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Short Pulse Laser Systems for Biomedical Applications (Paperback, 1st ed. 2017)
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Short Pulse Laser Systems for Biomedical Applications (Paperback, 1st ed. 2017)
Series: SpringerBriefs in Applied Sciences and Technology
Expected to ship within 10 - 15 working days
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This book presents practical information on the clinical
applications of short pulse laser systems and the techniques for
optimizing these applications in a manner that will be relevant to
a broad audience, including engineering and medical students as
well as researchers, clinicians, and technicians. Short pulse laser
systems are useful for both subsurface tissue imaging and laser
induced thermal therapy (LITT), which hold great promise in cancer
diagnostics and treatment. Such laser systems may be used alone or
in combination with optically active nanoparticles specifically
administered to the tissues of interest for enhanced contrast in
imaging and precise heating during LITT. Mathematical and
computational models of short pulse laser-tissue interactions that
consider the transient radiative transport equation coupled with a
bio-heat equation considering the initial transients of laser
heating were developed to analyze the laser-tissue interaction
during imaging and therapy. Experiments were first performed to
characterize the tissue optical properties needed to optimize the
dose for thermal therapy. Experiments were then performed on animal
models to characterize the heat affected zone for LITT. The
experimental measurements were also validated using the
computational models.
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