The articles appearing in this geriatrics-focused issue are consistent with the collaborative and translational concepts held by a life course perspective. Each supports interprofessional collaboration and some are either authored or coauthored by interdisciplinary colleagues. Three goals are reflected in these articles: keeping community-dwelling older adults safe, sensible, and secure with solutions that will enable them to stay healthy, wise, and aware. Topics include maintaining physical functions, benefits and consequences of weight-bearing exercise on foot health; cancer prevention; managing nocturia's effect on sleep quality and safety; protection from financial exploitation; and providing safe and affordable living environments. Several articles address physical or cognitive challenges that include monitoring medication adherence, threat of anxiety and stigma in dementia, and approaches to managing self-care in the home for persons with dementia. These evidence-based articles address emerging and best practices to support targeted interventions for persons in community-dwelling home settings. They provide a frame-work of person-centered approaches that foster good health in older age, a central tenet of aging in place and the global response to population aging.

This issue of Clinics in Geriatric Medicine is centered on the management of the geriatric fragility fracture patient. This issue features expert clinical reviews on topics such as Principles of comanagement, Lean business model and implementation of a Geriatric Fracture Center, Preoperative optimization and risk assessment, Preoperative reversal and management of anticoagulation and antiplatelet agents, Classification and surgical approach to hip fractures for non-surgeons, Special anesthetic consideration for the fragility fracture patient, Non-surgical management and palliation of fragility fractures, and Management of post-operative complications including Delerium, Anemia, Venous thromboembolism, and Cardiovascular disease and volume management. Also included are articles on Transitions in care and rehabilitation, Osteoporosis related secondary fracture prevention, Post-operative assessment of falls risk and prevention, and Fragility fractures requiring special consideration.

The rapidity of scientific progress over the last few years guarantees the utility of a new collection of state-of-the-art reviews on the immunology of ageing. The aim of this authoritative book is to summarize current knowledge on the cellular and molecular aspects of the ageing immune system and their clinical relevance. The book is a result of extensive collaboration of more than sixty of the greatest thinkers and scholars in the field, in cooperation with a number of junior colleagues. Immunology of Aging presents the most up-to-date information on the scientific issues addressed by research into ageing of the immune system, providing insights into the effects of this process on susceptibilities to those diseases which are most common among elders. The retrieval strategies used to slow down the decline in the immune system in the elderly are another subject detailed extensively. By providing a broad overview of immunosenescence and its consequences, as well as their potential modulation, this book will fill a gap in a timely manner. It will be of value to all immunologists, whether novice or experienced, as well as geriatricians and epidemiologists.

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Mild Cognitive Impairment which includes current information on topics such as Overview of Mild Cognitive Impairment, Aging and Cognition, Classification and Epidemiology of Mild Cognitive Impairment, Neuropsychiatric Symptoms of Mild Cognitive Impairment, Clinical Evaluation of Early Cognitive Symptoms, Emerging Biomarkers Relating to Cognition, Imaging Modalities in Evaluation of Cognition, Current Management Decisions in Mild Cognitive Impairment, Risk Factors for Progression to Dementia, Dealing with Mild Cognitive Impairment: Help for Patients and Caregivers.

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Geriatric Dermatology which includes current information on topics such as diagnosis and management of bullous disease, common skin cancers in older adults, psoriasis, management of pressure ulcers, management of venous stasis disease, approach to diabetic and vascular ulcers, diagnosis and management of soft tissue infections, cutaneous fungal infections in older adults, mangagment of scabies and generalized pruritus, herpes zoster and other herpes infections, and adverse drug effects in aging skin.

Following an introduction that outlines the history and projects the future of gerontology, the authors offer insightful profiles of roughly 300 researchers, teachers, and practitioners in aging. North Americans are heavily represented, though gerontologists from Great Britain and the Continent are included as well. The dictionary can be read for an overview of the field, while cross-listings and a complete name and subject index make it an ideal reference. Each entry contains a professional and academic biography, along with citations and succinct descriptions of the individual's important contributions to the study of the elderly and aging.

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Renal Disease in Older Adults which includes current information on topics such as Anatomic/ Physiological Changes with Aging, Acute Kidney Injury in Older Adults, Electrolyte Problems in Older Adults, Glomerular Disease in Older Adults, Hypertension in Older Adults, Chronic Kidney Disease in Older Adults, End-stage Renal Disease in Older Adults, Decision Making in the Older Adult Patient with Advanced Kidney Disease, Obstructive Uropathy in Older Adults, Drug Dosing, Transplantation in Older Adults, and Slowing the Aging Process.

