This book updates and expands on various aspects of the vasculature's microenvironment and how these regulate differentiation and assembly. Discussed in this new edition are efforts to capitalize on combing engineering techniques, to study and manipulate various biophysical cues, including: endothelial cell- pericyte interactions (Davis), mechanical forces to regulate vascularization in three-dimensional constructs (Levenberg), how matrix properties and oxygen tension regulate vascular fate and assembly (Gerecht), biophysical cues in relation to vascular aging (Ferreira), 3D printing of complex vascularized tissue (Hibino), the harnessing of biophysical cues for therapeutic vasculature interfacing with the damaged brain (Segura) and finally, the infarcted heart (Grayson). This second edition of Biophysical Regulation of Vascular Differentiation and Assembly provides an interdisciplinary view of vasculature regulation thru various biophysical cues and presents recent advances in measuring and controlling such parameters. This book will be of interest to biologists, biophysicists and engineers who work with vascular differentiation and assembly.

This newly-translated book takes the reader from the basic principles and conservation laws of hydrodynamics to the description of general atmospheric circulation. Among the topics covered are the Kelvin, Ertel and Rossby-Obukhov invariants, quasi-geostrophic equation, thermal wind, singular Helmholtz vortices, derivation of the Navier-Stokes equation, Kolmogorov's flow, hydrodynamic stability, and geophysical boundary layers. Generalizing V. Arnold's approach to hydrodynamics, the author ingeniously brings in an analogy of Coriolis forces acting on fluid with motion of the Euler heavy top and shows how this is used in the analysis of general atmospheric circulation.

This book is based on popular graduate and undergraduate courses given by F.V.Dolzhansky at the Moscow Institute of Physics and Technology, and is the result of the author's highly acclaimed work in Moscow's Laboratory of Geophysical Hydrodynamics. Each chapter is full of examples and figures, exercises and hints, motivating and illustrating both theoretical and experimental results. The exposition is comprehensive yet user-friendly in engaging and exploring the broad range of topics for students and researchers in mathematics, physics, meteorology and engineering. "

More than half of all stars in the universe formed and evolved as binary systems and their study is essential for understanding stellar and galactic evolution. The six lectures in this book give both a readable introduction and an up-to-date review of nearly all aspects of research into binary stars, including the range from common binaries to more exotic systems composed of white dwarfs, neutron stars and black holes.

Radar Remote Sensing: Applications and Challenges advances the scientific understanding, development, and application of radar remote sensing using monostatic, bistatic and multi-static radar geometry. This multidisciplinary reference pulls together a collection of the recent developments and applications of radar remote sensing using different radar geometry and platforms at local, regional and global levels. Radar Remote Sensing is for researchers and practitioners with earth and environmental and meteorological sciences, who are interested in radar remote sensing in ground based scatterometer and SAR systems; air borne scatterometer and SAR systems; space borne scatterometer and SAR systems.

These are the proceedings of an international meeting hosted by the Royal Observatory, Edinburgh, to commemorate the 30th anniversary of the dedication of the UKIRT, the United Kingdom InfraRed Telescope.

The volume comprises 31 professional level papers. The first part of the book has 10 thorough reviews of the conception, design and build of the telescope, as well as accounts of some its key instruments such as IRCAM (the common-user infrared camera), CGS4 (the fourth Cooled Grating Spectrometer) and the Wide Field Camera. The second part of the book comprises 14 reviews of scientific achievements during its twenty years of visitor mode operations. The final part of the book is a series of 7 reviews of the results from the multiple surveys being done as part of UKIDSS (UKIRT Infrared Deep Sky Survey).

The authors are all experts in their respective fields, for example instrument scientists, operations staff and leading astronomers.

With the success of Cherenkov Astronomy and more recently with the launch of NASA's Fermi mission, very-high-energy astrophysics has undergone a revolution in the last years. This book provides three comprehensive and up-to-date reviews of the recent advances in gamma-ray astrophysics and of multi-messenger astronomy. Felix Aharonian and Charles Dermer address our current knowledge on the sources of GeV and TeV photons, gleaned from the precise measurements made by the new instrumentation. Lars Bergstroem presents the challenges and prospects of astro-particle physics with a particular emphasis on the detection of dark matter candidates. The topics covered by the 40th Saas-Fee Course present the capabilities of current instrumentation and the physics at play in sources of very-high-energy radiation to students and researchers alike. This book will encourage and prepare readers for using space and ground-based gamma-ray observatories, as well as neutrino and other multi-messenger detectors.

