Presents a comprehensive review of classic hypersonic flow from the Newtonian theory to blast wave analogue. Introduces nonequilibrium chemical kinetics to gas dynamics for hypersonic flows in the high-enthalpy state. Integrates quantum mechanics to high-enthalpy hypersonic flows including dissociation and ionization. Covers the complete heat transfer process with radiative energy transfer for thermal protection of earth reentry vehicle. Develops and verifies the interdisciplinary governing equations for understanding and analyzing realistic hypersonic flows.

-- Covers the most relevant production and distribution channels of aquafeed and the ingredients used commonly as sources of proteins, lipids, and carbohydrates. This will help the industry understand how to position itself to meet the challenge of securing aquafeed to sustain aquaculture. -- 20 chapters cover different aspects of aquafeeds, from the market to cutting-edge technologies, including nutritional aspects and the impact of aquafeeds on climate change. This enables aquafeeds to be approached from different perspectives. -- Up until now, aquafeed-related issues were addressed as secondary subjects in undergraduate textbooks, being part of books covering a broad spectrum of subjects. Other book focus on processing techniques with aquafeed products mentioned in a tangential manner. This means a book focused on aquafeeds, covering different aspects of their production and commercialization chain, is a real necessity. -- Interdisciplinary chapters, with collaborations between academic researchers and industry professionals, cover not only technical aspects but also market analysis.

Combination products are therapeutic and diagnostic products that combine drugs, devices, and/ or biological products. According to the US Food and Drug Administration (FDA), “a combination product is one composed of any combination of a drug and a device; a biological product and a device; a drug and a biological product; or a drug, device and a biological product.� Examples include prefilled syringes, pen injectors, autoinjectors, inhalers, transdermal patches, drug-eluting stents, and kits containing drug administration devices co-packaged with drugs and/or biological products. This handbook provides the most up-to-date information on the development of combination products, from the technology involved to successful delivery to market. The authors present important and up-to-the-minute pre- and post-market reviews of combination product regulations, guidance, considerations and best practices. This handbook: • Brings clarity of understanding for combination products guidance and regulations • Reviews the current state-of-the-art considerations and best practices spanning the combination product lifecycle, pre-market through post-market • Reviews medical product classification and assignment issues faced by global regulatory authorities and industry The editor is a recognized international Combination Products and Medical Device expert with over 35 years of industry experience and has an outstanding team of contributors. Endorsed by AAMI – Association for the Advancement of Medical Instrumentation.

"A powerful and urgent introduction to lean marketing and the magic of getting it right." -- Seth Godin, author, This is Marketing You may be familiar with the Silicon Valley expression about the iterative approach to software development, "We're learning to fly the plane while we're building it." If so, think of a startup-with all its moving parts, phases, and personalities-as flying a plane, while you're building it, booking passengers, marketing the airline, interviewing co-pilots, and serving coffee. In this book, Orly Zeewy navigates the turbulence and provides a flight plan so you know when you've landed in the right airport. Orly Zeewy is a brand architect who helps startups cut through the noise. She has worked with dozens of founders and entrepreneurs to uncover their brands' DNA. In Ready, Launch, Brand: The Lean Marketing Guide for Startups you will learn how to close the marketing gaps that can slow down sales and make it harder to scale your business. Orly shares her brand process for building the right team, attracting brand evangelists, and cultivating a sustainable company culture. Prior to starting her brand consulting practice, Orly ran the award-winning Zeewy Design and Marketing Communications firm and directed marketing programs for national clients such as CIGNA, Kraft Foods, and Prince Tennis. She has lectured at the Wharton School of Business at the University of Pennsylvania, taught at the Charles D. Close School of Entrepreneurship at Drexel University, and been featured in the business section of the Philadelphia Inquirer.

