This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ss and tau proteins in Alzheimer's disease, -synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.

This book arises from a conference held in November 1996 designed to examine how competence can be improved in the different stages ofthe lifespan. To this end, we brought together eminent researchers in different areas of human development-infancy, childhood, and adulthood, including the late adult years. The conference was based on the premise that discussion arising from the interfaces of research and practice would increase our knowledge of and stimulate the further application of effective interventions designed to improve competence. The editors wish to acknowledge the contributions of Concordia University and the Fonds pour la Formation de Chercheurs et l'Aide a la Recherche (FCAR) in providing funding and other assistance toward the conference "Improving Competence Across the Lifespan" and toward the publication of this book. Finally, we wish to express our gratitude to the numerous students associated with our Centre for their help and to Gail Pitts and Lesley Husband of the Centre for Research in Human Development for their assistance. We are especially grateful to Donna Craven, Centre for Research in Human Development, for her heroic work on both the conference and the present volume. We could not have met our goals without you.

This book provides concrete scientific basis that we can conceive the possibility of modifying or even completely canceling aging process, despite the fact that aging is commonly regarded as the result of the overall effects of many uncontrollable degenerative phenomena. The authors illustrate in detail the mechanisms by which cells and the whole organism age. Actions by which it is possible, or will be possible within a limited time, to operate for modifying aging are also debated. The discussion is conducted within the frame and the concepts of evolutionary medicine, which is also indispensable for distinguishing between the manifestations of aging and: (i) diseases that worsen with age, and (ii) acceleration of normal aging rates, caused by unhealthy lifestyle habits and other avoidable factors. The book also discusses the impact of aging on overall mortality and the strange situation that, according to official statistics, aging does not exist as cause of death. This book is a turning point between a gerontology and geriatrics conceived as the study and vain treatment of an incurable condition and one in which these disciplines examine the how and why of a physiological phenomenon that can be modified up to a possible total control. This means transforming the medical prevention and treatment of physiological aging from the greatest failure to the greatest success of medicine.

Older patients carry some of the highest risks of suffering an adverse event or death following anesthesia and surgery. They are inherently vulnerable, presenting with numerous comorbidities and reduced physiological reserve, requiring 'gero-centric' perioperative care for everything from routine eye surgery to major cardiac surgeries. Dementia, frailty, and the need for palliative care and pain management for the orthopedic patient are important areas requiring special consideration in this group. This book provides a general overview of these topics for those healthcare providers who may not have extensive knowledge of this patient population, while at the same time offering practical tips for the more experienced clinician. Chapters cover the spectrum of perioperative care including preoperative management of comorbid conditions, intraoperative anesthetic management, postoperative pain control, and a primer on advanced directive discussions. This book is appropriate not only for anesthesiologists but for any perioperative physician caring for the older patient.

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

This book discusses the contemporary medico-social, psychological, legal, and therapeutic concerns related to people affected by dementia as a patient or as a caregiver. It provides global emerging responses to dementia. It highlights different dimensions of dementia in terms of issues, concerns, policies, and strategies all around the globe. The contributing authors present issues from cross-cultural education visible in dementia studies and discuss the power of music, art therapy, artistic collaborations, and many innovative practices in dealing with dementia. Written by international specialists from various disciplines, the chapters include challenges and emerging issues related to the role of family caregivers, the concern with vulnerability to elder abuse and neglect, and the role of technology in dementia care. The book provides a diverse perspective to dementia care not covered in such a broad way by any other books on the topic. This book is intended for academics from a wide range of fields such as sociology, geriatrics, community medicine, public health, clinical psychology, social work all of which, collectively, bear on the problem and the solutions for better dementia care.

This book assembles many of the great leaders of the senior living and care industry to discuss their paths to and views on leadership. Each chapter provides readers with ideas, information, and inspiration on how to achieve leadership in this dynamic, mission-focused industry. It includes various strategies for success, such as promoting meaning and purpose in corporate culture, making decisions in the absence of perfect information, managing your personal assets of relationships and reputation, and finding competitive advantages through technology, training, and team-building. These leaders also share their experiences responding to COVID-19 and discuss how the pandemic may change the future of leadership in the industry. Whether your path starts in gerontology, nursing, social work, design, real estate, finance, law, operations, or technology, and whether one pursues work in the private, nonprofit, or government sectors, this volume provides a valuable resource for all aspiring and developing leaders in the senior living industry.

