Assembling the work of an international panel of researchers, Mass
Spectrometry of Nucleosides and Nucleic Acids summarizes and
reviews the latest developments in the field and provides a window
on the next generation of analysis. Beginning with an overview of
recent developments, the book highlights the most popular
ionization methods and illustrates the diversity of strategies
employed in the characterization and sequencing of DNA and RNA
oligomers, nucleosides, nucleotides, and adducts. It describes
studies performed on deoxyinosine and its analogues and provides an
introduction to tandem mass spectrometry (MS/MS).
Next, the contributors examine mass spectrometric application in
the study of cyclic nucleotides in biochemical signal transduction.
They analyze urinary modified nucleosides and explore DNA adducts.
They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and
examine various uses of electrospray ionization mass spectrometry
(ESI-MS). The book reviews recent progress in the direct MS
characterization of noncovalent nucleic acid-protein complexes,
explores the interaction and ionization of guanidine-derived
compounds with highly acidic biomolecules, and examines
quantitative identification of nucleic acids via signature
digestion products detected using mass spectrometry.
The book describes a direct-infusion ESI-MS approach that can
serve as a screening technique for the presence of modified
nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS
method for the in vitro replication studies on damage-containing
DNA substrates, and concludes with an examination of the influence
of metal ions on the structure and reactivity of nucleic acids.
The exciting developments in mass spectrometry technology have
fueled incredible advances in our understanding of nucleic acids
and their complexes. The contributions presented in this volume
capture the range of these advances, helping to inspire new
findings and avenues of research.
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