Amyloids, Prions and Beta Proteins is the last volume of the three-part thematic series on Fibrous Proteins in the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells providing the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. This volume covers such topics as Beta-Structures in Fibrous Proteins; B-Silks: Enhancing and Controlling Aggregation; Beta-Rolls, Beta-Helices and Other Beta-Solenoid Proteins; Natural Triple B-Stranded Fibrous Folds; Structure, Function and Amyloidogenesis of Fungal Prions: Filament Polymorphism and Prion Variants; X-Ray Fiber and powder Diffraction of PRP Prion Peptides; From the Polymorphism of Amyloid Fibrils to Their Assembly Mechanism and Cytotoxicity; Structural Models of Amyloid-like Fibrils.

Linearity plays a critical role in the study of elementary differential equations; linear differential equations, especially systems thereof, demonstrate a fundamental application of linear algebra. In Differential Equations with Linear Algebra, we explore this interplay between linear algebra and differential equations and examine introductory and important ideas in each, usually through the lens of important problems that involve differential equations. Written at a sophomore level, the text is accessible to students who have completed multivariable calculus. With a systems-first approach, the book is appropriate for courses for majors in mathematics, science, and engineering that study systems of differential equations.
Because of its emphasis on linearity, the text opens with a full chapter devoted to essential ideas in linear algebra. Motivated by future problems in systems of differential equations, the chapter on linear algebra introduces such key ideas as systems of algebraic equations, linear combinations, the eigenvalue problem, and bases and dimension of vector spaces. This chapter enables students to quickly learn enough linear algebra to appreciate the structure of solutions to linear differential equations and systems thereof in subsequent study and to apply these ideas regularly.
The book offers an example-driven approach, beginning each chapter with one or two motivating problems that are applied in nature. The following chapter develops the mathematics necessary to solve these problems and explores related topics further. Even in more theoretical developments, we use an example-first style to build intuition and understanding before stating or proving general results. Over 100 figures provide visual demonstration of key ideas; the use of the computer algebra system Maple and Microsoft Excel are presented in detail throughout to provide further perspective and support students' use of technology in solving problems. Each chapter closes with several substantial projects for further study, many of which are based in applications.
Errata sheet available at: www.oup.com/us/companion.websites/9780195385861/pdf/errata.pdf

Devices of Curiosity excavates a largely unknown genre of early cinema, the popular-science film. Primarily a work of cinema history, it also draws on the insights of the history of science. Beginning around 1903, a variety of producers made films about scientific topics for general audiences, inspired by a vision of cinema as an educational medium. This book traces the development of popular-science films over the first half of the silent era, from its beginnings in England to its flourishing in France around 1910. Devices of Curiosity also considers how popular-science films exemplify the circulation of knowledge. These films initially relied upon previous traditions such as the magic-lantern lecture for their representational strategies, and they continually had recourse to established visual iconography, but they also created novel visual paradigms and led to the creation of ambitious new film collections. Finally, the book discerns a transit between nonfictional and fictional modes, seeing affinities between popular-science films and certain aspects of fiction films, particularly Louis Feuillade's crime melodramas. This kind of circulation is important for an understanding of the wider relevance of early popular-science films, which impacted the formation of the documentary, educational, and avant-garde cinemas.

In the last decade, science in the United States has become increasingly politicized, as government officials have been accused of manipulating, distorting, subverting, and censoring science for ideological purposes. Political gamesmanship has played a major role in many different areas of science, including the debate over global climate change, embryonic stem cell research, government funding of research, the FDA's approval process, military intelligence related to Iraq, research with human subjects, and the teaching of evolution in public schools.
In Playing Politics with Science, David B. Resnik explores the philosophical, political, and ethical issues related to the politicalization of science and develops a conceptual framework for thinking about government restrictions on scientific practice. Resnik argues that the public has a right and a duty to oversee scientific research to protect important social values and hold scientists accountable for their actions, but that inappropriate government control over science can erode the integrity and trustworthiness of research, hamper scientific creativity and innovation, undermine the fairness and effectiveness of government and policies informed by science, discourage talented researchers from working for the government, and violate the freedom of scientists.
Resnik also makes policy recommendations for protecting science from politicalization, and maintains that scientific autonomy and government control must be properly balanced so that restrictions on science can benefit society without undermining scientific research, education, and expert advice.

