Written by the foremost authorities on the topic, this reference provides quick access to essential information on specific antibiotics, major clinical infections, selected pathogens, and infections in long-term elderly-care facilities-summarizing the vast array of topics related to infectious diseases in older adults including epidemiology, clinical manifestations, altered host resistance, and pharmacology.

Alterations in sleep are common manifestations of aging that can lead to significant health problems and contribute to behavioural problems associated with age-related neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Recent advances have revealed key cellular and molecular mechanisms involved in sleep regulation, and this knowledge is helping to advance an understanding of both the normal functions of sleep and the mechanisms responsible for abnormalities in sleep in various neurological conditions and during normal aging. This volume of Advances in Cell Aging and Gerontology brings together chapters by leaders in the fields of sleep research and the neurobiology of aging. The book starts with chapters describing fundamental aspects of the neurocircuitry involved in sleep, patterns of brain activity during the different stages of sleep and disturbances of sleep during aging. The links between depression, anxiety and insomnia are reviewed in regards to the underlying neurochemical alterations that appear to involve abnormalities in neurotransmitter and neurotrophic factor signalling. The evolutionary basis of sleep is reviewed and the emerging evidence supporting a major role for sleep in learning and memory is described. The bulk of the book focuses on specific sleep disorders associated with aging and age-related neurodegenerative disorders. A comprehensive consideration of this topic is woven through a number of chapters that address both basic research and clinical aspects of sleep abnormalities during aging and in disease. The impact of sleep on the immune system is described. The articles are written in a high level of detail and are comprehensive, thus providing valuable information for a range of scientists and other well-educated people. In particular, the book will be a valuable resource for graduate students, postdoctoral and senior scientists in the fields of sleep, aging, neurodegenerative disorders and learning and memory. In addition, clinicians will find this book valuable as it provides a bridge between basic research and the treatment of the patients with sleep disorders.
* Covers the fields of sleep in aging and age-related disease from neurochemistry to the clinic
* Includes detailed summary diagrams that depict key concepts
* Provides views of the future of research on sleep and aging, and the potential for prevention and treatment of various sleep disorders

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur, new possibilities emerge for limiting the effects of aging on neural function. A single source reference is necessary to keep abreast of the recent advances and future directions of gerontology research. Brain Aging: Models, Methods, and Mechanisms offers a selective overview of the research in this rapidly expanding field. A valuable resource for new and established investigators of the aging brain, this volume reviews critical studies of brain aging in new animal models, as well as advances in brain imaging techniques that permit investigations in aging humans with increasingly higher resolution. Detailed discussions link the information from human and animal studies to illustrate a comprehensive picture of the mechanism of aging. Emphasizing normal brain aging rather than pathological degeneration, the text provides an understanding of fundamental age-related changes in the nervous system and hypothesis-driven research into their basis. The book includes critical analyses of the distinct methodological challenges inherent in investigating the aging nervous system. Contributions from distinguished leaders and pioneers in their respective fields address data and mechanisms, as well as models and methods that are key to the study of aging. Each chapter is extensively referenced and highlights experimental concerns that are magnified or unique to the aging brain. Outlining relevant methods and techniques, this book provides scientists, researchers, and clinicians with a broad understanding of the important progress and implications for the future of this significant field.

This unique volume teaches those in the medical fields about the scientific value of neuropsychology in assessing cognition, the 6th vital sign, as part of well integrated collaborative care. It offers physicians a comprehensive tour of the many dimensions neuropsychology can add to primary and specialized medical care across the lifespan. Noted experts examine cognitive ramifications of a wide range of medical, psychological, and neuropsychological conditions, among them brain tumors, stroke, epilepsy, pediatric and adult TBI, schizophrenia, and adult ADHD. The book's generous selection of case examples demonstrates the benefits of cognitive assessment in building accurate diagnoses, better understanding of patient needs, and more appropriate treatment and management strategies, as well as other neuropsychologist roles in consulting, referral, and forensic areas. In addition, tables, callout boxes, review questions, and other features are included throughout the text for ease in comprehension and retention. A sampling of the coverage:* The value of neuropsychological evaluation in medical practice. * A model of collaboration between primary care and neuropsychology. * Neuropsychological assessment of extremely preterm children. * Alzheimer's Disease and overview of dementia. * Deep brain stimulation for Parkinson's Disease. * Neuropsychology in the 21st century: the rise of multicultural assessment. * Neuropsychological interventions for individuals with brain injury. The Physician's Field Guide to Neuropsychology is both a rigorous and an accessible reference for clinicians in diverse disciplines including general practice, family medicine, neuropsychology, pediatrics, gerontology, and sports medicine.

