Atomic force microscopy (AFM) is an amazing technique that allies a versatile methodology (that allows measurement of samples in liquid, vacuum or air) to imaging with unprecedented resolution. But it goes one step further than conventional microscopic techniques; it allows us to make measurements of magnetic, electrical or mechanical properties of the widest possible range of samples, with nanometre resolution. This book will demystify AFM for the reader, making it easy to understand, and to use. It is written by authors who together have more than 30 years experience in the design, construction, and use of AFMs and will explain why the microscopes are made the way they are, how they should be used, what data they can produce, and what can be done with the data. Illustrative examples from the physical sciences, materials science, life sciences, nanotechnology and industry demonstrate the different capabilities of the technique.

A revealing and provocative look at the current state of global science We take the advance of science as given. But how does science really work? Is it truly as healthy as we tend to think? How does the system itself shape what scientists do? The Secret Life of Science takes a clear-eyed and provocative look at the current state of global science, shedding light on a cutthroat and tightly tensioned enterprise that even scientists themselves often don't fully understand. The Secret Life of Science is a dispatch from the front lines of modern science. It paints a startling picture of a complex scientific ecosystem that has become the most competitive free-market environment on the planet. It reveals how big this ecosystem really is, what motivates its participants, and who reaps the rewards. Are there too few scientists in the world or too many? Are some fields expanding at the expense of others? What science is shared or published, and who determines what the public gets to hear about? What is the future of science? Answering these and other questions, this controversial book explains why globalization is not necessarily good for science, nor is the continued growth in the number of scientists. It portrays a scientific community engaged in a race for limited resources that determines whether careers are lost or won, whose research visions become the mainstream, and whose vested interests end up in control. The Secret Life of Science explains why this hypercompetitive environment is stifling the diversity of research and the resiliency of science itself, and why new ideas are needed to ensure that the scientific enterprise remains healthy and vibrant.

This text is a compilation of practical information on the analysis of mineral type materials and products by the fused, cast bead method. It discusses the necessary equipment and its use; the processes involved in loss of ignition and decomposition by fusion and their chemistry. The book is also concerned with spectrometric parameters and the analytical procedures for a wide range of materials which, together with tables in the appendices, aim to allow easy reference to the parameters to be adopted to follow a defined procedure for most types of sample. The overall aim of the work is to help towards standardizing procedures, equipment and software, which should help to reduce costs and make for a better inter-laboratory comparison of results.

This book contains all the necessary information and advice for anyone wishing to obtain electron micrographs showing the most accurate ultrastructural detail in thin sections of any type of biological specimen. The guidelines for the choice of preparative methods are based on an extensive survey of current laboratory practice. For the first time, in a textbook of this kind, the molecular events occurring during fixation and embedding are analysed in detail. The reasons for choosing particular specimen preparation methods are explained and guidance is given on how to modify established techniques to suit individual requirements. All the practical methods advocated are clearly described, with accompanying tables and the results obtainable are illustrated with many electron micrographs. Portland Press Series: Practical Methods in Electron Microscopy, Volume 17, Audrey M. Glauert, Editor Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Theodore Gray has become a household name among fans, both young and old, of popular science and mechanics with his bestselling trilogy of books: The Elements, Molecules, and Reactions.

In How Things Work, he explores the mechanical underpinnings of dozens of types of machines, from the cotton gin to the wristwatch to an industrial loom, and shares his deep, firsthand appreciation and knowledge of the world's most essential mechanical systems.

Filled with stunning original photographs by Nick Mann, How Things Work is a must-have exploration of stuff-large and small-for any builder, maker or lover of mechanical things.

The Oxford Handbook of the History of Physics brings together cutting-edge writing by more than twenty leading authorities on the history of physics from the seventeenth century to the present day. By presenting a wide diversity of studies in a single volume, it provides authoritative introductions to scholarly contributions that have tended to be dispersed in journals and books not easily accessible to the general reader. While the core thread remains the theories and experimental practices of physics, the Handbook contains chapters on other dimensions that have their place in any rounded history. These include the role of lecturing and textbooks in the communication of knowledge, the contribution of instrument-makers and instrument-making companies in providing for the needs of both research and lecture demonstrations, and the growing importance of the many interfaces between academic physics, industry, and the military.

