Cytogenetic Laboratory Management: Chromosomal, FISH and Microarray-Based Best Practices and Procedures is a practical guide that describes how to develop and implement best practice processes and procedures in the genetic laboratory setting. The text first describes good laboratory practices, including quality management, design control of tests and FDA guidelines for laboratory developed tests, and pre-clinical validation study designs. The second focus of the book describes best practices for staffing and training, including cost of testing, staffing requirements, process improvement using Six Sigma techniques, training and competency guidelines and complete training programs for cytogenetic and molecular genetic technologists. The third part of the text provides step-wise standard operating procedures for chromosomal, FISH and microarray-based tests, including pre-analytic, analytic and post-analytic steps in testing, and divided into categories by specimen type, and test-type. All three sections of the book include example worksheets, procedures, and other illustrative examples that can be downloaded from the Wiley website to be used directly without having to develop prototypes in your laboratory. Providing both a wealth of information on laboratory management and molecular and cytogenetic testing, Cytogenetic Laboratory Management will be an essential tool for laboratorians world-wide in the field of laboratory testing and genetics testing in particular. This book gives the essentials of: * Developing and implementing good quality management programs in laboratories * Understanding design control of tests and pre-clinical validations studies and reports * FDA guidelines for laboratory developed tests * Use of reagents, instruments and equipment * Cost of testing assessment and process improvement using Six Sigma methodology * Staffing training and competency objectives * Complete training programs for molecular and cytogenetic technologists * Standard operating procedures for all components of chromosomal analysis, FISH and microarray testing of different specimen types This volume is a companion to Cytogenetic Abnormalities: Chromosomal, FISH and Microarray-Based Clinical Reporting. The combined volumes give an expansive approach to performing, reporting and interpreting cytogenetic laboratory testing and the necessary management practices, staff and testing requirements.

Kari Byron-former host of the wildly popular, iconic cult classic MythBusters-shows how to crash test your way through life, no lab coat required. Kari Byron's story hasn't been a straight line. She started out as a broke artist living in San Francisco, writing poems on a crowded bus on the way to one of her three jobs. Many curve balls, unexpected twists, and yes, literal and figurative explosions later, and she's one of the world's most respected women in science entertainment, blowing stuff up on national television and getting paid for it! In Crash Test Girl, Kari reveals her fascinating life story on the set of MythBusters and beyond. With her signature gusto and roll-up-your-sleeves enthusiasm, she invites readers behind the duct tape and the dynamite, to the unlikely friendships and low-budget sets that turned a crazy idea into a famously inventive show with a rabid fanbase. The truth is, Mythbusters was never meant to be a science show. But attaching a rocket to a car, riding a motorcycle on water, or lighting 500 pounds of coffee creamer on fire requires a decent understanding of chemistry, physics, and engineering. Thus, the cast and crew brought in the scientific method to work through each problem: Question. Hypothesize. Experiment. Analyze. Conclude. And as Kari came to learn in her own life, not only is the scientific method the best approach for busting myths, it's also the perfect tool for solving everyday issues, including: Career * Love * Creativity * Setbacks * Money * Sexuality * Depression * Bravery Crash Test Girl reminds us that science is for everyone, as long as you're willing to strap in, put on your safety goggles, hit a few walls, and learn from the results. Using a combination of methodical experimentation and unconventional creativity, you'll come to the most important conclusion of all: In life, sometimes you crash and burn, but you can always crash and learn.

This textbook helps you to prepare for your next exams and practical courses by combining theory with virtual lab simulations. The "Labster Virtual Lab Experiments" series gives you a unique opportunity to apply your newly acquired knowledge in a learning game that simulates exciting laboratory experiments. Try out different techniques and work with machines that you otherwise wouldn't have access to.In this book, you'll learn the fundamental concepts of basic biochemistry focusing on: Ionic and Covalent Bonds Introduction to Biological Macromolecules Carbohydrates Enzyme Kinetics In each chapter, you'll be introduced to one virtual lab simulation and a true-to-life challenge. Following a theory section, you'll be able to play the relevant simulation that includes quiz questions to reinforce your understanding of the covered topics. 3D animations will show you molecular processes not otherwise visible to the human eye. If you have purchased a printed copy of this book, you get free access to five simulations for the duration of six months. If you're using the e-book version, you can sign up and buy access to the simulations at www.labster.com/springer. If you like this book, try out other topics in this series, including "Basic Biology", "Basic Genetics", and "Genetics of Human Diseases". Please note that the simulations in the book are not virtual reality (VR) but 2D virtual experiments.