Understanding Wine Technology has become the most favoured book of many students. This book is aimed at the person with no formal scientific training, yet who is interested in the science behind wine and wants to know the mechanism behind the complex transformations that take place. Scientific terminology has been kept to a minimum and an attempt has been made to use everyday words and phrases. Indeed, there are places where the scientist might raise the eyebrows, places where perhaps science has had to give way to an easy understanding of a complex principle. In this fourth edition Nicolas Quille, a well-qualified and widely-experienced French winemaker working in Oregon USA has brought the information up-to-date so that this book remains the mainstay for those who are studying for the Diploma of the WSET or for membership of the Institute of Masters of Wine. The text has also been expanded to include more information on the making of the major styles of the wines of the world, which should be of interest to those who are not engaged in study, but who have an enquiring mind and therefore want to know the mechanisms behind their production. Hugh Johnson writes in the Foreword: I'm not sure whether to call this book a primer, a memory-jogger or a lifesaver. Which it is depends on the reader. For WSET students it is essentially the first, then the second. For people like me it is the third- than rather belatedly the first. What we all need is a crisp exposition of how wine is made and why, easy to refer to when a funny smell appears, to cover the physics, natural history, legislation and finally the appreciation of wine. David's first edition has been my stand-by for years. I have my Peynaud, my Amerine & Joslyn, my Michael Schuster for going deeper in certain areas where necessary, but I wouldn't be without Bird in the hand. This fourth edition adds freshly-focused insight into the production of the principal styles of the wines of the world, making it equally interesting for those who are simply lovers of wine and for those who are serious students of the Master of Wine examination. New concepts such as Orange, organic, biodynamic and 'natural' wines have been added to the public's vocabulary - leaving many baffled and curious. Modern food legislation adds another obstacle course for the winemaker to negotiate. The detailed explanation of the mysteries of Hazard Analysis make this book particularly useful for wineries that are faced with the new problems of food safety legislation. Essentially, though, this is the classic Bird, much updated from the third edition and available once more to ease the pangs of students young and old.

Reviews all known antifoam mechanisms, and discusses the appropriate practical approaches for solving foam control problems in a variety of industrial contexts. These range from crude oil production to detergent formulation.

Topical and transdermal drug delivery systems (TDDs) have several advantages over traditional drug delivery methods, as they can be less invasive, more sanitary, more cost-effective, and may result in better patient compliance. TDDs play a significant role in therapeutics with a variety of preparations and approaches designed by expert formulation scientists. This volume integrates a wide variety of case studies, research, and theories to reveal their diversity and capture the novel approaches of transdermal and topical drug delivery employed by developers and content experts in the field. It provides an abundance of important information and state-of-the-art research on topical and transdermal drug delivery systems and addresses the basics of drug delivery systems, strategies to enhance permeation across membranes, and formulation and evaluation of diverse dosage forms. The volume presents an evaluation of the pros and cons of conventional drug delivery systems against TDDs and discusses the nuances of micro- and nano-systems in TDDs. The extraordinary packages of nano systems (vesicular systems, polymeric nanoparticles, nanoemulsion and dendrimers) are broadly discussed, and their applications are reviewed through a transdermal route. The book looks at TDDs and the main nanoparticles used in skin diseases and lesions of the aging, such as psoriasis, vitiligo, cancer, lesions of the aging and others. Chapters also discuss polymeric micelles in topical and transdermal delivery; microneedles; emulsion, nanoemulsion and microemulsion; TDDs in pulmonary drug delivery systems; nanoencapsulated nasal drug delivery systems; skin sensitivity and irritation testing for transposing transdermal drug delivery systems; and regulatory aspects of drug development for dermal products. Topical and Transdermal Drug Delivery Systems: Applications and Prospects will be a valuable resource for pharmaceutical scientists and researchers, industry professionals, and academicians and students of the pharmaceutical and biomedical sciences.

Worldwide interest in Ayurveda is on the rise, ever since the World Health Organization adopted the Alma Ata Declaration in 1978. Ayurveda is increasingly being adopted and many phytotherapy schools in Europe and the Americas teach Ayurveda as a wellness system. Considering the prominent position that Aṣṭ�ṅgahṛdaya occupies in Ayurveda, a scientific synopsis of this masterpiece is now presented before the world of Ayurveda. In eight comprehensive chapters, Aṣṭ�ṅgahṛdaya: A Scientific Synopsis of the Classic Ayurveda Text presents a lucid summary of the teachings of V�gbhaṭa. Ayurvedic view of the human body, basic principles of Ayurveda, surgical armamentarium, diagnosis and treatment of diseases, herbs and other medicinal substances used in the preparation of various dosage forms, ayurvedic pharmaceutialcs, ayurvedic approach to food fortification, salient features of Aṣṭ�ṅgahṛdaya and a roadmap for the future are among the topics discussed. Key Features: Presents the ayurvedic view of conception and the human body. Discusses aspects of ayurvedic pharmaceuticals. Examines diagnosis of diseases, lines of treatment, prognosis of diseases, signs of imminent death, management of mishaps and treatment of new diseases. The voluminous information pertaining to the subjects of the various chapters is presented in the form of many tables for ready reference and quick survey. This book provides a helping hand to those interested in rediscovering the teachings of V�gbhaṭa and is a great resource for researchers of medicine, traditional and alternative medicine, pharmacology and drug discovery.

