Alzheimer's disease is the most common cause of senile dementia. Since the discovery in 1984 of the amyloid ?-peptide (A?) as the core protein of the senile plaques present in the brains of Alzheimer's disease sufferers, an immense amount of research has gone into mapping out the molecular basis of this debilitating disease. The aim of Alzheimer's Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate the molecular basis of Alzheimer's disease. This volume begins with chapters of an introductory/ review nature. Chapter 1 provides a historical introduction to Alzheimer's d- ease with particular emphasis on the central role played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.

The qualitative analysis of naturally occurring discourse in neurogenic communication disorders, specifically in dementia studies, has experienced recent burgeoning interest from wide-ranging disciplines. This multidisciplinarity has been exciting, but has added contextual confusion. This book advances the study of discourse in dementia by systematically exploring and applying different approaches to the same free conversational data sets, collected and transcribed by the authors. The applied methodologies and theories comprise a useful sourcebook for students, researchers, and practitioners alike.

This book promotes an understanding of ageism, discrimination and mistreatment of older adult workers, incorporating an international human rights perspective. The impact of ageism on the mistreatment of older adult workers has not to date been examined in depth through the lens of international human rights instruments, nor has discrimination against older adults in the workplace been framed as a form of elder abuse for research and policy making purposes. This book presents a multi-disciplinary exploration of these themes as they affect work and retirement of older adults. It reflects the view that older people who choose to work into old age should be able to do so in enabling work environments that promote dignity and are free of abuse. The contributing authors come from many disciplines, including law, psychology, social work, business, and international affairs. Many are members of the International Network for the Prevention of Elder Abuse (INPEA), a non-governmental organization with consultative status at the United Nations, and have devoted their professional careers to increase awareness and understanding of elder abuse in order to prevent it. The editors hope that broadening the framework within which elder abuse in the workplace is understood will stimulate further research, policy and program development to address this troubling social problem.

Human stories are the core of identity and meaning. This book is an invitation to the engaging and reforming power of telling stories. It is also an invitation to heal the story of health care for older adults by improving the communication between professionals in medicine, psychology, and religion.

At any age the process of genuinely listening and expressing hopes and fears is an intimacy rarely matched in human interaction. Life stories can be told, revised, and rewritten through psychotherapy and improved by a health care which integrates the best of medicine, religion, and psychology. This book invites health care reform by renewing old principles. Through clinical experience, research, and listening to seniors and their families, life stories can be retold to promote healthy treatment and healthy aging. This book will be of interest to students and professionals in psychology, medicine, nursing, religion, and social work.

Your indispensable guide to taking charge of the second half of your life. From Dr. Rosanne M. Leipzig, a top doctor with more than 35 years of experience caring for older people, Honest Aging is an indispensable guide to the second half of life, describing what to expect physically, psychologically, functionally, and emotionally as you age. Leipzig, an expert in evidence-based geriatrics, highlights how 80-year-olds differ from 60-year-olds and why knowing this is important for your health. With candor, humor, and empathy, this book will provide you with the knowledge and practical advice to optimize aging. The book * helps you recognize age-related changes in your body and mind and understand what's typical with aging and what's not; * offers guidance for common health concerns, including problems with memory, energy, mood, sleep, incontinence, mobility and falls, hearing and vision, aches and pains, gastrointestinal problems, weight, and sex; * shares advice on how to make decisions about health care, driving, and where to live; * includes helpful checklists and lists of medications to prepare for doctor and hospital visits; * recommends the best technology options, such as mobility devices, emergency device systems, and more; * counters common myths about aging; and * offers resources for additional information, self-help, and support. Enriched by illustrations, patient stories, and deep dives into science and the latest research, Honest Aging gives you the tools to take control of your health and well-being as you age.

Update your knowledge of mental health services delivery in long-term care settings! Authored by experts in the field of psychology practice in long-term care (LTC), this valuable book is designed to update psychologists and educators on developments in the evolving field of geriatric mental health in LTC settings. The editors and chapter authors are scientist-practitioners who use their expertise to cover applied topics while maintaining high scientific and scholarly standards. The first section of Emerging Trends in Psychological Practice in Long-Term Care examines modifications to traditional psychotherapy techniques that make them more appropriate for long-term care patients, with chapters reviewing: group therapy in long-term care brief psychotherapy for treating depression in patients with dementia the use of autobiographical memory techniques in cognitive-behavioral treatment for depression the treatment of disruptive behaviors in LTC residents The second section covers systematic therapy approaches in LTC settings, with chapters discussing: distinctive family therapy issues in LTC an LTC systems application of behavioral treatment for depression using pleasant events a comparison of patient and staff perceptions of characteristics that contribute to the quality of LTC facilities a multidisciplinary team approach to the treatment of dementia training LTC caregivers in behavioral techniques The third section of this remarkable volume addresses the thorny ethical and legal issues unique to LTC residents, including legal definitions, requirements for obtaining informed consent from LTC patients, and confidentiality dilemmas that are unique to clinical services in long-term care. With helpful charts, tables, and fascinating case studies that illustrate clinical issues, this user-friendly text belongs on the reference shelf of everyone involved in providing mental health services to people in long-term care settings!

