This practical handbook of gynecologic oncology provides a comprehensive and concise guide to the diagnosis and management of gynecologic cancer, including breast and colon cancers. Edited and written by the faculty of the gynecologic oncology programs of MD Anderson Cancer Center and Memorial Sloan-Kettering Cancer Center, the second edition reviews and updates the various chapters, including new developments in management and a new chapter on germ cell and sex cord-stromal tumors.

The text is aimed at fellows and residents in gynecologic oncology, radiation oncology and medical oncology as well as residents in obstetrics and gynecologic surgery and medicine. It will also be a handy guide for medical students and practising physicians.

This book provides practical and pragmatic guidance in breast MRI for all professionals involved in breast imaging or the care of patients with breast diseases.

eBook available with sample pages: 0203215435

Soft tissue sarcoma is an uncommon disease with a historically ominous prognosis, but there has been a great deal of progress in the last two decades in the understanding of these diseases, and accurate prognostic and therapeutic information is now available that removes much of the mystique.

Mesothelioma used to be a rare disease, but because of the widespread use of asbestos it has now been described as an epidemic around the world. The disease has proven exceptionally resistant to common forms of treatment (chemotherapy, radiotherapy and surgery). Mesothelioma has a very aggressive natural history with a median survival of around 9 months.
There has been an explosion in knowledge about mesothelioma in the past few years, partly stimulated by the formation of the International Mesothelioma Interest Group network. This book represents a state-of-the-art review of the disease, from laboratory through to the bedside, from diagnostic procedures through to treatment and from imaging and early detection through to medico-legal aspects. It will be of interest to any clinician or scientist with any involvement in asbestos-related diseases, as well as members of the legal profession and anyone with an interest in respiratory diseases.

Comprehensive, authoritative, and up to date, Oncologic Imaging: A Multidisciplinary Approach, 2nd Edition, covers every aspect of radiographic imaging for the diagnosis, treatment, and management of the cancer patient. Dr. Paul M. Silverman and an expert author team from MD Anderson Cancer Center provide all the current, practical information available, while incorporating their unique experience based upon extensive, daily clinical care of patients with cancer. In one convenient volume, this definitive, one-of-a-kind text discusses new diagnostic imaging and surgical approaches as well as therapeutic cutting-edge treatments from radiation and medical oncology, focusing on best practices and the newest standards for personalized medicine. Brings together a unique multidisciplinary team of authors including clinical radiologists, medical oncologists, radiation oncologists, and surgical oncologists who reflect team-based practice. Features an all-new chapter on head and neck imaging, authored by world experts in this complex area. Contains extensive updates throughout, including transformational state-of-the-art imaging modalities such as PET/CT, and the full range of traditional modalities, including multidetector CT (MDCT), ultrasound, and MR in conjunction with the latest advances in genetics, molecular oncology, and targeted therapies. Distills practical, up-to-date information into a concise and consistent format with key point summaries, algorithms, clear drawings, and full-color staging diagrams. Includes emerging options for care based on practice recommendations and evidence in the literature. Provides updated tumor staging information based on the AJCC Classification of Malignant Tumors, 8th edition. Highlights the text with 1,000 high-quality radiographic images: CT, MR, hybrid imaging (PET/CT, PET/MR), mammography, and ultrasound, as well as clear line anatomic drawings, graphs, and algorithms. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Oncological Functional Nutrition: Phytochemicals and Medicinal Plants presents the anticancer activities, metabolism, mechanism of action, doses, and sources of various phytochemicals and medicinal plants. Broken into five parts, this book addresses cancer epidemiology, molecular and therapeutic bases of cancer, macro and micronutrients in cancer prevention and treatment, phytochemicals in the cancer treatment, and medical plants as potential functional foods or resources for the obtention of metabolites with anticancer activity. Written for nutritionists, food scientists, health professionals, oncologists, endocrinologists, natural product chemists, ethnobotanists, chemists, pharmacists, biochemists, and students studying relating fields, Oncological Functional Nutrition: Phytochemicals and Medicinal Plants will be a useful reference for those interested in learning more about functional nutrition and cancer.