Most lab manuals assume a high level of knowledge among biochemistry students, as well as a large amount of experience combining knowledge from separate scientific disciplines. Biochemistry in the Lab: A Manual for Undergraduates expects little more than basic chemistry. It explains procedures clearly, as well as giving a clear explanation of the theoretical reason for those steps. Key Features: Presents a comprehensive approach to modern biochemistry laboratory teaching, together with a complete experimental experience Includes chemical biology as its foundation, teaching readers experimental methods specific to the field Provides instructor experiments that are easy to prepare and execute, at comparatively low cost Supersedes existing, older texts with information that is adjusted to modern experimental biochemistry Is written by an expert in the field This textbook presents a foundational approach to modern biochemistry laboratory teaching together with a complete experimental experience, from protein purification and characterization to advanced analytical techniques. It has modules to help instructors present the techniques used in a time critical manner, as well as several modules to study protein chemistry, including gel techniques, enzymology, crystal growth, unfolding studies, and fluorescence. It proceeds from the simplest and most important techniques to the most difficult and specialized ones. It offers instructors experiments that are easy to prepare and execute, at comparatively low cost.

This concise introductory guide explains the values that should inform the responsible conduct of scientific research in today's global setting. Featuring accessible discussions and ample real-world scenarios, Doing Global Science covers proper conduct, fraud and bias, the researcher's responsibilities to society, communication with the public, and much more. The book places special emphasis on the international and highly networked environment in which modern research is done, presenting science as an enterprise that is being transformed by globalization, interdisciplinary research projects, team science, and information technologies. Accessibly written by an InterAcademy Partnership committee comprised of leading scientists from around the world, Doing Global Science is required reading for students, practitioners, and anyone concerned about the responsible conduct of science today. * Provides practical guidance and instructions for doing scientific research in today's global setting * Covers everything from responsible conduct to communication with the public * Features numerous real-world scenarios drawn from an array of disciplines and national contexts * Focuses on issues commonly encountered in international collaborations * Written by a panel of leading experts from around the world * An essential guide for practicing scientists and anyone concerned about fostering research integrity

Goerg Michler summarizes the large field of electron microscopy and clearly presents the different techniques. The author clearly describes the possible applications of microscopy and the requirements for specimen preparation. He illustrates the descriptions with picture examples from practice. The Author: Prof. Dr. rer. nat. habil. Goerg H. Michler was head of the Institute for Materials Science at Martin Luther University Halle-Wittenberg, is honorary chairman of the Institute for Polymer Materials e.V. and chairman of the Heinz Bethge Foundation for Applied Electron Microscopy.

VOLUME 25

Reviews in Computational Chemistry

Kenny B. Lipkowitz and Thomas R. Cundari

This Volume, Like Those Prior To It, Features Pedagogically Driven Reviews By Experts In Various Fields Of Computational Chemistry. Volume 25 Contains: Eight Chapters Covering The Glass Transition In Polymer Melts, Atomistic Modeling Of Friction, The Computation Of Free Volume, Structural Order And Entropy Of Liquids And Glasses, The Reactivity Of Materials At Extreme Conditions, Magnetic Properties Of Transition Metal Clusters, Multiconfigurational Quantum Methods For The Treatment Of Heavy Metals, Recursive Solutions To Large Eigenvalue Problems, And The Development And Uses Of Artificial Intelligence In Chemistry.

From Reviews of the Series

"Reviews in Computational Chemistry remains the most valuable reference to methods and techniques in computational chemistry."
--JOURNAL OF MOLECULAR GRAPHICS AND MODELLING

