Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

This Vascular Surgery Atlas is a 'How to' book that allows the reader to focus on the technical aspects of the most commonly performed vascular procedures. The book is edited by two seasoned vascular surgeons with a well established experience in surgical education. The authors have been selected from both sides of the Atlantic to provide the expertise necessary to cover the various procedures.The atlas is focused on open surgical procedures and also covers essential endovascular procedures such as 'Endovascular Abdominal Aortic Aneurysm Repair and Carotid stenting.' It also includes a section on exposures of the infrainguinal vessels. The format allows the reader to easily follow the various steps of procedures. The art work shows all the details necessary to understand the anatomy and the technical aspects of the procedure. The layout of having text on one side and the associated art on the opposite page allows the reader to easily follow and understand the various steps on the described procedure.The atlas will benefit surgical residents, vascular surgery fellows and vascular surgeons.

This atlas provides all the basic and advanced information required by surgeons in order to understand fully the skull base anatomy. It is organized according to anatomo-surgical pathways to the hidden areas of the skull base. These pathways are described in step-by-step fashion with the aid of a wealth of color images and illustrations. The emphasis is on endoscopic anatomy, but in order to provide a holistic perspective, informative three-dimensional reconstructions are presented alongside the endoscopic images and radiologic images are included when appropriate. In effect, windows are opened on the anatomy so that the reader is guided on a journey throughout the skull base region. This anatomically oriented atlas will serve as an ideal learning tool for novice surgeons and will also prove an invaluable reference for the more experienced surgeon

Patients with peripheral vascular disease (PVD) are at increased risk of death when compared with age-matched healthy controls. They are also, whether symptomatic or not, six times more likely to die within ten years when compared to patients without the disease. This excess mortality exists even if coronary artery disease is not clinically present, and makes the treatment of PVD a highly important and pressing topic. In this fully up-to-date text, Dr. Mukherjee and his excellent team of twenty-one contributors present the reader with all of the currently available clinical information for treating PVD patients effectively.

This book identifies the 50 key scientific articles in the field of vascular and endovascular surgery. It provides a commentary to each carefully selected paper and explains why these papers are so important, thus providing every surgeon with the foundation stones of knowledge in this fast-moving area. There has been an exponential increase in the volume and quality of published research relating to vascular and endovascular surgery in recent decades. Among thousands of articles, a small fraction is truly "game changing." Such studies form the foundations of vascular surgery today and the selection of papers within this book provide the 50 landmark papers every 21st-century vascular and endovascular surgeon needs to know. A valuable reference not only to the established surgeon, but also to vascular surgery residents and trainees, as well as to more experienced surgeons as they continue to learn new techniques and approaches and to improve their knowledge of vascular disorders and treatments. The papers provide an evidence-based resource for those surgeons preparing for professional exams and may inspire clinicians to produce new research. About the Editors Juan Carlos Jimenez MD, MBA Professor of Surgery Gonda (Goldschmied) Vascular Center David Geffen School of Medicine at UCLA Los Angeles, California Samuel Eric Wilson, MD Distinguished Professor of Surgery and Chair Emeritus University of California Irvine Irvine, California

This book identifies the 50 key scientific articles in the field of vascular and endovascular surgery. It provides a commentary to each carefully selected paper and explains why these papers are so important, thus providing every surgeon with the foundation stones of knowledge in this fast-moving area. There has been an exponential increase in the volume and quality of published research relating to vascular and endovascular surgery in recent decades. Among thousands of articles, a small fraction is truly "game changing." Such studies form the foundations of vascular surgery today and the selection of papers within this book provide the 50 landmark papers every 21st-century vascular and endovascular surgeon needs to know. A valuable reference not only to the established surgeon, but also to vascular surgery residents and trainees, as well as to more experienced surgeons as they continue to learn new techniques and approaches and to improve their knowledge of vascular disorders and treatments. The papers provide an evidence-based resource for those surgeons preparing for professional exams and may inspire clinicians to produce new research. About the Editors Juan Carlos Jimenez MD, MBA Professor of Surgery Gonda (Goldschmied) Vascular Center David Geffen School of Medicine at UCLA Los Angeles, California Samuel Eric Wilson, MD Distinguished Professor of Surgery and Chair Emeritus University of California Irvine Irvine, California