Volume 8: Hyphenated Methods

Starting with gas chromatography-mass spectrometry (GC-MS) and continuing through GCxGC-MS, LC-MSn, and LC-NMR-MS, hyphenated methods have revolutionized chemical analysis. This volume covers that revolution in two parts. The first (Chapters 1-4) describes principles, instrumentation, and technology, and the second (Chapters 5-10) organizes major application areas in GC-MS and LC-MS.

After a general introduction (Chapter 1), attention is paid to principles and instrumentation of GC-MS (Chapter 2) and LC-MS (Chapter 3). Other hyphenated methods, including online combinations of capillary electromigration methods and supercritical fluid chromatography with mass spectrometry, are in Chapter 4.

Applications are then covered in the remaining chapters. The application-oriented chapters are focused on the role of mainly LC-MS in the pharmaceutical field (Chapter 5) and biochemical and biotechnological applications (Chapter 10), and the application of both GC-MS and LC-MS in relation to environmental analysis (Chapter 6), food safety and food analysis (Chapter 7), characterization of natural products (Chapter 8), and clinical, toxicological, and forensic analysis (Chapter 9).
. Covers principles, instrumentation and applications of hyphenated methods involving mass spectrometry
. Details applications of hyphenated methods in the most important fields
. Written in the style of tutorials, providing sufficient detail to bring the reader up-to date on the subject area"

Modelling and Control in Biomedical Systems (including Biological Systems) was held in Reims, France, 20-22 August 2006. This Symposium was organised by the University of Reims Champagne Ardenne and the Societe de l Electricite, de l Electronique et des TIC (SEE).
The Symposium attracted practitioners in engineering, information technology, mathematics, medicine and biology, and other related disciplines, with authors from 24 countries. Besides the abstracts of the four plenary lectures, this volume contains the 92 papers that were presented by their authors at the Symposium
The papers included two invited keynote presentations given by internationally prominent and well-recognised research leaders: Claudio Cobelli, whose talk is titled "Dynamic modelling in diabetes: from whole body to genes"; and Irving J. Bigio, whose talk is titled "Elastic scattering spectroscopy for non-invasive detection of cancer." Two prestigious industrial speakers were also invited to give keynote presentations: Terry O'Brien from LIDCO, whose talk is titled "LIDCO: From the laboratory to protocolized goal directed therapy"; and Lorenzo Quinzio of Philips, whose talk is titled "Clinical decision support in monitoring and information systems."
* A valuable source of information on the state-of- the-art in Modelling and Control in Biomedical Systems
* Including abstracts of four plenary lectures, and 92 papers presented by their authors"

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.
* Includes many descriptive figures
* Topics covered include neurodegenerative diseases, extracellular matrix proteins, fibrillins and more
* Latest volume in the series that covers seven reviews in 288 pages

Volume 6: Ionization Methods

Volume 6 captures the story of molecular ionization and its phenomenal evolution that makes mass spectrometry the powerful method it is today. Chapters 1 and 2 cover fundamentals and various issues that are common to all ionization (e.g., accurate mass, isotope clusters, and derivatization).

Chapters 3-9 acknowledge that some ionization methods are appropriate for gas-phase molecules and others for molecules that are in the solid or liquid states. Chapters 3-6 cover gas-phase molecules, dividing the subject into: (1) ionization of gas-phase molecules by particles (e.g., EI), (2) ionization by photons, (3) ionization by ion-molecule and molecule-molecule reactions (e.g., APCI and DART), and ionization in Strong electric fields (i.e., Electrohydrodynamic and Field Ionization/Desorption).

"Ionization in a Strong Electric Field" illustrates the transition to ionization of molecules in the solid or liquid states, covered in Chapters 7-9: (1) spray methods for ionization (e.g., electrospray), (2) desorption ionization by particle bombardment (e.g., FAB), and (3) desorption by photons (e.g., MALDI). Electrospray and MALDI also lead to applications in biophysical chemistry, the theme of Chapter 10.

