface impedance of an obstacle from the far field pattern. The second problem investigates the detection of corrosion by electric measurement, while the third concerns the determination of an attenuation coefficient from internal data, which is motivated by a problem encountered in biomedical imaging.
Survival rates for cancer depend on where the patient lives and whether they are rich or poor. This report presents trends for almost 60 different cancers in adults and children in the eight English NHS regions and Wales. It reports on the survival of almost three million cancer patients and examines inequalities in cancer survival in five categories of deprivation, from affluent to deprived. The report should provide valuable information for doctors in order to advise patients when planning their treatment, for oncologists carrying out clinical trials to test the efficacy of new cancer treatment regimes, for health care planners and administrators, and for cancer patients themselves.
This book provides an up-to-date review of the risk factors and genetics influencing the development of this rare disease. This volume presents clinical features and recent advances in histopathology and molecular profiling are analyzed, providing a valuable aid to clinicians in tailoring treatment to both the patient and the tumour. Readers will find important insights into the most effective strategies for making or negating a diagnosis of MBC. Within this timely volume, consideration is also given to the psychological needs of men with breast cancer alongside a discussion of the most effective support methods. The surgical management of the disease is examined, together with algorithms for local and systemic therapy. Owing to the problem of late diagnosis in MBC, many men have advanced or disseminated disease at diagnosis and, as such, the evidence-based management of these cases is reviewed. Male Breast Cancer concludes with a discussion on determining prognosis and the likely future developments in MBC with a focus on improved diagnosis and survival. Male Breast Cancer will be of interest to breast surgeons, oncologists, breast radiologists, breast histopathologists and breast care nurses worldwide.
"...Useful background information is displayed in blue boxes, and good use is made of numerous tables and diagrams...a useful book for the undergraduate medical or allied health professional..." -Oncology News, May/June 2010 This forward looking cancer biology book appeals to a wide ranging audience. Introductory chapters that provide the molecular, cellular, and genetic information needed to comprehend the material of the subsequent chapters bring unprepared students up to speed for the rest of the book and serve as a useful refresher for those with previous biology background. The second set of chapters focuses on the main cancers in terms of risk factors, diagnostic and treatment methods and relevant current research. The final section encompasses the immune system's role in the prevention and development of cancer and the impact that the Human Genome Project will have on future approaches to cancer care. While best suited to non-majors cancer biology courses, the depth provided satisfies courses that combine both majors and non-majors. Also, and deliberately, the authors have incorporated relevant information on diagnosis and treatment options that lend appeal to the lay reader.
This volume describes a uniform international approach for classifying and reporting salivary gland FNA samples. The new reporting system is evidence-based using data from the literature as well as upon the experience of a multi-disciplinary group of leading experts involved in the field of salivary gland cytopathology. Each diagnostic category of this novel salivary gland reporting system includes detailed descriptions of the cytologic criteria as well as a comprehensive set of photomicrographs demonstrating all of the key microscopic features along with annotated descriptions for each image. Designed as a practical book with easy readability, The Milan System for Reporting Salivary Gland Cytopathology combines the high-quality images of an atlas with a logical approach described in concise text-form and in line-drawing algorithms. It presents for the first time, an international cytologic reporting system for salivary gland lesions designed and endorsed by a panel of experts in the field.
This book provides patients and their physicians (especially "non-oncologist" health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient's own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today's daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors' expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.
Utilizing the teaching value of real-world case discussions, "Cancer Biology Review" presents the principles of cancer biology in a clear and memorable manner, allowing the clinician to relate the cases shown in the book to those seen in practice. Focusing on ten topics in cancer biology for which there have been major changes in fundamental understanding, the authors provide a concise overview of the principles of each topic, followed by presentation of clinical cases illuminating the topic and detailed discussions. Summaries and key teaching points are highlighted at the end of each chapter to facilitate quick recall and review. The chapter authors are established translational experts in the biology being discussed as well practicing master clinicians.