Cognitive Analytic Therapy and Later Life highlights that any attempt to work psychotherapeutically with older people must take into account the effects of working within a context of institutional ageism. It explores the specialist skills required when working with older people, covering: * the delayed effects of early trauma * narcissism and the re-emergence of borderline traits and dissociative states * the emergence of treatment resistant depression and anxiety * the use of the cognitive analytic therapy model to challenge the child centred paradigm of psychoanalytic theory. Clinical psychologists, psychiatrists, psychotherapists, nurses, social workers, and occupational therapists alike will find this an illuminating and thought provoking book.

It can be argued that ATP is the most important molecule in cells. Not only is ATP the key energy source for cells, but it is also the source of phosphate groups that are transferred to a variety of substrate proteins via the action of elaborate families of protein kinases. An equally elaborate array of protein phosphatases can remove phosphate groups from proteins. It is now well established that protein phosphorylation is a widely used mechanism for cells to selectively modulate the function of a variety of proteins including enzymes, ion channels and pumps and structural proteins. In this volume of ACAG leading experts describe the evidence that protein phosphorylation is altered in aging and age-related disease. Protein phosphorylation controls fundamental processes such as transcription and translation, regulation of the cell cycle, signalling within and between cells, cell motility, synaptic function and so on. Recent findings are revealing how phosphorylation dependent signalling cascades may control lifespan with a prime example being the insulin-signalling pathway first described in c-elegans and now emerging as an important regulator of lifespan of mammals also. Many of the functional changes that occur during aging such as impaired learning and memory and altered energy metabolism are controlled by protein phosphorylation and it is, therefore, important to understand how mechanisms of protein phosphorylation may either mediate aging or provide adaptive responses that allow successful disease-free aging. The authors in addition to considering the roles of protein phosphorylation in aging describe the evidence that abnormalities in protein phosphorylation contribute to the pathogenesis of major age-related diseases including diabetes, atherosclerosis and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

Experts in the fields of energy metabolism, aging and oxidative stress provide an integrated view of how mechanisms involved in regulating energy metabolism are linked to fundamental processes of aging including cellular stress resistance and free radical production.

During evolution signal transduction pathways and organ systems have been optimised for the efficient seeking, ingestion, storing and using of energy. These signalling pathways play prominent roles in lifespan determination with insulin and related signalling pathways being prime examples. The authors consider how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG will foster novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.

A comprehensive, multidisciplinary annotated bibliography of the chronic pain in later life literature. It consists of 302 entries covering, assessment of chronic pain, the human body and chronic pain, perceptions of chronic pain, treatment of chronic pain, and correlates and consequences of chronic pain.

This volume includes a select citation list of 150 articles that focus on older persons and cancer pain. It suggests the use of both aggressive and holistic treatments to treat pain in the elderly. It will be of interest to scholars and practitioners in the disciplines including medicine, psychology, sociology, social work, pharmacology, and any social services which focus on the care of the elderly.

Much has been written about healthcare for older people, but the ageing process affects people of all ages. Ageing, rather than old people, has received scant attention within healthcare literature. This book addresses this paucity. It explores key perspectives of the ageing process. Ageing and old age are not necessarily synonymous. Ageing is a complex, multi--faceted concept and therefore is explored through three different perspectives: chronological, sociological and physiological. Although the majority of chapter authors are nurses, topics covered in this book extend beyond purely nursing issues.

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases.

This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

Population aging is a growing challenge worldwide. As such, new models of provision, organization, and allocation of resources, particularly in healthcare, are needed. As the self-care and long-term care needs of this age group become more prevalent, the importance of improved health services and effective health management strategies are apparent. The Handbook of Research on Health Systems and Organizations for an Aging Society provides emerging research exploring the challenges and opportunities for the development and management of health systems and organizations in relation to people aged 65 and over. Featuring coverage on a broad range of topics such as emotional wellness, long-term care, and professional caregiving, this book is ideally designed for health technicians, doctors, nurses, pharmacists, hospital administrators, clinical directors, laboratory technicians, medical professionals, researchers, and students.

This book belongs to a long tradition at the Tavistock Clinic of work focused on the mental and emotional well-being of the elderly. It applies psychoanalytic thinking to areas that have generally attracted very little sustained attention over the years.

This book brings together a selection of classic psychoanalytical papers related to ageing, dying and death that have appeared in the renowned International Journal of Psychoanalysis (IJP). Two papers address the analysis of an elderly patient directly and bring the work and the challenges it brings vividly to life. Also explored are such issues as death and the midlife crisis, loneliness and the ageing process, ageing and psychopathology, fear of death, transference and countertransference issues, and the final stage of the dying process. 'The idea behind this monograph is to alert interested psychoanalysts, students and those working from an interdisciplinary standpoint to the possibility of a better understanding of the ageing process as well as a group of potential analysis that seem to exist in the shadow of our professional communications. 'Each stage of life has its own somatic and psychic normality as well as pathology.