As societies have aged and aortic diseases have become more prevalent, advances in diagnostic imaging and surgical techniques have brought significantly improved results for patients. In cardiovascular surgery, important questions remain to be addressed, however. "Strategy for Cardio-aortic and Aortic Surgery" was the theme of the 7th Keio University International Symposium for Life Sciences and Medicine. Meeting in Tokyo, researchers and specialists in cardiac surgery from around the world discussed crucial issues in their field. Papers from the symposium, collected in this volume, cover a broad range of topics, including recent advances in diagnostic imaging, brain protection during aortic surgery, spinal protection during thoracoabdominal aneurysm repair, treatment of type A acute aortic dissection, and stent-grafts and less-invasive aortic surgery. This unique book provides valuable information especially for aortic, cardiovascular, and thoracic surgeons.

Featuring up-to-date information on current topics in vascular surgery, the second edition of Postgraduate Vascular Surgery is aimed at surgical trainees to help them prepare for the FRCS intercollegiate and Board exams. With chapters written by experts in their respective fields, the book contains concise information on surgical procedures, diagnosis and management of vascular conditions. Each section includes bullet point summaries, relevant clinical trials, and references for further research, making it the ideal resource for study. This book will also help candidates preparing for the European and Australian board exams. Practicing surgeons will also find this title useful for updating their knowledge.

Featuring up-to-date information on current topics in vascular surgery, the second edition of Postgraduate Vascular Surgery is aimed at surgical trainees to help them prepare for the FRCS intercollegiate and Board exams. With chapters written by experts in their respective fields, the book contains concise information on surgical procedures, diagnosis and management of vascular conditions. Each section includes bullet point summaries, relevant clinical trials, and references for further research, making it the ideal resource for study. This book will also help candidates preparing for the European and Australian board exams. Practicing surgeons will also find this title useful for updating their knowledge.

Focusing on the latest safe and effective techniques, Endovascular Treatment of Aortic Aneurysms: Standard and Advanced Techniques provides step-by-step, comprehensive coverage of endovascular repairs of complex aneurysms of the aorta, from basic to advanced. Explains how to perform the techniques in a step-by-step manner, using high-quality images and practical tips and tricks to optimize results. Contains chapters devoted to the repair of leaks that may occur after a repair and the best ways to minimize radiation exposure. Presents information in a consistent, standardized format: introduction, indications for the technique, how to perform the technique, complications and techniques for rescue, and concluding thoughts.

A comprehensive review the state-of-the-art in atherosclerosis of the arteries of the legs and feet. The authors discuss in detail the primary symptom-claudication-an intermittent pain in the leg or foot while walking, its predisposing factors, the current diagnostic methodologies, the impressive advances in the therapeutic armamentarium, and the need to screen for co-existing coronary artery disease. Additional chapters describe cutting-edge noninvasive angiography and vascular flow studies, specific drug therapy for claudication, regression of atherosclerosis therapy, gene therapy, and drug eluting stents for peripheral arterial disease. The authors also examine the epidemiology of LEAD, the effects of smoking and effective smoking cessation programs, its pathogenesis and its association with lipid abnormalities and hypertension, aggressive risk factor modification, and the need to measure the ankle brachial index of every patient over 45.

With an invaluable selection of color images, this guide authoritatively covers the identification, assessment, pathophysiology, epidemiology, and treatment of disorders affecting the venous and lymphatic anatomy. Written by experts from several fields, this source considers topics including the management of deep venous thrombosis, chronic venous insufficiency, venous trauma, and surgical and pharmacologic therapies for these conditions.