Die rasante Entwicklung der Informationstechnologien forciert den Wandel im Gesundheitswesen und damit die neuen Rollenverstandnisse von Patient, Arzt, Gesundheitsdienstleister und Life-Science-Industrie. Die sich anbahnenden Chancen und Risiken im Gesundheitswesen sind so vielseitig, wie das Verstandnis des Begriffes e-Health. In kompakter und verstandlicher Form werden sowohl fundierte Basiskenntnisse vermittelt als auch Praxis-Perspektiven mit Fallbeispielen fur e-Health aufgezeigt.

Featuring new experiments, a new essay, and new coverage of nanotechnology, this organic chemistry laboratory textbook offers a comprehensive treatment of laboratory techniques including small scale and some microscale methods that use standard-scale ("macroscale") glassware and equipment. The book is organized based on essays and topics of current interest and covers a large number of traditional organic reactions and syntheses, as well as experiments with a biological or health science focus. Seven introductory technique-based experiments, thirteen project-based experiments, and sections on green chemistry and biofuels spark students' interest and engage them in the learning process. Instructors may choose to offer Cengage Learning's optional Premium Website, which contains videos on basic organic laboratory techniques.

As molecular and cellular biologists move toward nano-techniques for performing experiments on single molecules rather than on populations of molecules, a comprehensive manual on how (and why) to carry out such experiments is needed. Single-Molecule Techniques: A Laboratory Manual fills this requirement - it is the first to take researchers who know nothing about single-molecule analyses to the point where they can successfully design and execute appropriate experiments. Geared toward research scientists in structural and molecular biology, biochemistry, and biophysics, the manual will be useful to all who are interested in observing, manipulating, and elucidating the molecular mechanisms and discrete properties of macromolecules. Techniques range from in vivo and in vitro fluorescent-based methods to the use of atomic force microscopy, optical and magnetic tweezers, and nanopores. The book is edited by Paul R. Selvin and Taekjip Ha, two pioneers in the field of experimental biophysics who have made significant contributions to the development and application of single-molecule technologies.

Die nichtinvasive Erfassung des arteriellen Pulswellensignals erlaubt Pulsmessung, Pulsoximetrie bis hin zu Gefassrisikobewertung direkt am Unterarm. Robert Couronne beschreibt zwei Modellsimulationen der Photonenausbreitung im Unterarmgewebe. Anhand gemessener Intensitaten verifiziert der Autor die erweiterte Lambert-Beer-Beziehung eines planaren Schichtenmodells und untersucht mithilfe eines Zylindermodells die Intensitatsverteilung entlang des Unterarmumfangs, wobei bevorzugte Ableitregionen identifiziert werden. Zum experimentellen Nachweis stellt der Autor den Prototyp eines optisch-transmissiven Mehrkanalsensorsystems vor und zeigt anhand von Probandenmessungen die technische Signalgewinnung und praktische Anwendbarkeit. Mit einem Klassifikationsverfahren kann die automatische Signalidentifikation sowie eine Qualitatsbewertung im Realzeitbetrieb erreicht werden. Die vorgestellten Verfahren sind dabei auf gangigen Mikrocontroller-Plattformen lauffahig."

Il libro prende le mosse dai pensieri di un giovane che alla maturita liceale si trova affascinato dalla cultura dei classici greco-latini, dai rudimenti filosofici e dall impatto con le scienze fisiche e naturali. Il latino e i suoi naturalisti hanno suscitato un fervore verso la Botanica Sistematica che lo riporta a Linneo e quindi alla conoscenza del mondo naturale, all esperienza della denominazione dell esistente come conoscenza e quindi agli universali di Guglielmo d Occam. La scelta della facolta di Medicina fungera da mediazione fra la filosofia, vista come via alla verita, e la biologia con il grande mistero dell uomo nella sua dualita di mente/corpo. L incontro con il microscopio aprira la strada all approfondimento della biologia, ma anche alla ricerca dei significati e delle interpretazioni del mondo. I meccanismi della percezione, visiva in particolare, nelle articolazioni della Gestaltpsychologie, e i suoi rapporti con il mondo interiore, sia quello della memoria esplicita che della memoria implicita, sono affrontati nell esplorazione del mondo attraverso il microscopico e nella ricerca di una obiettivita scientifica. Locke e Kant, Popper e Heidegger fanno da contraltare a Ramon y Cajal, Golgi, Kandel, Heisenberg, mentre la semiotica illumina e confonde sull importanza del linguaggio per la conoscenza. Il segno e il suo riconoscimento si trasferiscono nella scienza attraverso l inter-soggettivita e il linguaggio appare come l unico modo di penetrare l esistente. Il libro si dilunga sull origine di certe denominazioni in patologia tratte dalla vita quotidiana, sull antropomorfismo spesso applicato agli oggetti del campo microscopico, sempre illustrati su base fenomenologica e psicologica.