Contributions by Aneesh Barai, Clementine Beauvais, Justyna Deszcz-Tryhubczak, Terri Doughty, Aneta Dybska, Blanka Grzegorczyk, Zoe Jaques, Vanessa Joosen, Maria Nikolajeva, Marek Oziewicz, Ashley N. Reese, Malini Roy, Sabine Steels, Lucy Stone, Bjoern Sundmark, Michelle Superle, Nozomi Uematsu, Anastasia Ulanowicz, Helma van Lierop-Debrauwer, and Jean Webb. Intergenerational solidarity is a vital element of societal relationships that ensures survival of humanity. It connects generations, fostering transfer of common values, cumulative knowledge, experience, and culture essential to human development. In the face of global aging, changing family structures, family separations, economic insecurity, and political trends pitting young and old against each other, intergenerational solidarity is now, more than ever, a pressing need. Intergenerational Solidarity in Children's Literature and Film argues that productions for young audiences can stimulate intellectual and emotional connections between generations by representing intergenerational solidarity. For example, one essayist focuses on Disney films, which have shown a long-time commitment to variously highlighting, and then conservatively healing, fissures between generations. However, Disney-Pixar's Up and Coco instead portray intergenerational alliances - young collaborating with old, the living working alongside the dead - as necessary to achieving goals. The collection also testifies to the cultural, social, and political significance of children's culture in the development of generational intelligence and empathy towards age-others and positions the field of children's literature studies as a site of intergenerational solidarity, opening possibilities for a new socially consequential inquiry into the culture of childhood.

This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

The diagnosis and treatment of the elderly psychotic is problematical due to the fact that many of them have either Alzheimer's disease or vascular disease-related dementia. Expert contributors present the newest research based on clinical studies of the handling and treatment of elderly patients whose psychosis may be directly related to an incurable organic disease. They offer a multi-faceted approach to the treatment of these patients ranging from the medical, neurological, psychopharmacological, and therapeutic to social and family considerations. Assessment and Treatment of the Elderly Neuropsychiatric Patient also includes chapters dealing with attitudes toward death and dying as well as psychoanalysis.

With the aging of the baby boomers and medical advances that promote longevity, older adults are rapidly becoming the fastest growing segment of the population. As the population ages, so does the incidence of age related disorders. Many predict that 15% - 20% of the baby-boomer generation will develop some form of cognitive decline over the course of their lifetime, with estimates escalating to up to 50% in those achieving advanced age. Although much attention has been directed at Alzheimer's disease, the most common form of dementia, it is estimated that nearly one third of those cases of cognitive decline result from other neuropathological mechanisms. In fact, many patients diagnosed with Alzheimer's disease likely have co-morbid disorders that can also influence cognition (i.e., vascular cognitive impairment), suggesting mixed dementias are grossly under diagnosed. The Clinical Handbook on the Neuropsychology of Aging and Dementia is a unique work that provides clinicians with expert guidance and a hands-on approach to neuropsychological practice with older adults. The book will be divided into two sections, the first addressing special considerations for the evaluation of older adults, and the second half focusing on common referral questions likely to be encountered when working with this age group. The authors of the chapters are experts and are recognized by their peers as opinion leaders in their chosen chapter topics. The field of neuropsychology has played a critical role in developing methods for early identification of late life cognitive disorders as well as the differential diagnosis of dementia. Neuropsychological assessment provides valuable clinical information regarding the nature and severity of cognitive symptoms associated with dementia. Each chapter will reinforce the notion that neuropsychological measures provide the clinician with sensitive tools to differentiate normal age-related cognitive decline from disease-associated impairment, aid in differential diagnosis of cognitive dysfunction in older adults, as well as identify cognitive deficits most likely to translate into functional impairments in everyday life.

An in-depth and wide-ranging approach to the study of older adults in society Taking a holistic approach to the study of aging, this volume uses biological, archaeological, medical, and cultural perspectives to explore how older adults have functioned in societies around the globe and throughout human history. As the world's population over 65 years of age continues to increase, this wide-ranging approach fills a growing need for both academics and service professionals in gerontology, geriatrics, and related fields. Case studies from the United States, Tibet, Turkey, China, Nigeria, and Mexico provide examples of the ways age-related changes are influenced by environmental, genetic, sociocultural, and political-economic variables. Taken together, they help explain how the experience of aging varies across time and space. These contributions from noted anthropological scholars examine evolutionary and biological understandings of human aging, the roles of elders in various societies, issues of gender and ageism, and the role of chronic illness and "successful aging" among older adults. This volume highlights how an anthropology of aging can illustrate how older adults adapt to shifting life circumstances and environments, including changes to the ways in which individuals and families care for them. The research in Anthropological Perspectives on Aging can also help researchers, students, and practitioners reach across disciplines to address age discrimination and help improve health outcomes throughout the life course.