The lives of urban Chinese daughters have changed. Education and employment have propelled them from dependency to self-sufficiency, resulting in new attitudes and lifestyles. However, traditional filial obligation has remained. This book asks why it continues and how it is currently discharged, focusing on the emotion work daughters do to sustain the parent relationship, deal with conflict and maintain their self-esteem. Based on interviews with women living in Hong Kong, Singapore and mainland China, the book further explores whether the structural or relational motivations underpinning support and care may be less important than the standards daughters impose on themselves; why care may be discontinued or not undertaken in the first place; why care provided to parents may be different from in-laws, and the importance of domestic helpers to the modern caregiving paradigm. To undertake this exploration, a typology of support and care was created, allowing for the first time to distinguish between what daughters do for healthy parents and in-laws versus parents who require temporary or full time care, specifically addressing how providing support and care affects the daughters' well-being.

The sixth volume of the Handbook is devoted to topics related to aging and dementia. The volume is introduced by two chapters dealing with age-related cognitive and neurobiological alterations in animals, including a detailed review of data obtained with transgenic and knockout technology. The next chapter reviews the cognitive changes associated with normal aging. The gamut of symptoms that occur in Alzheimer's disease (AD) are then described and analyzed, they include effects on attention, language, memory, non-verbal functions with emphasis on spatial abilities, olfaction and the motor system. The discussion of dementia syndromes is presented in two sections. The first concerns AD, which is discussed from the points of view of epidemiology, neuropathology and neurochemistry and concludes with a review of current and future treatments. The other section deals with non-AD dementias including Fronto-temporal and Lewy body dementias and specific conditions such as Parkinson's and Huntington's disease, as well as HIV infection. The volume includes a review of brain imaging and cerebral metabolism findings in aging and dementia. The final chapters review the relations between culture and dementia and the special syndrome of severe dementia.

Contents:
Preface. Aging and Trauma: Good Enough Understanding of Age, "Good Enough" Understanding of Trauma, Moderating Variables of Trauma in the Aging Person, Older People in Need of Help, Conclusion. PTSD in the Context of Aging: Prevalence of PTSD, PTSD's Historical Roots: Military Combat, What is PTSD? Oh, Well, What's in a Diagnosis? Theories of PTSD, Other Influences of Trauma, Special Problems, Conclusion. Life Story of the Aging Person: Two Faces of Aging, Life Story, Conclusion. Person and Memory: Memory Overall, Autobiographical Memory and Decline, Facts of the Aging Memory, Core Memory, Internal Organization, Schemas Personality Memories, Conclusion. Treatment: PTSD Personality Memories, Conclusion. Chapter 5: Treatment: and Beyond: Overall Treatment, PTSD Treatment, Information Processing, Old Folks and Rx, Conclusion. Key Ingredients to Psychotherapy: Dosed Exposure, Goals, Relationships, Relaxation, Assimilation, Emotion: Keeping in the Zone, Presentness Power, The Marker/Reflexiceness, Integrating, Little and Big Stuff, Conclusion. Treatment Model: Early Stages: Integration. Stage 1: Stabilize the Client. Stage 2: Relationship. Stage 3: Balance. Conclusion. Personality: Stage 4: Personality: PTSD and Personality. Aging and Personality. Theoretical Directions. Conclusion. Chapter 9: Core Memory: The "Good" Memory: Narrative Perspective. Assessment of Memory. The Good Memory: PCM. Principles for PCM. Last Resort. Special Case: Constructivism. Conclusion. Chapter 10: The Trauma Memory: The "Bad" Memory: Extant Models. Aging and the "Bad" Memory. The Trauma Memory. Aftercare and Relapse Prevention. Necessary Treatment: Family. Conclusion. Chapter 11: Grief Work and Forgiveness in the Context of PTSD: The Self. Grief Constructs. Growth in Grief. Treatment Model. Forgiveness: The Special Ingredient of Grief Therapy. A Caution. Conclusion. Using Assessment Data to Inform the Treatment Plan: Overall Considerations. Idiographic Formulation. The Players. Measures of Comorbid Issues. Conclusion. References. Appendix A: Cognitive Behavioral Therapy: Application. Appendix B: Treatment Rules for Axis II. Appendix C: EMDR Relaxation Procedure. Index

Understanding socially disruptive behavior in dementia is never easy. Most explanations offer neither solace nor solutions for families and carers, and treatment is often characterized by policies of control and containment. The result of Graham Stokes' 15 years of clinical work with people who are challenging, this book: disputes the traditional medical model of dementia and asserts that if we reach behind the barrier of cognitive devastation and decipher the cryptic messages, it can be shown that much behavior is not meaningless but meaningful. It contrasts the medical interpretation that sees anti-social behavior as mere symptoms of disease with a person-centered interpretation that resonates change and resolution. It offers a radical and innovative interpretation of challenging behavior consistent with the new culture of dementia care, focusing on needs to be met rather than problems to be managed.

