In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight.The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well.

"A Practical Guide to Frozen Section Technique" offers an easy to learn approach to frozen section technique in the form of a highly illustrated handbook intended for onsite use in the laboratory. The book begins with a novel, clearly delineated, step by step approach to learning continuous motion brush technique. Emphasis is placed on recognizing and correcting artifacts during the preparation process. The book addresses all of the steps in the preparation of slides from cutting through cover-slipping. The author's unique, original techniques for tissue embedding including face down embedding in steel well bars, frozen block cryoembedding and paper cryoembedding are detailed.Variables key to the quality of the preparation including block temperature, tissue properties and section thickness are detailed. The book also covers understanding the cryostat and basic maintenance and care. Sections covering techniques used in Mohs dermatologic surgery, and techniques used in basic animal and human research are discussed by noted experts in their field. "A Practical Guide to Frozen Section Technique" will be of great value to pathologists, pathology residents in training and also experimental pathology researchers that rely upon this methodology to perform tissue analysis in research.

Depuis sa premiere edition en 1983, il y a plus de vingt ans, le Manuel de securite biologique en laboratoire a donne des conseils pratiques sur les techniques de securite a appliquer dans les laboratoires a tous les niveaux. La bonne application des techniques microbiologiques et l'utilisation de l'equipement de securite biologique par du personnel bien entraine restent les piliers de la securite en laboratoire. Toutefois, la mondialisation, les progres technologiques, l'apparition de nouvelles maladies et les graves menaces liees a une utilisation ou a une mise en circulation deliberees de micro-organismes ou de toxines ont impose de revoir les procedures. Pour cette nouvelle edition, le manuel a donc ete considerablement revu et developpe.Le manuel couvre desormais aussi l'evaluation du risque et l'utilisation sans risque des techniques faisant appel a l'ADN recombinant. Il donne par ailleurs des lignes directrices pour la mise en service et la certification des laboratoires. Il presente les concepts de la securite biologique et les reglementations internationales les plus recentes sur le transport des matieres infectieuses. On y a egalement integre les informations sur la securite dans les laboratoires d'analyses medicales, publiees auparavant dans d'autres documents de l'OMS. Nous esperons que le manuel continuera d'inciter les pays a instituer des programmes de securite biologique et des codes nationaux de bonnes pratiques pour manipuler sans danger les matieres potentiellement infectieuses."

"Lab Literacy for Canadian Doctors" helps you to make better decisions about the right tests for typical clinical situations, quickly and efficiently, to improve patient care. Refer to this essential guide for: Advice and information on lab errors, false positives and negatives, and blood and tissue collection. A quick index summarizing the clinical utility of common tests. Sections on dermatology, ENT and respiratory system, endocrine system, fatigue, GI and hepatic system, gynecology and pregnancy, routine screening, and more.

Lieber EXPERIMENTATOR, dieses Buch vermittelt Ihnen das nAtige Grundlagenwissen und ist eine Orientierungshilfe im verwirrenden Dschungel von Zellen, Medien, Seren, GerAten und Vorschriften. Anschauliche Vergleiche und Beispiele sowie der lockere Schreibstil machen es zu einer informativen und spannenden LektA1/4re. HAufig auftretende Probleme (z.B. Kontaminationen in der Zellkultur) werden eingehend behandelt und LAsungsvorschlAge angeboten. Die 2. Auflage wurde um das Thema Kreuzkontaminationen und falsch identifizierte Zelllinien erweitert. Schwerpunkte wie Steriltechnik, Subkultur, AdhAsion und Detachment, Kryokonservierung und Langzeitlagerung von Zellen sowie zellbiologische Methoden werden verstAndlich dargestellt. Der Einsatz neuer Techniken wie siRNA wird an einem aktualisierten Praxisbeispiel erklArt und um einen Beitrag zur in vitro-Differenzierung mesenchymaler Stammzellen ergAnzt.

DarA1/4ber hinaus enthAlt das Buch eine A1/4berarbeitete Sammlung von Ressourcen fA1/4r die Beschaffung von Zelllinien, Kontaktadressen fA1/4r Fortbildungskurse und Dienstleistungsangebote rund um die Zellkultur sowie Listen informativer Datenbanken und nA1/4tzlicher Adressen. Solch ein umfangreicher Fundus lAdt Sie zum StAbern und SchmAkern ein und bietet auch dem erfahrenen Zellkultur-Profi neue Informationen. Diese Auflage bietet einen Aoeberblick A1/4ber den neuesten Stand von Verordnungen und Regelwerken.

Das Buch richtet sich an Studierende, Praktikanten, technische Assistent(inn)en, Diplomanden, Doktoranden und an alle, die sich neben einem "Kochbuch" zur Zellkultur einen Begleiter im Laboralltag wA1/4nschen, der Hilfestellung bei Problemen anbietet, erst recht wenn Murphys Gesetz mal wieder zugeschlagen hat.

The book brings together experts working in public health and multi-disciplinary areas to present recent issues in statistical methodological development and their applications. This timely book will impact model development and data analyses of public health research across a wide spectrum of analysis. Data and software used in the studies are available for the reader to replicate the models and outcomes. The fifteen chapters range in focus from techniques for dealing with missing data with Bayesian estimation, health surveillance and population definition and implications in applied latent class analysis, to multiple comparison and meta-analysis in public health data. Researchers in biomedical and public health research will find this book to be a useful reference and it can be used in graduate level classes.