This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or 'healthspan.' The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer's diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.

A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated activation of astrocytes and microglia and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize

This book critically explores the world of older prisoners to provide a more nuanced understanding of imprisonment at old age. Through an ethnographical study of male and female older prisoners in two Belgian prison settings, one in which older prisoners are integrated and one in which they are segregated, it informs debates and seeks to recognise ageist discourse, attitudes, practices in prison. The Older Prisoner seeks to situate the older prisoner from both a penological and gerontological perspective, organised around the following broad themes: the construction of the older prisoner, the physical prison world, the social prison world, surviving prison and giving meaning. The book allows readers to navigate between contrasting perspectives and voices rather than reinforcing traditional narratives and prevailing discourses on the older prisoner. In doing so, it hopes to open up a broader dialogue on ageing and punishment. It also offers insights into the concept of meaning in life as an analytical tool to study prisoners.

A leading expert answers your questions about how to live to your fullest with COPD. Significant lung damage from smoking, exposure in some jobs, or even diseases such as AIDS and tuberculosis can lead to COPD. Having chronic obstructive pulmonary disease can leave you feeling short of breath, sometimes reluctant to go shopping or for a walk because you are afraid of more difficulties. You may have wheezing, tightness in the chest, or frequent coughing. Although you see a doctor for your COPD, you often have questions and need answers. In this concise and practical guide, leading medical expert Donald A. Mahler answers some of the most pressing questions that he has been asked over 30 years of seeing patients with COPD, including * Why am I short of breath? * What medications can treat my COPD? * Can surgery improve COPD? * What are flare-ups-and how can I prevent them? * How can I stop smoking? * What should I do if my breathing isn't getting better? * Can exercise help? If so, which exercises are the most beneficial? * What's the best way to prevent lung infections? * How does COVID-19 affect COPD? * How can I travel with oxygen? * Can I be sexually active with COPD? and much more. Each chapter includes a patient vignette and key points. Tables and boxes offering helpful tips are included throughout. Providing up-to-date, evidence-based content that covers more than just medications, COPD gives you the tools you need to keep active-and thrive.

Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.
Key Features
* Organized by function, making it easy to find and understand the material
* Addresses impairments both associated with diseases and not associated with diseases
* Written by leading researchers in the field
* Most comprehensive source of information on the neurobiology of aging

Most scholars do not consider the long-term nature of caregiving, but rather focus on a specific developmental period (e.g., old age) or a specific disability (e.g., cancer). Yet the most important lessons about caregiving may occur at any age, regardless of disabilities or other limitations. Caregiving is a lifelong process. It begins in a mother's womb, continues throughout the lifespan, and ends after death. Caregiving Across the Lifespan emphasizes caregiving as a process that occurs throughout one's life. It discusses infant care, the developmental needs of children and adolescents, the many caregiving issues in adulthood and mid-life, and finally end-of-life care and bereavement. Key coverage includes: Examining caregiving issues across a developmental perspective. Caregiving from infancy through early childhood through end of life. Mid-life and multigenerational bonds and responsibilities. Caregiver identity in older adults. Family caregiving at the end of life. This must-have volume offers a wealth of insights and ideas for researchers, practitioners, and graduate students across the caregiving fields, including psychology, social work, public health, geriatrics and gerontology, and medicine as well as public and education policy makers.

Comprehensive overview of literary works that illuminate the experiences of aging. Bibliographical essays analyze the ideas or themes relating to over 70 topics. Lengthy critical annotations accompany the more than 350 literary works, across various genres, on the different topics. An introduction, how to use the work section, careful cross-referencing, and author and subject indexes make this a useful research tool for gerontologists, health-care professionals, and general readers concerned with aging.

Selective, annotated bibliography aimed at providing gerontologists, health care professionals, and general readers interested in the aging process, a useful tool for identifying and utilizing literary works that provide insight into various topics in gerontology.

