This detailed guide is a must for medical students preparing for clinical attachment and final exams. Its wide-ranging approach is also ideal for those sitting GP entrance exams. Presenting short answer questions encompassing the entire current curriculum, this informative revision aid covers all bases. Each of the twenty separate subject areas thoroughly tests you with ten or more questions and the detailed, comprehensive answers reinforce understanding. Topic summaries are provided to strengthen recall and a practice paper section is ideal for testing yourself under exam conditions.

Understanding Major Depressive Disorder, Third Edition anatomical chart features sections that define depression and describe how it affects the brain, contributing factors, signs and symptoms, and treatment, including an illustrated box on the role of neurotransmitters. Featured sections: How Does Depression Affect the Brain Changes in Parts of the Limbic System can Affect Mood and Behavior What is Depression? Several Factors can Contribute to Depression Signs and Symptoms of Major Depressive Disorder Treatment Boxed feature on Chemical Imbalance with coverage of The Role of Neurotransmitters. Illustrations included: Neurons: Abnormal and Normal Brain: Amygdala, Hypothalamus, and Thalamus 20" x 26" heavyweight paper laminated with grommets at top corners

A practical manual of clinical medicine, arranged systematically and concisely as a wide-ranging systems-based survey of the main points of clinical practice - perfectly geared towards study for the MRCP(UK) Part 1 examination. Neil Black, in the Foreword The MRCP exam is not only a necessary hurdle to pass for any junior doctor wishing to become a hospital physician in the UK, but also an excellent training in the theory and clinical skills needed to be a senior physician. This book is a comprehensive revision text covering all the clinical subjects of the MRCP Part 1 and 2 examination. It adheres to the MRCP official syllabus and also reflects UK clinical guidelines as well as peer-reviewed medical research papers. The information is set out in an easily accessible way, making studying for this important exam productive and enjoyable. Organised by subject area, salient points are noted and the contents give appropriate weighting to the individual topics. Boxed text, tables and figures all add to this concise guide's appeal. Whilst it covers much traditional material such as lists of causes and differential diagnoses, this is the only book written entirely according to the current evidence-base as published by NICE, SCIE and the Cochrane Collaboration. This is a one-stop manual for candidates of the MRCP Part 1 and 2 but is also highly recommended for MRCP Part 2 written candidates and undergraduates sitting their final year examinations.

In this collection, the authors review novel findings strongly suggesting that YS110, a humanized monoclonal antibody with high affinity to the CD26 antigen, represents a promising novel therapy for refractory cancers, immune disorders and MERS-CoV infection. This book show that in vivo administration of YS110 inhibits tumor cell growth, migration and invasion, and enhances survival of mouse xenograft models inoculated with malignant mesothelioma (MPM), renal cell carcinoma, non-small-cell lung carcinoma, ovarian carcinoma or T-cell lymphoma via multiple mechanisms of action. Afterwards, several of the antibacterial resistance mechanisms employed by bacteria are discussed, especially those that can be targeted by novel antibacterial agents to combat resistant organisms. These mechanisms include alterations of cell wall or cell wall metabolites, mutations in antibiotic target, antibiotic deactivation by bacterial enzymes and biofilm formation. Later, the authors introduce AdRx as a treatment modality in musculo-skeletal pain, explain its rationale and techniques offering indications and contraindications for its usage. While AdRx takes its original theory from Eunice Inghams teaching and from followers of her teachings, this chapter confines the content to AdRx as standalone therapy in the context of musculo-skeletal pain. Near-infrared spectroscopy (NIRS) is also introduced as a non-invasive monitoring method that allows continuous real-time monitoring of cerebral hemoglobin oxygen saturation in a small area of the frontal cortex. This monitoring tool is based on the principle that some biological materials are relatively permeable to near-infrared light. In a separate study, trans-synaptic tracing from the visually responsive sites in the superior colliculus to the retina were studied using attenuated pseudorabies virus. The results demonstrated the presence of synaptic connections between the transplant and the host retina that contribute to the visual improvement observed in the superior colliculus. Continuing, in 2015, a novel pathogenesis of Crohns disease (the Hruska Postulate) was published. The authors aim to take what is known about Mycobacterium avium subspecies paratuberculosis, Crohns disease, and the Hruska Postulate and determine why Crohns disease is potentially curable. Several researchers have been trying to identify biomarkers that can be used for Crohns disease in clinical practice, however, further studies are required in order to validate most of their findings. The closing chapter introduces several diagnostic imaging techniques for kidney stone detection. A new imaging technique of C-arm tomosynthesis is described to generate volumetric information of the kidney to identify the size and location of kidney stones with limited amount of radiation dose.