Written by a pioneer in the field, this text provides a complete introduction to X-ray microscopy, providing all of the technical background required to use, understand and even develop X-ray microscopes. Starting from the basics of X-ray physics and focusing optics, it goes on to cover imaging theory, tomography, chemical and elemental analysis, lensless imaging, computational methods, instrumentation, radiation damage, and cryomicroscopy, and includes a survey of recent scientific applications. Designed as a 'one-stop' text, it provides a unified notation, and shows how computational methods in different areas are linked with one another. Including numerous derivations, and illustrated with dozens of examples throughout, this is an essential text for academics and practitioners across engineering, the physical sciences and the life sciences who use X-ray microscopy to analyze their specimens, as well as those taking courses in X-ray microscopy.

The experiments in this manual are designed in a discovery format and the majority require only small quantities of reagents.

This book was first published in 2006. The standard model brings together two theories of particle physics in order to describe the interactions of subatomic particles, except those due to gravity. This book uses the standard model as a vehicle for introducing quantum field theory. In doing this the book also introduces much of the phenomenology on which this model is based. The book uses a modern approach, emphasizing effective field theory techniques, and contains brief discussions of some of the main proposals for going beyond the standard model, such as seesaw neutrino masses, supersymmetry, and grand unification. Requiring only a minimum of background material, this book is ideal for graduate students in theoretical and experimental particle physics. It concentrates on getting students to the level of being able to use this theory by doing real calculations with the minimum of formal development, and contains several problems.

Atom-probe field ion microscopy is currently the only technique capable of imaging solid surfaces with atomic resolution, and at the same time of chemically analysing surface atoms selected by the observer from the field ion image. Field ion microscopy has been successfully used to study most metals and many alloys, and recently good field ion images of some semiconductors and even ceramic materials such as high temperature superconductors have been obtained. Although other microscopies are capable of achieving the same resolution, there are some experiments unique to field ion microscopy - for example the study of the behaviour of single atoms and clusters on a solid surface. The elegant development of the field ion microscope with the atom probe has provided a powerful and useful technique for highly sensitive chemical analysis. This book presents the basic principles of atom-probe field ion microscopy and illustrates the various capabilities of the technique in the study of solid surfaces and interfaces at atomic resolution. A useful comparison is given with two related techniques, electron microscopy and scanning tunnelling microscopy. The book will be of interest to scientists working on surfaces and interfaces of materials at the atomic level and will provide a useful reference for those using this technique.

Scientists' views on what makes an experiment successful have developed dramatically throughout history. Different criteria for proper experimentation were privileged at different times, entirely new criteria for securing experimental results emerged, and the meaning of commitment to experimentation altered. In About Method, Schickore captures this complex trajectory of change from 1660 to the twentieth century through the history of snake venom research. As experiments with poisonous snakes and venom were both challenging and controversial, the experimenters produced very detailed accounts of their investigations, which go back three hundred years-making venom research uniquely suited for such a long-term study. By analyzing key episodes in the transformation of venom research, Schickore is able to draw out the factors that have shaped methods discourse in science. About Method shows that methodological advancement throughout history has not been simply a steady progression toward better, more sophisticated and improved methodologies of experimentation. Rather, it was a progression in awareness of the obstacles and limitations that scientists face in developing strategies to probe the myriad unknown complexities of nature. The first long-term history of this development and of snake venom research, About Method offers a major contribution to integrated history and philosophy of science.

This monograph describes the theoretical bases and experimental prerequisites for methods such as spin fluorescence, triplet, Mo ssbauer, photochromic and electron-density labeling, including the procedures used to obtain specifically modified proteins, enzymes, biomembranes, nucleic acids, and other biological molecules. The fundamentals of the physical theory behind each technique is explained and details are given of how to interpret the experimental data obtained. Special sections deal with critical reviews of recent data on the structure, molecular dynamics and conformational transitions of biological molecules. Each section concludes with a discussion of the results obtained from these techniques in connection with various problems of enzyme catalysis, electron transfer, molecular biophysics and molecular biology. The uses that labeling techniques can be put to for the investigation of whole cells and tissues are also discussed.

The past six years have seen a substantial increase in the attention paid by research workers to the principles of experimental design. The Second Edition of brings this handbook up to date, while retaining the basic framework that made it so popular. Describes the most useful of the designs that have been developed with accompanying plans and an account of the experimental situations for which each design is most suitable. Examples come from diverse fields of research, with an emphasis on biology and agriculture, two of the authors' specialties. New chapters have been added: one discusses the fractional replication of experiments. A second is concerned with experiments of the factorial type that present new methods and designs in which the factors represent quantitative variables measured on a continuous scale. Other new material includes an introductory account of experimental strategies for finding the levels at which the factors must be set in order to obtain maximum response and coverage of new incomplete block designs.

This book covers the fundamentals of conventional transmission electron microscopy (CTEM) as applied to crystalline solids. In addition to including a large selection of worked examples and homework problems, the volume is accompanied by a supplementary website (http://ctem.web.cmu.edu/) containing interactive modules and over 30,000 lines of free Fortran 90 source code. The work is based on a lecture course given by Marc De Graef in the Department of Materials Science and Engineering at Carnegie Mellon University.