Chapter 11 reconsiders ionization from the view of choosing an ionization method. The range of subjects is from ionization of organic and biomolecules to the study of microorganisms.
* reviews range of ionization methods used in mass spectrometry today
* includes tutorials describing the principles and instrumentation applied to each method
* considers appropriate methods of ionization for analysis of various substances

Cognitive psychology has matured and flourished in the last half-century, as new theories, research tools, and theoretical frameworks have allowed cognitive psychologists and researchers to explore a broad array of topics. In the same vein, the depth of understanding and the methodological and theoretical sophistication have also grown in wonderful ways. Given the expanse of the field, an up-to-date and inclusive resource such as this handbook is needed for aspiring generalists who wish to read the book cover to cover, and for the many readers who are simply curious to know the current happenings in other cognition laboratories. Guided by this need, this volume's 64 chapters cover all aspects of cognition, spanning perceptual issues, attention, memory, knowledge representation, language, emotional influences, judgment, problem solving, and the study of individual differences in cognition. Additional chapters turn to the control of complex actions and the social, cultural, and developmental context of cognition. The authors include a mix of well-established influential figures and younger colleagues in order to gain an understanding of the field's forward trajectory. The volume also includes a mix of "tutorial" chapters and chapters that powerfully represent a particular research team's point of view.

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.
* Includes 20 color figures
* Latest volume in series, with eight reviews in more than 250 pages
* Topics covered include bone remodeling, ex vivo adult stem cell expansion, calcium sensing receptors and more

This volume consists of written chapters taken from the presentations at the symposium "100+ Years of Plastics: Leo Baekeland and Beyond," held March 22, 2010, at the 239th ACS National Meeting in San Francisco. The symposium celebrates the 100th anniversary of the formation of General Bakelite Corp., which was preceded by Leo Baekland's synthesis of Bakelite in 1907 and the unveiling of the Bakelite process in 1909. It is quite reasonable to use the synthesis of Bakelite as the starting point of the Age of Plastics. Indeed, Time magazine in its June 14, 1999, issue on the 100 most influential people of the 20th century chose Leo Baekeland and his Bakelite synthesis as the sole representative of chemistry.
Leo Baekeland and Bakelite are the topics of the first four chapters of this volume. The first two chapters come from the perspective of Baekeland family members. Carl Kaufmann is related to the Baekeland family through marriage and is the author of the only full-length biography of Baekeland, published as a master's thesis from the University of Delaware. As a family member Kaufmann had access to all of Baekeland's papers. This first chapter (Leo H. Baekeland) is not only a biographical sketch, but an exploration of Baekeland's effect on the chemical industry. Hugh Karraker is Baekeland's great-grandson, and his chapter (A Portrait of Leo H. Baekeland) provides a family picture of the great inventor. Gary Patterson's chapter (Materia Polymerica: Bakelite) goes into the history of Bakelite chemistry, while Burkhard Wagner's contribution (Leo Baekeland's Legacy-100 Years of Plastics) covers the history of Bakelite manufacture through time and space, finishing with a description of another Baekeland legacy, the Baekeland Award given through the North Jersey Section of the ACS.
In later chapters, Les Sperling (History of Interpenetrating Polymer Networks Starting with Bakelite-Based Compositions) covers the improvements in interpenetrating networks. James Economy and Z. Parkar (Historical Perspectives on Phenolic Resins and High-Temperature Aromatic Polyesters of p-Hydroxybenzoic Acid and Their Copolyesters) follow the paths of resoles, novolaks, and related chemicals.

The Nobel Prize is the only scientific prize that has achieved worldwide recognition among the general public. Each year, announcement of the prizes is covered by the national news media, and countries and universities brag about how many Nobel Prize winners they have. As of 2015, 172 individuals have received the Nobel Prize in chemistry. This book explores the reasons why the Nobel Prize has not been awarded to various deserving chemists over the years, and points specifically to eleven deceased chemists in particular who did not receive the Nobel Prize in Chemistry.

Recently, the 50th anniversary of the publication of Animal Behaviour has passed. To mark the occasion, a group of prominent behaviourists have written essays relevant to their fields. These essays provide a glimpse of the study of behaviour looking in all directions. History and future aside, it is imperative to broadcast this information from the perspective of the behaviourists who have helped shape both the past and the future. It is important for any field to be both retrospective and prospective: where have we been, where are we going, where are we now? These essays provide a unique personal reflection on the history of animal behaviour from John Alcock, Stuart and Jeanne Altmann, Steve Arnold, Geoff Parker, and Felicity Huntingford. Six topics are reflected on and include: The History of Animal Behavioural Research, Proximate Mechanisms, Development, Adaptation, and Animal Welfare.
* Broad range of essays on animal behaviour
* Written by leaders in the field
* Offers a history of the study of behaviour plus essays on the future of behavioural studies
* Contains over 30 full color illustrations
* Includes essays on development, mechanisms and adaptive significance of behaviour