Metabolic Aspects of Aging, Volume 155, the latest release in the Progress in Molecular Biology and Translational Science series seeks to provide the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on the molecular, biological aspects of organismal physiology and function, with this release including chapters on Longevity, Metabolic Disease and Community Health, the Metabolic Aspects of Aging, Obesity, Metabolism, and Aging: A Multiscalar Approach, The Intersection of Curandismo and Western Medicine and Their Epidemiological Impact for Aging Mexican Americans, and more.

The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.
Key Features
* Covers all aspects of the aging skeleton in one comprehensive volume
* Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass
* Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton
* Reviews current therapeutic approaches and methods
* Written by internationally renowned authors and edited by leaders in the field
* Is the only book available on this subject

Most studies of geriatric patients have focused on nursing homes. In fact, most people are placed in these institutions only after being evaluated by medical and social service staff. This ethnography details the day-to-day experiences of a geriatric and assessment unit by examining the staff, families, and patients themselves. It looks at the activities that take place in the unit as well as the less obvious cultural patterns of the process. Using the Ethnography of Speaking method, it explores the human side of this most difficult of life's decisions.

This issue of Clinics in Geriatric Medicine, guest edited by Drs. Sidney S. Braman and Gwen S. Skloot, is devoted to Pulmonary Disease in the Aging Patient. Articles in this issue include: The Effects of Aging on Lung Structure and Function; Immunosenescence and the Lungs; Epidemiology of Lung Disease in the Elderly; The Evaluation of Dyspnea in the Elderly; Asthma in the Elderly; COPD in the Elderly Patient; Pulmonary Vascular Diseases in the Elderly; Granulomatous Lung Diseases in the Elderly; Lung Cancer in the Older Patient; Sleep Disorders in the Elderly; Idiopathic Pulmonary Fibrosis in the Older Patient; and Co-morbidities of Lung Disease in the Elderly.

This issue of Clinics in Geriatric Medicine, Guest Edtied by Drs. Danelle Cayea and Samuel C. Durso, is devoted to Screening and Prevention in Geriatric Medicine. Articles in this issue include: The Medicare Annual Wellness Visit; Individualized Cancer Screening; Frailty; Medication Appropriateness; Geriatric Syndromes; Mental Health; Cardiovascular Screening; Preoperative Screening; Safety; Substance Use Disorders; Sexuality; Vaccines; and Excercise.

This issue of Clinics in Geriatric Medicine, guest edited by Dr. John Morley, is devoted to Rapid Geriatric Assessment. Articles in this issue will address Frailty; Sarcopenia; Anorexia of Aging; Mild Cognitive Impairment; Cognitive Frailty; Falls; Hip Fracture; Depression; Delirium; and Advanced Directives and Palliative Care.

This issue of Primary Care: Clinics in Office Practice, guest edited by Drs. Antimisiaris and Gopalraj, is devoted to Geriatrics. Articles in this issue include: Geriatric Assessment for the Primary Care Provider; Ageism in Medicine: What is Normal Aging?; Management of Polypharmacy in the 15 Minute Office Visit; Sexuality in the Older Adult; Alzheimer's Disease and the Future; Evaluating the Older Driver; Diabetes in the Older Adult; Hormone Replacement: The Fountain of Youth?; Mental Health in Older Age; Advanced Care Planning in the Office; Pain in the Older Adult; Hyperlipidemia and Hypertension in the Older Adult; and Delirium: Assessment and Prognosis.

Experts in gerontology, clinical psychology, and geriatric medicine provide an analytical survey and abstracts of the significant literature and research dealing with alcoholism and aging over the last 30 years. This research guide offers a general survey with sections dealing separately with the prevalence, precipitants, effects, diagnosis, prevention, and treatment of alcoholism in the older generation. The book also offers directions for future research. The narrative ends with a listing of references that have been assessed. The annotated bibliography gives abstracts for 301 sources that are arranged by types of works: bibliographies, overview articles, books and book chapters, empirical studies, and miscellaneous works. Cross-references and author and subject indexes make this guide readily accessible to students and teachers in the field of sociology, gerontology, psychology, medicine, and public health.

This book aims to address the major aspects of future drug product development and therapy for older adults, giving practical guidance for the rational product and clinical development and prescribing of drug products to this ever growing segment of the population. With authors coming from key "aging" markets such as Europe, the USA, China and Japan, the book will provide valuable information for students, scientists, regulators, practitioners, and other healthcare professionals from academia, industry and regulatory bodies.

This issue of Clinics in Geriatric Medicine, guest edited by Drs. James D. Katz and Brian Walitt of the NIH, is devoted to Rheumatic Diseases in Older Adults. Articles in this outstanding issue include Rheumatology Pharmacotherapy Pearls for the General Practitioner; Sarcopenia - Pathogenesis and Management; Osteoporosis and Metabolic Bone Diseases; Osteoarthritis; Regional Rheumatic Disorders and Rehabilitation in Older Adults; Rheumatological Manifestations of Malignancy; Sjoegren's Syndrome; Cardiovascular Disease Risk in Patients with Rheumatic Diseases; Gaps in Aging Research as it Applies to Rheumatological Clinical Care; and Update on Crystal-induced Arthritides.