Improvements in health care in the 21st century mean people are living longer, but with the paradox that chronic illness is increasingly prevalent. Dementia, a term used to describe various different brain disorders that involve a loss of brain function that is usually progressive and eventually severe, is a condition associated with an ageing population and is becoming increasingly common. Worldwide there are approximately 24 million people with dementia, expected to rise to 81 million by 2040. Inevitably, people living with dementia will die, but their needs at the end of life are not well known. This book describes what might be achieved if the values and best practice of both dementia care and palliative care are brought together, to achieve quality end of life care for this specific group of patients. It explores what is known about the experience of dying with dementia, using a narrative approach, and develops a model that draws together a 'person-centred' approach to care. The book examines the possibilities and the challenges faced when trying to improve quality of life for people with dementia, and presents examples of good practice from across the world.

In this interdisciplinary book, experts from philosophy, medicine, law, psychology, economics, and social sciences address questions and develop solutions for a well-designed society of long life. Young as well as old people have to actively shape more and more of their life span. At the same time, aging becomes more multifaceted: the individual view on one's own life course is changing, and the needs and demands for a fulfilled life are diversifying. The implications affect all spheres of life - from education and workplace to health care and the culture of interaction. They require content-related and structural adjustments for a diverse society of longevity in which multiple generations live alongside each other. But how can change be managed responsibly, how can individual and collective responsibility be distributed appropriately, and how can a sustainable and fair social future be ensured?

This open access book turns the research attention of social policy scholars and long-term care researchers from comparative descriptions of care systems, focusing mostly on expenditures and volumes of long-term care services, to outcomes, and in particular to the question whether older people really receive the support that they need. Without knowledge about which needs and which social groups are currently inadequately covered, it is impossible to guide policy development. The book puts forward a novel theoretical framework to guide future research work and public discussion on the issue of unmet long-term care needs, by broadening the current discussion so that inadequate care is seen in its societal and policy contexts, taking structural issues and policy designs into account. Kroeger outlines three different domains of care poverty (personal care poverty, practical care poverty and socio-emotional care poverty) and differentiates between main methods how unmet needs are measured. This book summarises the existing knowledge on the prevalence, factors and consequences of unmet care needs and interprets these comparatively in the light of social inequalities and care policy models of different welfare states. It will be invaluable to students and scholars of social policy, social work, social gerontology, sociology and political science, and to all disciplines across the field of social sciences that study welfare state policies and care for older people.

Aging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.

Although textbooks on the subject of Osteopathy have been in print for over 100 years, there is little material specifically addressing the treatment of adults over the age of 50, in spite of the increase in this demographic group. This book is intended to provide a study of the biomechanics and physiology of somatic dysfunction as it relates to individuals over the age of 50. Practitioners require information about the diagnosis of somatic dysfunction and application of osteopathic manipulative treatment specifically as it relates to this age group - and this is where this book is invaluable. - The main body of the text considers the relevance of somatic function and dysfunction in multiple clinical areas including cardiology, pulmonology, gastroenterology, urology, neurology and rheumatology. - The diagnostic approach to the patient over the age of 50 and osteopathic manipulative treatment is thoroughly described. This book provides information on the biomechanics and physiology of somatic dysfunction for the osteopathic treatment of older adults in a thorough, yet easy to approach, fashion for practitioners of osteopathy and osteopathic medicine.

When aging adults struggle with social isolation, financial instability, or the difficult work of caring for a spouse with a chronic illness, their levels of stress can be enormous. But many older adults are living longer and are trying to make the best of their later years despite being more vulnerable to stress. In "Resilience and Aging," renowned geriatric psychiatrist Dr. Helen Lavretsky explains how enhanced resilience--which involves positively adapting to adversity in a way that maintains a person's biological and psychological equilibrium--can counter that vulnerability. She describes how care, practice, and research all can be redirected toward emphasizing the positive aspects of aging and prevention.

Lavretsky summarizes the most up-to-date research on resilience, neurobiology, and preventive care. She also describes novel interventions--including yoga, Tai Chi, meditation, and allopathic techniques--that can help older adults improve their cognition and quality of life. Finally, she explores relevant clinical cases from her practice.

Designed for geriatric practitioners, researchers, and family caregivers, this practical book offers critical information on measuring resilience, the role of spirituality in reducing stress, and incorporating resilience-building procedures into clinical practice or everyday life. Throughout, the book's revolutionary integrative approach aims to amplify personal happiness by allowing aging adults to remain healthy and active while simultaneously reducing the cost of chronic disease to families and society.

