The Porphyrin Handbook, Volume 15: Phthalocyanines: Synthesis provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into five chapters, this volume begins with an overview of the importance of compounds such as heme and chlorophyll that play vital roles in the biological systems responsible for the transportation of oxygen to cells in the body. This text then explores the different methods used for the preparation of phthalocyanine and its metallated derivatives. Other chapters consider the detailed survey of phthalocyanine formation, characterization, and purification. This book discusses as well the synthesis of low-symmetry phthalocyanines and related compounds. The final chapter deals with a survey of the structure, synthesis, and physiochemical properties of porphyrazines with annulated heterocycles. This book is a valuable resource for research scientists, engineers, and clinicians.

Loop groups, the simplest class of infinite dimensional Lie groups, have recently been the subject of intense study. This book gives a complete and self-contained account of what is known about them from a geometrical and analytical point of view, drawing together the many branches of mathematics from which current theory developed--algebra, geometry, analysis, combinatorics, and the mathematics of quantum field theory. The authors discuss Loop groups' applications to simple particle physics and explain how the mathematics used in connection with Loop groups is itself interesting and valuable, thereby making this work accessible to mathematicians in many fields.

Nanoscience and nanotechnology have functioned as effective "buzzwords " for at least a decade due to the unique properties that materials possess on the nanometer scale. The interest in nanoscience and nanotechnology is so great and so widespread that these topics are even being introduced at the K-12 level in some school districts. Nanoscience and nanotechnology have already improved many applications and have the potential to continue to do so, making it important for all types of scientists to stay up-to-date on research related to nanomaterials. In the first section of this book, a variety of synthetic methods used to make or functionalize nanomaterials are presented with work related to mesoporous materials, semiconductor nanowires, graphene, and carbon nanotubes included. The second section of the book presents accounts of using nanotechnology and nanoscience in a variety of ways. Overall, this book presents a snapshot of research covering synthetic studies of nanomaterials to applications of nanomaterials.

The volume begins with an overview of POGIL and a discussion of the science education reform context in which it was developed. Next, cognitive models that serve as the basis for POGIL are presented, including Johnstone's Information Processing Model and a novel extension of it.
Adoption, facilitation and implementation of POGIL are addressed next. Faculty who have made the transformation from a traditional approach to a POGIL student-centered approach discuss their motivations and implementation processes. Issues related to implementing POGIL in large classes are discussed and possible solutions are provided. Behaviors of a quality facilitator are presented and steps to create a facilitation plan are outlined.
Succeeding chapters describe how POGIL has been successfully implemented in diverse academic settings, including high school and college classrooms, with both science and non-science majors. The challenges for implementation of POGIL are presented, classroom practice is described, and topic selection is addressed. Successful POGIL instruction can incorporate a variety of instructional techniques. Tablet PC's have been used in a POGIL classroom to allow extensive communication between students and instructor. In a POGIL laboratory section, students work in groups to carry out experiments rather than merely verifying previously taught principles.
Instructors need to know if students are benefiting from POGIL practices. In the final chapters, assessment of student performance is discussed. The concept of a feedback loop, which can consist of self-analysis, student and peer assessments, and input from other instructors, and its importance in assessment is detailed. Datais provided on POGIL instruction in organic and general chemistry courses at several institutions. POGIL is shown to reduce attrition, improve student learning, and enhance process skills.

The Porphyrin Handbook, Volume 14: Medical Aspects of Porphyrins provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into 12 chapters, this volume begins with an overview of the underlying diagnostic features, mechanisms, and available treatments of erythropoietic disorders due to defective heme biosynthesis. This text then examines the physiopathology of acute intermittent porphyria, which is transmitted as autosomal dominant disorders with incomplete penetrance. Other chapters consider the main characteristics of congenital erythropoietic porphyria, which includes an increased synthesis, accumulation, ad excretion of porphyrins. This book discusses as well the biochemistry, pathophysiology, and clinical features of variegate porphyria in the light of several essential advances in the understanding, management, and diagnosis of variegate porphyria. The final chapter deals with the legal use of herbal and complementary medicines. This book is a valuable resource for research scientists, engineers, and clinicians.

