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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 8Human Diseases (Hardcover): M. A.... Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 8Human Diseases (Hardcover)
M. A. Hayat
R4,446 R4,133 Discovery Miles 41 330 Save R313 (7%) Ships in 12 - 19 working days

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington's disease, Parkin's disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death. Considering that autophagy is associated with numerous biological processes including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Human Diseases and Autophagosome. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

Oncoviruses - Cellular and Molecular Virology (Hardcover): Abubakar Yaro (Khalifa) Oncoviruses - Cellular and Molecular Virology (Hardcover)
Abubakar Yaro (Khalifa)
R1,080 Discovery Miles 10 800 Ships in 12 - 19 working days
Current Advances in Breast Cancer Research (Hardcover): Sandra Lekin Current Advances in Breast Cancer Research (Hardcover)
Sandra Lekin
R3,624 R3,270 Discovery Miles 32 700 Save R354 (10%) Ships in 10 - 15 working days
Life Blood - Lessons from one woman who survived serious illness against the odds (Hardcover): Cathy Koning Life Blood - Lessons from one woman who survived serious illness against the odds (Hardcover)
Cathy Koning
R569 Discovery Miles 5 690 Ships in 12 - 19 working days
Cancer Immunotherapy and Biological Cancer Treatments (Hardcover): Hilal Arnouk Cancer Immunotherapy and Biological Cancer Treatments (Hardcover)
Hilal Arnouk
R3,307 Discovery Miles 33 070 Ships in 10 - 15 working days
Biomedical Computing for Breast Cancer Detection and Diagnosis (Hardcover): Wellington Pinheiro dos Santos, Washington Wagner... Biomedical Computing for Breast Cancer Detection and Diagnosis (Hardcover)
Wellington Pinheiro dos Santos, Washington Wagner Azevedo Da Silva, Maira Araujo de Santana
R8,743 Discovery Miles 87 430 Ships in 10 - 15 working days

Despite success with treatment when diagnosed early, breast cancer is still one of the most fatal forms of cancer for women. Imaging diagnosis is still one of the most efficient ways to detect early breast changes with mammography among the most used techniques. However, there are other techniques that have emerged as alternatives or even complementary tests in the early detection of breast lesions (e.g., breast thermography and electrical impedance tomography). Artificial intelligence can be used to optimize image diagnosis, increasing the reliability of the reports and supporting professionals who do not have enough knowledge or experience to make good diagnoses. Biomedical Computing for Breast Cancer Detection and Diagnosis is a collection of research that presents a review of the physiology and anatomy of the breast; the dynamics of breast cancer; principles of pattern recognition, artificial neural networks, and computer graphics; and the breast imaging techniques and computational methods to support and optimize the diagnosis. While highlighting topics including mammograms, thermographic imaging, and intelligent systems, this book is ideally designed for medical oncologists, surgeons, biomedical engineers, medical imaging professionals, cancer researchers, academicians, and students in medicine, biomedicine, biomedical engineering, and computer science.

Immunotherapy of Cancer, Volume 128 (Hardcover): Xiang-Yang Wang, Paul B. Fisher Immunotherapy of Cancer, Volume 128 (Hardcover)
Xiang-Yang Wang, Paul B. Fisher
R4,695 R3,936 Discovery Miles 39 360 Save R759 (16%) Ships in 12 - 19 working days

Immunotherapy of Cancer provides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology.

Encyclopedia of Prostate Cancer (Hardcover): Karl Meloni Encyclopedia of Prostate Cancer (Hardcover)
Karl Meloni
R4,488 R3,133 Discovery Miles 31 330 Save R1,355 (30%) Ships in 12 - 19 working days
Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, Volume 74 (Hardcover): James P. Hardwick Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, Volume 74 (Hardcover)
James P. Hardwick
R6,988 R5,850 Discovery Miles 58 500 Save R1,138 (16%) Ships in 12 - 19 working days

Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, the latest volume in the Advances in Pharmacology series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer.

