This book is about the statistical principles behind the design of effective experiments and focuses on the practical needs of applied statisticians and experimenters engaged in design, implementation and analysis. Emphasising the logical principles of statistical design, rather than mathematical calculation, the authors demonstrate how all available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from real experiments in medicine, industry, agriculture and many experimental disciplines. Numerous exercises are given to help the reader practise techniques and to appreciate the difference that good design can make to an experimental research project. Based on Roger Mead's excellent Design of Experiments, this new edition is thoroughly revised and updated to include modern methods relevant to applications in industry, engineering and modern biology. It also contains seven new chapters on contemporary topics, including restricted randomisation and fractional replication.

The Oxford Handbook of the History of Physics brings together cutting-edge writing by more than twenty leading authorities on the history of physics from the seventeenth century to the present day. By presenting a wide diversity of studies in a single volume, it provides authoritative introductions to scholarly contributions that have tended to be dispersed in journals and books not easily accessible to the general reader. While the core thread remains the theories and experimental practices of physics, the Handbook contains chapters on other dimensions that have their place in any rounded history. These include the role of lecturing and textbooks in the communication of knowledge, the contribution of instrument-makers and instrument-making companies in providing for the needs of both research and lecture demonstrations, and the growing importance of the many interfaces between academic physics, industry, and the military.

Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.

In 1876 the South Kensington Museum held a major international exhibition of scientific instruments and equipment, both historical and contemporary. Many of the items were retained and eventually formed the basis of important collections now held at the Science Museum, London. This is the 1877 third edition of the exhibition catalogue, which was expanded to include a 'large number of objects' received since the publication of the second edition, and which also included corrections in order to 'afford a complete record of the collection for future reference'. In two volumes and twenty sections comprising over 4,500 entries, the catalogue lists a huge variety of items, ranging from slide rules and telescopes to lighthouse parts and medical equipment. It gives detailed explanations of how they were used, and notes of their ownership and provenance, while the opening pages comprehensively record the contributing individuals and institutions in Britain, Europe and America.

Covering a diverse range of practical applications and real-world examples, Scanning Probe Microscopy for Industrial Applications examines important and successful applications of SPM in various industries, including food science, personal care industry, and forestry applications. Author D. G. Yablon details how SPM has impacted the industrial sector leading to improved product formulation, new understanding of processes, and improvements in manufacturing. The book provides chemists, materials scientists, physicists, polymer scientists, and biophysicists with the most important and successful applications of SPM.

THIS VOLUME, WHICH IS DESIGNED FOR STAND-ALONE USE IN TEACHING AND RESEARCH, FOCUSES ON QUANTUM CHEMISTRY, AN AREA OF SCIENCE THAT MANY CONSIDER TO BE THE CENTRAL CORE OF COMPUTATIONAL CHEMISTRY. TUTORIALS AND REVIEWS COVER

1. HOW TO OBTAIN SIMPLE CHEMICAL INSIGHT AND CONCEPTS FROM DENSITY FUNCTIONAL THEORY CALCULATIONS,
2. HOW TO MODEL PHOTOCHEMICAL REACTIONS AND EXCITED STATES, AND
3. HOW TO COMPUTE ENTHALPIES OF FORMATION OF MOLECULES.

A FOURTH CHAPTER TRACES CANADIAN RESEARCH IN THE EVOLUTION OF COMPUTATIONAL CHEMISTRY. ALSO INCLUDED WITH THIS VOLUME IS A SPECIAL TRIBUTE TO QCPE.FROM REVIEWS OF THE SERIES

"Reviews in Computational Chemistry proves itself an invaluable resource to the computational chemist. This series has a place in every computational chemist’s library."—Journal of the American Chemical Society

New trends in solid-phase extraction for analytical use—a practical introduction.

Owing to its low cost, ease of use, and nonpolluting means of preparing samples for analysis, solid-phase extraction (SPE) is fast overtaking traditional liquid—liquid methods in clinical, pharmaceutical, agricultural, and industrial applications. This book describes what analytical scientists and technicians need to know about this emerging procedure: how it works, how to choose from available techniques, how to utilize it effectively in the laboratory. Along with the historical perspective and fundamental principles, this practical book reviews the latest literature on solid-phase materials, equipment, and applications—including EPA-endorsed techniques. Special features include:

• Coverage of separation and uptake methods.
• Promising developments in the use of membrane disks.
• The advantages of using polymeric resins over silica materials.
• Mechanism and use of ion-exchange materials for SPE.
• A remarkably complete chapter on the extraction of metal ions.
• Groundbreaking research in the miniaturized SPE technique.