Millionen von Medizin-Seiten im Internet machen den Durchblick schwer. Als kompakter, praxisbezogener Wegweiser durch diesen Informationsdschungel hilft das Buch Medizinern, das Internet optimal fur sich zu nutzen. Es erklart schrittweise den Umgang mit Daten und Datenbanken, bewertet die wichtigsten Internetadressen und informiert uber interessante Websites. Wer sich fur eine eigene Praxis-Homepage, Praxis-Netze oder telemedizinische Anwendungen interessiert, findet hier verstandliche Informationen und Anleitungen.

Die Fort- und Weiterbildungskurse der ASG-Fellows sind seit uber 10 Jahren ein Fortbildungsprogramm und mit jeweils 5-6 Schwerpunktthemen fester Bestandteil des Kongresses der DGOT. Die Fortbildungskurse richten sich an angehende Facharzte fur Orthopadie, aber auch an erfahrene Orthopaden in Praxis und Klinik, die von bestausgewiesenen Wissenschaftlern eine kompetente UEbersicht uber Neues zu aktuellen und modernen Krankheitsbildern erfahren und Strategien in Diagnostik und Therapie dargestellt bekommen. Die verschiedenen UEbersichtsreferate sind topographisch jeweils in einem Band zusammengefasst.

Proven and tested guidelines for designing ideal labs for scientific investigations

Now in its "Fourth Edition, Guidelines for Laboratory Design "continues to enable readers to design labs that make it possible to conduct scientific investigations in a safe and healthy environment. The book brings together all the professionals who are critical to a successful lab design, discussing the roles of architects, engineers, health and safety professionals, and laboratory researchers. It provides the design team with the information needed to ask the right questions and then determine the best design, while complying with current regulations and best practices.

"Guidelines for Laboratory Design" features concise, straightforward advice organized in an easy-to-use format that facilitates the design of safe, efficient laboratories. Divided into five sections, the book records some of the most important discoveries and achievements in: Part IA, Common Elements of Laboratory Design, sets forth technical specifications that apply to most laboratory buildings and modulesPart IB, Common Elements of Renovations, offers general design principles for the renovation and modernization of existing labsPart II, Design Guidelines for a Number of Commonly Used Laboratories, explains specifications, best practices, and guidelines for nineteen types of laboratories, with three new chapters covering nanotechnology, engineering, and autopsy labsPart III, Laboratory Support Services, addresses design issues for imaging facilities, support shops, hazardous waste facilities, and laboratory storeroomsPart IV, HVAC Systems, explains how to heat, cool, and ventilate labs with an eye towards energy conservationPart V, Administrative Procedures, deals with bidding procedures, final acceptance inspections, and sustainability

The final part of the book features five appendices filled with commonly needed data and reference materials.

This "Fourth Edition" is indispensable for all laboratory design teams, whether constructing a new laboratory or renovating an old facility to meet new objectives.

An award-winning science journalist details the quest to isolate and understand dark matter-and shows how that search has helped us to understand the universe we inhabit. When you train a telescope on outer space, you can see luminous galaxies, nebulae, stars, and planets. But if you add all that together, it constitutes only 15 percent of the matter in the universe. Despite decades of research, the nature of the remaining 85 percent is unknown. We call it dark matter. In The Elephant in the Universe, Govert Schilling explores the fascinating history of the search for dark matter. Evidence for its existence comes from a wealth of astronomical observations. Theories and computer simulations of the evolution of the universe are also suggestive: they can be reconciled with astronomical measurements only if dark matter is a dominant component of nature. Physicists have devised huge, sensitive instruments to search for dark matter, which may be unlike anything else in the cosmos-some unknown elementary particle. Yet so far dark matter has escaped every experiment. Indeed, dark matter is so elusive that some scientists are beginning to suspect there might be something wrong with our theories about gravity or with the current paradigms of cosmology. Schilling interviews both believers and heretics and paints a colorful picture of the history and current status of dark matter research, with astronomers and physicists alike trying to make sense of theory and observation. Taking a holistic view of dark matter as a problem, an opportunity, and an example of science in action, The Elephant in the Universe is a vivid tale of scientists puzzling their way toward the true nature of the universe.

As careers in science have become increasingly demanding, they require much more than a keen scientific mind and practical ability. If you are considering a career in research, have already embarked on your career and want to succeed, are uncertain which route to take or advise, train or supervise scientists, this book offers some helpful advice. Nancy Rothwell, a senior scientist with extensive experience training scientists and communicating with the public, covers topics ranging from choosing a PhD or postdoctoral position, successful interviews and preparing your cv to managing your supervisor; how to give successful talks, publish high quality papers and become known within your field. Broader aspects of science which are so important today are also covered, including ethics and fraud, intellectual property and exploitation and disseminating science to the public.

Special Details: Equipment Testing Procedure. Softcover Member and other discounts do not apply to this title.