Advances in the Diagnosis and Treatment of Thyroid Carcinoma (Hardcover): Fabio Medas, Pier Francesco Alesina Advances in the Diagnosis and Treatment of Thyroid Carcinoma (Hardcover)
Fabio Medas, Pier Francesco Alesina
R2,081 R1,777 Discovery Miles 17 770 Save R304 (15%) Ships in 10 - 15 working days
Imaging of Bone and Soft Tissue Tumors and Their Mimickers, An Issue of Radiologic Clinics of North America, Volume 60-2... Imaging of Bone and Soft Tissue Tumors and Their Mimickers, An Issue of Radiologic Clinics of North America, Volume 60-2 (Hardcover)
Hillary W Garner
R2,767 Discovery Miles 27 670 Ships in 12 - 19 working days

In this issue of Radiologic Clinics, guest editor Dr. Hillary W. Garner brings her considerable expertise to the topic of Imaging of Bone and Soft Tissue Tumors and Mimickers. Top experts provide timely articles on the imaging findings and other relevant clinical information of frequently encountered benign and malignant tumors of bone and soft tissue, in addition to separate reviews on common and potentially confusing tumor mimics. In addition, orthopaedic oncologists have contributed valuable perspectives on how they incorporate imaging information into their patient care plans. Contains 11 relevant, practice-oriented topics including bone tumors: what the oncology team wants to know; bone tumors: imaging features of common and rare benign entities; bone tumors: common mimickers; soft tissue tumors: what the oncology team wants to know; soft tissue tumors: common mimickers; bone and soft tissue tumors: horizons in radiomics and artificial intelligence; and more. Provides in-depth clinical reviews on imaging of bone and soft tissue tumors and mimickers, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Advances in Cancer Research, Volume 127 (Hardcover): Kenneth D. Tew, Paul B. Fisher Advances in Cancer Research, Volume 127 (Hardcover)
Kenneth D. Tew, Paul B. Fisher
R4,692 R3,933 Discovery Miles 39 330 Save R759 (16%) Ships in 12 - 19 working days

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including taxane-anti-androgens cross-resistance in advanced prostate cancer and proteasome inhibitors in the treatment of multiple myeloma.

Exploring Skin Cancer (Hardcover): Deb Willis Exploring Skin Cancer (Hardcover)
Deb Willis
R2,584 R2,353 Discovery Miles 23 530 Save R231 (9%) Ships in 10 - 15 working days
Mesothelioma (Hardcover): Sonia Macia Mesothelioma (Hardcover)
Sonia Macia
R3,310 Discovery Miles 33 100 Ships in 10 - 15 working days
Glycosylation and Cancer, Volume 126 (Hardcover): Richard R Drake, Lauren Ball Glycosylation and Cancer, Volume 126 (Hardcover)
Richard R Drake, Lauren Ball
R4,697 R3,937 Discovery Miles 39 370 Save R760 (16%) Ships in 12 - 19 working days

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 18 (Hardcover): Lucia Morbidelli Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 18 (Hardcover)
Lucia Morbidelli
R3,672 Discovery Miles 36 720 Ships in 12 - 19 working days

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds-molecules that inhibit the growth of vessels inside a tumor-together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field.

Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer (Hardcover): Muthupandian Saravanan,... Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer (Hardcover)
Muthupandian Saravanan, Venkatraman Gopinath, Karthik Deekonda
R11,171 Discovery Miles 111 710 Ships in 10 - 15 working days

Multidrug-resistant bacteria play a significant role in public health by destroying the potency of existing antibiotics. Meanwhile, cancer remains one of the most common health problems that impact society, resulting in many deaths worldwide. Novel strategies are required to combat antimicrobial resistance and create efficient anticancer drugs that could revolutionize treatment. Nanomedicine is one such innovation that plays a significant role in developing alternative and more effective treatment strategies for antimicrobial resistance and cancer theranostics. The Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer is an essential scholarly resource that examines (1) how to overcome the existing, traditional approaches to combat antimicrobial resistance and cancer; (2) how to apply multiple mechanisms to target the cancer cells and microbes; and (3) how the nanomaterials can be used as carriers. Featuring a range of topics such as bacteriophage, nanomedicine, and oncology, this book is ideal for molecular biologists, microbiologists, nanotechnologists, academicians, chemists, pharmacists, oncologists, researchers, healthcare professionals, and students.