This book on electromagnetic resonance phenomena describes a general approach to physical problems, ways to solve them, and properties of the solutions obtained. Attention is given to the discussion and interpretation of formal and experimental data and their links to global atmospheric conditions such as the dynamics of global thunderstorm activity, variations of the effective height of the lower ionosphere, etc.

Schumann resonance is related to worldwide thunderstorm activity, and simultaneously, to global properties of the lower ionosphere. Transverse resonance is predominantly a local phenomenon containing information on the local height and conductivity of the lower ionosphere and on nearby thunderstorm activity.

Transient events in ELF-VLF radio propagation are also treated. These are natural pulsed radio signals and/or abrupt changes of manmade VLF radio signals. The transients associated with cloud-to-ionosphere discharges (red sprites, blue jets, trolls) are discussed, and clarification of the underlying physical ideas and their practical applications to pioneer results achieved in the field recently are emphasised.

The retrieval problems arising in atmospheric remote sensing belong to the class of the - called discrete ill-posed problems. These problems are unstable under data perturbations, and can be solved by numerical regularization methods, in which the solution is stabilized by taking additional information into account. The goal of this research monograph is to present and analyze numerical algorithms for atmospheric retrieval. The book is aimed at physicists and engineers with some ba- ground in numerical linear algebra and matrix computations. Although there are many practical details in this book, for a robust and ef?cient implementation of all numerical algorithms, the reader should consult the literature cited. The data model adopted in our analysis is semi-stochastic. From a practical point of view, there are no signi?cant differences between a semi-stochastic and a determin- tic framework; the differences are relevant from a theoretical point of view, e.g., in the convergence and convergence rates analysis. After an introductory chapter providing the state of the art in passive atmospheric remote sensing, Chapter 2 introduces the concept of ill-posedness for linear discrete eq- tions. To illustrate the dif?culties associated with the solution of discrete ill-posed pr- lems, we consider the temperature retrieval by nadir sounding and analyze the solvability of the discrete equation by using the singular value decomposition of the forward model matrix.

Books published during recent years in the field of applied geo physics can be, in general, divided into two main types. The first type covers such multiaspect books as "Introduction to Geophysics," while the second-special works on fundamental theoretical prob lems with an elaborate mathematical description. The books of the first type are mainly intended for beginner students and specialists in adjacent fields. The books of the second type may be useful for teachers and theorists. However, there are also books of another (third) type. These books describe the experience in geophysical in vestigation under specific conditions or propose solutions to concrete geological problems, being a methodological guide for geophysicists and concentrating ideas both for advanced students and researchers. Authors hope to give the readers a book of this kind. Interpretation of geophysical fields is a complex consistent pro cess. Its successful realization requires: (a) knowledge of geological regularities and geological situation; (b) availability of petrophysical support; (c) mathematical methods of solving direct and inverse problems of geophysics (i.e. computation of geophysical fields from a known source and determination of source characteristics from known fields); (d) application of statistical and logico-informational procedures to the analysis and synthesis of observation results for revealing desired objects and peculiarities of the geological structure."

This volume describes current fundamental advances in the experimental and theoretical study of molecular dynamics and stochastic dynamic simulations, X-ray crystallography and NMR of biomolecules, the structure of proteins and its prediction, time resolved Fourier transform IR spectroscopy of biomolecules, the computation of free energy, applications of vibrational CD of nucleic acids, and solid state NMR. Further presentations include recent advances in UV resonance Raman spectroscopy of biomolecules, semiempirical MO methods, empirical force fields, quantitative studies of the structure of proteins in water by Fourier transform IR, and density functional theory. Metal-ligand interactions, DFT treatment of organometallic and biological systems, and simulation vs. X-ray and far IR experiments are also discussed in some detail. The text provides a broad perspective of the current theoretical aspects and experimental findings in the field of biomolecular dynamics, revealing future research trends, especially in areas where theoreticians and experimentalists could collaborate.

This book describes radionanomedicine as an integrated medicine using exogenous and endogenous This book describes radionanomedicine as an integrated approach that uses exogenous and endogenous nanomaterials for in vivo and human applications. It comprehensively explains radionanomedicine comprising nuclear and nanomedicine, demonstrating that it is more than radionanodrugs and that radionanomedicine also takes advantage of nuclear medicine using trace technology, in which miniscule amounts of materials and tracer kinetic elucidate in vivo biodistribution. It also discusses exogenous nanomaterials such as inorganic silica, iron oxide, upconversion nanoparticles and quantum dots or organic liposomes labelled with radioisotopes, and radionanomaterials used for targeted delivery and imaging for theranostic purposes. Further, it examines endogenous nanomaterials i.e. extracellular vesicles labelled with radioisotopes, known as radiolabelled extracellular vesicles, as well as positron emission tomography (PET) and single photon emission computed tomography (SPECT), which elucidate the biodistribution and potential for therapeutic success.