"One cannot generally do better than to try to find an appropriate article in the highly successful Reviews in Computational Chemistry. The basic philosophy of the editors seems to be to help the authors produce chapters that are complete, accurate, clear, and accessible to experimentalists (in particular) and other nonspecialists (in general)."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electron tunnelling spectroscopy is a research tool which has strongly advanced understanding of superconductivity. With the invention of the scanning tunneling microscope, STM, by Nobelists G. Binnig and H. Rohrer, beautiful images of atoms, rings of atoms and of exotic states in high temperature superconductors have appeared. Some of the most famous images of any kind, at this date, are STM topographs. This book explains the physics and the instrumentation behind the advances illustrated in the famous images, and summarizes the state of knowledge that has resulted. It presents the current state of the art of tunneling- and scanning tunneling spectroscopies of atoms, molecules and especially superconductors. The first edition of Principles of Electron Tunneling Spectroscopy has been a standard reference for active researchers for many years. This second edition fully embraces the advances represented by the scanning tunnelling microscope and, especially, scanning tunnelling spectroscopy. Stunning images of single atoms and spectral images of impurity states in high temperature superconductors will set this volume apart from its predecessor. The background and current status are provided for applications of Scanning Tunneling Microscopy and Spectroscopy to single atoms and molecules, including determination of bonding energies and vibrational frequencies. The applications to high temperature superconductivity are carefully introduced and the current status is described. A new section covers the astounding advances in instrumentation, which now routinely provide atomic resolution, and, in addition, developments in imaging and image processing, such as Fourier Transform Scanning Tunneling Spectroscopy.

Computational Methods in Physics, Chemistry and Biology offers an accessible introduction to key computational techniques used within science, including quantum mechanics, dynamics, evolutionary methods and molecular dynamics. Assuming only a limited background in computational methods, this book provides the reader with a series of comprehensive examples, problems and practical-based tasks from the basics through to more complex ideas and techniques.

Beginning with an introduction to a numerical solution of Schrödinger's Equation the text moves on to discuss perturbation theory, variational calculations, diffusion, dynamics, Monte Carlo simulations and genetic algorithms. Aimed at those new to the field, the book will enable the reader to develop and implement computational methods for the solutions of a range of problems in science.

Features:

• An accessible introduction covering a range of essential techniques applicable to key problems
• Numerous examples, problems and practical-based exercises.
• A supplementary website including solutions

This book explicates the optical controls of antiferromagnetic spins by intense terahertz (THz) electromagnetic waves. The book comprises two key components: (1) the experimental demonstration of the enhancement of a THz magnetic field using a split-ring resonator (SRR) and (2) the control of the direction of magnetization by using the enhanced THz magnetic field to break the symmetry of optically-induced phase transition. These make up the first step leading to future spintronics devices. In the beginning of the book, the author reviews the basics of the ultrafast laser and nonlinear optical techniques as well as the previously achieved experiments to control spin dynamics by THz magnetic fields. In this context, a new experimental protocol is described, in which electron spins in a ferromagnetic material are redirected at the unprecedented level in cooperation with the enhanced THz magnetic field. Subsequently, the author demonstrates that the THz magnetic field is significantly amplified as a nearfield around the SRR structured metamaterial, which is implemented by measuring spin precession in a solid. At the end, the author presents the key experiment in which the amplified THz magnetic nearfield is applied to the weak ferromagnet ErFeO3 along with the femtosecond near-infrared pulse, demonstrating the successful control of symmetry breaking of the spin system due to coherent control of the optically-induced spin reorientation phase transition pathways. The comprehensive introductory review in this book allows readers to overview state-of-the-art terahertz spectroscopic techniques. In addition, the skillful description of the experiments is highly informative for readers in ultrafast magnonics, ultrafast optics, terahertz technology and plasmonic science.

In Laser Physics the interaction of radiation and matter, and the principles of laser operation are treated at a level suitable for fourth-year undergraduate courses or introductory graduate courses in physics, chemistry or engineering. The factors which determine efficiency, wavelength coverage, output power, and beam quality of the different classes of laser are treated both in terms of fundamental theory and practical construction aspects. Details of established types of solid-state, semiconductor, and gas lasers are examined together with the techniques that enable their output to be converted widely across the spectrum. The latest advances in high power fibre lasers, femtosecond lasers, and X-ray lasers are explained. The text is liberally illustrated with more than 300 diagrams. An extensive bibliography is provided, together with numerical problems in each chapter. Solutions are available via the web.
To request a copy of the Solutions Manual, visit: http: //global.oup.com/uk/academic/physics/admin/solutions

Scientific techniques developed in materials science offer invaluable information to archaeology, art history, and conservation. A rapidly growing number of innovative methods, as well as many established techniques, are constantly being improved and optimized for the analysis of cultural heritage materials. The result is that on the one hand more complex problems and questions can be confronted, but on the other hand the required level of technical competence is widening the existing cultural gap between scientists and end users, such as archaeologists, museum curators, art historians, and many managers of cultural heritage who have a purely humanistic background.
The book is intended as an entry-level introduction to the methods and rationales of scientific investigation of cultural heritage materials, with emphasis placed on the analytical strategies, modes of operation, and resulting information rather than on technicalities. The extensive and updated reference list should be a useful starting point for further reading. Students and researchers from the humanities approaching scientific investigations should find it useful, as well as scientists applying familiar techniques and methods to unfamiliar problems related to cultural heritage.