SOLID-PHASE MICROEXTRACTION Theory and Practice Janusz Pawliszyn 1997 (0-471-19034-9) 264 pp.

In Laser Physics the interaction of radiation and matter, and the principles of laser operation are treated at a level suitable for fourth-year undergraduate courses or introductory graduate courses in physics, chemistry or engineering. The factors which determine efficiency, wavelength coverage, output power, and beam quality of the different classes of laser are treated both in terms of fundamental theory and practical construction aspects. Details of established types of solid-state, semiconductor, and gas lasers are examined together with the techniques that enable their output to be converted widely across the spectrum. The latest advances in high power fibre lasers, femtosecond lasers, and X-ray lasers are explained. The text is liberally illustrated with more than 300 diagrams. An extensive bibliography is provided, together with numerical problems in each chapter. Solutions are available via the web.
To request a copy of the Solutions Manual, visit: http: //global.oup.com/uk/academic/physics/admin/solutions

A complete guide to choosing and using the best analytical technique for the job at hand

Today's new generation of spectroscopic instrumentation allows for more accurate and varied measurements than ever before. At the same time, increasingly powerful, user-friendly PC hardware and software make running those instruments relative child's play. However, although they may have solved many of the problems traditionally associated with conducting molecular spectroscopic analyses, these refinements tend to obscure inherent technical challenges which, if not taken into consideration, can seriously undermine a research initiative. Modern Techniques in Applied Molecular Spectroscopy gives scientists and technicians the knowledge they need to address those challenges and to make optimal selection and use of contemporary molecular spectroscopic techniques and technologies.

While editor Francis Mirabella and contributors provide ample background information about how and why individual techniques work, they concentrate on practical considerations of crucial concern to researchers working in industry. For each technique covered, they provide expert guidance on method selection, sample preparation, troubleshooting, data handling and analysis, and more. Adhering principally to mid-IR molecular spectroscopic techniques, they clearly describe the guiding principles behind, characteristics of, and suitable applications for transmission spectroscopy, reflectance spectroscopies, photoacoustic spectroscopy, infrared and Raman microspectroscopy, fiber optic techniques, and emission spectroscopy.

Modern Techniques in Applied Molecular Spectroscopy is an indispensable working resource for analytical scientists and technicians working in an array of industries.

Dealing with the principles of calibration—both the theoretical and mathematical constructs which relate features of calibration equations to the physical phenomena that affect instruments and samples used on generating information. Among derivations in leading spectroscopic and statistical literature, numerous necessary mathematical derivations have been specifically designed for this book. Covers the practical aspects of generating a calibration equation including how to recognize and deal with various types of problems affecting calibration dataset, relating theoretical ideas, and their affect on data and how to deal with unusual situations.

Written by a pioneer in the field, this text provides a complete introduction to X-ray microscopy, providing all of the technical background required to use, understand and even develop X-ray microscopes. Starting from the basics of X-ray physics and focusing optics, it goes on to cover imaging theory, tomography, chemical and elemental analysis, lensless imaging, computational methods, instrumentation, radiation damage, and cryomicroscopy, and includes a survey of recent scientific applications. Designed as a 'one-stop' text, it provides a unified notation, and shows how computational methods in different areas are linked with one another. Including numerous derivations, and illustrated with dozens of examples throughout, this is an essential text for academics and practitioners across engineering, the physical sciences and the life sciences who use X-ray microscopy to analyze their specimens, as well as those taking courses in X-ray microscopy.

Proven and tested guidelines for designing ideal labs for scientific investigations

Now in its "Fourth Edition, Guidelines for Laboratory Design "continues to enable readers to design labs that make it possible to conduct scientific investigations in a safe and healthy environment. The book brings together all the professionals who are critical to a successful lab design, discussing the roles of architects, engineers, health and safety professionals, and laboratory researchers. It provides the design team with the information needed to ask the right questions and then determine the best design, while complying with current regulations and best practices.