Part One contains bibliographical essays on more than 70 topics in gerontology. Each essay analyzes the ideas or themes that a number of literary works provide on a specific topic. The essays illustrate the relevance of literary works to gerontology study, introducing readers to a variety of works whose characters, plots, themes, or images bear on current topics in gerontology. Part Two includes detailed critical annotations of more than 350 literary works, including anthologies, autobiographies, novels, plays, poems, and stories. Annotations are detailed and draw out specific issues related to characterization, plot, conflicts, themes, imagery, and metaphors. This comprehensive overview includes an introduction, a chapter about how to use the guide, and author and subject indexes.

This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson's disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson's disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson's etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson's disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson's disease, efforts to postpone, prevent and "cure" onset mitochondrial aberrations and neurodegeneration associated with Parkinson's disease in various models are encouraging. While only about ten percent of Parkinson's patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson's disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.

A vital roadmap to planning your own end-of-life care. While modern Americans strive to control nearly every aspect of their lives, many of us abandon control of life's final passage. But the realities of twenty-first-century medicine will allow most of us to have a say in how, when, and where we die, so we need to make decisions surrounding death, too. Or those decisions may be made for us. Threading compelling real-life stories and practical guidance throughout, this book helps readers navigate end-of-life care for themselves and their loved ones. In this practical guidebook, Dr. Dan Morhaim and Shelley Morhaim offer readers hope, empowerment, and inspiration. What we choose for our end-of-life care, they assert, depends on accurate information and on our personal values. We need these not only to understand new medical advances but also to appreciate the wisdom of humanity's past and present. Dan Morhaim, an emergency medicine physician and former Maryland state legislator, guides readers through the medical, legal, and financial maze of end-of-life care. He details the care choices available to patients and explains why living wills and advance directives are a necessity for every American. He tells readers where to find free and readily available living wills and advance directives and why it is so important for everyone-young and old-to complete them. Meanwhile, Shelley Morhaim draws on her experience as a therapeutic music practitioner for hospice and hospital patients to offer compassion to readers facing hard decisions. The authors reflect on a number of timely topics, including * what doctors-including Dr. Morhaim specifically-want for themselves in terms of end-of-life care * how legislative initiatives on assisted dying vary by state * how to obtain medical orders for life-sustaining treatment (MOLST/POLST) * how to deal with dementia * what to expect from palliative and hospice care * how to cope with pain at the end of life, including with medical cannabis and narcotics * how organ donation and body disposition work * how to communicate individual needs to lawyers, physicians, and family members * how to make decisions when selecting the best care for yourself and others and more. Organized as a roadmap that people should follow when they plan end-of-life care and contingencies, this book helps readers keep decisions in their own hands and spare their families the uncertainty and trauma of guessing about their end-of-life wishes. Breaking down the barriers to a difficult but essential topic, Preparing for a Better End helps readers open this often-avoided discussion with their loved ones while providing the information and guidance needed to ensure that deeply held values are reflected and honored. Praise for the Author "In The Better End, Dr. Morhaim helps the reader to see that while death does have its sting, it need not be bitter, and each of us can prepare for the end in better ways."-Maya Angelou "Dan Morhaim's message is a must read for anyone who is facing end-of-life crisis issues and concerns, whether it be for themselves or for a family member or loved one. When so many others shun away from the topic, Dan Morhaim addresses the situation with clarity, insight, and sensitivity."-Montel Williams

In this volume of Reviews of Physiology, Biochemistry and Pharmacology there a contributions by M.D. Swope, E. Lolis, F.Hofmann, L. Lacinova, N. Klugbauer, M. Hermann, P. Berger, S.S. Shen, J.S. Kim, M.E. Weksler, M. Hirsch-Kauffmann and M.Schweiger.

The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.
Key Features
* Covers all aspects of the aging skeleton in one comprehensive volume
* Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass
* Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton
* Reviews current therapeutic approaches and methods
* Written by internationally renowned authors and edited by leaders in the field
* Is the only book available on this subject

It 's a core issue at the heart of elder care: while best-practice data exist for long-term care, quality of life as a concept, measure and standard for care outcomes remains elusive. The result of an ambitious European research initiative, the Care Keys Project addresses quality of life issues among frail, care-dependent seniors, taking their social as well as health needs into account. This resulting volume explains the theory behind Care Keys, its methodology, empirical findings, and practical considerations in promoting effective, efficient elder care aimed at social and emotional well-being and including disabled and cognitively impaired patients.