It is well known that the class of steroid hormones known as estrogens have powerful effects on organs related to reproduction such as the uterus and the breast. What is less well known is that estrogens also profoundly modulate brain function and behavior. Estrogens, such as estradiol, can occur in brain as the result of ovarian secretion of the hormone into the blood that then finds its way to the brain. In male vertebrates, the testes secrete androgens, such as testosterone, into the blood and this class of steroid hormones can be converted into estrogens in the brain via the action of the enzyme aromatase which is expressed in the male brain in many species. Finally estradiol can be synthesized de novo from cholesterol as it has been shown in a variety of species that all the enzymes required to synthesize estrogens are expressed in the brain. This book collects chapters by experts in the field that considers, how estradiol is synthesized in the brain and what its effects are on a variety of behaviors. Special attention is paid to the enzyme aromatase that is distributed in discrete regions of the brain and is highly regulated in a sex specific and seasonal specific manner. Recently it has become clear that estrogens can act in the brain at two very different time scales, one is rather long lasting (days to weeks) and involves the modulation of gene transcription by the hormone-receptor complex. A second mode of action is much quicker and involves the action of estrogens on cell membranes that can result in effects on second messenger systems and ultimately behavior within minutes. Thus this book highlights novel views of estrogen action that are still under-appreciated namely that estrogens have significant effects on the male brain and that they can act on two very different times scales. This volume will be of interest to both basic researchers and clinicians interested in the action of estrogens.

This book gathers the lecture notes of courses given at the 2011 summer school in theoretical physics in Les Houches, France, Session XCVI. What is a quantum machine? Can we say that lasers and transistors are quantum machines? After all, physicists advertise these devices as the two main spin-offs of the understanding of quantum mechanical phenomena. However, while quantum mechanics must be used to predict the wavelength of a laser and the operation voltage of a transistor, it does not intervene at the level of the signals processed by these systems. Signals involve macroscopic collective variables like voltages and currents in a circuit or the amplitude of the oscillating electric field in an electromagnetic cavity resonator. In a true quantum machine, the signal collective variables, which both inform the outside on the state of the machine and receive controlling instructions, must themselves be treated as quantum operators, just as the position of the electron in a hydrogen atom. Quantum superconducting circuits, quantum dots, and quantum nanomechanical resonators satisfy the definition of quantum machines. These mesoscopic systems exhibit a few collective dynamical variables, whose fluctuations are well in the quantum regime and whose measurement is essentially limited in precision by the Heisenberg uncertainty principle. Other engineered quantum systems based on natural, rather than artificial degrees of freedom can also qualify as quantum machines: trapped ions, single Rydberg atoms in superconducting cavities, and lattices of ultracold atoms. This book provides the basic knowledge needed to understand and investigate the physics of these novel systems.

Developed for the new International A Level specification, these new resources are specifically designed for international students, with a strong focus on progression, recognition and transferable skills, allowing learning in a local context to a global standard. Recognised by universities worldwide and fully comparable to UK reformed GCE A levels. Supports a modular approach, in line with the specification. Appropriate international content puts learning in a real-world context, to a global standard, making it engaging and relevant for all learners. Reviewed by a language specialist to ensure materials are written in a clear and accessible style. The embedded transferable skills, needed for progression to higher education and employment, are signposted so students understand what skills they are developing and therefore go on to use these skills more effectively in the future. Exam practice provides opportunities to assess understanding and progress, so students can make the best progress they can.

This book summarizes the enormous amount of material accumulated in the field of nuclear density functional theory over the last few decades. The goal of the theory is to provide a complete quantum-mechanical description and explanation of nuclear phenomena in terms of the local density distribution as a basic ingredient rather than the many-particle wavefunction. This leads to a considerable reduction in the mathematical complexity of nuclear many-body problems and to a great conceptual simplicity and visual clarity in its theoretical treatment. The authors develop the mathematical framework on which the theory is based and consider the associated approaches used to analyse experimental data in a variety of nuclei and nuclear processes with widely differing properties.

In the field of economic analysis, computability in the formation of economic hypotheses is seen as the way forward. In this book, Professor Velupillai implements a theoretical research program along these lines. Choice theory, learning rational expectations equlibria, the persistence of adaptive behaviour, arithmetical games, aspects of production theory, and economic dynamics are given recursion theoretic (i.e. computable) interpretations. These interpretations lead to new kinds of questions being posed by the economic theorist. In particular, recurison theoretic decision problems replace standard optimisation paradigms in economic analysis. Economic theoretic questions, posed recursion-theoretically, lead to answers that are ambiguous: undecidable choices, uncomputable learning processes, and algorithmically unplayable games become standard answers. Professor Velupillai argues that a recursion theoretic formalisation of economic analysisComputable Economicsmakes the subject intrinsically inductive and computational.