This guide covers aspects of designing microarray experiments and analysing the data generated, including information on some of the tools that are available from non--commercial sources. Concepts and principles underpinning gene expression analysis are emphasised and wherever possible, the mathematics has been simplified. The guide is intended for use by graduates and researchers in bioinformatics and the life sciences and is also suitable for statisticians who are interested in the approaches currently used to study gene expression.* Microarrays are an automated way of carrying out thousands of experiments at once, and allows scientists to obtain huge amounts of information very quickly* Short, concise text on this difficult topic area* Clear illustrations throughout* Written by well--known teachers in the subject* Provides insight into how to analyse the data produced from microarrays

The first book on the topic, with each chapter written by pioneers in the field, this essential resource details the fundamental theory, applications, and future developments of liquid cell electron microscopy. This book describes the techniques that have been developed to image liquids in both transmission and scanning electron microscopes, including general strategies for examining liquids, closed and open cell electron microscopy, experimental design, resolution, and electron beam effects. A wealth of practical guidance is provided, and applications are described in areas such as electrochemistry, corrosion and batteries, nanocrystal growth, biomineralization, biomaterials and biological processes, beam-induced processing, and fluid physics. The book also looks ahead to the future development of the technique, discussing technical advances that will enable higher resolution, analytical microscopy, and even holography of liquid samples. This is essential reading for researchers and practitioners alike.

All you need to explore science is a kitchen, this book - and a dash of curiosity The Kitchen Science Cookbook is a beautifully crafted book with a unique twist: each recipe is a science experiment that you can do at home, using the everyday ingredients you'll find in your kitchen. No need to be a science expert -- these easy-to-follow recipes make mind-blowing science experiments fun for everyone. From sticky ice and raising raisins to balloon science and scrumptious slime, nanotechnologist and educator Michelle Dickinson shows that we can all be scientists, no matter how young or old. With recipes tested by hundreds of enthusiastic families around the world, The Kitchen Science Cookbook is the perfect gift for all ages.

Originally published in 2005, this book covers the closely related techniques of electron microprobe analysis (EMPA) and scanning electron microscopy (SEM) specifically from a geological viewpoint. Topics discussed include: principles of electron-target interactions, electron beam instrumentation, X-ray spectrometry, general principles of SEM image formation, production of X-ray 'maps' showing elemental distributions, procedures for qualitative and quantitative X-ray analysis (both energy-dispersive and wavelength-dispersive), the use of both 'true' electron microprobes and SEMs fitted with X-ray spectrometers, and practical matters such as sample preparation and treatment of results. Throughout, there is an emphasis on geological aspects not mentioned in similar books aimed at a more general readership. The book avoids unnecessary technical detail in order to be easily accessible, and forms a comprehensive text on EMPA and SEM for geological postgraduate and postdoctoral researchers, as well as those working in industrial laboratories.

If you're taking a basic course in classical physics, or have a healthy curiosity for the way things work in the physical world, the Illustrated Guide to Home Physics Experiments provides an ideal hands-on introduction to physics lab techniques and data analysis. With this book and a few simple (and inexpensive) tools and materials, you'll learn to conduct experiments that answer questions about our world, make demonstrations to show off physical principles, and do theoretical lab work to discover how the world works. Perfect for do-it-yourselfers, home-schooled high school students, and college students, this book will help you: Learn everything from the basics of motion all the way to particle physics - including energy, thermodynamics, magnetic fields, optics, and much more Take careful measurements of physical phenomena and conduct data analysis Build and perform physics demonstrations that are fascinating and fun Construct computer models to represent aspects of the physical world It's easy to get started. You can build most of the experiments and demonstrations in this book with ordinary household tools, using materials that you can scrounge, borrow, or get free. The most important thing is your willingness to enter the door of discovery that awaits you. The Illustrated Guide to Home Physics Experiments is your key.

