A description of the social, educational, and economic impact of living with a neurological genetic disorder, neurofibromatosis 1. The many unpredictable and potentially stigmatizing possible symptoms of NF1, which range from physical disfigurement to severe learning disorders, may have serious consequences in every aspect of daily life. NF1 was for many years wrongly diagnosed as the Elephant Man's Disease.

Ablon examines the psychosocial costs of this misdiagnosis and the ways in which stage, screen, and television parlayed The Elephant Man into the personification of the grimmist extreme of ugliness. This portrayal engendered fear and anxiety for affected persons and their families and also had an impact on the scientific and medical communities. Ablon analyzes the factors that affect individual positive adaptation to NF1 and the demands of American society, and offers suggestions for families, support systems, and health care providers for treatment of affected individuals.

This ethnography, based on a five-year field study, presents a holistic view of a nearly invisible ethnic minority in the urban Midwest, Cambodian refugees. Hopkins begins with a brief look at Cambodian history and the reign which led these farmers to flee their homeland, and then presents an intimate portrait of ordinary family life and also of Buddhist ceremonial life. The book details their struggles to adjust in the face of the many barriers presented by American urban life, such as poverty, dangerous neighborhoods, and unemployment, and also by the conflict between their particular needs and American institutions such as schools, health care, law, and even the agencies intended to help them.

In 1991, the centrifugal forces of ethnic nationalism destroyed the Soviet Union. Religious and ethnic issues will be the defining principles of political life in East Europe, Transcaucasia, and Central Asia for the next decade. Yet when most Americans and Europeans read, for instance, of the Ossetians and Ingush, they have no idea who these peoples are or why they are fighting. This volume will provide a ready reference for students, researchers, and librarians who are trying to sort out the political and social struggles in that part of the world. Focusing on ethnolinguistic groups rather than peoples with purely religious orientations, Olson provides entries on over 450 ethnic groups, with appropriate cross-references. Each entry concludes with references, and the volume includes a selected bibliography of English-language titles. The volume also includes a chronology, several appendixes providing statistical information, and an appendix essay on Islam in Russia and the Soviet Union.

Breast cancer research has never been in such an exciting and hopeful phase as today. From a clinical perspective, the discovery of genetic markers of risk in a proportion of familial breast cancer cases has opened up new vistas for understanding and ultimately preventing this disease. On the other hand, aggressive - even daring - therapies are being proven to be effective against advanced breast cancer. For the breast cancer experimentalist, this is also a time of great advance. Although animal and cell culture breast cancer models have proven to be of great use, there are now increasing opportunities to test the concepts developed in these models in actual clinical samples and cases. It is gratifying to see how well these concepts "translate" into the clinical setting. A very active area of research that is linking the laboratory to the clinic is the dissection of the biology and elucidation of the significance of proliferate breast disease and the identification of true, "high risk" or "preneoplastic" legions within the previously ill-defined spectrum of fibrocystic or benign breast disease. One anticipates that discoveries made here will also lead to earlier detection, intervention and prevention of life-threatening cancer.
Even, however, as we look with optimism to the eventual eradication of breast cancer, we are once again forced to face the reality that we have not yet achieved our goal. Thus, we are saddened by the much too premature death of Dr. Helene Smith from breast cancer. Helena's work was at the forefront of efforts to understand the biology of human breast cancer at the molecular level. Her insight, open-mindedness, and refusal to sacrifice relevance for convenience will continue to set the standard for all breast cancer researchers. This volume is dedicated to her memory.

A breakthrough theory that tools and technology are the real drivers of human evolution. Although humans are one of the great apes, along with chimpanzees, gorillas, and orangutans, we are remarkably different from them. Unlike our cousins who subsist on raw food, spend their days and nights outdoors, and wear a thick coat of hair, humans are entirely dependent on artificial things, such as clothing, shelter, and the use of tools, and would die in nature without them. Yet, despite our status as the weakest ape, we are the masters of this planet. Given these inherent deficits, how did humans come out on top? In this fascinating new account of our origins, leading archaeologist Timothy Taylor proposes a new way of thinking about human evolution through our relationship with objects. Drawing on the latest fossil evidence, Taylor argues that at each step of our species' development, humans made choices that caused us to assume greater control of our evolution. Our appropriation of objects allowed us to walk upright, lose our body hair, and grow significantly larger brains. As we push the frontiers of scientific technology, creating prosthetics, intelligent implants, and artificially modified genes, we continue a process that started in the prehistoric past, when we first began to extend our powers through objects. Weaving together lively discussions of major discoveries of human skeletons and artifacts with a reexamination of Darwin's theory of evolution, Taylor takes us on an exciting and challenging journey that begins to answer the fundamental question about our existence: what makes humans unique, and what does that mean for our future?

