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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Molecular and Cell Biology of Neuropsychiatric Diseases (Paperback, Softcover reprint of the original 1st ed. 1994)
Loot Price: R2,933
Discovery Miles 29 330
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Molecular and Cell Biology of Neuropsychiatric Diseases (Paperback, Softcover reprint of the original 1st ed. 1994)
Series: Molecular and Cell Biology of Human Diseases Series
Expected to ship within 10 - 15 working days
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is"0l m 5-HT Ante-mortem (m = metabolite) . ". ~ Post-mortem m 0
Noradrenaline ,,-'-'-'-'0-J ,,-'-'-'-'-'-'- m Dopamine ~ .
'-'-'-'-'- . " Somatostatin . '1 Plaques Tangles * . ". . ". . 'I
Synapse loss * ChAT " ACh synthesis l"-,.
'-'-'-'-'-'-'-'-'-'-'-'-'- ,,-'-'-'-'-'-'-'-'-'-'-'-'-'-'- *
Neuronal loss ,,- ,,- . ". * o 0. 1 0. 2 0. 3 0. 4 0. 5 0. 6 0. 7
0. 8 0. 9 1. 0 Correlation coefficient with dementia rating Figure
2. 1 Various neurotransmitter and neuropathological measures on
neocortex obtained either at diagnostic craniotomy (ante-mortem) or
post-mortem and re- lationship to cognitive impairment (dementia
rating). Asterisks identify significant correlations. Negative and
positive correlations are not identified in this represen- tation
of the data. Only the physiologically relevant measure of
cholinergic neurones (acetylcholine synthesis) and indices of
cortical pyramidal neurone degeneration (neuronal loss, synapse
loss and tangles) correlate with severity of dementia. Note the
lack of correlation with the structural marker of cholinergic
neurones, ChAT activity. Loss of enzyme exceeded that of
acetylcholine synthesis (Sims et al. , 1983a), suggesting a
compensatory increase in synthesis in the few remaining neurones.
Data derived from Palmer (1987) and Terry et al. (1991). emission
tomography (PET) and magnetic resonance, may some day pro- vide
routine insight into differences in brain functioning. Success in
developing rapid and reliable diagnostic procedures, perhaps based
on changes in body fluid that reflect specific alterations in brain
protein metabolism, should ultimately play an important role in the
clinical development of new therapeutic agents.
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