Ageing, Cancer and the Genome. Genetics of Ageing and Multifactorial Diseases; P.E. Slagboom, D.L. Knook. Ageing and Cancer: A Struggle of Tendencies; A. Derventzi, et al. Maintaining the Stability of the Genome; A. Burkle. Nuclear-Mitochondrial Interactions Involved in Biological Ageing; H.D. Osiewacz. From Genes to Functional Gene Products During Ageing; L. Brock Andersen, et al. Cells, Systems and Organisms. Ageing of Cells in Vitro; S. Shall. Stress and Energy Metabolism in Age-Related Processes; O. Toussaint, J. Remacle. Growth Factors and Ageing: The Case of Wound Healing;D. Stathakos, et al.

Chronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain explores the important and often overlooked connection between how chronic medical diseases of the body can affect cognitive function and brain health. As population demographics shift to that of an aging population it has become more important to understand and improve cognitive function in late life. Chronic medical diseases often increase the risk of cognitive impairment, and those with cognitive impairment may be less able to effectively manage their medical conditions, suggesting a reciprocal relationship may exist where medical disease impacts cognition that in turn may exacerbate physical health. Chronic Medical Disease and Cognitive Aging discusses current research on the association between a variety of chronic medical diseases and cognition and, where appropriate, promising interventions or accepted treatment strategies. While a cure for many diseases continues to be elusive, insights garnered from the interplay between diseases of the body and mind may help point the way to novel therapeutic strategies to improve cognitive function in late life.

This book focuses on the nutrients and nutraceuticals that promote active and healthy ageing - recently defined by the WHO as the process of development and maintenance of functional capacity that allows well-being at an advanced stage of life. There has been a rapid rise in the use of nutritional interventions as well as specific nutraceuticals in the management of multifactorial aspects of clinical health outcomes. Written by leading experts this book comprehensively discusses the various ageing phenotypes and age-related diseases. It also assesses the nutritional status of the elderly and the various epidemiological factors that influence it. It reviews the role of dietary fiber in disease-free and fully functional ageing. Further, the book explores the benefits of polyphenols, which are secondary plant metabolites, in protecting against cancer, cardiovascular diseases, and various neurodegenerative diseases.

Though mental health recommendations for the elderly is rapidly evolving, the few current textbooks on this subject are either too voluminous or complex for regular review by clinicians, and most do not contain the latest information available in the field. Written by experts in geriatric psychiatry, this book provides a comprehensive yet concise review of the subject.The text covers topics that include the social aspect of aging, treatment and diagnosis options unique to the elderly in need of psychiatric care, policy and ethics, and particular geriatric health concerns that may influence psychiatric considerations. Psychiatric Disorders Late in Life is the ultimate resource for practicing psychiatrists, physicians, geriatricians, and medical students concerned with the mental healthcare of the elderly.

A leading expert answers your questions about how to live to your fullest with COPD. Significant lung damage from smoking, exposure in some jobs, or even diseases such as AIDS and tuberculosis can lead to COPD. Having chronic obstructive pulmonary disease can leave you feeling short of breath, sometimes reluctant to go shopping or for a walk because you are afraid of more difficulties. You may have wheezing, tightness in the chest, or frequent coughing. Although you see a doctor for your COPD, you often have questions and need answers. In this concise and practical guide, leading medical expert Donald A. Mahler answers some of the most pressing questions that he has been asked over 30 years of seeing patients with COPD, including * Why am I short of breath? * What medications can treat my COPD? * Can surgery improve COPD? * What are flare-ups-and how can I prevent them? * How can I stop smoking? * What should I do if my breathing isn't getting better? * Can exercise help? If so, which exercises are the most beneficial? * What's the best way to prevent lung infections? * How does COVID-19 affect COPD? * How can I travel with oxygen? * Can I be sexually active with COPD? and much more. Each chapter includes a patient vignette and key points. Tables and boxes offering helpful tips are included throughout. Providing up-to-date, evidence-based content that covers more than just medications, COPD gives you the tools you need to keep active-and thrive.

This issue of Clinics in Geriatric Medicine, guest edited by Drs. Thomas T. Yoshikawa and Dean C. Norman, is devoted to Infectious Diseases in Geriatric Medicine. Articles in this issue include: Host Resistance and Immunology of Aging; Clinical Features of Infection; Principles of Antimicrobial Therapy; Bacterial Pneumonia; Tuberculosis; Intraabdominal Infections; Infectious Diarrhea: Clostridium Difficile and Norovirus; Urinary Tract Infection; Herpes Zoster; Bone and Joint Infections; Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome; Infections in the Long-Term Care Setting; and Vaccinations.