Patients with peripheral vascular disease (PVD) are at increased risk of death when compared with age-matched healthy controls, and patients with PVD, whether symptomatic or not, are six times more likely to die within ten years when compared to patients without the disease. This excess mortality exists even if coronary artery disease is not clinically present, and makes the treatment of PVD a highly important and pressing topic. shown that risk factors in peripheral vascular disease are less likely to be treated, and because patients with PVD have a decreased exercising capacity, a cycle of sedentary lifestyle impacts upon quality of life and the progression of atherosclerosis. Furthermore, the improvement of symptoms without a pharmacological or non-pharmacological intervention is unlikely, making appropriate therapy for PVD critical. twenty-one contributors present the reader with all of the currently available clinical information for treating PVD patients effectively, discussing, for example, treatments such as: * risk factor modification and therapy to prevent cardiovascular events * pharmacological therapy for claudication * exercise training for the treatment of claudication * surgical or endovascular revascularization.

Peripheral vascular disease is a common, disabling malady, and patients seeking treatment may turn to their cardiologist for advice and treatment. Conventional treatment has always been medical management and, inevitably, surgical bypass, even amputation. Stents have had a significantly high impact on endoluminal treatment outcomes by preventing injury to the lumen, reducing the potential for hyperplasia and restenosis, as well as the likelihood of plaque disruption and embolization. This second edition brings together a combination of all the current evidence-based information with personal experience and is presented by a team of distinguished operators.
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This comprehensive reference details the techniques for establishing vascular access for hemodialysis and other acute and chronic conditions that require access to the circulation along with peritoneal dialysis access methods. Includes over 960 references and more than 160 tables, figures, and photographs. Vascular Access in Clinical Practice contains the latest material on -autogenous AV fistula formation and maintenance methods -diagnosis of fistula problems prior to thrombosis -salvaging acutely thrombosed grafts -percutaneous methods of salvaging access sites -preoperative assessment of the access patient -materials used for vascular access and their healing responses -access techniques for pediatric patients and features extensive coverage of central venous catheters including -catheter selection -catheter placement techniques -catheter related complications -operative imaging -catheter care and maintenance Vascular Access in Clinical Practice is an essential reference for general and vascular surgeons, residents, and fellows; nephrologists; dialysis practitioners; intravenous infusion practices; and medical, physician assistant, and nursing students who have contact with dialysis and other critically ill patients.

Current Therapy in Vascular and Endovascular Surgery is an ideal medical reference book to consult for information in this ever-changing field! Thoroughly revised to reflect the most recent innovations in vascular and endovascular surgery, it features more than 150 chapters on topics new to this edition, and equips residents and practitioners alike with the latest procedures and techniques in this rapidly growing area. Internationally recognized experts present expanded coverage of a wide array of topics, keeping you abreast of all of today's developments! Quickly locate key information with concise, to-the-point chapters. Prepare for boards or certification exams through coverage that spans the entire spectrum of vascular surgery. Explore brand-new coverage of endovascular procedures and techniques. Learn from leaders in the field, including internationally recognized editors and numerous global experts in specialized disciplines. Access in-depth, detailed coverage of various vascular diseases, each sub-divided into discrete topics for a more focused approach. View procedures more clearly than ever before with the help of more than 800 full-color illustrations throughout. Access the full text and videos online at Expert Consult.

This book reviews the surgical management of patients with aortic disease, revealing many options open to cardiovascular specialists in this often controversial area of management. It reviews each controversy and provides clinical information for cardiac surgery, and discusses the spectrum of disorders and their management. With the knowledge base in this discipline changing rapidly, Controversies in Aortic Dissection and Aneurysmal Disease meets an important requirement to consolidate the wide-ranging information on which clinicians must base their practice. It is directed towards surgeons, physicians, and healthcare workers involved in the care of patients requiring cardiac, cardiothoracic and cardiovascular surgery. This book will be an essential resource for these professionals looking to accelerate the translation of basic research findings into clinical study and practice.

