Describes the thermodynamics and kinetics underlying hydrophobic
interaction chromatography of proteins. Outlines use of a kinetic
model in the predictive modeling of evaporation processes that
eliminates the need to know the composition and identity of the
chemical constituents in the sample. Explores building and
employing QSRR models in cyclodextrin modified high-performance
liquid chromatography (HPLC). Reviews chemometric methods commonly
paired with comprehensive 2D separations and key instrumental and
preprocessing considerations.
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