There is no doubt that the need for a multidisciplinary cadre of informed and skilled health professionals in geriatrics is growing as the population ages. This book was developed as a response to that need and is designed to assist health care professionals in locating some of the best materials in geriatrics available in the various disciplines. The annotations found in this volume are written clearly and concisely so that the reader can quickly grasp the essence of each reference. The book is organized into two sections, the first of which identifies resources for specific health care disciplines, and the second focuses on resources in health care issues that cut across all disciplines. Specifically, Section I (Geriatrics in the Health Care Disciplines) provides annotations for most major health care disciplines. Section II (Special Issues in Geriatric Health Care) includes ethnic and minority health issues in aging, geriatric care and older women, medical ethics in geriatrics, and new reimbursement systems for medical care for the elderly. Each chapter has been compiled by experienced geriatric professionals who are trained and actively practice in the discipline they cover. This book will be a useful tool for health practitioners, educators, and researchers involved in promoting geriatric education and quality clinical care of older adults.

This book examines the social aspects of healthy ageing for older individuals. It features more than 15 papers that explore the relevance of the social environment for health on the micro, meso, and macro level. Overall, the book applies a comprehensive contextual approach that includes discussion of how family and friends, neighborhoods, nations, and welfare regimes influence health. The book first explores the issue on the individual level. It looks at the importance of social capital for health among older people, examines types of social networks and health among older Americans, as well as discusses dynamic social capital and mental health in late life. Next, the book looks at the issue through a neighborhood and societal context, which takes into account day-to-day interaction in the immediate environment as well as the social, health, and economic policies in place in different regions in the world, including America, Europe, Asia, and Africa. From there, the book goes on to offer implications and recommendations for research and practice, including the management of related concepts of research on well-being and health. It also offers a psychosocial approach to promoting social capital and mental health among older adults. This book provides health professionals as well as researchers and students in gerontology, sociology, social policy, psychology, and social work with vital insights into the social factors that increase healthy life years and promote well-being.

This multiauthored introductory textbook could not have been conceived or brought to fruition 10 or 15 years ago. Indeed, at that time relatively little attention was accorded to the psychological needs of older adults. The general tenor of the field then was that older adults would not benefit from psychological intervention. As we now know, this was a faulty assumption that has been discredited with empirical data. Indeed, clinical research data adduced, primar ily in the last decade, clearly documents that older adults do benefit from specific psychotherapies that are tailored to their unique presentation of symptoms. Given the explosion of interest in this area (as evinced by increased investi gatory activity, national funding, and media attention) and the increased number of masters-and doctoral-level courses devoted to this topic, we felt that the time was right for a textbook in the area. Such flurry of activity also has been fueled by statistics showing how our population by the year 2030 will consist of 30% who are senior citizens. Moreover, since 12% of older adults in the community are estimated to have diagnosable psychiatric disorders and 40% to 50% of older adult medical inpatients have a concomitant psychiatric disorder, the task for clinicians in the next century will be overwhelming."

The current edition of Video Microscopy has been totally revised to reflect the advances in the tools for electronic imaging, processing, recording, and analysis, as well as applications that are being made in video microscopy and related modes of electronic imaging. The less spiral organization of the revised edition reflects an audience expected to be more experi enced in video and computer image processing than in the earlier days when coupling of video equipment and computers to the light microscope was still considered to be a novelty. Nevertheless, we have emphasi2;ed the how-tos, as well as the fundamental principles, involved in imaging and processing ih the light microscope, the human visual system, video and related electronic imaging, and the digital image processor in the hope that the reader will develop enough understanding, not only to apply rationally what is available, but also to contribute actively to the development of this evolving field. In the text, the terms appearing in the Glossary are printed in bold type, generally, at first appearance. Italics are used for emphasis.