This issue of Clinics in Geriatric Medicine, guest edited by Drs. Cynthia Boyd, James T. Pacala, and Michael W. Rich, is devoted to Chronic Conditions in Older Adults with Cardiovascular Disease. Articles in this issue include: Epidemiology of multimorbidity in older adults with cardiovascular disease; Impact of multimorbidity on clinical outcomes in older adults with cardiovascular disease; Assessment of goals of care in patients with multiple chronic conditions; Challenges in decision-making: balancing trade-offs; Multimorbidity in older adults with heart failure; Multimorbidity in older adults with acute coronary syndromes; Multimorbidity in older adults with aortic stenosis; Multimorbidity in older adults with atrial fibrillation;Anticoagulation in older adults with multimorbidity; Approach to evaluating the multimorbid patient with cardiovascular disease undergoing non-cardiac surgery; Integrating care across disciplines; Assessing risks and benefits of invasive cardiac procedures in patients with advanced multimorbidity; Multimorbidity and end of life care in patients with cardiovascular disease; and Future research directions for cardiovascular disease.

The 1990s have been characterized by a reappraisal of allocating expenditure for health care interventions. Coronary artery bypass in the elderly has emerged as an example of burgeoning expensive surgery whose appropriateness is under challenge. This book comprises the proceedings of an international symposium where leading experts in aspects such as health economics, ethics, clinical cardiology, cardiac surgery, epidemiology and health-care policy discussed the need and outcome of the operation in old and very old patients. Clinical issues and operative results complement national costs and quantitated benefits in terms of quality of life as a justification of surgery. The book is addressed to cardiologists, geriatricians, cardiac surgeons, psychiatrists, rehabilitation physicians and public health-care administrators.

This book documents the state of the art in the field of ambient assisted living (AAL), highlighting the impressive potential of novel methodologies and technologies to enhance well-being and promote active ageing. The coverage is wide ranging, with sections on assistive devices, elderly people monitoring, home rehabilitation, ICT solutions for AAL, living with chronic conditions, robotic assistance for the elderly, sensing technologies for AAL, and smart housing. The book comprises a selection of the best papers presented at the 7th Italian Forum on Ambient Assisted Living (ForitAAL 2016), which was held in Pisa, Italy, in June 2016 and brought together end users, technology teams, and policy makers to develop a consensus on how to improve provision for elderly and impaired people. Readers will find that the expert contributions offer clear insights into the ways in which the most recent exciti ng advances may be expected to assist in addressing the needs of the elderly and those with chronic conditions.

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer's disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson's disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer's Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

This issue of Clinics in Geriatric Medicine is devoted to Geriatric Urology. Guest Editor Tomas L. Griebling, MD, MPH has assembled a group of expert authors to review the following topics: Non-Surgical Treatment of Urinary Incontinence in Elderly Women; Outcomes of Surgery for Stress Urinary Incontinence in Older Women; Evaluation and Management of Pelvic Organ Prolapse in Elderly Women; Underactive Bladder in Older Adults; Translational Research and Voiding Dysfunction in Older Adults; Functional Brain Imaging and Voiding Dysfunction in Older Adults; The Role of Urodynamics in Elderly Patients; Associations Between Voiding Symptoms and Sexual Health in Older Adults; Asymptomatic Bacteriuria and Urinary Tract Infections in Older Adults; Comorbidity and Surgical Risk in Older Urologic Patients; Small Renal Masses in Older Adults; Prostate Cancer in Elderly Men: Active Surveillance and Other Considerations; Late Onset Hypogonadism and Testosterone Replacement in Elderly Men; and Contemporary Chemotherapy for Urologic Malignancies in Geriatric Patients.

As the American population ages, health care for the elderly grows in importance. This bibliography overviews the most significant books and journal articles on the ethical issues related to health care for older Americans. The topics covered are of interest to practitioners and the general public alike, as well as to professionals from a wide range of fields. The author has provided more than five hundred bibliographic citations. These entries are arranged in eleven topical chapters to facilitate use by the reader. Each citation is accompanied by an annotation that concisely summarizes and assesses the contents of the work. The volume begins with an informative introductory essay on the ethical issues pertinent to health care for older adults. The chapters that follow are devoted to broad topics, such as financial considerations, treatment for the terminally ill, and decision-making by and for the impaired elderly. The work concludes with author and subject indexes that add to its utility. Researchers and practitioners from all fields will find this work an indispensable guide to the wealth of literature on the ethical aspects of health care for older Americans.

This book highlights international efforts to better understand the role of individual differences in healthy aging by exploring new directions, methods, and questions within the field. The book considers how to measure personality and personality change during adulthood, the associations between personality and healthy aging outcomes over time, and the role of personality in building interventions to promote healthy aging. The first section considers the value of personality constructs for healthy aging outcomes beyond the broad Big Five personality dimensions. It discusses the role of attachment, purpose, and affect, and also touches on the issue of psychopathology. The second section presents innovative assessment methods, research designs beyond classical longitudinal approaches, as well as sophisticated and integrative techniques for analyzing personality change processes. The third section raises new important questions, such as how interventionists from non-personality domains can incorporate personality processes in their intervention programs. It also discusses how different domains of individual functioning may interact in concert to predict healthy aging outcomes, as well as how more integrative lifespan models of healthy aging may advance research on personality and healthy aging. Overall, this book will spark interest and chart new directions for researchers, practitioners and interventionists in healthy aging, gerontology and applied fields.