The Monster in Mummy (Hardcover): Donia Youssef The Monster in Mummy (Hardcover)
Donia Youssef
R577 Discovery Miles 5 770 Ships in 12 - 19 working days
New Insights Into Acute Lymphoblastic Leukemia (Hardcover): George Singer New Insights Into Acute Lymphoblastic Leukemia (Hardcover)
George Singer
R2,523 Discovery Miles 25 230 Ships in 12 - 19 working days
Brain and Spinal Tumors - Primary and Secondary (Hardcover): Lee Roy Morgan, Feyzi Birol Sarica Brain and Spinal Tumors - Primary and Secondary (Hardcover)
Lee Roy Morgan, Feyzi Birol Sarica
R3,369 Discovery Miles 33 690 Ships in 10 - 15 working days
Pheochromocytoma, Paraganglioma and Neuroblastoma (Hardcover): Pasquale Cianci, Enrico Restini, Amit Agrawal Pheochromocytoma, Paraganglioma and Neuroblastoma (Hardcover)
Pasquale Cianci, Enrico Restini, Amit Agrawal
R3,315 Discovery Miles 33 150 Ships in 10 - 15 working days
Dietary Phytochemicals - A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes (Hardcover,... Dietary Phytochemicals - A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes (Hardcover, 1st ed. 2021)
Chukwuebuka Egbuna, Sadia Hassan
R5,602 Discovery Miles 56 020 Ships in 10 - 15 working days

This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.

Op-Ed on Cancer (Hardcover): Ann Wax R. N. Op-Ed on Cancer (Hardcover)
Ann Wax R. N.
R574 Discovery Miles 5 740 Ships in 12 - 19 working days

The traditional approach to cancer is that the patient must view cancer as the enemy and engage in a war to vanquish that enemy. Ann Wax, RN, argues that this approach is incorrect and invariably leads to pain, self doubt, and depression. Instead, she argues that one must find calm and inner-peace first, in order to promote healing.

Discoidin Domain Receptors in Health and Disease (Hardcover, 1st ed. 2016): Rafael Fridman, Paul H. Huang Discoidin Domain Receptors in Health and Disease (Hardcover, 1st ed. 2016)
Rafael Fridman, Paul H. Huang
R5,416 R5,069 Discovery Miles 50 690 Save R347 (6%) Ships in 12 - 19 working days

The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Lung Cancer 2021, Part 2, An Issue of Thoracic Surgery Clinics, Volume 31-4 (Hardcover): Farid M. Shamji Lung Cancer 2021, Part 2, An Issue of Thoracic Surgery Clinics, Volume 31-4 (Hardcover)
Farid M. Shamji
R2,764 Discovery Miles 27 640 Ships in 12 - 19 working days

In this issue of Thoracic Surgery Clinics, Guest Editor Farid Shamji brings considerable expertise to the topic of Lung Cancer in this second issue covering this topic. Top experts in the field cover key topics such as biological treatments, improving anesthesia safety in pulmonary resection for lung cancer, history of surgical instruments in thoracic surgery, The Hemithorax - the empty chest syndrome, and more. Provides in-depth, clinical reviews on lung cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 16 relevant, practice-oriented topics including Assessment of Operability and Resectability in Lung Cancer; Complications of chest wall resection in conjunction with pulmonary resection; Sepsis in the postpneumonectomy space: pathogenesis, recognition and management; Neuroendocrine cancers of the lung: natural history, pathological classification, biological behaviour and treatment; and more.

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