Authored by world experts, the Handbook of Food Processing, Two-Volume Set discusses the basic principles and applications of major commercial food processing technologies. The handbook discusses food preservation processes, including blanching, pasteurization, chilling, freezing, aseptic packaging, and non-thermal food processing. It describes common food engineering unit operations as well as preservation processes required to convert raw materials into final products. Also covered are topics surrounding food safety and quality. Highlights: Case study on the effect of blanching conditions on sulforaphane content in purple and roman cauliflower (brassica oleracea l. Var. Botrytis) Principles of thermal processing described along with thermal process calculations Case study on microwave preservation of fruit-based products: application to kiwifruit puree Principles and applications of Ohmic heating Advances in food additives and contaminants Use of edible films and coatings in fresh fruits and vegetables preservation Handling and management of raw materials of foods Sensory evaluation of foods Hygiene and food sanitation Case studies on the implementation of ISO22000, HACCP, and other management tools for the implementation of food safety-traceability Food waste management case studies from the food industry along with life cycle analysis This two-volume set brings together aspects of food preservation and food processing operations methods of the basic food manufacturing processes addressing the relevant food safety and quality issues. Taking an innovative approach, the editors combine coverage of food preservation methods, the equipment needed to carry them out, and food processing operations methods of basic food manufacturing processes. The set helps you keep up with diverse consumer demands and rapidly developing markets.

Covers the various pharmacological and therapeutic aspects of bioactive compounds. Analyses their methods of extraction, their phytochemistry, their pharmacological and biological activities, their medicinal properties, and their applications for disease management and prevention.

The global lubricants market exceeds $110 billion, with strong future-estimated annual growth projections. While much has been written about the technical aspects of lubricant development, Lubricant Marketing, Selling, and Key Account Management fills a need for a comprehensive guide on the important commercial aspects of the business, offering unique and valuable insights from a veteran of the industry. It answers questions and offers insights on how to effectively market and sell all types of lubricants, including automotive, industrial, mining, marine, agricultural and aerospace, among others. Covers how and why people and companies buy lubricants. Instructs readers how to research and analyze markets and use the results to plan marketing and sales campaigns and activities. Details how to identify specific target market segments and sell to key lubricant accounts. Discusses how to forecast future demand for lubricants in all types of global markets. This practical book is written for technical and non-technical readers involved in the sale and management of lubricant products and offers hands-on guidance for how to successfully navigate and grow your profitability in this vitally important product sector.

Application of additive manufacturing and tissue engineering in the fields of science and technology enables the manufacturing of biocompatible, customized, reliable, and cost-effective parts, restoring the functionality of a failed human body part. This book offers a platform for recent breakthroughs in additive manufacturing related to biomedical applications. This book highlights some of the top innovations and advances in additive manufacturing and processing technologies that are the future of the manufacturing industry while also presenting current challenges and opportunities regarding the choice of material. This book includes areas of applications such as surgical guides, tissue regeneration, artificial scaffolds, implants, and drug delivery and release. Throughout the book, an emphasis is placed on rapid tooling for engineering applications. Additive Manufacturing of Polymers for Tissue Engineering: Fundamentals, Applications, and Future Advancements acts as a first-hand source of information for academic scholars and commercial manufacturers as they make strategic manufacturing and development plans.

Fibre reinforced composite materials are showing sustained growth in an ever widening range of applications from food trays to spacecraft as well as contributing to resolving environmental problems, including enabling the forthcoming hydrogen economy to be realised. This second edition of Fundamentals of Fibre Reinforced Composite Materials has been fully updated throughout, providing an authoritative and modern introduction to the topic with a brief history of composite development, a review of composite applications, manufacture and markets, types of fibres and matrices used, and their properties with a detailed introduction into the computer simulation of composite behaviour. With extensive sets of sample problems accompanying each chapter, this book is ideally suited to undergraduate and graduate students of materials science, structural, mechanical, and aeronautical engineering, polymer science, metallurgy, and other courses. It will also be of use as a reference to researchers and engineers working with composite materials and material scientists in general. Features: Presents thorough discussions on composite history, composite applications and markets, types of fibres and resins used, and their respective properties Relates mathematical concepts to the structure of the material under discussion leading to the quantitative evaluation of safety factors Provides numerous sets of sample problems in each chapter

