This issue of Clinics in Geriatric Medicine, guest edited by Drs. Thomas T. Yoshikawa and Dean C. Norman, is devoted to Infectious Diseases in Geriatric Medicine. Articles in this issue include: Host Resistance and Immunology of Aging; Clinical Features of Infection; Principles of Antimicrobial Therapy; Bacterial Pneumonia; Tuberculosis; Intraabdominal Infections; Infectious Diarrhea: Clostridium Difficile and Norovirus; Urinary Tract Infection; Herpes Zoster; Bone and Joint Infections; Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome; Infections in the Long-Term Care Setting; and Vaccinations.

This book documents the state of the art in the field of ambient assisted living (AAL), highlighting the impressive potential of novel methodologies and technologies to enhance well-being and promote active ageing. The coverage is wide ranging, with sections on assistive devices, elderly people monitoring, home rehabilitation, ICT solutions for AAL, living with chronic conditions, robotic assistance for the elderly, sensing technologies for AAL, and smart housing. The book comprises a selection of the best papers presented at the 7th Italian Forum on Ambient Assisted Living (ForitAAL 2016), which was held in Pisa, Italy, in June 2016 and brought together end users, technology teams, and policy makers to develop a consensus on how to improve provision for elderly and impaired people. Readers will find that the expert contributions offer clear insights into the ways in which the most recent exciti ng advances may be expected to assist in addressing the needs of the elderly and those with chronic conditions.

This issue of Clinics in Geriatric Medicine, guest edited by Drs. Cynthia Boyd, James T. Pacala, and Michael W. Rich, is devoted to Chronic Conditions in Older Adults with Cardiovascular Disease. Articles in this issue include: Epidemiology of multimorbidity in older adults with cardiovascular disease; Impact of multimorbidity on clinical outcomes in older adults with cardiovascular disease; Assessment of goals of care in patients with multiple chronic conditions; Challenges in decision-making: balancing trade-offs; Multimorbidity in older adults with heart failure; Multimorbidity in older adults with acute coronary syndromes; Multimorbidity in older adults with aortic stenosis; Multimorbidity in older adults with atrial fibrillation;Anticoagulation in older adults with multimorbidity; Approach to evaluating the multimorbid patient with cardiovascular disease undergoing non-cardiac surgery; Integrating care across disciplines; Assessing risks and benefits of invasive cardiac procedures in patients with advanced multimorbidity; Multimorbidity and end of life care in patients with cardiovascular disease; and Future research directions for cardiovascular disease.

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer's disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson's disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer's Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

This issue of Clinics in Geriatric Medicine is devoted to Geriatric Urology. Guest Editor Tomas L. Griebling, MD, MPH has assembled a group of expert authors to review the following topics: Non-Surgical Treatment of Urinary Incontinence in Elderly Women; Outcomes of Surgery for Stress Urinary Incontinence in Older Women; Evaluation and Management of Pelvic Organ Prolapse in Elderly Women; Underactive Bladder in Older Adults; Translational Research and Voiding Dysfunction in Older Adults; Functional Brain Imaging and Voiding Dysfunction in Older Adults; The Role of Urodynamics in Elderly Patients; Associations Between Voiding Symptoms and Sexual Health in Older Adults; Asymptomatic Bacteriuria and Urinary Tract Infections in Older Adults; Comorbidity and Surgical Risk in Older Urologic Patients; Small Renal Masses in Older Adults; Prostate Cancer in Elderly Men: Active Surveillance and Other Considerations; Late Onset Hypogonadism and Testosterone Replacement in Elderly Men; and Contemporary Chemotherapy for Urologic Malignancies in Geriatric Patients.

As the American population ages, health care for the elderly grows in importance. This bibliography overviews the most significant books and journal articles on the ethical issues related to health care for older Americans. The topics covered are of interest to practitioners and the general public alike, as well as to professionals from a wide range of fields. The author has provided more than five hundred bibliographic citations. These entries are arranged in eleven topical chapters to facilitate use by the reader. Each citation is accompanied by an annotation that concisely summarizes and assesses the contents of the work. The volume begins with an informative introductory essay on the ethical issues pertinent to health care for older adults. The chapters that follow are devoted to broad topics, such as financial considerations, treatment for the terminally ill, and decision-making by and for the impaired elderly. The work concludes with author and subject indexes that add to its utility. Researchers and practitioners from all fields will find this work an indispensable guide to the wealth of literature on the ethical aspects of health care for older Americans.

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process. Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns. Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.