In Europe and the USA we have a 40-50% chance of getting cancer at some time in our lives. So what do you do if you are diagnosed with the disease? The harshness of orthodox treatments (surgery, radiation and chemotherapy) are well-known. Their use is widespread, but their results are not impressive. Faced with these options, informed patients are increasingly seeking out alternative or complementary strategies to take control of their own healing. This book provides an overview of them. Jonathan Chamberlain watched his wife suffer and eventually die - both from her cancer and from the direct effects of the orthodox treatments she had undergone. This experience led him on a journey in search of other methods of overcoming cancer. What he discovered stunned him. There are cures out there - dozens of them - many offering very good chances of recovery. In Cancer Recovery Guide Chamberlain presents 15 simple, practical strategies for becoming well again. These strategies are grouped in three families: those relating to the mind and the emotions (did you know stress makes cancers more aggressive?) ; those relating to the health of the whole body (cancer cannot survive in a tissue environment that is truly healthy); and those that focus on directly attacking the cancer tumours. The personal stories cited throughout the book testify to the curative possibilities of the strategies presented.

Collaborative Practice in Palliative Care explores how different professions work collaboratively across professional, institutional, social, and cultural boundaries to enhance palliative care. Analysing palliative care as an interaction between different professionals, clients, and carers, and the social context or community within which the interaction takes place, it is grounded in up-to-date evidence, includes global aspects of palliative care and cultural diversity as themes running throughout the book, and is replete with examples of good and innovative practice. Drawing on experiences from within traditional specialist palliative care settings like hospices and community palliative care services, as well as more generalist contexts of the general hospital and primary care, this practical text highlights the social or public health model of palliative care. Designed to support active learning, it includes features such as case studies, summaries, and pointers to other learning resources. This text is an important reference for all professionals engaged in palliative care, particularly those studying for post-qualification programmes in the area.

The prospect of entering treatment is overwhelming for anyone facing a diagnosis of cancer. While patients have access to a vast amount of medical information online, this advice is often unreliable or confusing. In Living with Cancer, Drs. Vicki A. Jackson and David P. Ryan have crafted the first step-by-step guide aimed at helping people with this life-defining disease grasp what's happening to them while coping physically and emotionally with cancer treatment. An empathetic resource full of relatable patient stories, this book teaches patients and caregivers how to ask the right questions to get the best possible care-beginning at the moment of diagnosis. Drs. Jackson and Ryan explain how to work with a team of doctors and nurse practitioners to minimize symptoms and side effects while living as fully as possible in the face of cancer. They relay important information about understanding prognosis, and they translate what doctors mean when they describe tests, treatments, and medical procedures. Finally, they discuss hospice care and answer questions about continuing treatment and managing the final phase of life. Based on new research and a groundbreaking program in which patients are treated with palliative care-along with the best cancer care-during the course of their illness, this honest and caring book provides the right advice to use at the right time throughout a journey with cancer. It allows a person with cancer to concentrate on living the best life possible, despite an uncertain future. Patients at every stage will find Living with Cancer a comprehensive, thoughtful, and accessible guide for navigating the illness and its treatment.

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to "molecules and cells that negatively regulate T-cell activation". Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

Demonstrating the role of nuclear medicine as a complementary technique to mammography and other imaging modalities for the diagnosis of breast cancer, Radionuclide Imaging of the Breast provides a comprehensive overview of scintimammography-an accurate, safe, and noninvasive imaging method for the evaluation of breast lesions and malignancies. Reveals the encouraging results of multicenter clinical trials in the U.S. and Canada using 99mTc sestamibi breast imaging for the diagnosis of primary breast carcinoma! Addressing nonsurgical sampling of nonpalpable breast lesions as an effective means of providing diagnostic and prognostic information, Radionuclide Imaging of the Breast -discusses increasing the diagnostic value of mammography and its widespread use -examines the reliability of FDG-PET and FDG-SPECT in detecting lymph node involvement and distant metastases -reviews breast cancer imaging with monoclonal antibodies, including murine and bioengineered antibodies -compares the benefits and limitations of Thallium-20l to 99mTc-sestamibi breast imaging in evaluating suspected malignancy -assesses the clinical impact of scintimammography as an adjunctive test to mammography to improve the dependability of diagnoses -considers the possibility of replacing axillary lymph node dissection in patients with small breast cancers with the sentinel node approach -clarifies the importance of surgery in the multimodality treatment of breast cancer -elucidates pathologic difficulties for breast cancer diagnosis -and more! Radionuclide Imaging of the Breast serves as an essential reference for nuclear medicine physicians, radiologists, breast surgeons, medical and surgical oncologists, gynecologists, pathologists, internists, and primary care physicians.