This classic companion to undergraduate practical work in physics describes the purposeful, critical approach that should be made to all physics experiments. It covers the statistical treatment of data and experimental methods, and gives advice on keeping efficient records, calculations, and scientific writing. The new edition features treatment of the c2 distribution, a section on atomic clocks, worked examples based on spreadsheets, and additional exercises. Existing examples and references have been brought up to date. The text is liberally illustrated with examples and exercises, with solutions to the latter. Although intended for undergraduates, Practical Physics will be of interest to researchers, not only in physics, but in other sciences as well.

This textbook provides a comprehensive introduction to the theory and practice of validated numerics, an emerging new field that combines the strengths of scientific computing and pure mathematics. In numerous fields ranging from pharmaceutics and engineering to weather prediction and robotics, fast and precise computations are essential. Based on the theory of set-valued analysis, a new suite of numerical methods is developed, producing efficient and reliable solvers for numerous problems in nonlinear analysis. Validated numerics yields rigorous computations that can find all possible solutions to a problem while taking into account all possible sources of error--fast, and with guaranteed accuracy.

"Validated Numerics" offers a self-contained primer on the subject, guiding readers from the basics to more advanced concepts and techniques. This book is an essential resource for those entering this fast-developing field, and it is also the ideal textbook for graduate students and advanced undergraduates needing an accessible introduction to the subject. "Validated Numerics" features many examples, exercises, and computer labs using MATLAB/C++, as well as detailed appendixes and an extensive bibliography for further reading.Provides a comprehensive, self-contained introduction to validated numerics Requires no advanced mathematics or programming skills Features many examples, exercises, and computer labs Includes code snippets that illustrate implementation Suitable as a textbook for graduate students and advanced undergraduates

What can you learn about your world in just a moment? Have you ever wondered why the sky is blue? Or whether dogs can read our facial expressions? Don Glass and experts in their fields answer these questions and many more. Written for readers of all ages with no background in science required, How the World Looks to a Bee is the perfect armchair companion for curious people who want to know more about the science of everyday life but have only a moment to spare. With intriguing everyday phenomena as a starting point, this entertaining collection uses short tutorials and quick and simple experiments to invite readers to test the science for themselves. These fascinating and topical science stories are sure to delight the curious child in all of us.

The first book of its kind on marrow stromal cells, and written by leading experts in the field, this concise handbook aims to provide all that is needed to those new to this relatively young area of research. It provides a historical perspective and a summary of present knowledge of the marrow stromal lineages which are currently best understood. Detailed protocols for the isolation, culture and characterization of marrow stromal cell types from human and other animal species are given. The breadth and depth of the subject matter included makes the book equally suitable for new researchers and the more experienced investigator in this rapidly expanding field, including clinicians and bioscientists.

In recent years, imaging has rapidly become a tremendously valuable approach in nearly every field of biological research. Finding the right method and optimizing it for data collection can be a daunting process, even for an established imaging laboratory. Imaging: A Laboratory Manual is the cornerstone of a new laboratory manual series, designed as an essential guide for investigators who need these visualization techniques. This first volume is meant as a general reference for all fields, and describes the theory and practice of a wide array of imaging methods. From the basic chapters on optics, equipment and labeling to detailed explanations of advanced, cutting-edge methods like PALM, STORM, light sheet and high speed microscopy, Imaging: A Laboratory Manual is a vital resource for the modern biology laboratory.

The Works of Archimedes: Edited in Modern Notation With Introductory Chapters Authored by T.L. Heath Sc.D.

This completely revised new edition contains expanded coverage of existing topics and much new material. The author presents the subject of electron microscopy in a readable way, open both to those inexperienced in the technique, and also to practicing electron microscopists. He describes currently hot topics such as computer control of microscopes, energy-filtered imaging, cryomicroscopy and environmental microscopy, digital imaging, high resolution scanning, and transmission microscopy. The author has expanded the highly praised case studies of the first edition to include some interesting new examples. This indispensable guide to electron microscopy, written by an author with thirty years' practical experience, will be invaluable to new and experienced electron microscopists in any area of science and technology.

Research powers innovation and technoscientific advance, but it is due for a rethink, one consistent with its deeply holistic nature, requiring deeply human nurturing. Research is a deeply human endeavor that must be nurtured to achieve its full potential. As with tending a garden, care must be taken to organize, plant, feed, and weed-and the manner in which this nurturing is done must be consistent with the nature of what is being nurtured. In The Genesis of Technoscientific Revolutions, Venkatesh Narayanamurti and Jeffrey Tsao propose a new and holistic system, a rethinking of the nature and nurturing of research. They share lessons from their vast research experience in the physical sciences and engineering, as well as from perspectives drawn from the history and philosophy of science and technology, research policy and management, and the evolutionary biological, complexity, physical, and economic sciences. Narayanamurti and Tsao argue that research is a recursive, reciprocal process at many levels: between science and technology; between questions and answer finding; and between the consolidation and challenging of conventional wisdom. These fundamental aspects of the nature of research should be reflected in how it is nurtured. To that end, Narayanamurti and Tsao propose aligning organization, funding, and governance with research; embracing a culture of holistic technoscientific exploration; and instructing people with care and accountability.