As the average age of the population rises, mental health professionals have become increasingly aware of the critical importance of personality in mediating successful adaptation in later life. Personality disorders were once thought to "age out," and accordingly to have an inconsequential impact on the lives of the elderly. But recent clinical experience and studies underscore not only the prevalence of personality disorders in older people, but the pivotal roles they play in the onset, course, and treatment outcomes of other emotional and cognitive problems and physical problems as well. Clearly, mental health professionals must further develop research methods, assessment techniques, and intervention strategies targeting these disorders; and they must more effectively integrate what is being learned from advances in research and theory into clinical practice.
Inspired by these needs, the editors have brought together a distinguished group of behavioral scientists and clinicians dedicated to understanding the interaction of personality and aging. Offering a rich array of theoretical perspectives (intrapsychic, interpersonal, neuropsychological, and systems), they summarize the empirical literature, present phenomenological case reports, and review psychodynamic, cognitive-behavioral, and pharmacological treatment approaches. This comprehensive state-of-the-art guide will be welcomed by all those who must confront the complexity and the challenge of working with this population.

nly two things are certain in life, one is that all of us will inevita Obly grow older, the other is that at some point during or at the end of this process we shall die. Inherent to the passage of time is a deterio ration in the structural and functional integrity of our bodies, this pro gressing to such an extent that one or more organ systems will eventu ally begin to fail with the continued health and well-being of the individual coming under threat. Age-associated deficiencies in the musculo-skeletal, cardiovascular, or endocrine systems producing arthri tis, hypertension, stroke or diabetes are all too apparent in our elderly population yet internally caused failures in the function of the nervous system provide the common, and mostly intractable, problems of memory and intellect or locomotion that face and frustrate clinicians. Perhaps the most important factor which can decide the outcome of research studies professing to examine the effects of the passage of time (i. e. the 'process of aging') on the function of the nervous system, or indeed any other organ system, is the selection of appropriate or repre sentative subjects for investigation. The heart of this problem lies in defining what might be considered as 'normal' aging as distinct from age-associated disease; setting the 'goal posts of normality' continues to 1 be a matter of considerable debate."

This book broadens the visioning on new care environments that are designed to be inclusive, progressive, and convergent with the needs of an aging population. The contents cover a range of long-term care (LTC) settings in a single collection to address the needs of a wide audience. Due to the recent COVID-19 pandemic, rethinking the spatial design of care facilities in order to prepare for future respiratory and contagious pathogens is one of the prime concerns across the globe, along with social connectedness and autonomy in care settings. This book contributes to the next generation of knowledge and understanding of the growing field of the design of technology, programs, and environments for LTC that are more effective in infection prevention and control as well as social connectedness. To address these issues, the chapters are organized in four sections: Part I: Home- and community-based care; Part II: Facility-based care; Part III: Memory care and end-of-life care; and Part IV: Evidence-based applied projects and next steps. (Re)designing the Continuum of Care for Older Adults: The Future of Long-Term Care Settings is an essential resource for researchers, practitioners, educators, policymakers, and students associated with LTC home and healthcare settings. With diverse topics in theory, substantive issues, and methods, the contributions from notable researchers and scholars cover a range of innovative programming, environments, and technologies which can impact the changing needs and support for older adults and their families across the continuum of care.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older gynecological cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

The second edition of the Handbook of Pain Relief in Older Adults: An Evidence-Based Approach expands on the first edition by providing a number of timely new features. Most important of these are the revised recommendations from the American Geriatrics Society on prescribing that reflect the many new agents available since the last guidelines were released in 2001. Additionally, concepts such as synergy in prescribing for older adults have been better delineated in this edition. The most salient features of the original edition have been retained and updated, including the full range of approaches for pain assessment and prevention, interventional strategies, guidance on pharmacotherapy and nonpharmacologic pain relief strategies for seniors, preventive analgesia, the role of rehabilitation in sound pain treatment, legal and public policy issues in pain care for seniors, pain management in long-term care, and even the issue of spirituality as an adjunct to pain management. The second edition also includes a new chapter on resources, which includes organizations, internet websites, and guidance on acquiring additional consultation for pain intervention. Of particular interest is an updated discussion of the effect that electronic medical records and internet-based personal health records will have on pain relief in older adults and a new chapter that serves as a resource guide for patients and caregivers trying to navigate the waters of pain relief assistance. This issue has not been addressed substantively in the pain management literature and the ramifications for older adults are particularly poignant. Comprehensive and practical, the Handbook of Pain Relief in Older Adults: An Evidence-Based Approach (Second Edition) is a comprehensive resource with targeted, practical information that will be of vital importance for all clinicians who provide care for seniors.

Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.

With this book, Siegel, an internationally known demographer and gerontologist, has made a unique contribution to the fledgling fields of health demography, and the demography and epidemiology of aging. The book represents a felicitous union of epidemiology, gerontology, and demography, and appears to be the first and only comprehensive text on this subject now available. Drawing on a wide range of sciences in addition to demography, gerontology, and epidemiology, including medical sociology, biostatistics, public policy, bioethics, and molecular biology, the author treats theoretical and applied issues, links methods and findings, covers the material internationally, nationally, and locally, and while focusing on the elderly, treats the entire life course. The methods, materials, and pespectives of demography and epidemiology are brought to bear on such topics as the prospects for future increases in human longevity, the relative contribution of life style, environment, genetics, and chance in human longevity, the measurement of the share of healthy years in total life expectancy, the role of population growth in the rising costs of health care, and the applications of health demography in serving the health needs of local communities. The separate chapters systematically develop the topics of the sources and quality of health data; mortality, life tables, and the measurement of health status; the interrelationships of health, on the one hand, and mortality, fertility, migration, and age structure, on the other; health conditions in the less developed countries; the concepts and theories of aging and projections of the aged population; and local health applications, public health policy, and bioethical issues in health demography. Given its comprehensiveness, clarity, interdisciplinary scope, and authencity, this book appeals to a wide range of users, from students and teachers of medical sociology, the demography of aging, and public health studies to practitioners in these areas, both as a text in health demography and the demography/epidemiology of aging, and as a reference work in these fields.

The present volume provides overviews of aging and changes in renal function over time; it devotes chapters to renal parenchymal disease and urinary tract infections; and the sections on geriatric urology cover urinary incontinence and urinary-tract neoplasm, including prostatic cancer. The book summarizes current information on renal replacement therapy in the elderly and reviews such important topics as hemodialysis, peritoneal dialysis, fluid and acid-base abnormalities as they are seen in older patients, and transplantation in the elderly. Concerning medical care of older nephrology patients, the contributors have reviewed the management of hypertension, current understanding of glomerular disease, current approaches to the diabetic with renal disease, and use of antineoplastic and antimicrobial therapy, all in these special patients. They discuss the prevention of renal failure in older patients, both in diagnostic and therapeutic aspects, and examine sexual dysfunction and indications for surgery in the older patient with obstruction. Finally, the text examines such ethical issues as the use of advanced directives and the allocation of scarce resources.

This book focuses on the concept of subjective views of aging. This concept refers to the way individuals conceptualize and perceive the aging process. Social and cultural perceptions regarding older adults are incorporated and internalized into views people hold regarding their own aging process. The book contains three parts which present theoretical, empirical, and translational perspectives about subjective views of aging. The theoretical section expands the framework of subjective views of aging with the inclusion of additional concepts, and further integrates these concepts by accounting for their synergistic effects. The empirical section presents recent developments in the field starting at the intra-individual level as assessed by ecological momentary assessments, going through the level of interpersonal relationships, and concluding at the social and cultural levels. Finally, the translational section presents recent endeavours to develop interventions aimed at advancing favourable views of aging. This cutting-edge edited book includes chapters written by internationally renowned scholars in the field and serves as an up-to-date resource for scholars in the field as well as a textbook for students in courses like social gerontology, lifespan psychology, and life course sociology.

This pertinent book assists occupational therapists and other health care providers in developing up-to-date psychogeriatric programs and understanding details of treating the cognitively impaired elderly. There exists a significant demand for occupational therapy in psychogeriatrics now. As the elderly population increases, especially elderly requiring rehabilitative care, the need for occupational therapy in psychogeriatrics will increase markably. Evaluation and Treatment of the Psychogeriatric Patient emphasizes the expertise of leading psychogeriatric occupational therapists, focusing on transitional programming, treating cognitive deficits, and recognizing the malignant cultural myths which continue to disenfranchise and denigrate the elderly.Appropriate diagnosis and management of the elderly population is vital to their ability to function independently. Through detailed, operationally useful descriptions of current geriatric day care hospitals and psychogeriatric transitional programs, this book will be an invaluable aid for social workers, nurses, geriatric counselors, and physical therapists. These helping professionals will be better equipped to develop up-to-date psychogeriatric programs and will better understand the details involved in treating the mentally impaired elderly.