While it seems possible to present a fairly complete uni?ed theory of undistorted polytropes, as attempted in the previous chapter, the theory of distorted polytropes is much more extended and - phisticated, so that I present merely a brief overview of the theories that seem to me most interesting and important. Basically, the methods proposed to study the hydrostatic equilibrium of a distorted self-gravitating mass can be divided into two major groups (Blinnikov 1975): (i) Analytic or semia- lytic methods using a small parameter connected with the distortion of the polytrope. (ii) More or less accurate numerical methods. Lyapunov and later Carleman (see Jardetzky 1958, p. 13) have demonstrated that a sphere is a unique solution to the problem of hydrostatic equilibrium for a ?uid mass at rest in tridimensional space. The problem complicates enormously if the sphere is rotating rigidly or di?erentially in space round an axis, and/or if it is distorted magnetically or tidally. Even for the simplest case of a uniformly rotating ?uid body with constant density not all possible solutions have been found (Zharkov and Trubitsyn 1978, p. 222). The sphere becomes an oblate ?gure, and we have no a priori knowledge of its strati? cation, boundary shape, planes of symmetry, transfer of angular momentum in di?erentially rotating bodies, etc.

Physical models of gas discharge processes in gas flows and numerical simulation methods, which are used for numerical simulation of these phenomena are considered in the book. Significant attention is given to a solution of two-dimensional problems of physical mechanics of electric arc, radio-frequency, micro-wave, and optical discharges, as well as to investigation of electrodynamic structure of direct current glow discharges. Problems of modern computational magnetohydrodynamics (MHD) are considered also. Prospects of the different kinds of discharges use in aerospace applications are discussed. This book is intended for scientists and engineers concerned with physical gas dynamics, physics of the low-temperature plasma and gas discharges, and also for students and post-graduate students of physical and technical specialties of universities.

This chapter has shown a small sample of GIS applications in economic devel- ment. GIS is a powerful tool for data analysis and presentation, and the economic development rami cations are truly signi cant. The speed at which data and stra- gies can be coordinated is clearly changing the way economic developers approach their job. There are a number of important trends that are likely to result in GIS becoming more pervasive in the economic development community. These include declining costs of GIS software, increased computing power, and the growth of Web-based GIS applications. There also has been increase in GIS skills among economic development professionals. References Bastian, L. (2002). Getting the best from the web. Area Development Site and Facility Planning, March 1-7. Accessed 5 September 2008. Batheldt, H. (2005). Geographies of production: growth regimes in spatial perspective (II) - kno- edge creation and growth in clusters. Progress in Human Geography, 29(2), 204-216. Bathelt,H.,Malmberg,A.,Maskell,P.(2004). Clustersandknowledge: localbuzz,globalpipelines and the process of knowledge creation. Progress in Human Geography, 28(1), 31-56. Bernthal, M., Regan, T. (2004). The economic impact of a NASCAR racetrack on a rural com- nity and region. Sports Marketing Quarterly, 13(1), 26-34. Blackwell, M., Cobb, S. Weinbert, D. (2002). The economic impact of educational institutions: Issues and methodology. Economic Development Quarterly, 16(1), 88-95. Blair, J. (1995). Local Economic Development, Analysis and Practice. Thousand Oaks, CA: Sage Publications.

This book presents a physicists view of life. The primary life functions of animals, such as eating, growing, reproducing and getting around all depend on motion: Motion of materials through the body, motion of limbs and motion of the entire body through water, air and on land. These activities are driven by internal information stored in the genes or in the brain and by external information transmitted by the senses. This book models these life functions with the tools of physics. It will appeal to all scientists, from the undergraduate level upwards, who are interested in the role played by physics in the animal kingdom.

Everything you wanted to know about physics, biology, and the world at large becomes straightforward once you understand the life-organizing principle. Author E.M. Elsheikh, a mathematician and longtime professor, examines what the principle tells us about nature and life in this academic work. He proves that the secrets of our world reside in the quantum information contained in our DNA and genome.Discover the inner workings of life, and develop a better understanding of a maximum-action principle that explains self-organization, self-replication, and self-evolution. He also explores such topics as laws that describe phylogenetic evolution and ontogenetic development; little-known facts about genetics and evolution, including why Darwinian theory facilitates a more dynamic conception of human nature; extensions of quantum theory; and new foundations of knowledge.By challenging the notions of mainstream biology and physics and questioning assumptions about life being a physical rather than a supernatural phenomenon, you'll stumble upon truths that few others know. Get ready to go on a fascinating journey that challenges paradigms and leads you to the Discovery of the Life-Organizing Principle.

