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Fluorescent Tools for Imaging Oxidative Stress in Biology (Hardcover, 1st ed. 2018)
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Fluorescent Tools for Imaging Oxidative Stress in Biology (Hardcover, 1st ed. 2018)
Series: Springer Theses
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This thesis advances the long-standing challenge of measuring
oxidative stress and deciphering its underlying mechanisms, and
also outlines the advantages and limitations of existing design
strategies. It presents a range of approaches for the chemical
synthesis of fluorescent probes that detect reversible changes in
cellular oxidative stress. The ability to visualise cellular
processes in real-time is crucial to understanding disease
development and streamline treatment, and this can be achieved
using fluorescent tools that can sense reversible disturbances in
cellular environments during pathogenesis. The perturbations in
cellular redox state are of particular current interest in medical
research, since oxidative stress is implicated in the pathogenesis
of a number of diseases. The book investigates different strategies
used to achieve ratiometric fluorescence output of the reversible
redox probes, which nullify concentration effects associated with
intensity-based probes. It also describes suitable approaches to
target these probes to specific cellular organelles, thereby
enabling medical researchers to visualise sub-cellular oxidative
stress levels, and addressing the typically poor uptake of chemical
tools into biological studies. In total it reports on four new
probes that are now being used by over twenty research groups
around the globe, and two of which have been commercialised. The
final chapters of this thesis demonstrate successful applications
of the sensors in a variety of biological systems ranging from
prokaryotes to mammalian cells and whole organisms. The results
described clearly indicate the immense value of collaborative,
cross-disciplinary research.
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