This text assembles together advances in knowledge about dementia, Alzheimers disease and related disorders as they affect persons with intellectual disabilities. Diagnosis, assessment, treatment, management and care practices are detailed in a practical manner for both students and professionals.

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Mental Health Practice in Geriatric Health Care Settings emphasizes the major research and clinical findings realized in five years of research on mental health issues in older urban medical patients, many of whom represent minority groups. Chapters cover the high comorbidity of health and mental health problems in geriatric patients, neuropsychological (or cognitive) assessment, depression, alcohol abuse in health care settings, emerging behavioral medicine issues, and family relations and their tie to medical settings. As a practitioner, you'll find this book helps your practice by representing the first assessment and treatment techniques normed and validated on minority elderly. If you're a professional working in the mental health system, you'll see how to expand your services to health care markets.Mental Health Practice in Geriatric Health Care Settings devotes three chapters to neuropsychological assessment--first, a review of major principles; second, a new test battery for minorities; and third, extensive review on how to use test results in clinical decision making. Other chapters provide valuable information on: the analysis of outcomes for one thousand 60--103-year-olds a new validated behavioral treatment method for depression methods of detection and treatment of alcohol abuse emerging issues in behavioral medicine, including competency assessments; anxiety and pain disorders; and shaping the referral process family relations and health care, including caregiving and nursing home placement nursing home consultation and survival strategies in health care systemsAs Author Peter A. Lichtenberg describes in the Introduction, each chapter in Mental Health Practice in Geriatric Health Care Settings is multidisciplinary, empirically and statistically investigated, and focused upon urban elderly. "In addition, the major objectives are to provide clinicians with new understandings and new assessment and treatment knowledge to utilize in their practices. Finally, this book is hoped to provide clinicians [with] information about emerging trends in the field, and effective strategies for practice in healthcare settings."

Mental Health Practice in Geriatric Health Care Settings emphasizes the major research and clinical findings realized in five years of research on mental health issues in older urban medical patients, many of whom represent minority groups. Chapters cover the high comorbidity of health and mental health problems in geriatric patients, neuropsychological (or cognitive) assessment, depression, alcohol abuse in health care settings, emerging behavioral medicine issues, and family relations and their tie to medical settings. As a practitioner, you ll find this book helps your practice by representing the first assessment and treatment techniques normed and validated on minority elderly. If you re a professional working in the mental health system, you ll see how to expand your services to health care markets.Mental Health Practice in Geriatric Health Care Settings devotes three chapters to neuropsychological assessment--first, a review of major principles; second, a new test battery for minorities; and third, extensive review on how to use test results in clinical decision making. Other chapters provide valuable information on: the analysis of outcomes for one thousand 60--103-year-olds a new validated behavioral treatment method for depression methods of detection and treatment of alcohol abuse emerging issues in behavioral medicine, including competency assessments; anxiety and pain disorders; and shaping the referral process family relations and health care, including caregiving and nursing home placement nursing home consultation and survival strategies in health care systemsAs Author Peter A. Lichtenberg describes in the Introduction, each chapter in Mental Health Practice in Geriatric Health Care Settings is multidisciplinary, empirically and statistically investigated, and focused upon urban elderly. "In addition, the major objectives are to provide clinicians with new understandings and new assessment and treatment knowledge to utilize in their practices. Finally, this book is hoped to provide clinicians with] information about emerging trends in the field, and effective strategies for practice in healthcare settings.""

This comprehensive book gives an up-to-date profile of all aspects of the care of older people in the community, with particular emphasis on the importance of maintaining function and independence as well as health. In a uniquely broad approach, the book is edited by two family doctors with a particular interest in the elderly and a consultant geriatrician, and the varied subjects are each presented by experts in their field. This accessible book enables primary care teams to produce optimal standards of care in old age, and is helpful in the organization of preventive care programmes. Emphasizing the need for joint working, the book draws together practical knowledge and skills to produce an essential source of reference and advice for all those involved in delivering a co-ordinated service. It is essential reading for all doctors in general practice and in public health, medical students and all other professionals whose work brings them into contact with elderly people. It is particularly useful for general practice teams, allied professionals such as nurses and physiotherapists, as well as patients and carers seeking an understanding of good practice. It also contains much practical information vital to the work of voluntary agencies, social service departments and specialists in geriatric medicine.