This book provides a comprehensive research-based source of material, which focuses on the important issue of dementia and family care. It critically examines how dementia is defined, diagnosed and "treated" and provides a new environmentally focused approach to this challenging and growing issue for nurses and other care givers.

A much needed practical nursing text addressing the complex problems posed by the growing number of elderly people with mental health problems. The book can be used as an everyday companion for qualified nurses or for teaching health care assistants and students about practical interventions, therapeutic approaches and for developing knowledge and attitudes. Wider issues are considered, including the care continuum through acute to continuing care, and different care environments. * Practical advice for dealing with every-day problems * Examines common mental health problems in depth, to develop nurses' understanding of clients' needs * Positive approach, challenging stereotypical views and giving guidance for good care practices

< B> Handbook of the Aging Brain< /B> brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition.

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Demographically, the care of older people is a growing area of concern. The growth in nursing care in this area has been tremendous both within and without the NHS. Nursing texts have tended to be limited to medical aspects of ill-health, but nursing older people as a specialty is developing a much more positive, holistic focus. This book provides a practice-based text concentrating on how nursing should focus on positive aspects of care and developing quality of life. Growing older is often regarded purely in negative terms and this has a profound influence on the practice of caring for older people. This innovative text focuses on promoting a positive approach to practice and the value of older people in our society. Unlike other books in this field, it avoids a medical approach and instead focuses on health, individuality and relationships in caring--the quality of life which should be the aim of care. Section 1--Values, Attitudes and Beliefs: cultural perspectives, choice and autonomy, risk management Section 2--Optimum Health: positive approaches to health, sexuality, spirituality, social networks Section 3: Therapeutic Interventions: communication, touch, sensory environments, relaxation Section 4: Future Issues: outcome measures, resource issues, policy dimensions. Drawing on a range of contributors from the fields of learning disabilities and mental health as well as adult health, the editors have recognised that many different disciplines can contribute to developing new partnerships in approaches to care. Practice-focused, the text features case studies and activities extensively to encourage readers to reflect on their own values and experiences and the experiences of older people. This practice-based text will inspire both students and practitioners working with older people to reflect upon their practice, think differently and discover new approaches to care.positive approach integrates theory and practice from different disciplines chapters included on innovative practical approaches to therapeutic communication including the use of touch and relaxationcolour plate section extensive use of case studies provides links to readers practiceuser-friendly text design includes reflection and discussion points

Aging Issues in Cardiology provides an overview of the practical clinical areas involved in managing cardiovascular disease in the elderly. This volume will be useful to any physician managing the cardiovascular health of elderly individuals.
Topics covered include:

-Delirium in Elderly Cardiac Patients,
-Depression,
- Pharmacologic Issues,
- Primary Prevention,
- Syncope,
- Heart Failure,
- Coronary Revascularization.

Designed to provide a highly visual reference for surgeons and other members of the patient management team, Atlas of Intestinal Stomas is based on the 1967 gold standard text, Turnbull and Weakly's Atlas of Intestinal Stomas. Additions include chapters on anatomy and physiology, biliary stomas, pediatric ostomies, the continent ileostomy, urostomy, laparoscopic stoma construction, stomas in trauma surgery, stomas for antegrade continence enema, percutaneous ostomies, and quality of life. There are also sections on ileostomy, colostomy, enterostomal therapy and on the management of complications of stomas such as management of the high output ostomy, enterocutaneous fistula, parastomal hernia, prolapse, and skin conditions. The Cleveland Clinic pioneered the entire practice of ostomies, beginning in 1858 and continuing to this day as the world's leading academic and clinical center. The editors and contributors are all current or former Cleveland Clinic physicians and instructors. The fundamental focus of the book is not only how to install ostomies, but how to avoid complications and how to treat complications when they arise. Atlas of Intestinal Stomas will be of great value to colorectal and general surgeons, both in practice and in training.

Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life.

Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a rising incidence of obesity. Thus our increasing food and calorie intake has been linked to the rising incidence of cardiovascular disease and diabetes in early adult life. It is accepted that overeating, accompanied by reduced physical exercise, will lead to more age-related diseases and shortening of life-span. The answer is to reduce our calorie intake, improve our diet, and exercise more. But calorie restriction is extremely difficult to maintain for long periods. How then can we solve this problem?