Various effects of the atmosphere have to be considered in space geodesy and all of them are described and treated consistently in this textbook. Two chapters are concerned with ionospheric and tropospheric path delays of microwave and optical signals used by space geodetic techniques, such as the Global Navigation Satellite Systems (GNSS), Very Long Baseline Interferometry (VLBI), or Satellite Laser Ranging (SLR). It is explained how these effects are best reduced and modelled to improve the accuracy of space geodetic measurements. Other chapters are on the deformation of the Earth's crust due to atmospheric loading, on atmospheric excitation of Earth rotation, and on atmospheric effects on gravity field measurements from special satellite missions such as CHAMP, GRACE, and GOCE. All chapters have been written by staff members of the Department of Geodesy and Geoinformation at TU Wien who are experts in the particular fields.

This book deals with different aspects of small satellites for Earth observation: programmatics; current and planned Earth observation missions; spacebased instruments; satellite constellations; satellite subsystems;spacecraft bus systems; lessons learned; special aspects (e.g. thermal control, integration and test, launch services, ground station).The material provided is collected from the 6th IAA Symposium on Small Satellites for Earth Observation, initiated by the International Academy of Astronautics (IAA), and hosted by DLR, the German Aerospace Center. The participation of scientists, engineers, and managers from 24 countries reflected the high interest in the use of small satellites for dedicated missions applied to Earth observation.

Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties. The benefits of medical image synthesis have sparked growing interest in a number of advanced clinical applications, such as magnetic resonance imaging (MRI)-only radiation therapy treatment planning and positron emission tomography (PET)/MRI scanning. This book will be a comprehensive and exciting resource for undergraduates, graduates, researchers, and practitioners.

This book systematizes data on the heterophase states and their evolution in perovskite-type ferroelectric solid solutions. It also provides a general interpretation of heterophase and domain structures on changing temperature, composition or electric field, as well as the complete analysis of interconnections domain structures, unit-cell parameters changes, heterophase structures and stress relief. The description of numerous examples of heterophase states in lead-free ferroelectric solid solutions is also included. Domain state-interface diagrams contribute to the interpretation of heterophase states in perovskite-type ferroelectric solid solutions and describe the stress relief in the presence of polydomain phases, the behavior of unit-cell parameters of coexisting phases, the effect of external electric field etc. This 2nd edition generalizes the results on the heterophase ferroelectric solid solutions and the stress relief and presents new results on heterophase/domain structures and phase contents in lead-free ferroelectric solid solutions.

The biophysics of excitable membranes and extracellular potential fields emerged at the end of the 18th century, together with electrophysiology, and has been used ever since as a basis for the development of electrophysiological investigations. This holds true even for the contemporary stage of initial discoveries concerning the molecular mechanisms of membrane excitability. The biophysics of ionic channels has gradually revealed the genesis of the ionic currents and of the biopotentials in different excitable structures. On the basis of electrodynamics, the extracellular potential fields in the living body, considered as a volume conductor, have been studied intensively. The knowledge accumulated constitutes the theoretical basis for interpretation of the electrophysiological data. Over a period of more than 15 years a group of Bulgarian investigators led by A. Gydikov has systematically studied the dependence between the intra- and extracellular potentials of the skeletal muscles. The present book summarizes these investigations. Using a great amount of factual material from experiments and model investigations on the skeletal muscle potentials, the author considers: (a) the extracellular potential field of single skeletal muscle fibres and their dependence of the parameters of intracellular action potentials, the geometric parameters of the fibres and of the volume conductor; (b) the potentials of single motor units; (c) the compound and reflex muscle potentials, and (d) the interference electromyogram. The comprehensive consideration of the biophysics of skeletal muscle potentials is of interest to a broad circle of specialists. The book summarizes contemporary knowledge in thisfield and presents a consistent theoretical basis of electromyography which is of great importance not only for the neurological clinic, but also for different fields of applied physiology.