Alzheimer's disease can be thought of as a multi-faceted neuropsychological disorder, with diverse impairments in cognitive abilities, such as attention, memory, language and executive functioning. Over the last decade cognitive neuropsychology has provided a far richer understanding of these impairments, and this book describes these advances, placing them in their clinical context. The first section deals with background theoretical and clinical issues, such as the extent to which Alzheimer's disease can be considered as a single entity or whether it is more fruitful to explore the neuropsychology of individual patients. It considers the diagnostic aspects of Alzheimer's disease, the natural history of the disease, how it progresses over time and the characteristics of the prodromal phase. A second section, the core of the book, covers major cognitive functions and delineates how impairments can be differentiated from each other. A third portion integrates what is known about cognitive decline with the underlying neurobiological basis, including pathological structural brain abnormality and neuropharmacological changes. A final section explores the clinical implications of the research with an overview of the neuropsychological assessment of this disease, cognitive approaches to management, and neurobiological treatment.
As an introduction to this field, The Cognitive Neuropsychology of Alzheimer's Disease brings together the opinion of leading researchers in a book that will provide a useful source of information for neurologists, neuropsychologists, psychiatrists and neuroscientists who wish to broaden their knowledge concerning this debilitating illness.

This book aims to address the major aspects of future drug product development and therapy for older adults, giving practical guidance for the rational product and clinical development and prescribing of drug products to this ever growing segment of the population. With authors coming from key "aging" markets such as Europe, the USA, China and Japan, the book will provide valuable information for students, scientists, regulators, practitioners, and other healthcare professionals from academia, industry and regulatory bodies.

This book documents the state of the art in the field of ambient assisted living (AAL), highlighting the impressive potential of novel methodologies and technologies to enhance well-being and promote active ageing. It covers a broad range of topics, with sections on technological sensors and platforms, social robotics for assistance, assistance and care applications, health and medical support methodologies and technologies, as well as the analysis, modelling and design of AAL services. The book comprises a selection of the best papers presented at the 8th Italian Forum on Ambient Assisted Living (ForitAAL 2017), which was held in Genoa, Italy, in June 2017 and brought together researchers, technology teams and professional associations, as well as representatives of the Italian regions and advisors to the Italian Ministry of Education, University and Research, with the goal of developing a consensus on how to improve provisions for the elderly and impaired. The respective contributions offer valuable insights into how the latest advances can help address the needs of the elderly and those with chronic health conditions. They also underscore the need for AAL to continue moving toward multidisciplinary integration, so as to embrace the various disciplines that place the user of services at the centre of the design process.

This book presents a comprehensive and state-of the-art approach to vascular disease for the geriatric patient, focusing on vascular pathology and interventions but also on perioperative care, anesthetic care, functional outcomes and quality of life, as well as ethical considerations that impact decision making. The book addresses open and endovascular interventions in different vascular beds, as well as preoperative workup and optimization, anesthetic considerations, all aspects and expectations of the postoperative care and recovery and is the only book to include specialize in the intricacies of the care of the geriatric patients, the challenging recovery and neurocognitive changes, and ethical considerations for the end stage geriatric patient or in the setting of postoperative complications. Written by experts in the field, each section addresses patient selection, pre-operative considerations, technical conduct of the most common operations with open or endovascular options, and avoiding complications. A brief review of the existing literature addressing the particular topic follows in each section. With its concise yet comprehensive summary of the field, Vascular Disease in Older Adults is the ultimate resource for geriatricians, cardiologists, surgeons, anesthesiologists, and all physicians of who care for the aging patient with vascular disease.

Anemia in the elderly has been properly defined as the silent epidemic, representing 3 million people in the United States aged 65 years and older. Incidence and prevalence of this condition increase with age. It differs in its etiology, pathogenesis and treatment from anemia in children and younger adults. Anemia is associated with reduced survival, increased risk of functional dependence and hospitalization, increased risk of congestive heart failure and stage renal disease and cognitive disorders. Approximately 70% of anemia in older individuals is reversible.

This book focuses on the nutrients and nutraceuticals that promote active and healthy ageing - recently defined by the WHO as the process of development and maintenance of functional capacity that allows well-being at an advanced stage of life. There has been a rapid rise in the use of nutritional interventions as well as specific nutraceuticals in the management of multifactorial aspects of clinical health outcomes. Written by leading experts this book comprehensively discusses the various ageing phenotypes and age-related diseases. It also assesses the nutritional status of the elderly and the various epidemiological factors that influence it. It reviews the role of dietary fiber in disease-free and fully functional ageing. Further, the book explores the benefits of polyphenols, which are secondary plant metabolites, in protecting against cancer, cardiovascular diseases, and various neurodegenerative diseases.

Though mental health recommendations for the elderly is rapidly evolving, the few current textbooks on this subject are either too voluminous or complex for regular review by clinicians, and most do not contain the latest information available in the field. Written by experts in geriatric psychiatry, this book provides a comprehensive yet concise review of the subject.The text covers topics that include the social aspect of aging, treatment and diagnosis options unique to the elderly in need of psychiatric care, policy and ethics, and particular geriatric health concerns that may influence psychiatric considerations. Psychiatric Disorders Late in Life is the ultimate resource for practicing psychiatrists, physicians, geriatricians, and medical students concerned with the mental healthcare of the elderly.