This work provides cancer incidence, mortality, risks, trends and management information distilled into a concise text. It aims to bridge the gap between the information in general medical and surgical texts and the large oncology reference volumes used by practicing oncologists. Topics covered include epidemiology, basic medical science, major treatment modalities, oncological emergencies, cancer in AIDS patients, and the doctor-patient relationship. For ease of reference, "Fast Fact Sheets" present the key data on lung, breast, colorectal and prostate cancer, melanoma, and tumours of the endocrine system.

Since the last edition of the Tumors of Prostate Gland, Seminal Vesicles, Penis, and Scrotum, there have been numerous significant developments in the diagnosis and treatment of prostate and penile cancers. The new Fifth Series Fascicle of the AFIP Atlas of Tumor and Non-tumor Pathology includes these developments as well as abundant images and diagrams to depict the morphological spectrum of disease entities. In this richly illustrated atlas, the authors emphasize the gross and light microscopic diagnosis and differential diagnosis, present immunohistochemistry and molecular pathology studies that are of current value in diagnosis, and discuss pathological diagnosis in terms of prognosis and treatment.

A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don't necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer's evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer's ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn't mean we should give up on treating cancer-in fact, evolutionary approaches offer new and promising options for the disease's prevention and treatments that aim at long-term management rather than simple eradication. Looking across species-from sponges and cacti to dogs and elephants-we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future-and that we cannot win a war against evolution-treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer's fundamental nature and our relationship to it.

This volume provides both the scientific and medical background to manipulation, as well as sound practical advice on how to carry out manipulative techniques. Manipulation is a now well-founded technique for the treatment of musculo-skeletal problems, and especially back pain. The Royal College of General Practitioners has recommended manipulation as a therapy, as has the Clinical standards Advisory Group. Manipulation is now also part of the core training of rheumatologists. The text is accompanied with illustrations showing how to manipulate safely, and key references are provided throughout. The book should be of i nterest to all those interested in manipulatio, including rheumatologists, general practitioners, physiotherapists, osteopaths and chiropractors.

This book deals with the emerging concept that certain pathogenic bacteria and viruses, when infecting people with cancer, actively fight tumors, allowing their regression. Although such observations go back more than 100 years, use of specific bacterial strains, or viruses, usually genetically modified with known anticancer drugs, and their protein/peptide products, has gained ground in recent years, allowing significant cancer regression in clinical trials with stage III/IV cancer patients or even in pediatric brain tumor patients, often without any demonstration of toxicity. It is composed of 12 chapters written by pioneers in microbial, biotech, and cancer research and covers the emerging roles of various microorganisms and their products in cancer therapy. The book highlights the benefits of using conventional cancer treatments (such as chemo- and radiotherapies) with microbial-based therapies. Such combinatorial therapies have gained particular attention as a strategy to overcome drug resistance, and the readers of the book will discover their impact on fundamental research and promising results from clinical trials.

This valuable self-help book for people affected by cancer, their loved ones and friends focuses on self-care when life hurts. It explores the impact of cancer and explains why the usual ways of coping may leave people stuck. The first book of its kind to focus on the scientifically based Acceptance and Commitment Therapy (ACT) approach, it helps people to find ways to cope with painful thoughts and feelings, and to rebuild a meaningful life despite the cancer. With an emphasis on value-based living the book illustrates skills such as mindfulness and the development of acceptance to help people affected by cancer to participate in a fuller life and gain a greater sense of well-being. It combines evidence-based practice with the experiences of people who are living with cancer in the form of numerous quotations throughout, as well as paper and pencil 'thought' exercises. Living Your Life with Cancer through Acceptance and Commitment Therapy helps people affected by cancer to feel more able to sit with the uncertainty of their future, show themselves kindness and compassion and to learn to be true to themselves, no matter what the cancer throws at them. It is also important reading for psychological therapists working in oncology.

Whether you're a newly diagnosed ovarian cancer patient, a survivor, or a friend or relative of either, this book offers help. Completely updated, the new fourth edition of 100 Questions & Answers About Ovarian Cancer gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a gynecologic oncologist and a gynecologic surgeon, with actual patient commentary, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

This book comes out of an in-depth, qualitative study of the experiences of twenty-three families in which one parent was dying of cancer. The study attempted to better understand the impact of terminal illness on the entire family system and sought to develop a theoretical framework that would guide the assessment of and services to such families. As a result of interviews with patients, spouses and their adult children over three phases of the study, the process of ""fading away"" was identified and conceptualized in terms of various phases which contributed to this process. The book is not a research report but rather presents more generally the ideas that developed from the study, with two purposes: to increase the reader's understanding of particular experiences that families encounter when dealing with terminal illness, specifically cancer. The intended readership also includes families themselves: to propose guidelines for care to be considered by practitioners working with such families.

