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Molecular Biology and Pathogenicity of Mycoplasmas (Paperback, Softcover reprint of the original 1st ed. 2002)
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Molecular Biology and Pathogenicity of Mycoplasmas (Paperback, Softcover reprint of the original 1st ed. 2002)
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The recent sequencing of mycoplasma genomes has marked a turning
point in the molecular genetic analysis of these microorganisms.
Transcriptome and proteome analyses promise to provide the first
definition of the total protein complement of a cell. The
mycoplasma group includes the smallest known self-replicating
organisms carrying the smallest number of genes. No wonder,
therefore, that mycoplasmas have a special appeal to those
interested in deciphering the minimal set of genes essential for
life. Mycoplasma genomics facilitated better understanding of
mycoplasma pathogenesis. Most impressive are the findings
concerning the interaction of mycoplasmas with the immune system,
macrophage activation, cytokine induction, mycoplasma cell
components acting as superantigens, and autoimmune manifestations.
The molecular definition of mycoplasmal adhesins responsible for
mycoplasma attachment to host cells and evasion of the host immune
system by antigenic variation of mycoplasmal surface components are
other 'hot' subjects of research.Demonstration of the ability of
mycoplasmas to enter host cells, cause fusogenic, apoptotic and
oncogenic effects, as well as the possible association of
mycoplasmas with arthritis, had their share in intensifying
research on mycoplasma pathogenesis, bringing more researchers into
the circle of those interested in this group of organisms. The
present book is a comprehensive, up-to-date, multi-authored
treatise.
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