It is time to learn about living things! Can you spot which things are living? Can you tell which things are nonliving? With images that are easy to identify and clear, simple sentence structures, this science reader simplifies scientific concepts for young readers. A fun and easy science experiment and Your Turn! activity provide more in-depth opportunities for additional learning. Nonfiction text features include a glossary and an index. Engage young learners with this dynamic text!

Most of us believe everything happens for a reason. Whether it is "God's will," "karma", or "fate," we want to believe that an overarching purpose undergirds everything, and that nothing in the world, especially a disaster or tragedy, is a random, meaningless event. Abraham's Dice explores the interplay between chance and randomness, as well as between providence and divine action in the monotheistic religious traditions, looking at how their interaction has been conceptualized as our understanding of the workings of nature has changed. This lively historical conversation has generated intense and engaging theological debates, and provocative responses from science: what of the history of our universe, where chance and law have played out in complex ways? Or the evolution of life, where random mutations have challenged attempts to find purpose within evolution and convinced many that human beings are a "glorious accident." The enduring belief that everything happens for a reason is examined through a conversation with major scholars, among them holders of prestigious chairs at Oxford and Cambridge universities and the University of Basel, as well as several Gifford lecturers, and two Templeton prize winners. Now, as never before, confident scientific assertions that the world embodies a profound contingency are challenging theological claims that God acts providentially in the world. The random and meandering path of evolution is widely used as an argument that God did not create life. Organized historically, Abraham's Dice provides a wide-ranging scientific, theological, and biblical foundation to address the question of divine action in a world shot through with contingency.

The purpose of this book is to provide an update on some of the latest research and applications in the broad field of ionic liquids. This volume spans research and development activities ranging from fundamental and experimental investigations to commercial applications. A brief history of the field is included, as well as both new developments and reviews organized in the general topical areas of applications, materials, biomass processing, and fundamental studies. This book attempts to propel the field forward by bringing together contributions from some of the foremost researchers on ionic liquids. Recent products and new large-scale processes using ionic liquids, both in operation and being announced, indicate that an exciting new chapter in this field is about to begin. The authors summarize some of the history, applications, conferences, books, databases, issues related to data quality and toxicity for researchers working in the field of ionic liquids and includes an overview for each proceeding chapter with an introduction about the authors.

Developed for the new International A Level specification, these new resources are specifically designed for international students, with a strong focus on progression, recognition and transferable skills, allowing learning in a local context to a global standard. Recognised by universities worldwide and fully comparable to UK reformed GCE A levels. Supports a modular approach, in line with the specification. Appropriate international content puts learning in a real-world context, to a global standard, making it engaging and relevant for all learners. Reviewed by a language specialist to ensure materials are written in a clear and accessible style. The embedded transferable skills, needed for progression to higher education and employment, are signposted so students understand what skills they are developing and therefore go on to use these skills more effectively in the future. Exam practice provides opportunities to assess understanding and progress, so students can make the best progress they can.

The world's most comprehensive reference for clinical and forensic toxicologists has once more been extensively updated: 2,000 data sets have been added for a total of 10,430 spectra of potentially harmful substances, including 7,800 from metabolites. In two hardbound volumes, the printed atlas contains a comprehensive listing of full reference mass spectra in order or molecular mass with the structural formula, exact mass, GC retention times and other experimental data that are relevant to the analytical toxicologist. To aid in compound identification, all substances are classified according to their toxicological categories. In addition, volume 1 contains an overview on experimental methods, plus a compound index by name. An electronic database for use with all major mass spectrometers is also available. For details, please visit www.wiley.com/go/databases.

Thomas C. Vinci aims to reveal and assess the structure of Kant's argument in the Critique of Pure Reason called the "Transcendental Deduction of the Categories." At the end of the first part of the Deduction in the B-edition Kant states that his purpose is achieved: to show that all intuitions in general are subject to the categories. On the standard reading, this means that all of our mental representations, including those originating in sense-experience, are structured by conceptualization. But this reading encounters an exegetical problem: Kant states in the second part of the Deduction that a major part of what remains to be shown is that empirical intuitions are subject to the categories. How can this be if it has already been shown that intuitions in general are subject to the categories? Vinci calls this the Triviality Problem, and he argues that solving it requires denying the standard reading. In its place he proposes that intuitions in general and empirical intuitions constitute disjoint classes and that, while all intuitions for Kant are unified, there are two kinds of unification: logical unification vs. aesthetic unification. Only the former is due to the categories. A second major theme of the book is that Kant's Idealism comes in two versions-for laws of nature and for objects of empirical intuition-and that demonstrating these versions is the ultimate goal of the Deduction of the Categories and the similarly structured Deduction of the Concepts of Space, respectively. Vinci shows that the Deductions have the argument structure of an inference to the best explanation for correlated domains of explananda, each arrived at by independent applications of Kantian epistemic and geometrical methods.