This book describes the recent advancement of basic research on the biology of aging and longevity studies in various organisms, as well as the neurobiology of aging and neurodegeneration mechanisms. Chapters present new findings and conceptual developments concerning the basic mechanisms of aging and longevity determination. As a follow-up volume to the previous book Aging Mechanisms (2015), it overviews the rapid progress of aging research introducing new topics from leading laboratories in Japan. Chapter contributors are selected based on recent scientific achievements on the mechanisms of aging in various model organisms, including yeast, worm (C. elegans), fly (Drosophila), mice, and rats. Chapters are ordered from the discussion on molecular and cellular levels to physiological and systemic levels. The book also provides an overview of aging science in the region and helps readers quickly grasp who is doing what in this research area. As the aging of population becomes an ever more pressing issue in Asia, advancing the understanding of basic mechanisms of organism aging and longevity determination will be crucial to developing more effective therapies and protective strategies. Researchers and graduate students in biomedical aging research will find this as a rich source of information and a stimulus to novel research directions.

This handbook integrates and discusses a growing evidence base concerning individual development across middle and late adulthood. The book includes a comprehensive analysis of what growth implies within midlife and older age and considers how different developmental areas are intertwined (i.e., physical, cognitive, social and emotional development as well as personality growth). As the gap between theory and practice still constitutes an issue in developmental research, the handbook also aims to provide illustrative examples of prevention and intervention from a positive psychology perspective. These were selected to represent a variety of topics, relevant for individual development where research informs practice, ranging from happiness, grandparenthood, love and sexuality to loneliness, depression, anxiety, suicide prevention and coping with death. This handbook is a must-have resource for students and researchers working in developmental psychology, health psychology, gerontology and, public health. It will also be of interest to practitioners such as counsellors, life coaches, psychotherapists, organizational psychologists, health professionals, social workers or public health planners.

Spending the final chapter of your life in a nursing home is considered, by many, a fate worse than death. Others, however, have found that through enlightened, imaginative care even the frailest of lives can flourish. The key to such a transformation is to replace the constricting custodial centres of the past with a more informed, research-based approach. This book is timely, responding to evidence of the urgent need for change described in the Australian Royal Commission into Aged Care Quality and Safety Final Report: Care, Dignity and Respect and its predecessor subtitled Neglect. In this book, the author proposes a model of care that places the whole person at its centre, sidestepping the constraints of a reductionist funding model that focusses on residents' deficits - and the proprietor's financial gain. Aged care requires a comprehensive research-based guide to fulfil this aim. Narratives are included throughout the book to reinforce the fact that nursing home care is about individual residents and their unique lives. Topics explored in various chapters include: * Ageing in a Changing Community * Social, Gerontological Care * A Palliative Approach * Community Expectations Ageing in a Nursing Home: Foundations for Care takes a realistic approach that draws on contemporary research and narratives from the unique lives of older Australians who, despite their frailty, teach us how to care. Such knowledge informs and influences their future. The book is a resource intended for all who have a stake in the provision of best practice residential aged care, and all who benefit from such care. Its academic appeal will include those who design and teach courses in aged care: gerontology, general practice medicine, nursing, attendant care, allied health, and chaplaincy. Academics and teachers will find useful, well-referenced material for their courses, together with ample scope for researchers.

A collection of easy-to-follow activities, organized by seasons of the year, to help family members and caregivers engage with memory-challenged adults. Dementia and related disorders impact the lives of those affected in countless ways, making it difficult to remain independent at work, at home, and in the wider world. But recent studies have shown that structured activities can make a significant, positive difference by stimulating mental engagement while improving interactions between caregivers and memory-challenged adults. Fun and easy to use, this large-format, full-color picture book is divided into themes representing the four seasons. Each section describes several multisensory experiences-such as walking on the beach, making ice cream, or planting flowers-along with related topics for discussion and activities to elicit memories and encourage new positive associations. The topics and activities incorporate all five senses to facilitate connections and conversations. The book adopts a compassionate, person-centered approach and is designed so that two people can easily look together while sitting side by side. This latest edition, which has been thoroughly revised, * takes a multicultural approach * includes all-new images, as well as 14 completely new highlighted activities * integrates modern wellness concepts * features a new introduction and an updated resource section * offers guidance about activity planning and optimizing interactions between care partners and the individual with dementia Helping you and your loved one make cherished new memories, Through the Seasons is an indispensable solution to the question of what to do together to maintain well-being and connection.