"Guidelines for Laboratory Design" features concise, straightforward advice organized in an easy-to-use format that facilitates the design of safe, efficient laboratories. Divided into five sections, the book records some of the most important discoveries and achievements in: Part IA, Common Elements of Laboratory Design, sets forth technical specifications that apply to most laboratory buildings and modulesPart IB, Common Elements of Renovations, offers general design principles for the renovation and modernization of existing labsPart II, Design Guidelines for a Number of Commonly Used Laboratories, explains specifications, best practices, and guidelines for nineteen types of laboratories, with three new chapters covering nanotechnology, engineering, and autopsy labsPart III, Laboratory Support Services, addresses design issues for imaging facilities, support shops, hazardous waste facilities, and laboratory storeroomsPart IV, HVAC Systems, explains how to heat, cool, and ventilate labs with an eye towards energy conservationPart V, Administrative Procedures, deals with bidding procedures, final acceptance inspections, and sustainability

The final part of the book features five appendices filled with commonly needed data and reference materials.

This "Fourth Edition" is indispensable for all laboratory design teams, whether constructing a new laboratory or renovating an old facility to meet new objectives.

Best-selling author Theodore Gray is back with all-new, spectacular experiments that demonstrate basic principles of chemistry and physics in thrilling, and memorable ways.

For nearly a decade, Theodore Gray has been demonstrating basic principles of chemistry and physics through exciting, sometimes daredevil experiments that he executes, photographs, and writes about for his monthly Popular Science column "Gray Matter."

Theo Gray's Mad Science: Experiments You Can Do at Home, But Probably Shouldn't, published by Black Dog in 2009, collected Gray's Popular Science columns, along with hundreds of photographs, many of which were not published with the original columns.

Now comes the second volume of mad-scientist experiments, which includes more dramatic, enlightening, and sometimes daring demonstrations in which Gray dips his hand into molten lead to demonstrate the Leidenfrost effect; crushes a tomato between two small magnets to demonstrate the power of neodymium-iron-boron magnets; and creates trinkets out of solid mercury to demonstrate how the state of matter depends very much on the temperature at which it exists.

Other experiments include:

A foil boat floating on an invisible sea

DIY X-ray photos

A bacon lance that cuts steel

Charging a smart phone with apples and pennies

And dozens more

Now in full color, "Hematology Techniques and Concepts for Veterinary Technicians, Second Edition" is a thorough update to this introduction to the fundamental concepts of collecting, handling, and preparing hematology samples. Covering the basics of blood composition, cell morphology, and sample collection, handling, and preparation, the book is designed specifically for veterinary technicians and students to gain a full understanding of why each test is performed and ensure accurate test results. In addition to addressing advances in technology, equipment, and test techniques throughout, a new chapter covers automated testing, and a companion website provides review questions and images from the book for download at www.wiley.com/go/voigt.

Key concepts have also been added to each chapter to better promote learning, and terms are now defined throughout the text, with the definitions collected into a glossary. User-friendly and well-illustrated with charts, reference values, algorithms and photomicrographs, "Hematology Techniques and Concepts for Veterinary Technicians, Second Edition" is a key reference for veterinary technicians and veterinary technology students.

If you're taking a basic course in classical physics, or have a healthy curiosity for the way things work in the physical world, the Illustrated Guide to Home Physics Experiments provides an ideal hands-on introduction to physics lab techniques and data analysis. With this book and a few simple (and inexpensive) tools and materials, you'll learn to conduct experiments that answer questions about our world, make demonstrations to show off physical principles, and do theoretical lab work to discover how the world works. Perfect for do-it-yourselfers, home-schooled high school students, and college students, this book will help you: Learn everything from the basics of motion all the way to particle physics - including energy, thermodynamics, magnetic fields, optics, and much more Take careful measurements of physical phenomena and conduct data analysis Build and perform physics demonstrations that are fascinating and fun Construct computer models to represent aspects of the physical world It's easy to get started. You can build most of the experiments and demonstrations in this book with ordinary household tools, using materials that you can scrounge, borrow, or get free. The most important thing is your willingness to enter the door of discovery that awaits you. The Illustrated Guide to Home Physics Experiments is your key.