"Cancer Biology Review" is a useful tool for any oncology clinician in training or preparing for boards, and for the oncology practitioner preparing for recertification or who sees the need to be more fully conversant in the current science of the field as clinically applied. Features of "Cancer Biology Review" include Presents principles of cancer biology through clinical translations and therapeutic perspective Clinical cases illustrate scientific principles as the clinician will observe them in practice Emphasis on scientific basis of current and emerging therapeutics Leading translational scientists/clinicians provide current, authoritative discussions
This book is a practical guide to the management of patients with breast malignancies. It serves as a quick reference book that gives the most up-to-date routine practical management strategies of breast cancer. Written and edited by leading experts, this handbook focuses on the application of conventional and novel treatment strategies to the care of patients with malignant breast disease and all stages of breast cancer. The chapters provide evidence-based treatment strategies for all patient subsets. Surgical, radiation, and medical treatment options are all discussed for each stage of breast cancer. It also includes the definitions of statistical terminologies and their usage in clinical practice and research. This is a comprehensive yet concise resource for residents, fellows, and early-career practitioners.
This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.
This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient's genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
Maintaining quality and improving cancer care does not occur in a vacuum. It requires a coordinated effort among many team members to whom this book is directed. Cancer care in the United States is in crisis as per a recent National Institute of Health publication. Much of this has to do with the complexity of the cancer care, its delivery systems, the aging population and the diminishing workforce. We need to be smarter and more efficient to de-escalate this crisis and improve the survival and survivorship of our cancer patients. Improved survivorship of families and caregivers will be included as well. The book will follow the continuum of cancer care model as its outline vide infra. It will provide many concrete instances of successful practices and programs which improve survivorship. Initially it will discuss the current crisis on a global and then national platform. There will be a discussion about disability adjusted life years lost, lost productivity, loss of life and its impact upon the nation and communities. The financial impact of cancer on society and government will be included in this. Population health management as regards cancer will then look at communities served, community health needs assessments and social determinants of health. How prevention and screening programs can be formulated from the above will be illustrated. Compliance with treatments as promulgated by the Commission on Cancer's Cancer Program Practice Performance Reports (CP3R) will be reviewed. The relationship between compliance and improved survival will be highlighted. Navigation and distress management to assure patients complete planned treatments will be included in this section. Quality of survivorship will review the four domains of life- spiritual, social, psychological and physical. How these can be maximized through system improvement and program development will be illustrated. Financial issues and legal protections will also be included in this section. Survivorship care planning i.e. surveillance for recurrent cancer, prevention of related and new cancers will be an integral part of this section. Palliative, end of life care and bereavement care will complete the continuum cycle. Identifying hospitalized patients in need of palliative needs will be refreshed. How to establish an in-patient palliative care team and creating a seamless transition from in-patient to out-patient palliative care will be presented. Intended AudienceAdministrative and clinical staff involved in the delivery of cancer care including: hospital executives, physicians, nurses, radiation therapists, psychology counselors, social workers, physical therapists, occupation therapists, nutritionists, government, healthcare insurance representatives, etc.
This book summarizes the etiology, presentation, and treatment of the complex symptoms, infections, and opportunistic cancers of people living with HIV/AIDS. Presents therapies that strike a balance between controlling and eliminating cancer and minimizing the damage to the immune system. Illustrates points with clear and easily read figures, tables, and flow charts! Written to survey the magnitude of the impact HIV and AIDS have had on public health and oncology, AIDS-Related Cancers and Their Treatment -identifies types of cancer and gives evidence for their associations with immunosuppression -compares and contrasts AIDS-related cancer with non-HIV malignancies -investigates the pathogenesis of malignancy in HIV/AIDS patients -provides guidelines for recognizing possible symptoms and making accurate diagnoses -supplies algorithms for evaluating and staging patients at presentation -outlines potential problems and obstacles in caring for AIDS-related cancer patients -suggests optimal therapeutic approaches for the care of patients with AIDS and cancer -discusses prognostic factors in response to therapy and survival statistics -describes preliminary experience with emerging therapies and projects new approaches -advises how to enroll patients to participate in clinical trials of new therapies -considers the psychological impact on patients and their need for counseling and support -reviews access-to-care issues in AIDS and the community burden of this epidemic -provides information sources for both AIDS patients and their physicians -and more With contributions from nearly 25 clinicians and citing more than 1200 references to support and elaborate on text material, AIDS-RelatedCancers and Their Treatment is a crucial reference for oncologists, immunologists, infectious disease specialists, hematologists, internists, microbiologists, virologists, epidemiologists, molecular and cell biologists, pathologists, and medical students in these disciplines.
