Nanoscale Imaging and Characterisation of Amyloid- (Hardcover, 1st ed. 2016)

This thesis presents a method for reliably and robustly producing samples of amyloid- (A ) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide's nanomechanical, elastic, thermal or spectroscopical properties. Amyloid- (A ) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of A with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	July 2016
First published:	2016
Authors:	Claire Louisa Tinker-Mill
Dimensions:	235 x 155 x 11mm (L x W x T)
Format:	Hardcover
Pages:	149
Edition:	1st ed. 2016
ISBN-13:	978-3-319-39533-3
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Professional & Technical > Technology: general issues > Nanotechnology Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Physics > States of matter > General Books > Science & Mathematics > Chemistry > Analytical chemistry > Qualitative analytical chemistry > Chemical spectroscopy, spectrochemistry > General Promotions
LSN:	3-319-39533-5
Barcode:	9783319395333

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