Cytogenetic Laboratory Management: Chromosomal, FISH and Microarray-Based Best Practices and Procedures is a practical guide that describes how to develop and implement best practice processes and procedures in the genetic laboratory setting. The text first describes good laboratory practices, including quality management, design control of tests and FDA guidelines for laboratory developed tests, and pre-clinical validation study designs. The second focus of the book describes best practices for staffing and training, including cost of testing, staffing requirements, process improvement using Six Sigma techniques, training and competency guidelines and complete training programs for cytogenetic and molecular genetic technologists. The third part of the text provides step-wise standard operating procedures for chromosomal, FISH and microarray-based tests, including pre-analytic, analytic and post-analytic steps in testing, and divided into categories by specimen type, and test-type. All three sections of the book include example worksheets, procedures, and other illustrative examples that can be downloaded from the Wiley website to be used directly without having to develop prototypes in your laboratory. Providing both a wealth of information on laboratory management and molecular and cytogenetic testing, Cytogenetic Laboratory Management will be an essential tool for laboratorians world-wide in the field of laboratory testing and genetics testing in particular. This book gives the essentials of: * Developing and implementing good quality management programs in laboratories * Understanding design control of tests and pre-clinical validations studies and reports * FDA guidelines for laboratory developed tests * Use of reagents, instruments and equipment * Cost of testing assessment and process improvement using Six Sigma methodology * Staffing training and competency objectives * Complete training programs for molecular and cytogenetic technologists * Standard operating procedures for all components of chromosomal analysis, FISH and microarray testing of different specimen types This volume is a companion to Cytogenetic Abnormalities: Chromosomal, FISH and Microarray-Based Clinical Reporting. The combined volumes give an expansive approach to performing, reporting and interpreting cytogenetic laboratory testing and the necessary management practices, staff and testing requirements.

Special Details: Equipment Testing Procedure. Softcover Member and other discounts do not apply to this title.

Written for animal researchers, this book provides a comprehensive guide to the design and statistical analysis of animal experiments. It has long been recognised that the proper implementation of these techniques helps reduce the number of animals needed. By using real-life examples to make them more accessible, this book explains the statistical tools employed by practitioners. A wide range of design types are considered, including block, factorial, nested, cross-over, dose-escalation and repeated measures and techniques are introduced to analyse the experimental data generated. Each analysis technique is described in non-mathematical terms, helping readers without a statistical background to understand key techniques such as t-tests, ANOVA, repeated measures, analysis of covariance, multiple comparison tests, non-parametric and survival analysis. This is also the first text to describe technical aspects of InVivoStat, a powerful open-source software package developed by the authors to enable animal researchers to analyse their data and obtain informative results.

Die rasante Entwicklung der Informationstechnologien forciert den Wandel im Gesundheitswesen und damit die neuen Rollenverstandnisse von Patient, Arzt, Gesundheitsdienstleister und Life-Science-Industrie. Die sich anbahnenden Chancen und Risiken im Gesundheitswesen sind so vielseitig, wie das Verstandnis des Begriffes e-Health. In kompakter und verstandlicher Form werden sowohl fundierte Basiskenntnisse vermittelt als auch Praxis-Perspektiven mit Fallbeispielen fur e-Health aufgezeigt.

How do scientists impact society in the twenty-first century? Many scientists are increasingly interested in the impact that their research will have on the public. Scientists likewise must answer the question above when applying for funding from government agencies, particularly as part of the 'Broader Impacts' criterion of proposals to the US National Science Foundation. This book equips scientists in all disciplines to do just that, by providing an overview of the origins, history, rationale, examples, and case studies of broader impacts, primarily drawn from the author's experiences over the past five decades. Beyond including theory and evidence, it serves as a 'how to' guide for best practices for scientists. Although this book primarily uses examples from the NSF, the themes and best practices are applicable to scientists and applications around the world where funding also requires impacts and activities that benefit society.

The 'post genomics' era has seen a surge in demand for the techniques of cell biology, to aid in interpreting the function and location of the cell's myriad proteins and macromolecules. This new edition of Plant Cell Biology provides a grounding in established procedures before guiding the reader through the field's most current techniques. It provides advanced undergraduates, postgraduates and research staff in the plant sciences with a uniquely comprehensive guide to this rapidly expanding discipline.