This book highlights and discusses recent developments that have contributed to an improved understanding of observed mantle heterogeneities and their relation to the thermo-chemical state of Earth's mantle, which ultimately holds the key to unlocking the secrets of the evolution of our planet. This series of topical reviews and original contributions address 4 themes. Theme 1 covers topics in geophysics, including global and regional seismic tomography, electrical conductivity and seismic imaging of mantle discontinuities and heterogeneities in the upper mantle, transition zone and lower mantle. Theme 2 addresses geochemical views of the mantle including lithospheric evolution from analysis of mantle xenoliths, composition of the deep Earth and the effect of water on subduction-zone processes. Theme 3 discusses geodynamical perspectives on the global thermo-chemical structure of the deep mantle. Theme 4 covers application of mineral physics data and phase equilibrium computations to infer the regional-scale thermo-chemical structure of the mantle.

This book is devoted to current advances in the field of nonlinear mathematical physics and modeling of critical phenomena that can lead to catastrophic events. Pursuing a multidisciplinary approach, it gathers the work of scientists who are developing mathematical and computational methods for the study and analysis of nonlinear phenomena and who are working actively to apply these tools and create conditions to mitigate and reduce the negative consequences of natural and socio-economic disaster risk. This book summarizes the contributions of the International School and Workshop on Nonlinear Mathematical Physics and Natural Hazards, organized within the framework of the South East Europe Network in Mathematical and Theoretical Physics (SEENET MTP) and supported by UNESCO. It was held at the Bulgarian Academy of Sciences from November 28 to December 2, 2013. The contributions are divided into two major parts in keeping with the scientific program of the meeting. Among the topics covered in Part I (Nonlinear Mathematical Physics towards Critical Phenomena) are predictions and correlations in self organized criticality, space-time structure of extreme current and activity events in exclusion processes, quantum spin chains and integrability of many-body systems, applications of discriminantly separable polynomials, MKdV-type equations, and chaotic behavior in Yang-Mills theories. Part II (Seismic Hazard and Risk) is devoted to probabilistic seismic hazard assessment, seismic risk mapping, seismic monitoring, networking and data processing in Europe, mainly in South-East Europe. The book aims to promote collaboration at the regional and European level to better understand and model phenomena that can cause natural and socio-economic disasters, and to contribute to the joint efforts to mitigate the negative consequence of natural disasters. This collection of papers reflects contemporary efforts on capacity building through developing skills, exchanging knowledge and practicing mathematical methods for modeling nonlinear phenomena, disaster risk preparedness and natural hazards mitigation. The target audience includes students and researchers in mathematical and theoretical physics, earth physics, applied physics, geophysics, seismology and earthquake danger and risk mitigation.

The symbiosis between particles physics and cosmology has virtually become a conjugal relationship. Hence the 9th Biennial Course of the International School of Cosmic-Ray Astrophysics was designed to bridge these formerly disparate disciplines. This NATO Advanced Study Institute took place at the Ettore Majorana Centre in Erice, Italy, June 20-30, 1992. Seventy participants from 17 countries participated in lively interactions and enjoyed the stimulating lectures that form the basis for this volume. The book includes current advances in both astrophysics (cosmic gamma ravs, X-rays, cosmic rays) and cosmology (an introduction to inflation in big-bang theory, the age of the universe, nucleosynthesis in the early universe). It is suitable for reading and study by all interested physical scientists, especially those having a limited specialized background in astrophysics and cosmology.

This volume contains lectures given at the NATO Advanced Study Institute on Long-Time Predictions in Dynamics conducted in Cortina d'Ampezzo, Italy during August 3-16, 1975. The lectures were presented in groups, according to the original structure of the Institute. Under "Fundamentals" the general concepts were treated by Contopoulos, DeWitt, Reichl, Stiefel, Szebehely, Bartlett, Kirchgraber, Verhults and Sigrist. This was followed by the series of lectures on "Numerical and Statistical Analysis" offered by Aarseth, Baumgarte and Tapley. The third principal subject was "Three and Many-Body Problems" with Garfinkel, Broucke, Hadjidemetriou, Marchal, Nahon, Waldvogel, Lasco, and Markellos as the major speakers. The last group of lectures treated "Dynamics in Astronomy" by Colombo, Message, Ovenden, Vicente, and Douglas. Some of the outstanding lectures were rather didactic in nature or were published elsewhere or could not meet the deadline for publication. The Editors will be delighted to furnish leads to those interested in these lectures. Some of the lectures were presented in form of seminar-contributions. These are published as Summaries at the end of this Volume. The Institute was dedicated to the conceptual, analytical, numerical and applied aspects of the problem of long-time predic tion in dynamics. This fundamental problem emerged in all lectures: linearization, regularization, stabilization, averaging, estimation, periodic orbits, qualitative aspects, secular variations, resonance, invariants, etc. were some of the subjects treated in depth. Some conclusions are offered here with the utmost humility and with the advance acknowledgement of the fact that we all hear what we want to hear."