Edited by a team of highly distinguished academics, this book provides the latest information on the beneficial effects of calorie restriction on health and life-span. This book brings us closer to an understanding at the molecular, cellular and whole organism level of the way forward.

Clinical Neurology of Aging, Third Edition continues the tradition of the First (1984) and Second (1994) editions with 60 chapters written by the world's elite clinicians from neurology, geriatrics and research on all aspects of geriatric neurology. Aging does not automatically imply decline. Many older people find joy in their friendships and their willingness to look at the world with a calmer view than they may have had in youth. This clinically focused book is designed to help clinicians help older persons maintain that joy. Now divided into 9 comprehensive sections, the Third Edition contains subjects ranging from geriatric assessment to pain management and palliative care. Specific sections include: Introduction to Geriatric Neurology; Neurological Assessment in Aging; Cognitive Disorders in Aging; Motor Disorders in Aging; Neuropsychiatric Illness in Aging; Sensory Disturbance in Aging; Peripheral Neurology of Aging; Disease States in Elderly; and Neurological Therapeutics. With a deft touch, the editors - Drs. Martin Albert and Janice Knoefel - have incorporated the geriatric care perspective and a quality-oriented approach to health care throughout the volume. The result: the definitive reference, useful for all clinicians caring for older people and informative to those who set policies that affect research and clinical practice.

This book is designed to present the clinical geriatric trends within general internal medicine and family practice, which practitioners often encounter in caring for their older adult patients. Chapters focus on increasingly difficult clinical decisions that practitioners have to make in caring for older adults, who often experience medical complications due to memory loss, physical disability, and multiple chronic conditions. Written by experts in geriatric medicine, each of these chapters start with the most up-to-date clinical geriatric research and provide specific examples or case studies on how to use this information to address the clinical needs of older adult patients. In addition, there is a set of concise "take-home points" for each chapter that are easy to commit to memory and implement in clinical care of aging patients. As the only book to focus on current trends in geriatric research and evidence-based eldercare practice, Clinical Trends in Geriatric Medicine is of great value to internists, family practitioners, geriatricians, nurses, and physician assistants who care for older adults.

Because of many advances in medicine and biotechnology, an increasing number of individuals are surviving into old age, and we are now challenged to apply sophisticated medical knowledge to the care of the elderly citizen. In nephrology, individuals older than 65 are the fastest-growing group of patients requiring dialysis. Similarly, in increasing numbers, elderly persons present themselves with renal complaints to their family doctor, the geriatrician or the nephrologist. In August 1998, with the financial support of the John A. Hartford Foundation, leaders in geriatrics, nephrology and urology met in Jasper, Alberta, for one week to discuss their areas of special knowledge and to learn from each other. Geriatricians learned from nephrologists, nephrologists learned from geriatricians, and both came to see that they had much in common. All participants discovered a common interest, challenge and commitment, namely, to provide the best renal care to a progressively aging population and to teach their fellows the principles of the other collaborating specialties. This book contains all the papers presented at this meeting and also the text of group discussions on Training and Education, Special Clinical Problems in Geriatric Patients, and Recommendations in Basic and Clinical Research. Nephrology and Geriatrics Integrated will prove useful to both nephrologists and geriatricians in their efforts to manage the renal complaints of the elderly, who come to them in increasing numbers.

This book provides a current perspective on alcohol and aging to better understand the trends, costs, benefits, and clinical and community evidenced-based strategies. This book embraces not only the physical, cognitive, psychological, and social health benefits of moderate drinking in the elderly, it also delves into the risks of excessive drinking, including physical and psychiatric morbidity, neurodegeneration, medication complications, and accidents and injuries, and loss of independence. Written by experts in the field, this book is the only current text that includes the most current scientific, research, empirical, and practice information alongside a comprehensive review of the status of the field that will help guide alcohol use management and stimulate future research. Alcohol and Aging is the ultimate resource for all researchers, educators, clinicians, and professionals working with older adults who drink.