This book provides healthcare professionals with a practice theory for the care and management of patients who have been diagnosed with cancer. It explores what patients experience and how healthcare professionals can assist them in dealing with their uncertainty and fear as well as planning for the future. Unique to the book is its explication of the emerging theory, 'The Omnipresence of Cancer', which is set in the context of a discussion of earlier theories also concerned with cancer care. Chapters demonstrate how 'The Omnipresence of Cancer' has been developed, validated through research and being further tested in relation to cancer care. In particular, a chapter on philosophical reflections using theory to produce knowledge for practice is included. Each chapter provides essential background, a synthesis of the current state of knowledge, and practice examples associated with cancer care. The combination of theoretical reflection and practice examples is designed to promote comprehension and guidance on implementation of the theory, as well as recommendations for practice. This book will be of significant interest to healthcare students and professionals working in the field of cancer care and oncology, particularly healthcare professionals working in advanced practice roles and nurse educators. It is also anticipated that professionals working in pastoral care, occupational therapy, social work and radiography will be interested in this book.

This book provides a contemporary and comprehensive examination of cancer in everyday life, drawing on qualitative research with people living with cancer, their family members and health professionals. It explores the evolving and enduring affects of cancer for individuals, families and communities, with attention to the changing dynamics of survivorship, including social relations around waiting, uncertainty, hope, wilfulness, obligation, responsibility and healing. Challenging simplistic deployments of survivorship and drawing on contemporary and classical social theory, it critically examines survivorship through innovative qualitative methodologies including interviews, focus groups, participant produced photos and solicited diaries. In assembling this panoramic view of cancer in the twenty-first century, it also enlivens core debates in sociology, including questions around individual agency, subjectivity, temporality, normativity, resistance, affect and embodiment. A thoughtful account of cancer embedded in the undulations of the everyday, narrated by its subjects and those who informally and formally care for them, Survivorship: A Sociology of Cancer in Everyday Life outlines new ways of thinking about survivorship for sociologists, health and medical researchers and those working in cancer care settings.

This volume covers advances in the field of respiratory diseases, reflecting the recent and dramatic expansion of knowledge regarding the determinants of respiratory health, screening tests for early pulmonary lesions, therapeutic interventions for respiratory infections and strategies for prevention. It examines indoor and outdoor environmental sources of respiratory diseases, including levels of pollutants, air conditioning, indoor air quality and airborne allergens. Exploring ways to promote the respiratory health of both the individual and the community, Prevention of Respiratory Diseases covers areas including: the role of most of the known extrinsic and potentially preventable determinants in respiratory diseases; developments in epidemiology and children's respiratory health; the relationship between respiratory diseases and occupations; individual sensitivity or susceptibility to the effects of air pollutants; genetic, epidemiological and immunological markers, markers for bronchial cancer and the protease-antiprotease system; and the connection between tobacco smoke and respiratory diseases.;This resource is intended for pulmonologists, clinical immunologists and allergists, oncologists, physiologists, infectious disease specialists, respiratory therapists and graduate and medical school students in these disciplines.

Mesotheliomas of Animals is the first book to provide a comprehensive compilation of the diverse and often disparate literature regarding animal mesotheliomas. The compendium presents evidence to support the existence of "background" and "threshold," both of which are concepts central to the controversy surrounding nonasbestos-related mesotheliomas. Examples of "background" tumors (those which are nonasbestos-related) are described in detail, and indications of "threshold" for the induction of mesotheliomas following exposure to asbestiform and nonasbestiform agents are evident from the "positive dose-response" studies that are discussed.
This compendium also allows for easy comparison of tumor yields elicited in "inoculation" studies performed with the same fiber types at similar doses. These comparisons often demonstrate markedly different tumor yields and highlight the limitations of injection techniques for fiber safety assessment. Mesotheliomas of Animals will be an essential reference for industrial hygienists, environmental lawyers, cancer researchers, and pulmonary scientists. It will be particularly useful to anyone involved with the design of fiber safety tests or with developing experimental models and protocols to assess the manner in which mesotheliomagenesis occurs.

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.