This book deals with the essential factors in the personalization of treatment for primary breast cancer. These include host issues, lymph node surgery, radiation therapy, and preoperative systemic treatment requiring specialized knowledge, multidisciplinary care experience, techniques, and research. Locoregional treatment in conjunction with systemic treatments is another important factor, with options for local therapy significantly affected by genetic BRCA mutation. Axillary treatment issues have become top priorities in recent primary breast cancer care, and these are highlighted in the book's presentation of technological advances in lymph node mapping and diagnosis, axillary clearance in patients with nodal metastasis, and the role of axillary surgery. Attention is also given to locoregional treatment after preoperative systemic therapy. Because therapeutic impact differs depending upon biological characteristics such as tumor subtype, local therapy should be based both on tumor biology and on therapeutic response in parallel. Associated translational research and mathematical prediction tools such as nomograms also are introduced. This book provides the essence of primary breast cancer care, particularly its individualization with novel therapeutic concepts and strategies, and will greatly benefit physicians and clinical investigators in breast cancer institutions.
This book analyzes all aspects of modern multimodal treatment of locally recurrent rectal cancer in the pelvis in order to offer a panoramic overview of the different therapeutic options and enable the reader to balance their benefits and drawbacks. Indications for surgery and the surgical techniques themselves, including reconstruction techniques after major exenterative surgery, are clearly described and evaluated. The role of new imaging tools, such as MRI and PET-CT, in staging recurrences and guiding therapy is assessed and detailed consideration is given to the use of neoadjuvant and iterative radiotherapy and the indications for systemic chemotherapy. Morbidity, mortality, oncologic outcomes, and quality of life issues are carefully analyzed and options for pain control and palliation are examined. Finally, a national survey is presented on the state of the art in the surgical treatment of locally recurrent rectal cancer in Italy. While there has been a dramatic fall in the incidence of local pelvic recurrences, their treatment remains a major clinical challenge which requires a multidisciplinary approach and careful selection of the most appropriate strategy in each case. This book will aid practitioners in making the correct decisions in individual patients.
This volume presents state of the art of methods that can be useful for both basic and translational researchers to conduct chemoprevention preclinical studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Chemoprevention: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.
This book provides a comprehensive description of the screening and clinical applications of digital breast tomosynthesis (DBT) and offers straightforward, clear guidance on use of the technique. Informative clinical cases are presented to illustrate how to take advantage of DBT in clinical practice. The importance of DBT as a diagnostic tool for both screening and diagnosis is increasing rapidly. DBT improves upon mammography by depicting breast tissue on a video clip made of cross-sectional images reconstructed in correspondence with their mammographic planes of acquisition. DBT results in markedly reduced summation of overlapping breast tissue and offers the potential to improve mammographic breast cancer surveillance and diagnosis. This book will be an excellent practical teaching guide for beginners and a useful reference for more experienced radiologists.
An overview of the different approaches to cancer risk assessment of environmental factors - including "-omics" technologies, discussing the strengths and weaknesses of the methods in different fields. The main focus is on the carcinogenic effects of ionizing and non-ionizing radiation, demonstrating the difficulties in accurately assessing those factors that may or may not pose a significant cancer risk. The book extends the view to a broader context of risk assessment, highlighting various aspects of risk management. Written by leading experts in the field, this is a resource for policy makers and professionals in health risk assessment, and public health workers, as well as oncologists and researchers in academia.
Vitamin D deficiency is prevalent today not only among the elderly but pervasively throughout all ages of life.This is due, in part, to systemic diseases that affect vitamin D metabolism, to changes in lifestyle, such as insufficient exposure to sunlight, and to increased use of sunscreen. Apart from the obvious effects of vitamin D deficiency on skeletal metabolism, the problem is assuming even greater significance because observational and interventional studies have linked vitamin D deficiency to cardiovascular disease, cancer, and diabetes. This book addresses a variety of important issues that have emerged from this fast-moving area of clinical medicine. The topics include assays of vitamin D and its binding protein, effects on aging and associated complications, primary and secondary states of altered parathyroid hormone secretion, vitamin D in the growing years of children and adolescents, nutritional requirements, and vitamin D as it relates to systemic disorders such as diabetes mellitus. Vitamin D in Clinical Medicine aims to offer new insights, in an evidence-based way, on important issues related to vitamin D. It is written for general practitioners and internists, as well as for endocrinologists, nutritionists, pulmonologists, cardiologists, and oncologists.
Whether you're a newly diagnosed ovarian cancer patient, a survivor, or a friend or relative of either, this book offers help. Completely updated, the new third edition of 100 Questions & Answers About Ovarian Cancer gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a gynecologic oncologist and a gynecologic surgeon, with actual patient commentary, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.
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