The Toyota Production System (TPS) is regarded as a sophisticated concept that helps us understand the world of manufacturing. It evolved from the system of mass-producing cars, established by Ford, and the Japanese have since endeavored to make their own universal production system. Though much has been accomplished, TPS' progress is a continuous process. The theme of this book is how to understand and learn TPS. There is a TPS concept that seems to elude many, and that is that manufacturers should be able to make a product available at the moment a customer comes and asks for it. There are various ways and various tools that can be used to pursue the ideal state, and therefore we need to focus on the basic principles of TPS. This book tries to explain those Toyota Production System concepts that may otherwise be elusive. This book focuses on the factory to help readers understand the fundamental ideology of TPS. The main character started his career as a technical expert in the R&D division of an automotive Company and eventually becomes an Instructor of TPS. His broad career in companies is used to vividly describe the form of the Toyota Production System. To explain the growth of apprentices of various titles and positions, this story is woven with several short stories presented from the perspective of the main character, who grows from being a group leader to section leader to manager to general manager. Essentially, this book describes the Toyota Production System as based on the philosophy: "Always sketching out and pursuing the ideal state of manufacturing."

Discusses advances in the computation of phase diagrams Offers expanded treatment of eutectic solidification with practical examples and new coverage of ternary phase diagrams, covering the concepts of orthoequilibrium and paraequilibrium Updates discussion of bainite transformation to reflect current opinions Includes new case studies covering grain refiners in aluminium alloys, additive manufacturing, thin film growth, important aerospace Al-Li alloys, and quenched and partitioned steels, and metastable austenitic stainless steels. Each chapter now begins with a list of key concepts, includes simpler illustrative exercises with relevance to real practical applications, and references to scientific publications updated to reflect experimental and computational advances in metallurgy

Comprehensive Gut Microbiota, Three Volume Set provides new insights into gut microbiota as a critical mediator of human health and well-being. Comprehensive chapters, split across three volumes, present trusted and authoritative sources of information for novel human gut microbiome and health research. The book focuses on the fascinating intestinal microbiome and its interaction with food, food bioactive components, nutrition and human health. Chapters address the core science in the microbiota field and draw links between the microbiome, food, nutrition and health interaction. The text reflects the current state of evidence available in the field of microbiota, its regulation at the individual and population level, and the importance of the microbiome to human health. Each section includes introductory chapters that present key concepts about the section objective. Later sections focus on the novel findings of the gut microbiome, food and nutrition science. Human studies and systematic literature reviews are also discussed throughout the work.

This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms.
Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions.
Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference.

Explores Cost Impact of Process Intensification, and their relative magnitudes, as a universal metric. Covers a range of industrial applications, including heat and mass transfer, atomization and comminution, and nano-composite synthesis. Discusses the application of Process Intensification for clean technology and environmental remediation. Includes end-of-chapter problems, examples, and case studies.

An outstanding resource which enables readers to better understand the conditions that led to these Nobel Prize amazing discoveries To an extent the roots of organic chemistry have been forgotten or lost and this set of volumes bridges the gap Unique set of volumes, no other book publication in the field competes and only press releases announcing the prizes from recent years exist "More than any other branch of chemistry, organic chemists look to history, so the readers will certainly enjoy this compilation " Appeals to a diverse audience including upcoming as well as modern practicing chemists, and provides the historical context of these discoveries

The manufacturing industries remain the foundation of local, regional, and global economies. Manufacturing plants operate in dynamic markets that demand upgrading with transformational technologies for maintaining profitability, competitiveness, and business sustainability. Yet most manufacturing plants currently use technologies that are no longer competitive and industry leaders face an overwhelming array of operational challenges that require agile and enhanced transformational solutions. This book offers manufacturers effective strategies and tools for the adoption and implementation of advanced operational technologies to ensure long-term innovation, efficiency, and profitability. The book covers advanced automation integration in manufacturing, including digitization, AI, machine learning, IIoT, and cybersecurity. It describes innovation, development, and integration of control technologies for sustainable manufacturing. It explains how to upgrade existing manufacturing plants for the global market. It shows how to apply emerging technologies including asset optimization and process integration for product lifecycle improvements, plant operation and maintenance enhancement, and supply chain integration. This book serves as a strategic guide to applying advanced operational technologies for engineers, industry professionals, and management in the manufacturing sector.