This book introduces the fundamentals of biobanking and guides through the practical planning thereof, with a special focus on the situation in low- and middle-income countries. On the example of the setup of a Ukrainian biobank the book discusses the main steps and aspects of successful biorepository implementation and management. Topics covered include collection, storage and shipping of samples, establishment of an IT system, development of a sustainability plan, and project and risk management. Furthermore, the importance of the formation of international biobanking societies such as the Ukraine Association of Biobanks is highlighted, and their main objectives and tasks are discussed.The book addresses life science and business professionals as well as national authorities who are interested in biobanking in general and in setting up a biobank in particular.

Acoustic microscopy enables the elastic properties of materials to be imaged and measured with the resolution of a good microscope. By using frequencies in the microwave regime, it is possible to make the acoustic wavelength comparable with the wavelength of light, and hence to achieve a resolution comparable with an optical microscope. Solids can support both longitudinal and transverse acoustic waves. At surfaces a unique combination of the two known as Raleigh waves can propagate, and in many circumstances these dominate the contrast in acoustic microscopy. Following the invention of scanning probe microscopes, it is now possible to use an atomic force microscope to detect the acoustic vibration of a surface with resolution in the nanometre range, thus beating the diffraction limit by operating in the extreme near-field. This second edition of Acoustic Microscopy has a major new chapter on the technique and applications of acoustically excited probe microscopy.

A sweeping tour of the infrared universe as seen through the eyes of NASA's Spitzer Space Telescope Astronomers have been studying the heavens for thousands of years, but until recently much of the cosmos has been invisible to the human eye. Launched in 2003, the Spitzer Space Telescope has brought the infrared universe into focus as never before. Michael Werner and Peter Eisenhardt are among the scientists who worked for decades to bring this historic mission to life. Here is their inside story of how Spitzer continues to carry out cutting-edge infrared astronomy to help answer fundamental questions that have intrigued humankind since time immemorial: Where did we come from? How did the universe evolve? Are we alone? In this panoramic book, Werner and Eisenhardt take readers on a breathtaking guided tour of the cosmos in the infrared, beginning in our solar system and venturing ever outward toward the distant origins of the expanding universe. They explain how astronomers use the infrared to observe celestial bodies that are too cold or too far away for their light to be seen by the eye, to conduct deep surveys of galaxies as they appeared at the dawn of time, and to peer through dense cosmic clouds that obscure major events in the life cycles of planets, stars, and galaxies. Featuring many of Spitzer's spectacular images, More Things in the Heavens provides a thrilling look at how infrared astronomy is aiding the search for exoplanets and extraterrestrial life, and transforming our understanding of the history and evolution of our universe.

This new book aims to guide both the experimentalist and theoretician through their compulsory laboratory courses forming part of an undergraduate physics degree. The rationale behind this book is to show students and interested readers the value and beauty within a carefully planned and executed experiment, and to help them to develop the skills to carry out experiments themselves.

Handbook of Radioactivity Analysis: Radiation Physics and Detectors, Volume One, and Radioanalytical Applications, Volume Two, Fourth Edition, constitute an authoritative reference on the principles, practical techniques and procedures for the accurate measurement of radioactivity - everything from the very low levels encountered in the environment, to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, and fuel cycle facilities, and in the implementation of nuclear forensic analysis and nuclear safeguards. It includes sample preparation techniques for all types of matrices found in the environment, including soil, water, air, plant matter and animal tissue, and surface swipes. Users will find the latest advances in the applications of radioactivity analysis across various fields, including environmental monitoring, radiochemical standardization, high-resolution beta imaging, automated radiochemical separation, nuclear forensics, and more.