This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

In this deeply considered meditation on aging in Western culture, Jan Baars argues that, in today's world, living longer does not necessarily mean living better. He contends that there has been an overall loss of respect for aging, to the point that understanding and "dealing with" aging people has become a process focused on the decline of potential and the advance of disease rather than on the accumulation of wisdom and the creation of new skills.

To make his case, Baars compares and contrasts the works of such modern-era thinkers as Foucault, Heidegger, and Husserl with the thought of Plato, Aristotle, Sophocles, Cicero, and other Ancient and Stoic philosophers. He shows how people in the classical period--less able to control health hazards--had a far better sense of the provisional nature of living, which led to a philosophical and religious emphasis on cultivating the art of living and the idea of wisdom. This is not to say that modern society's assessments of aging are insignificant, but they do need to balance an emphasis on the measuring of age with the concept of "living in time."

Gerontologists, philosophers, and students will find Baars' discussion to be a powerful, perceptive conversation starter.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older lung cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

It is increasingly important for physicians who treat older persons, and for researchers on aging, to understand how molecular biology informs clinical expressions of aging and age-related conditions such as osteoporosis, diabetes, osteoarthritis, frailty, cancer, and dementia. Dr. David Hamerman translates basic scientific concepts into precepts of clinical practice and sheds light on the links among biology, natural aging, longevity, and disease.

Exploring the connections between disease and the science behind it, Geriatric Bioscience addresses how mechanisms of inflammation, cytokine expression, and stress responses influence disease and how preventive gerontology in the practice of medicine could compress morbidity. Hamerman also discusses cutting-edge therapies such as cyclo-oxygenases, bisphosphonates, statins, cytokine inhibitors, and hormone therapies.

Examining the science of geriatrics and converting its concepts into clinical applications, this groundbreaking work provides clinicians and researchers with a solid foundation for a greater understanding of the diagnosis, treatment, and prevention of age-related diseases as well as recommendations for promoting healthy aging.

Based on open-ended interviews with adult children and children-in-law, this book documents how plain folk from the working and middle classes manage to provide care for their frail, elderly parents while simultaneously meeting the obligations of their jobs and their own immediate families.

Adult children who care for elderly parents are pressured daily trying to juggle the responsibilities of work, family, and caregiving. Deborah Merrill shows how plain folk (as one caregiver termed herself) from the working and lower middle classes manage to provide care for their frail, elderly parents while simultaneously meeting the obligations of their jobs and their own immediate families. The evidence is drawn from open-ended, in-depth interviews with adult children and children-in-law, all of whom have worked outside of the home at some point during caregiving.

Merrill examines the strategies that caregivers use to combine work and caregiving and the accommodations they make in their jobs. She also points to the pathways that lead family members to caregiving roles and how those pathways vary according to family history, gender, and in-law status. By focusing on class differences in caregiving and pointing to policy implications, Merrill has provided an invaluable resource for students, researchers, and policymakers in social work, gerontology, family studies, and social issues.

This issue of Clinics in Geriatric Medicine focuses on the pharmacological, non-pharmacological, and device therapies in the medical management of cardiac rhythm disorders in the elderly population. It also reviews the epidemiology of arrhythmias and conduction disorders in older adults, atrial fibrillation and atrial flutter: stroke prevention, bradyarrhythmias and conduction disorders, and comorbidities, quality of life, and end-of-life issues in older patients with heart rhythm disorders.

This authoritative guide is quite unique in how it covers sources dealing with injury prevention for the elderly in a comprehensive manner. This survey of 621 references covers injury prevention in general and all types of accidents and problems by topic--from alcohol use and problems, burns and scalds, elder abuse, hypothermia and hyperthermia, malnutrition, medication effects, motor accidents, and suicide.

A short introduction in each chapter gives an overview of what is available on each topic. This guide is designed for researchers and teachers in all levels of gerontology, social work, and health care, as well as for those who care for elders in long-term facilities and in the community. The arrangement of materials by topic and full author and subject indexes make this research tool easy to use in many different ways.

Total joint replacement is an effective procedure, resulting in decreased pain and improved function and quality of life in patients of all age groups including the elderly. The use of TJR is increasing and therefore this issue reviews topics such as patient satisfaction with total joint arthroplasty, patient reported outcomes, rehabilitation with total joint arthroplasty, minimally Invasive total joint arthroplasty, and peri-operative complications of total joint arthroplasty.