This book is an introduction to concepts needed in the different parts of the process of doing science. It includes topics that will help achieve clarity in the posing of scientific questions, the design of ways to answer the questions, and the methods to evaluate the results and effectively communicate scientific information. It will be useful to the professional or student in the practice of writing papers, books or journal articles and can be applied to almost any area of science that requires presentation of data in an effective and informative way.

Thomas Hankins and Robert Silverman investigate an array of instruments from the seventeenth through the nineteenth century that seem at first to be marginal to science--magnetic clocks that were said to operate by the movements of sunflower seeds, magic lanterns, ocular harpsichords (machines that played different colored lights in harmonious mixtures), Aeolian harps (a form of wind chime), and other instruments of "natural magic" designed to produce wondrous effects. By looking at these and the first recording instruments, the stereoscope, and speaking machines, the authors show that "scientific instruments" first made their appearance as devices used to evoke wonder in the beholder, as in works of magic and the theater. The authors also demonstrate that these instruments, even though they were often "tricks," were seen by their inventors as more than trickery. In the view of Athanasius Kircher, for instance, the sunflower clock was not merely a hoax, but an effort to demonstrate, however fraudulently, his truly held belief that the ability of a flower to follow the sun was due to the same cosmic magnetic influence as that which moved the planets and caused the rotation of the earth. The marvels revealed in this work raise and answer questions about the connections between natural science and natural magic, the meaning of demonstration, the role of language and the senses in science, and the connections among art, music, literature, and natural science. Originally published in 1995. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

There is an increasing need for analysts to understand and be able to quantify the performance of analytical instruments, in particular with respect to the following:
* specifying equipment for purchase
* estimating uncertainties in intrumental measurements
* quantifying and demonstrating performance quality
This text links together an understanding of performance characteristics with an appreciation of the limitations imposed by instrument design, leading to the interplay of the validation and qualification processes within quality assurance systems.
A unique framework of topics covers the major instrumental techniques of spectrophotometry, chromatography, capillary electrophoresis, and atomic emission spectroscopy. The use of over 200 questions and answers, together with cross-referencing, helps to develop a thorough understanding of the various concepts that underpin the different techniques.
This book will appeal to a broad range of professional chemists, technicians and students, weither with reference to specific analytical techniques, or within a general course of study in instrumental performance.
Analytical Techniques in the Sciences
This series of books provides coverage of all the major analytical techniques and their application in the most important areas of physical, life and materials sciences. Each text is presented in an open learning/distant learning style, in which the learning objectives are clearly identified. The reader's understanding of the material is constantly evaluated by the use of self-assessment and discussion questions.

Wie geht es weiter - nach der erfolgreichen Promotion? Wohin soll die medizinische Laufbahn fuhren? Dieser Leitfaden wird Ihnen bei der schwierigen Entscheidung eine wertvolle Stutze sein. Eine erfahrene Medizinjournalistin portratiert hier alle Facharztrichtungen der Ausbildungsordnung der OEsterreichischen AErztekammer - von der Anasthesie bis hin zur Zahnmedizin. Zusatzlich prasentiert sie die Additivfacher der einzelnen Sonderfacher und informiert Sie uber die neue Ausbildung zum Allgemein- bzw. Zahnmediziner. Kompakt und ubersichtlich beantwortet sie folgende Fragen: Wie gestaltet sich die Ausbildung? Welche Fahigkeiten und persoenlichen Eigenschaften sind in welchem Fach gefragt? Und: An welches Fach haben Sie bisher noch nie gedacht?

This book should be on the shelf of every practising statistician who designs experiments. Good design considers units and treatments first, and then allocates treatments to units. It does not choose from a menu of named designs. This approach requires a notation for units that does not depend on the treatments applied. Most structure on the set of observational units, or on the set of treatments, can be defined by factors. This book develops a coherent framework for thinking about factors and their relationships, including the use of Hasse diagrams. These are used to elucidate structure, calculate degrees of freedom and allocate treatment subspaces to appropriate strata. Based on a one-term course the author has taught since 1989, the book is ideal for advanced undergraduate and beginning graduate courses. Examples, exercises and discussion questions are drawn from a wide range of real applications: from drug development, to agriculture, to manufacturing.