This issue of Clinics in Geriatric Medicine, guest edited by Dr. Soo Borson, is devoted to Geriatric Psychiatry. Articles in this issue include: Diagnosis; Providing high quality care for dementia patients and family caregivers; Common psychiatric problems in cognitively impaired patients - causes and management; Partnering with family caregivers; Palliation and end of life care; Geriatric depression; Treatment for depression and evaluating response; Post-traumatic stress in older adults; Sleep disorders; Substance Abuse; Suicide; and Mental Health Services for Older Adults.

This issue of Clinics in Geriatric Medicine is devoted to Palliative Care. Guest Editors Thomas Smith, MD and Madeline Leong, MD have assembled a group of expert authors to review the following topics: Palliative Care in the Era of Healthcare Redesign; Communications to Patients; Communications by Professionals; International Palliative Care; Public Health and Palliative Care; Culturally Relevant Palliative Care; Spirituality, Religion, and Healing in Palliative Care; Alternative, Complementary and Mainstream Therapies in Palliative Care; Symptom Management in the Older Adult; Interaction of Palliative Care and Primary Care; Palliative Care in the Ambulatory Geriatric Practice; Choosing Cancer Therapy Based on Geriatric Assessment; and Emergency Medicine and Palliative Care.

Caring for the Geriatric Surgical Patient is covered extensively in this important Surgical Clinics of North America issue. Articles include: Changing Demographics of the American Population; Effect of Aging on Cardiac Function plus Monitoring and Support; Effect of Aging on Vascular System plus Monitoring and Support; Effect of Aging on Pulmonary Function plus Monitoring and Support; Effect of Aging on Renal Function plus Monitoring and Support; Management of the Gastrointestinal Tract and Nutrition in the Geriatric Surgical Patient; Management of Skin/Soft Tissue/Pressure Sores in the Geriatric Surgical Patient; Hematologic Issues in the Geriatric Surgical Patient; Healthcare-Economic Impact of Caring for the Elderly; Operative Risk Stratification in the Geriatric Surgical Patient; Management of Fractures in the Geriatric Surgical Patient; Pharmacology for the Geriatric Surgical Patient; Rehabilitation of the Geriatric Surgical Patient; End-of-Life Care of the Geriatric Surgical Patient, and more.

This major reference is a substantially revised edition of Palmore's "International Handbook on Aging," which was voted Choice Outstanding Academic Book of 1980. The reference collects and summarizes information on programs and research in gerontology in most countries where significant work is taking place. The chapters are arranged alphabetically, with each chapter devoted to a particular country. The countries selected represent a wide range of social, political, geographic, and economic conditions, and ten new countries are included in this edition.

Each chapter provides current information on the unique features of the country profiled; the roles and status of the aged; problems of the elderly; programs for older adults; research in biomedical, psychological, and sociological aspects of aging; and sources of additional information. Each chapter closes with a list of works for further consultation, and the handbook concludes with an appendix of gerontological associations and a bibliography. Gerontologists, social scientists, and policymakers will find this reference a valuable and current guide to developments and research on aging around the world.

This issue of Medical Clinics of North America, edited by Drs. Jeffrey Wallace and Susan Merel, is devoted to Gerontology. Articles in this issue include: Preventative care in geriatrics; Geriatric syndromes and assessment in the outpatient setting; Assessment and management of fall risk; Drug interactions and side effects; Evaluation and management of elderly patients presenting with cognitive complaints; Pain management in the elderly; Diabetes management in the elderly; Hypertension in the elderly; End-of-life care; Urinary incontinence; Nutrition in the elderly; Anti-thrombotic management in the elderly; and Sleep problems in the elderly.

The rapidity of scientific progress over the last few years guarantees the utility of a new collection of state-of-the-art reviews on the immunology of ageing. The aim of this authoritative book is to summarize current knowledge on the cellular and molecular aspects of the ageing immune system and their clinical relevance. The book is a result of extensive collaboration of more than sixty of the greatest thinkers and scholars in the field, in cooperation with a number of junior colleagues. Immunology of Aging presents the most up-to-date information on the scientific issues addressed by research into ageing of the immune system, providing insights into the effects of this process on susceptibilities to those diseases which are most common among elders. The retrieval strategies used to slow down the decline in the immune system in the elderly are another subject detailed extensively. By providing a broad overview of immunosenescence and its consequences, as well as their potential modulation, this book will fill a gap in a timely manner. It will be of value to all immunologists, whether novice or experienced, as well as geriatricians and epidemiologists.