This book is a hands-on single-source reference of tools, techniques, and processes integrating both Lean and Six Sigma. This comprehensive handbook provides up-to-date guidance on how to use these tools and processes in different settings, such as start-up companies and stalled projects, as well as establish enterprises where the ongoing drive is to improve processes, profitability, and long-term growth. It contains the "hard" Six Sigma approach as well as the flexible approach of FIT SIGMA, which is adaptable to manufacturing and service industries and also public sector organisations. You will also discover how climate change initiatives can be accelerated to sustainable outcomes by the holistic approach of Green Six Sigma. The book is about what we can do now with leadership, training, and teamwork in every sphere of our businesses. Lean, originally developed by Toyota, is a set of processes and tools aimed at minimising wastes. Six Sigma provides a set of data-driven techniques to minimise defects and improve processes. Integrating these two approaches provides a comprehensive and proven approach that can transform an organisation. To make change happen, we need both digital tools and analog approaches. We know that there has been a continuous push to generate newer approaches to operational excellence, such as Total Quality Management, Six Sigma, Lean Sigma, Lean Six Sigma, and FIT SIGMA. It is vital that we harness all our tools and resources to regenerate the economy after the Covid-19 pandemic and make climate change initiatives successful for the survival of our planet. Six Sigma and its hybrids (e.g., Lean Six Sigma) should also play a significant part. Over the last three decades, operational performance levels of both public sector and private sector organisations improved significantly and Lean Six Sigma has also acted as a powerful change agent. We urgently need an updated version of these tools and approaches. The Green Six Sigma Handbook not only applies appropriate Lean and Six Sigma tools and approaches, fitness for the purpose, but it aims at sustainable changes. This goal of sustainability is a stable bridge between Lean Six Sigma and climate change initiatives. Hence, when the tools and approaches of Lean Six Sigma are focused and adapted primarily to climate change demands, we get Green Six Sigma.

Datsun 510 (PL521 Pickup) 1968-73 Shop Manual Haynes.

This compilation on the degradation of 1,100 commercially important chemical products is the first publication to make this knowledge publicly accessible in one book. The data and annotations have been painstakingly assembled over a 10-year period in a collaboration between academia and regulatory authorities. The work explains in detail the methods, including computational ones, for the environmental assessment of volatile and semi-volatile substances, and is rounded off with data tables of degradation rates.
A key resource for manufacturers and regulators of such substances.

Copper Plate Photogravure describes in comprehensive detail the technique of traditional copper plate photogravure as would be practiced by visual artists using normally available facilities and materials. Attention is paid to step-by-step guidance through the many stages of the process. A detailed manual of technique, Copper Plate Photogravure also offers the history of the medium and reference to past alternative methods of practice. Copper Plate Photogravure: Demystifying the Process is part of the current revitalization of one of the most satisfyingly beautiful image-making processes. The range of ink color and paper quality possibilities is endless. The potential for handwork and alteration of the copper plate provides yet another realm of expressive variation. The subject matter and the treatment are as variable and broad as photography itself. This book's purpose is to demystify and clarify what is a complex but altogether "do-able" photomechanical process using currently available materials. With Copper Plate Photogravure, you will learn how to: * produce a full-scale film positive from a photographic negative * sensitize the gravure tissue to prepare it for exposure to the positive * prepare the plate and develop the gelatin resist prior to etching * prepare the various strengths of etching solutions and etch the plate to achieve a full tonal scale * rework the plate using printmaking tools to correct flaws or to adjust the image for aesthetic reasons * use the appropriate printing inks, ink additives, quality papers, and printshop equipment to produce a high quality print A historical survey and appendices of detailed technical information, charts, and tables are included, as well as a list of suppliers and sources for the materials required, some of which are highly specialized. A comprehensive glossary introduces the non-photographer or non-printmaker to many of the terms particular to those fields and associated with this process.

Business Intelligence (BI) is a solution to modern business problems. This book discusses the relationship between BI and Human Resource Management (HRM). In addition, it discusses how BI can be used as a strategic decision-making tool for the sustainable growth of an organization or business. BI helps organizations generate interactive reports with clear and reliable data for making numerous business decisions. This book covers topics spanning the important areas of BI in the context of HRM. It gives an overview of the aspects, tools, and techniques of BI and how it can assist HRM in creating a successful future for organizations. Some of the tools and techniques discussed in the book are analysis, data preparation, BI-testing, implementation, and optimization on GR and management disciplines. It will include a chapter on text mining as well as a section of case studies for practical use. This book will be useful for business professionals, including but not limited to, HR professionals, and budding business students.