1.Provides clinical certainty about difficult and controversial areas of vascular malformation 2. Explains how to incorporate genetic studies to aid diagnosis 3. Illustrates and explains unique findings from world experts 4. Includes evidence-based material to reflect research from the last 2 decades 5.Multiple colour illustrations and clear explanations make the text easy to absorb.

In the 4th edition of Endovascular Surgery, Drs. Wesley S. Moore, Samuel S. Ahn, and a host of experts guide you through the latest developments in this innovative field. New procedures and special features, such as key points and case reviews, help illustrate effective patient care, and new topics such as endoscopic management of aneurismal disease and traumatic injuries review with you the latest endovascular surgical techniques. Full-text online access at www.expertconsult.com allows you to rapidly search this reference anytime, anywhere. Review basic principles and new techniques, and follow a practical, problem-solving approach to help address challenging areas. Gain greater detail and depth than other current texts, as well as fresh perspectives with contributions from new authors. Broaden your surgical skills with new chapters on endoscopic management of aneurismal disease and traumatic injuries, and review a valuable new section covering the TIPS Procedure for Portal Hypertension, Anesthetic Management for Endovascular Procedures, the Use of Coil Embolization in Endovascular Surgery, and more. See case presentations from the author's own review course to help you apply key information to real clinical situations. Reference the complete text and access case studies online at www.expertconsult.com. Keep your surgical practice current thanks to comprehensive updates throughout. An in-depth, core reference on the best practices and techniques in endovascular surgery. Perfect for both the training vascular surgeon who needs a comprehensive view of endovascular surgery as well as a refresher on current techniques and optimal outcomes for the practitioner.

Fundamentals of Frontline Surgery is an easy to read text, written by world class faculty, that provides clinicians with succinct and didactic information about what to do in high intensity, resource limited situations.With global conflicts and humanitarian emergencies on the rise, there has been a dramatic uptake in the number of volunteers for both military and humanitarian operations. This manual aids best practice and fast decision making in the field.

This new, comprehensive analysis of human cardiovascular control explains the control of pressure, vascular volume and blood flow during orthostatis and exercise. Analysis of the physical properties of the vascular system and their modification by mechanical, neural, and humoural factors is highlighted by novel graphical representations of basic concepts. Interactive effects of the vasculature on cardiac performance and factors that both control and limit oxygen transfer from lungs to cells are stressed. This complete account will prove invaluable for all medical students, physiologists and clinicians who wish to better understand the reflex and hormonal control of the human cardiovascular system.

Increasing evidence suggests that particularly in high-risk patients, endovascular solutions offer substantial advantages compared to vascular surgical procedures. Nevertheless, growing numbers of procedures are associated with an increased incidence of complications. Knowledge of specific complications in different vessel areas will support the interventionist in preventing such adverse events and if necessary, provide considerable reassurance if such complications need to be resolved. In Complications in Peripheral Vascular Interventions, typical and atypical complications are described for all peripheral vessel areas, and methods for how to handle these events are outlined. The book is divided in two parts. Part 1 reviews general aspects on complications in peripheral interventions, and Part II covers the specific vessel areas. Each chapter on the specific vessel area includes Introduction to the frequency and kind of complications in this vessel area Factors identifying high-risk patients for these complications Complications of specific interventional steps and tools Endovascular techniques to resolve these complications Methods to avoid complications Summary Checklist for emergency equipment Offering practical tips for the interventionist in the cath lab, high-volume interventionists share their experiences by reviewing complicated cases and outlining different strategies used in real-life scenarios.

A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.

The Royal College of Surgeons' of England two-day "definitive surgical trauma skills course" is run by the authors. The course began in 1997 but a new syllabus has recently been put in place.The focus is on thoracic ,abdominal and vascular injuries, caused by both penetrating trauma, such as a knife, and ballistic trauma caused by guns.This Manual accompanies the course and it's aim is to "demystify the body" and show how to control massive blood loss. Interventions, whether they be military or civilian, are descrbed in full, and techniques derived from the battlefield and world-wide hotspots in trauma -are exemplified within this book.