Since the second half of the eighteenth century, generations of scientists persisted in studying the relationships between the volume, weight or shape of the human brain and the degree of 'intelligence'. In Pogliano's book, the thread of time drives the narrative up to the mid-twentieth century. It investigates the duration and changes of a game that was intrinsically political, although having to do with bones and nervous matter. Races made its main object, during a long period when Western culture believed the human species to be naturally partitioned into a number of discrete types, with their innate and hereditary traits. Never leading to irrefutable achievements, the polycentric (as well as visual) enterprise herein described is full of growing tensions, doubts, and disillusionment.

This is the first international study of maternal care and maternal mortality. Over the last two hundred years, different countries developed quite different systems of maternal care. Death in Childbirth is a meticulously researched analysis, firmly grounded in the available statistics, of the evolution of those systems between 1800 and 1950 in Britain, the USA, Australia and New Zealand, and on the continent of Europe. Irvine Loudon examines the effectiveness of various forms of maternal care by means of the measurement of maternal mortality - the number of women who died as a result of childbirth. His scholarly and comprehensive study sets out to answer a number of important questions. What was the relative risk of a home or hospital delivery, or a delivery by a midwife as opposed to a doctor? What was the safest country in which to have a baby, and what were the factors which accounted for enormous international differences? Why, against all expectations, did maternal mortality fail to decline significantly until the late 1930s? Death in Childbirth makes an invaluable contribution to medical and social history.

Diasporas large-scale ethnic migrations have been a source of growing concern as we try to understand the nature of community, identity and nationalism. Traditionally, diaspora communities have been understood to be pariah communities, and most work on diasporas has focused on specific groups such as the Jewish or African Diaspora. This book is unique in arguing against traditional interpretations and in taking a comparative look at a range of diasporas, including the Jewish, Arab, Chinese, Japanese, Indian, Maltese, Greek and Armenian diasporas.Taking the past four centuries into consideration, the authors examine diaspora trading networks across the globe on both a regional and international level. They investigate the common patterns and practices in the enterprises of diaspora peoples and entrepreneurs. The regions covered include Western Europe, the Mediterranean, South West Asia and the Indian Ocean, and South East Asia. Global networks of diaspora trading groups were crucial to international trade well before the twentieth century, yet because they were not part of established institutions they have remained elusive to economists, sociologists and historians.Through an understanding of diaspora trading networks, we learn not only about diaspora communities but also about the roots of the modern global economy.

Osteoarchaeology: A Guide to the Macroscopic Study of Human Skeletal Remains covers the identification of bones and teeth, taphonomy, sex, ancestry assessment, age estimation, the analysis of biodistances, growth patterns and activity markers, and paleopathology. The book aims to familiarize the reader with the main applications of osteoarchaeology and provide the necessary knowledge required for the implementation of a broad range of osteological methods. It is ideal as a complement to existing textbooks used in upper level undergraduate and graduate courses on osteoarchaeology, human osteology, and, to some extent, forensic anthropology. Pedagogical features include ample illustrations, case study material, revision exercises, and a glossary. Additional features comprise macros that facilitate data processing and analysis, as well as an extensive chapter on applied statistics.

The essays in this volume offer the reader a broad, interdisciplinary perspective on the ways in which theories of alienation are influencing current debates in psychology, psychiatry, sociology, and social philosophy. In his introductory essay, Felix Geyer discusses how classical notions of alienation have been put to use to describe the dysfunctions within societies that are becoming sharply divided along racial lines and according to the disparities in power described by postmodernism. The essays that follow Geyer's introduction then take up the problems of alienation, ethnicity, and postmodernism in the contexts of increasing economic globalization and renewed racial hostility in communities both in the United States and abroad.

Research has consistently documented the failure of schools to reach students from linguistically and culturally diverse backgrounds. One reason suggested for this failure is teachers' lack of understanding and appreciation for students' home backgrounds, while most teachers are eager to becvome informed and supportive of their diverse students many have lacked the opportunity to develop the knowedge and skills appropriate to working with such students. Ethnic Diversity examines how migration and settlement patterns have varied for these populations throughout U.S. history, documenting what researchers have learned about Latino, Native American, African American, urban Appalachian, and Asian American families, neighborhoods, and communities as these relate to children's learning through case studies (in the form of vignettes) and suggests how schools, communites, and universities can address the needs of culturally diverse students and their families.

The Los Angeles riot of 1992 marked America's first high-profile multiethnic civil unrest. Latinos, Asian Americans, whites, and African Americans were involved as both victims and assailants. Nearly half of the businesses destroyed were Korean American owned, and nearly half of the people arrested were Latino.