This issue serves as a comprehensive review and update in the management of the geriatric cancer patient. Topics covered include: Cancer and Aging, Comprehensive Geriatric Assessment, Breast Cancer in the Elderly, Solid Tumors in the Elderly, Radiation Therapy with the Elderly, Liquid Tumors in the Elderly, Nursing and Palliation of Elderly Cancer Patients, Ethics and Religion in Care of the Elderly, and Surgery in the Elderly.

This volume of "Advances in Cell Aging and Gerontology" provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression.

This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

Lasting healthcare for the entire population, specifically the elderly, has become a main priority in society. It is imperative to find ways to boost the longevity of healthcare services for all users. Sustainable Health and Long-Term Care Solutions for an Aging Population is a pivotal reference source featuring the latest scholarly research on issues pertinent to health cost and finding effective ways of financing healthcare for the elderly. Including coverage on a number of topics such as provider accreditation, corporate social responsibility, and data management, this book is ideally designed for policy makers, academicians, researchers, and advanced-level students seeking current research on the innovative planning and development of healthcare.

This issue provides a unique perspective on the topic of Successful Aging whcih will cover article topics such as: Normal Aging: Theories, Aging and Disease Prevention, Aging, hormones and hormone replacement, Aging and Diet, Aging and the Effects of Vitamins and Supplements, ?Aging and Toxins, Aging and the Preservation of Neurologic Function, ?Aging and the Psychological Outlook, Aging and Exercise, State of the Art?"Anti Aging Centers" Around the World, and Interviews, anecdotes and wisdom from centurions in the US.

This book highlights (1) the significance of reciprocity for the maintenance of self-esteem in old age and (2) the negative implications for the well-being of dependent older people when that significance goes unrecognized and, as a consequence, opportunities to give back to society, as well as take from it, are not facilitated by those in a position to do so. The discussion draws on research undertaken in the UK and Southern India into the extent to which having the self-perception of being valued in the world is important to older people in receipt of care support and whether, in their experience, this is recognized by others. The author presents an analysis of theoretical insights from leading thinkers across a broad range of literature and from several disciplines, including social theory, social work, philosophy, and gerontology. The author also gives voice to the perspectives of those dependent older people not often heard because of marginalizing and disempowering processes that contribute to their having little opportunity to be heard in the first place. The emphasis of this book is on aspiration to a meaningful life and continuing personal growth as offering a challenge to dominant discourses the equate old age with decline.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older urological cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

In the last decade much attention has been paid to understanding and diagnosing Sarcopenia, the loss of muscle mass that results from the process of aging. This issue of Clinics in Geriatric Medicine, Guest Edited by Yves Rolland, MD, PhD, covers the History of Sarcopenia and works to define Sarcopenia based on recent workshops and meetings on the topic. This issue also covers the Epidemiology, Physiology, and Consequences of Sarcopenia. Also included are studies on Sarcopenia and Obesity, Sarcopenia and Frailty, Nutrition and Sarcopenia, Physical Activity and Sarcopenia, as well as a look at Clinical Trials on Sarcopenia.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older colorectal cancers patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

This issue?brings the geriatrician up to date on topics in Longer-Term-Care?such as: Doing Dementia Better: Anthropological Insights, Update on teaching in the Long-Term Care Setting, Pneumonia in the Long-Term Resident, Palliative Care for Patients with Dementia in Long Term Care, Urinary Tract Infections in Long-Term Care Residents, and Nausea and Other Non-Pain Symptoms in Long-term Care.

Neurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islet's evolution from an ancestral insulin-producing neuron. The islet-neuron connection becomes less surprising as we learn more about insulin's involvement in functions far from its traditional role in mediating glucose uptake in muscle. The importance of insulin in the regulation of corporal aging has been established by the dramatic increases in longevity experienced by animals in which the adipose insulin receptor has been genetically eliminated, or in which the insulin-related daf genes have been mutated. New research suggests that, analogous to its influence on corporal aging, insulin also makes important contributions to brain aging and the expression of late-life neurodegenerative disease. Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations and is associated with reduced insulin activity both in periphery and brain. The insulin resistance syndrome underlies conditions such as Type 2 diabetes mellitus and hypertension, which are associated with age-related cognitive impairment and Alzheimer's disease. This book discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects.