The biological and social sciences often generalize causal conclusions from one context or location to others that may differ in some relevant respects, as is illustrated by inferences from animal models to humans or from a pilot study to a broader population. Inferences like these are known as extrapolations. The question of how and when extrapolation can be legitimate is a fundamental issue for the biological and social sciences that has not received the attention it deserves. In Across the Boundaries, Steel argues that previous accounts of extrapolation are inadequate and proposes a better approach that is able to answer methodological critiques of extrapolation from animal models to humans.
Across the Boundaries develops the thought that knowledge of mechanisms linking cause to effect can serve as a basis for extrapolation. Despite its intuitive appeal, this idea faces several obstacles. Extrapolation is worthwhile only when there are stringent practical or ethical limitations on what can be learned about the target (say, human) population by studying it directly. Meanwhile, the mechanisms approach rests on the idea that extrapolation is justified when mechanisms are the same or similar enough. Yet since mechanisms may differ significantly between model and target, it needs to be explained how the suitability of the model could be established given only very limited information about the target. Moreover, since model and target are rarely alike in all relevant respects, an adequate account of extrapolation must also explain how extrapolation can be legitimate even when some causally relevant differences are present.
Steel explains how his proposal can answer thesechallenges, illustrates his account with a detailed biological case study, and explores its implications for such traditional philosophy of science topics ceteris paribus laws and reductionism. Finally, he considers whether mechanisms-based extrapolation can work in social science.

Restoring Layered Landscapes brings together historians, geographers, philosophers, and interdisciplinary scholars to explore ecological restoration in landscapes with complex histories shaped by ongoing interactions between humans and nature. For many decades, ecological restoration - particularly in the United States - focused on returning degraded sites to conditions that prevailed prior to human influence. This model has been broadened in recent decades, and restoration now increasingly focuses on the recovery of ecological functions and processes rather than on returning a site to a specific historical state. Nevertheless, neither the theory nor the practice of restoration has fully come to terms with the challenges of restoring layered landscapes, where nature and culture shape one another in deep and ongoing relationships. Former military and industrial sites provide paradigmatic examples of layered landscapes. Many of these sites are not only characterized by natural ecosystems worth preserving and restoring, but also embody significant political, social, and cultural histories. This volume grapples with the challenges of restoring and interpreting such complex sites: What should we aim to restore in such places? How can restoration adequately take the legacies of human use into account? Should traces of the past be left on the landscape, and how can interpretive strategies be creatively employed to make visible the complex legacies of an open pit mine or chemical weapons manufacturing plant? Restoration aims to create new value, but not always without loss. Restoration often disrupts existing ecosystems, infrastructure, and artifacts. The chapters in this volume consider what restoration can tell us more generally about the relationship between continuity and change, and how the past can and should inform our thinking about the future. These insights, in turn, will help foster a more thoughtful approach to human-environment relations in an era of unprecedented anthropogenic global environmental change.

In the later part of the 20th century, the United States experienced a remarkable surge in public interest toward medicinal and aromatic crops and this trend continues. This consumer interest helped create a significant demand for plants with culinary and medicinal applications as the public discovers their benefits for a wide range of applications. Consequently, this consumer call has generated a huge demand on farmers, but has also provided opportunities for new agricultural crops to support both fresh and dry raw material markets. Processing raw materials for end use by consumers introduces even more variables at all levels from harvesting to final desired product. Maintaining quality and authenticity throughout this process has inspired farmers, processing facilities, and regulatory agencies to adopt new practices and new laws to maintain safety and quality. Maintaining this quality and authenticity is often made possible using analytical methods for quality control, which subsequently triggered a demand for both regulatory agencies and scientists throughout the world. For aforementioned reasons, it is imperative that scientists continue to explore related topics from the field to the final consumer product. This book touches on many of the issues currently being addressed by scientists working to produce the desired consumer product while maintaining authenticity and quality and environmental stewardship.

The theory of Riemann surfaces occupies a very special place in mathematics. It is a culmination of much of traditional calculus, making surprising connections with geometry and arithmetic. It is an extremely useful part of mathematics, knowledge of which is needed by specialists in many other fields. It provides a model for a large number of more recent developments in areas including manifold topology, global analysis, algebraic geometry, Riemannian geometry, and diverse topics in mathematical physics.
This graduate text on Riemann surface theory proves the fundamental analytical results on the existence of meromorphic functions and the Uniformisation Theorem. The approach taken emphasises PDE methods, applicable more generally in global analysis. The connection with geometric topology, and in particular the role of the mapping class group, is also explained. To this end, some more sophisticated topics have been included, compared with traditional texts at this level. While the treatment is novel, the roots of the subject in traditional calculus and complex analysis are kept well in mind.
Part I sets up the interplay between complex analysis and topology, with the latter treated informally. Part II works as a rapid first course in Riemann surface theory, including elliptic curves. The core of the book is contained in Part III, where the fundamental analytical results are proved. Following this section, the remainder of the text illustrates various facets of the more advanced theory.

This textbook offers an accessible, modern introduction at undergraduate level to an area known variously as general topology, point-set topology or analytic topology with a particular focus on helping students to build theory for themselves. It is the result of several years of the authors' combined university teaching experience stimulated by sustained interest in advanced mathematical thinking and learning, alongside established research careers in analytic topology. Point-set topology is a discipline that needs relatively little background knowledge, but sufficient determination to grasp ideas precisely and to argue with straight and careful logic. Research and long experience in undergraduate mathematics education suggests that an optimal way to learn such a subject is to teach it to yourself, pro-actively, by guided reading of brief skeleton notes and by doing your own spadework to fill in the details and to flesh out the examples. This text will facilitate such an approach for those learners who opt to do it this way and for those instructors who would like to encourage this so-called 'Moore approach', even for a modest segment of the teaching term or for part of the class. In reality, most students simply do not have the combination of time, background and motivation needed to implement such a plan fully. The accessibility, flexibility and completeness of this text enable it to be used equally effectively for more conventional instructor-led courses. Critically, it furnishes a rich variety of exercises and examples, many of which have specimen solutions, through which to gain in confidence and competence.

This manual provides an easy guide to pain management for the veterinary practitioner. Beginning with pain terminology, it goes on to describe to physiology of pain, management strategies, various drugs and techniques, and the management of specific conditions and procedures. Strategies for the treatment of pain are comprehensively reviewed, with an overview of the mechanisms by which pain is perceived and the principles of pain management. The drugs currently used in the treatment of acute and chronic pain are discussed as well as the specific techniques that can be used to control intra- and post operative pain in dogs and cats. The book covers a broad range of information on specific aspects of pain management from analgesic techniques to management of chronic pain to pain perception. Published by Teton New Media USA and distributed by CRC Press outside of North America.

The world-wide sales of polysiloxanes or silicones at the beginning of this new millennium is approximately $10 billion per year. Commercial products range from those entirely composed of silicone to products where the silicone is a low level but key component. This symposium covered the recent academic and technological developments behind silicones and silicone-modified materials and the sessions were well attended of wide interest to both the academic and industrial communities. The papers from our two highly successful symposia in this important area were published in the books Silicones and Silicone-Modified Materials, (Eds. S. J. Clarson, J. J. Fitzgerald, M. J. Owen and S. D. Smith), ACS Symposium Series Vol. 729 / Oxford University Press, 2000, ISBN 0-8412-3613-5 and Synthesis and Properties of Silicones and Silicone-Modified Materials, (Eds. S. J. Clarson, J. J. Fitzgerald, M. J. Owen, S. D. Smith and M. E. Van Dyke), ACS Symposium Series Vol 838 / Oxford University Press, 2003, ISBN 0-8412-3804-9

The American Chemical Society Committee on Analytical Reagents is the only organization in the world that sets requirements and develops validated methods for determining the purity of analytical reagents. For the first time, Reagent Chemicals, 10th Edition includes general physical properties and analytical uses for all reagent chemicals, nearly 500 chemicals. Thirty-two new reagents and three new classes of standard grade reference materials are introduced in this edition. In addition, the use of Inductively Coupled Plasma Mass Spectrometry (ICP-MS), which is recognized as the most powerful and flexible trace element technique, is now accepted as an analytical method in the 10th edition. Other improvements include a CAS number index, a separate index for standard grade reference materials, updated atomic weights, frequently used mathematical equations, complete assay calculations with titer values, a tutorial on how to read a monograph, and detailed tables of contents introducing each section.

The UK's most trusted A level Mathematics resources With over 900,000 copies sold (plus 1.3 million copies sold of the previous edition), Pearson's own resources for Pearson Edexcel are the market-leading and most trusted for AS and A level Mathematics. This book can be used alongside the Year 1 book to cover all the content needed for the compulsory Edexcel A level Core Pure Mathematics exams Enhanced focus on problem-solving and modelling, as well as supporting the large data set and calculators Packed with worked examples with guidance, lots of exam-style questions, practice papers, and plenty of mixed and review exercises Full worked solutions to every question available free and online for quick and easy access. Plus free additional online content with GeoGebra interactives and Casio calculator tutorials Practice books also available offering the most comprehensive and flexible AS/A level Maths practice with over 2000 extra questions Includes access to an online digital edition (valid for 3 years once activated) Pearson Edexcel A level Further Mathematics Core Pure Mathematics Book 2 Textbook + e-book matches the Pearson Edexcel exam structure and is fully integrated with Pearson Edexcel's interactive scheme of work. All of the books in this series focus on problem-solving and modelling, as well as supporting the large data set and calculators. They are packed with worked examples with guidance, lots of exam-style questions, practice papers, and plenty of mixed and review exercises. There are full worked solutions to every question available free and online for quick and easy access. You will also have access to lots of free additional online content with GeoGebra interactives and Casio calculator tutorials. There are separate Pure and Applied textbooks for AS and A level Maths, and a textbook per option for AS and A level Further Maths. Practice books are also available offering the most comprehensive and flexible AS/A level Maths practice with over 2000 extra questions. Pearson's revision resources are the smart choice for those revising for Pearson Edexcel AS and A level Mathematics - there is a Revision Workbook for exam practice and a Revision Guide for classroom and independent study. Practice Papers Plus+ books contain additional full length practice papers, so you can practice answering questions by writing straight into the book and perfect your responses with targeted hints, guidance and support for every question, including fully worked solutions.

Understand the phases of the moon, learn to navigate by the North Star and discover how to travel through space and time from your own window in this book which uncovers how humankind has its history woven into the constellations that light up our skies. Written by NASA science writer Noelia González and fully illustrated by Sara Boccaccini Meadows, this is the perfect introduction to the night sky for families everywhere.

This book is a unique introduction to graph theory, written by one of its founding fathers. It is not intended as a comprehensive treatise, but rather as an account of those parts of the theory that have been of special interest to the author. Professor Tutte details his experiences in the area, and provides a fascinating insight into the processes leading to his proofs.

This series contains the most focused resources for the 'mainstream' modules of the AS and A-Level courses. Providing thorough exam preparation through detailed worked examples, practise questions and further practise on the CD-ROM, these are the most supportive, AQA revision resources available. Checked by examiners, students can have complete confidence in covering all the topics for their specification Maximises students' marks by honing their exam technique with examiner tips, a sample module paper and step-by-step solutions on CD-ROM Includes theory and strategies for answering each type of question with progressive questions and Powerpoint model answers to strengthen understanding and application. A perfect match to each module of AQA

The Shape of Thought: How Mental Adaptations Evolve presents a road map for an evolutionary psychology of the twenty-first century. It brings together theory from biology and cognitive science to show how the brain can be composed of specialized adaptations, and yet also an organ of plasticity. Although mental adaptations have typically been seen as monolithic, hard-wired components frozen in the evolutionary past, The Shape of Thought presents a new view of mental adaptations as diverse and variable, with distinct functions and evolutionary histories that shape how they develop, what information they use, and what they do with that information. The book describes how advances in evolutionary developmental biology can be applied to the brain by focusing on the design of the developmental systems that build it. Crucially, developmental systems can be plastic, designed by the process of natural selection to build adaptive phenotypes using the rich information available in our social and physical environments. This approach bridges the long-standing divide between "nativist" approaches to development, based on innateness, and "empiricist" approaches, based on learning. It shows how a view of humans as a flexible, culturally-dependent species is compatible with a complexly specialized brain, and how the nature of our flexibility can be better understood by confronting the evolved design of the organ on which that flexibility depends.

The theory of relativity convinced many philosophers that space and time are fundamentally alike, and that they are mere aspects of a more fundamental space-time. In The Nature of Time, Ulrich Meyer argues against this consensus view. Instead of a 'spatial' account of time that treats instants like positions in space, he presents the first comprehensive defense of a 'modal' account that emphasizes the similarities between times and the possible worlds in modal logic. Modal accounts of time are naturally cast in terms of a tense logic that accounts for temporal distinctions in terms of primitive tense operators. Tense logic was originally developed to provide a linguistic theory of verb tense in natural languages, but here Meyer proposes that it can be treated as a metaphysical theory of the nature of time. Contrary to popular belief, such modal accounts of time do not commit us to the view that there is something metaphysically special about the present moment, and they are easily reconciled with the theory of relativity.

While the significance of networks in various human behavior and activities has a history as long as human's existence, network awareness is a recent scientific phenomenon. The neologism network science is just one or two decades old. Nevertheless, with this limited time, network thinking has substantially reshaped the recent development in economics, and almost all solutions to real-world problems involve the network element. This book integrates agent-based modeling and network science. It is divided into three parts, namely, foundations, primary dynamics on and of social networks, and applications. The authors begin with the network origin of agent-based models, known as cellular automata, and introduce a number of classic models, such as Schelling's segregation model and Axelrod's spatial game. The essence of the foundation part is the network-based agent-based models in which agents follow network-based decision rules. Under the influence of the substantial progress in network science in late 1990s, these models have been extended from using lattices into using small-world networks, scale-free networks, etc. The text also shows that the modern network science mainly driven by game-theorists and sociophysicists has inspired agent-based social scientists to develop alternative formation algorithms, known as agent-based social networks. It reviews a number of pioneering and representative models in this family. Upon the given foundation, the second part reviews three primary forms of network dynamics, such as diffusions, cascades, and influences. These primary dynamics are further extended and enriched by practical networks in goods-and-service markets, labor markets, and international trade. At the end, the book considers two challenging issues using agent-based models of networks: network risks and economic growth.

Storrs McCall presents an original philosophical theory of the nature of the universe based on a striking new model of its space-time structure. He shows that this theory can illuminate a wide variety of hitherto unresolved philosophical problems. These include: the direction and flow of time; the nature of scientific laws; the interpretation of quantum mechanics; the definition of probability; counterfactual semantics; and the notions of identity, essential properties, deliberation, decision, and free will. A particular instance of the explanatory powers of the proposed space-time model is its account of quantum non-locality in the EPR and GHZ experiments. Professor McCall argues that the fact that the model explains and throws light on such a broad range of problems constitutes strong evidence that the universe is as the model portrays it.

Developed for the new International A Level specification, these new resources are specifically designed for international students, with a strong focus on progression, recognition and transferable skills, allowing learning in a local context to a global standard. Recognised by universities worldwide and fully comparable to UK reformed GCE A levels. Supports a modular approach, in line with the specification. Appropriate international content puts learning in a real-world context, to a global standard, making it engaging and relevant for all learners. Reviewed by a language specialist to ensure materials are written in a clear and accessible style. The embedded transferable skills, needed for progression to higher education and employment, are signposted so students understand what skills they are developing and therefore go on to use these skills more effectively in the future. Exam practice provides opportunities to assess understanding and progress, so students can make the best progress they can.

The role of parasites and pathogens in the evolution of life history traits is of increasing interest to both ecologists and evolutionary biologists. Immunology, which was once studied almost exclusively by immunologists, has become an important area of proximate investigation to animal physiologists as a means for understanding changes in disease susceptibility and the neural and neuroendocrine mechanisms that mediate these changes. The coalescence of these different perspectives has given rise to the field of ecological immunology, an interdisciplinary research field that examines interactions among host physiology and disease ecology in a wide range of environmentally relevant contexts. The goal of ecological immunology is to understand immune function in the context of life-history traits across a wide range of organisms. Research within the field combines diverse approaches from a wide range of scientific disciplines including evolution, ecology, and life history theory to endocrinology, neuroscience, molecular biology, and behavior. This book critically reviews recent advances in the discipline of ecoimmunology. Chapters are written by experts in their respective fields and cover diverse topics including how environmental factors can affect host immune function, the complex dynamics among host immunity, pathogen prevalence and disease susceptibility, and the physiological mechanisms that lead to adaptive changes in immune responses. By integrating analyses of immune system function within animal biology, investigators will gain will gain a more comprehensive and satisfying understanding of organism-environment interactions at both ultimate and proximate levels of analysis.

Trace and determinant functionals on operator algebras provide a means of constructing invariants in analysis, topology, differential geometry, analytic number theory, and quantum field theory. The consequent developments around such invariants have led to significant advances both in pure mathematics and theoretical physics. As the fundamental tools of trace theory have become well understood and clear general structures have emerged, so the need for specialist texts which explain the basic theoretical principles and computational techniques has become increasingly urgent. Providing a broad account of the theory of traces and determinants on algebras of differential and pseudodifferential operators over compact manifolds, this text is the first to deal with trace theory in general, encompassing a number of the principle applications and backed up by specific computations which set out in detail the nuts-and-bolts of the basic theory. Both the microanalytic approach to traces and determinants via pseudodifferential operator theory and the more computational approach directed by applications in geometric analysis, are developed in a general framework that will be of interest to mathematicians and physicists in a number of different fields.

Discover nontraditional applications of dielectric studies in this exceptionally crafted field reference or text for seniors and graduate students in power engineering tracks. This text contains more than 800 display equations and discusses polarization phenomena in dielectrics, the complex dielectric constant in an alternating electric field, dielectric relaxation and interfacial polarization, the measurement of absorption and desorption currents in time domains, and high field conduction phenomena. Dielectrics in Electric Fields is an interdisciplinary reference and text for professionals and students in electrical and electronics, chemical, biochemical, and environmental engineering; physical, surface, and colloid chemistry; materials science; and chemical physics.

Abstractionism, which is a development of Frege's original Logicism, is a recent and much debated position in the philosophy of mathematics. This volume contains 16 original papers by leading scholars on the philosophical and mathematical aspects of Abstractionism. After an extensive editors' introduction to the topic of abstractionism, five contributions deal with the semantics and meta-ontology of Abstractionism, as well as the so-called Caesar Problem. Four papers then discuss abstractionist epistemology, focusing on the idea of implicit definitions and non-evidential warrants (entitlements) to account for a priori mathematical knowledge. This is followed by four chapters concerning the mathematics of Abstractionism, in particular the issue of impredicativity, the Bad Company objection, and the question of abstractionist set theory. Finally, the last section of the book contains three contributions that discuss Frege's application constraint within an abstractionist setting.