In the aftermath of the unrest, Los Angeles, with its extremely diverse population, emerged as a particularly useful site in which to examine race relations. Ethnic Peace in the American City documents the nature of contemporary inter-ethnic relations in the United States by describing the economic, political, and psychological dynamics of race relations in inner-city Los Angeles. Drawing from local as well as international examples, the authors present strategies such as coalition building, dispute resolution, and community organizing.

Moving beyond the stereotyped focus on negative interactions between minority groups such as Korean-owned businesses and the African American community, and countering the white-black or bi-racial paradigms of American race relations, the authors explore practical means by which ethnically fragmented neighborhoods nationwide can work together to begin to address their common concerns before tensions become explosive.

The universality of health concerns and the complexity of dealing with them makes it increasingly important for professionals in sociology, health care, and policy making to become acquainted with the wide variety of strategies used in different social contexts. Although Israel is in some ways unique in its social problems and its approach to health care, many of its problems resemble those of other societies, and many of its solutions can be applied in other countries. Social Dimensions of Health looks at distinctive aspects of the Israeli health care system, while at the same time drawing comparisons with other societies.

Judith Shuval discusses the health and health behavior of a variety of groups in Israeli society that have not been systematically considered in other analyses: women, the elderly, alternative health care providers, immigrants, and Israeli Arabs. Shuval analyzes the critical influence of ultraorthodox parties on health policy in the context of a tenuously balanced coalition government, and shows how the pervasive conflict between Israel and the Arab world penetrates all aspects of social life, including health. Inequality in health is discussed with special reference to Israeli Arabs. The study concludes with a discussion of what can be learned from the Israeli experience, and how it can best be applied in other social contexts. Social Dimensions of Health will prove useful to scholars, health practitioners, and lay people seeking a broad understanding of the social factors underlying health and health care.

Whiteness is often looked upon and equated with being American, but this book seeks to discover how other American voices and experiences have been and are excluded from the American legacy. It directly addresses the notion of self and human division in a cultural climate that has historically fostered the marginalization of multiple racial identities. This is an interdisciplinary work on understanding and promoting intercultural communication and will be of interest to students and scholars in the fields of communication, multicultural studies, social psychology, and sociology.

Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.

Governmental social institutions are responsible for major policy decisions that deeply affect our everyday lives. This edited collection analyzes the effects of the main macro-social systems--law and politics, economic development, education, social welfare, health, mental health, transportation, housing, and religion--on the lives of African Americans, Hispanics, Asians, and Native Americans. The contributors, who are experts with the particular fields they address, reveal that macro-social systems are characterized by widespread, severe discrimination in the form of laws, attitudes, and behaviors towards ethnic minorities. Their analyses, which include both historical and contemporary perspectives, are accompanied by suggestions for policy measures aimed at improving the lives of ethnic minorities.

One of the world's leading geneticists, Bryan Sykes has helped thousands find their ancestry in the British Isles. Saxons, Vikings, and Celts, which resulted from a systematic ten-year DNA survey of more than 10,000 volunteers, traces the true genetic makeup of the British Isles and its descendants, taking readers from the Pontnewydd cave in North Wales to the resting place of "The Red Lady" of Paviland and the tomb of King Arthur. Genealogy has become a popular pastime of Americans interested in their heritage, and this is the perfect work for anyone interested in finding their heritage in England, Scotland, or Ireland.

Drawing heavily on the reminiscences of the Brownsville boys themselves, and skillfully integrating these with material from newspapers, books, and commentary of the time, Sorin creates an original and compelling picture of the communal and individual vitality that allowed an unusual and heartening social achievement.

The racially charged stereotype of "welfare queen"--an allegedly promiscuous waster who uses her children as meal tickets funded by tax-payers--is a familiar icon in modern America, but as Gunja SenGupta reveals in From Slavery to Poverty, her historical roots run deep. For, SenGupta argues, the language and institutions of poor relief and reform have historically served as forums for inventing and negotiating identity.

Mining a broad array of sources on nineteenth-century New York City's interlocking network of private benevolence and municipal relief, SenGupta shows that these institutions promoted a racialized definition of poverty and citizenship. But they also offered a framework within which working poor New Yorkers--recently freed slaves and disfranchised free blacks, Afro-Caribbean sojourners and Irish immigrants, sex workers and unemployed laborers, and mothers and children--could challenge stereotypes and offer alternative visions of community. Thus, SenGupta argues, long before the advent of the twentieth-century welfare state, the discourse of welfare in its nineteenth-century incarnation created a space to talk about community, race, and nation; about what it meant to be "American," who belonged, and who did not. Her work provides historical context for understanding why today the notion of "welfare"--with all its derogatory "un-American" connotations--is associated not with middle-class entitlements like Social Security and Medicare, but rather with programs targeted at the poor, which are wrongly assumed to benefit primarily urban African Americans.