Beverages derived from fruits and vegetables are a rich source of vitamin C, carotenoids, phenolics and polyphenolics as well as other bioactives. The bioactives in nutraceutical beverages may act synergistically with one another and their effect may be amplified through fortification, cultivating practices, or biotechnological means. This book discusses factors in the formulation, chemistry, nutrition, and health effects of nutraceutical beverages.

Energy, water, affordable healthcare and global warming are four major concerns resulting from resource depletion, record high oil prices, clean water shortages, high costs of pharmaceuticals, and changing climate conditions. Among many potential solutions, advance in membrane technology is one of the most direct, effective and feasible approaches to solve these sophisticated issues. This membrane book presents cutting-edge membrane research and development for water reuse and desalination, energy development including biofuels, CO2 capture, pharmaceutical purification and separation, and biomedical applications.

For one- or two-semester junior or senior level courses in Advanced Calculus, Analysis I, or Real Analysis. This text prepares students for future courses that use analytic ideas, such as real and complex analysis, partial and ordinary differential equations, numerical analysis, fluid mechanics, and differential geometry. This book is designed to challenge advanced students while encouraging and helping weaker students. Offering readability, practicality and flexibility, Wade presents fundamental theorems and ideas from a practical viewpoint, showing students the motivation behind the mathematics and enabling them to construct their own proofs.

The AQA A level Lab Books support students in completing the A level Practical requirements. This lab book includes: All the instructions students need to perform the required practicals, consistent with AQA's requirements and CPAC skills Writing frames for students to record their results and reflect on their work Questions that allow students to consolidate learning and develop reflective skills in their practical work Apparatus and Techniques (AT) skills self-assessment, so that students can track their progress covering AT practical requirements a full set of answers at the back. This lab book is designed to help students to: Structure their A level lab work to ensure that they cover the required Practical assessment criteria Track their progress in the development of A level practical skills Create a record of all of the practical work they will have completed, in preparation for revision.

Chiral molecules are ubiquitous in nature. Thus, it is not surprising to come across this phenomenon in the world of flavor substances. This book provides an overview on the analytical procedures currently applied to analyze chiral flavor substances at trace levels. It demonstrates several examples for the application of these techniques to determine naturally occurring enantiomeric compositions of chiral key flavor compounds in various natural systems. In addition to the analytical aspects, the contributions focus on the sensory properties of enantiomers and enlarge our knowledge on the correlation between configurations and odor properties and intensities of chiral flavor compounds. The practical importance of the topic is reflected by a discussion of merits and limitations of chiral analysis for the authenticity control of food flavorings. In addition, examples for the use of enzymes and microorganisms to obtain enantiopure flavor substances and thus to meet legal requirements for "natural" labeling are presented. Finally, the book covers aspects recently getting more and more in the focus of flavor science: What are the physiological mechanisms underlying the perception of sensory properties and does chirality matter in that respect?

Blitzer continues to raise the bar with his engaging applications developed to motivate students from diverse majors and backgrounds. Thinking Mathematically, Fifth Edition, draws from the author's unique background in art, psychology, and math to present math in the context of real-world applications. Students in this course are not math majors, and they may never take a subsequent math course, so they are often nervous about taking the class. Blitzer understands those students' needs and provides helpful tools in every chapter to help them master the material. Voice balloons appear right when students need them, showing what an instructor would say when leading a student through the problem. Study tips, chapter review grids, Chapter Tests, and abundant exercises provide ample review and practice. The Fifth Edition's MyMathLab(R) course boasts more than 2,000 assignable exercises, plus a new question type for applications-driven questions that correlate to section openers in the textbook. Chapter Test Prep Videos show students how to work out solutions to the Chapter Tests; the videos are available on DVD, in MyMathLab, and on YouTube(TM).