The articles appearing in this geriatrics-focused issue are consistent with the collaborative and translational concepts held by a life course perspective. Each supports interprofessional collaboration and some are either authored or coauthored by interdisciplinary colleagues. Three goals are reflected in these articles: keeping community-dwelling older adults safe, sensible, and secure with solutions that will enable them to stay healthy, wise, and aware. Topics include maintaining physical functions, benefits and consequences of weight-bearing exercise on foot health; cancer prevention; managing nocturia's effect on sleep quality and safety; protection from financial exploitation; and providing safe and affordable living environments. Several articles address physical or cognitive challenges that include monitoring medication adherence, threat of anxiety and stigma in dementia, and approaches to managing self-care in the home for persons with dementia. These evidence-based articles address emerging and best practices to support targeted interventions for persons in community-dwelling home settings. They provide a frame-work of person-centered approaches that foster good health in older age, a central tenet of aging in place and the global response to population aging.

This issue of Clinics in Geriatric Medicine is centered on the management of the geriatric fragility fracture patient. This issue features expert clinical reviews on topics such as Principles of comanagement, Lean business model and implementation of a Geriatric Fracture Center, Preoperative optimization and risk assessment, Preoperative reversal and management of anticoagulation and antiplatelet agents, Classification and surgical approach to hip fractures for non-surgeons, Special anesthetic consideration for the fragility fracture patient, Non-surgical management and palliation of fragility fractures, and Management of post-operative complications including Delerium, Anemia, Venous thromboembolism, and Cardiovascular disease and volume management. Also included are articles on Transitions in care and rehabilitation, Osteoporosis related secondary fracture prevention, Post-operative assessment of falls risk and prevention, and Fragility fractures requiring special consideration.

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Mild Cognitive Impairment which includes current information on topics such as Overview of Mild Cognitive Impairment, Aging and Cognition, Classification and Epidemiology of Mild Cognitive Impairment, Neuropsychiatric Symptoms of Mild Cognitive Impairment, Clinical Evaluation of Early Cognitive Symptoms, Emerging Biomarkers Relating to Cognition, Imaging Modalities in Evaluation of Cognition, Current Management Decisions in Mild Cognitive Impairment, Risk Factors for Progression to Dementia, Dealing with Mild Cognitive Impairment: Help for Patients and Caregivers.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older lung cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

Following an introduction that outlines the history and projects the future of gerontology, the authors offer insightful profiles of roughly 300 researchers, teachers, and practitioners in aging. North Americans are heavily represented, though gerontologists from Great Britain and the Continent are included as well. The dictionary can be read for an overview of the field, while cross-listings and a complete name and subject index make it an ideal reference. Each entry contains a professional and academic biography, along with citations and succinct descriptions of the individual's important contributions to the study of the elderly and aging.

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Renal Disease in Older Adults which includes current information on topics such as Anatomic/ Physiological Changes with Aging, Acute Kidney Injury in Older Adults, Electrolyte Problems in Older Adults, Glomerular Disease in Older Adults, Hypertension in Older Adults, Chronic Kidney Disease in Older Adults, End-stage Renal Disease in Older Adults, Decision Making in the Older Adult Patient with Advanced Kidney Disease, Obstructive Uropathy in Older Adults, Drug Dosing, Transplantation in Older Adults, and Slowing the Aging Process.

This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

In this deeply considered meditation on aging in Western culture, Jan Baars argues that, in today's world, living longer does not necessarily mean living better. He contends that there has been an overall loss of respect for aging, to the point that understanding and "dealing with" aging people has become a process focused on the decline of potential and the advance of disease rather than on the accumulation of wisdom and the creation of new skills.

To make his case, Baars compares and contrasts the works of such modern-era thinkers as Foucault, Heidegger, and Husserl with the thought of Plato, Aristotle, Sophocles, Cicero, and other Ancient and Stoic philosophers. He shows how people in the classical period--less able to control health hazards--had a far better sense of the provisional nature of living, which led to a philosophical and religious emphasis on cultivating the art of living and the idea of wisdom. This is not to say that modern society's assessments of aging are insignificant, but they do need to balance an emphasis on the measuring of age with the concept of "living in time."

Gerontologists, philosophers, and students will find Baars' discussion to be a powerful, perceptive conversation starter.

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Geriatric Dermatology which includes current information on topics such as diagnosis and management of bullous disease, common skin cancers in older adults, psoriasis, management of pressure ulcers, management of venous stasis disease, approach to diabetic and vascular ulcers, diagnosis and management of soft tissue infections, cutaneous fungal infections in older adults, mangagment of scabies and generalized pruritus, herpes zoster and other herpes infections, and adverse drug effects in aging skin.

This issue of Clinics in Geriatric Medicine focuses on the pharmacological, non-pharmacological, and device therapies in the medical management of cardiac rhythm disorders in the elderly population. It also reviews the epidemiology of arrhythmias and conduction disorders in older adults, atrial fibrillation and atrial flutter: stroke prevention, bradyarrhythmias and conduction disorders, and comorbidities, quality of life, and end-of-life issues in older patients with heart rhythm disorders.