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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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Nanoparticle-Mediated Immunotherapy (Paperback, 1st ed. 2021)
Loot Price: R4,343
Discovery Miles 43 430
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Nanoparticle-Mediated Immunotherapy (Paperback, 1st ed. 2021)
Series: Bioanalysis, 12
Expected to ship within 10 - 15 working days
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This book is intended to serve as an authoritative reference source
for a broad audience involved in the research, teaching, learning,
and practice of nanotechnology in immunotherapy. The combination of
nanotechnology and immunotherapy is recognized as a promising
treatment modality. In particular, the use of nanoparticles in
immunotherapy has attracted increased attention for their unique
efficacy and specificity in cancer treatment. A wide variety of
nanoparticles, such as polymeric and liposomal nanosystems, carbon
nanotubes, and gold nanoparticles have provided important
nanoplatforms for immunotherapeutic approaches. They have been
shown to improve delivery and efficacy of immunotherapeutic agents
such as vaccines or adjuvants. Nanoparticle-mediated thermal
therapy has demonstrated the effectiveness for precise tumor cell
ablation, radio-sensitization of hypoxic regions, enhancement of
drug delivery, activation of thermosensitive agents, and
enhancement of the immune system. Plasmonic nanoparticles are a
special type of metallic nanoparticles that has received great
interest due to their enhanced optical and electromagnetic
properties and their superior capacity to convert photon energy
into heat for selective photothermal therapy at the nanoscale
level. Nanoparticle sizes can also be controlled such that they
accumulate preferentially in tumors due to the enhanced
permeability and retention effect of tumor vasculature. Various
nanosystems such as gold nanoparticles have also been shown to
stimulate the immune system. Immunotherapies could thus
synergistically benefit from the combination with targeted
nanoparticle-mediated photothermal therapies, especially when
hyperthermia around immune-checkpoint inhibitors in the tumor bed
is combined with precise thermal ablation of cancer cells. Of great
importance is the possibility that such an approach can induce
long-term immunological memory that can provide protection against
tumor recurrence long after treatment of the initial tumors, like
an 'anticancer vaccine'. Nanoparticle-mediated immunotherapy could
lead to an entirely new treatment paradigm that challenges
traditional surgical resection approaches for many cancers and
metastases.
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