This textbook is an excellent guide to microscopy for students and scientists, who use microscopy as one of their primary research and analysis tool in the laboratory. The book covers key microscopy principles and explains the various techniques such as epifluorescence microscopy, confocal/live cell imaging, SIM/light sheet microscopy, and many more. Easy-to-understand protocols provide helpful guidance for practical implementation in various commercially available imaging systems. The reader is introduced to histology and further be guided through advanced image acquisition, classification and analysis. The book is written by experienced imaging specialists from the UK, other EU countries, the US and Asia, and is based on advanced training courses for master students and PhD students. Readers are not expected to be familiar with imaging and microscopy technologies, but are introduced to the subject step by step. This textbook is indented for biomedical and medical students, as well as scientists and postdocs who want to acquire a thorough knowledge of microscopy, or gain a comprehensive overview of modern microscopy techniques used in various research laboratories and imaging facilities. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Explore the miracles of the microscopic world. Find out all about the unique and beautiful kingdoms of life at a microscopic scale and how every organism meets the challenges of survival no matter its size. The perfect book for people who enjoy photography, nature, and biology. Inside the pages of this exciting nature book, you'll find: - Microscopic life-forms (often neglected), and their larger life-forms in extreme close-ups, revealing details such as nerve cells and hair follicles - Artworks support the beautiful images, providing a deeper insight into structure and function and building a picture of how living organisms work at a microscopic level - Comprehensive coverage of the natural world, including all the main groups of living things - Explores overlooked groups that have a huge role in the natural world: insects, which make up 80 percent of the world's animal species; and bacteria - of which there are more in a human mouth than there are people in the world - The book is organised according to the main functions of life: movement, reproduction, energy and feeding, sensing the surroundings, defence, etc. - Foreword for the book written by Chris Packham Explore the inhabitants of an invisible world in incredible detail with this book which contains macro photography and spectacular microscope imagery. You'll have so much information about the hidden world of intricate structures beyond the naked eye. From the tiniest spiders and insects to even microscopic creatures such as bacteria and viruses, this book contains it all! See the beauty of a pollen grain, a butterfly egg, the spore of a fungus, and a human's nerve cell in extreme close up. The amazing imagery in Micro Life contains focus-stacked macro photographs and micrographs (microscope images), including scanning electron micrographs. Illustrations in this book explain the science - from the workings of an insect's eye to how a plant "breathes" through its leaves. Micro Life is an unexpectedly breathtaking look at the natural world. Find out how life works and how organisms solve the fundamental problems of movement, reproduction, energy, communication, and defence. Suitable for all the family, this stunning book makes a wonderful gift for those interested in photography, nature or biology.

"Fundamentals of Light Microscopy and Electronic Imaging, Second Edition" provides a coherent introduction to the principles and applications of the integrated optical microscope system, covering both theoretical and practical considerations. It expands and updates discussions of multi-spectral imaging, intensified digital cameras, signal colocalization, and uses of objectives, and offers guidance in the selection of microscopes and electronic cameras, as well as appropriate auxiliary optical systems and fluorescent tags.The book is divided into three sections covering optical principles in diffraction and image formation, basic modes of light microscopy, and components of modern electronic imaging systems and image processing operations. Each chapter introduces relevant theory, followed by descriptions of instrument alignment and image interpretation. This revision includes new chapters on live cell imaging, measurement of protein dynamics, deconvolution microscopy, and interference microscopy.

PowerPoint slides of the figures as well as other supplementary materials for instructors are available at a companion website:

www.wiley.com/go/murphy/lightmicroscopy

A bestseller for nearly 25 years, Analysis of Messy Data, Volume 1: Designed Experiments helps applied statisticians and researchers analyze the kinds of data sets encountered in the real world. Written by two long-time researchers and professors, this second edition has been fully updated to reflect the many developments that have occurred since the original publication. New to the Second Edition Several modern suggestions for multiple comparison procedures Additional examples of split-plot designs and repeated measures designs The use of SAS-GLM to analyze an effects model The use of SAS-MIXED to analyze data in random effects experiments, mixed model experiments, and repeated measures experiments The book explores various techniques for multiple comparison procedures, random effects models, mixed models, split-plot experiments, and repeated measures designs. The authors implement the techniques using several statistical software packages and emphasize the distinction between design structure and the structure of treatments. They introduce each topic with examples, follow up with a theoretical discussion, and conclude with a case study. Bringing a classic work up to date, this edition will continue to show readers how to effectively analyze real-world, nonstandard data sets.