This book demonstrates the usefulness of tools from statistical mechanics for biology. It includes the new tendencies in topics like membranes, vesicles, microtubules, molecular motors, DNA, protein folding, phase transitions in biological systems, evolution, population dynamics, neural systems and biological oscillators, with special emphasis on the importance of statistical mechanics in their development. The book addresses researchers and graduate students.

Many important observational clues about our understanding of how stars and planets form in the interior of molecular clouds have been amassed using recent technological developments. ESO's very large telescope promises to be a major step forward in the investigation of stellar nurseries and infant stars. This volume collects papers from the leaders in this very timely field of astrophysical research. It presents theoretical and a host of observational results and many papers show the plans for future observations.

This book assembles chapters from experts in the Biophysics of RNA to provide a broadly accessible snapshot of the current status of this rapidly expanding field. The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, highlighting just one example of a large number of non-protein coding RNAs. Because non-protein coding RNAs outnumber protein coding genes in mammals and other higher eukaryotes, it is now thought that the complexity of organisms is correlated with the fraction of their genome that encodes non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic transposons, higher-level organization of eukaryotic chromosomes, and gene expression itself are found to largely be directed by non-protein coding RNAs. The biophysical study of these RNAs employs X-ray crystallography, NMR, ensemble and single molecule fluorescence spectroscopy, optical tweezers, cryo-electron microscopy, and other quantitative tools. This emerging field has begun to unravel the molecular underpinnings of how RNAs fulfill their multitude of roles in sustaining cellular life. The physical and chemical understanding of RNA biology that results from biophysical studies is critical to our ability to harness RNAs for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry.

This thesis focuses on the theoretical foundation of the Standard Model valid up to the Planck scale, based on the current experimental facts from the Large Hadron Collider. The thesis consists of two themes: (1) to open up a new window of the Higgs inflation scenario, and (2) to explore a new solution to the naturalness problem in particle physics. In the first area, on the Higgs inflation scenario, the author successfully improves a large value problem on a coupling constant relevant to the Higgs mass in the Standard Model, in which the coupling value of the order of 105 predicted in a conventional scenario is reduced to the order of 10. This result makes the Higgs inflation more attractive because the small value of coupling is natural in the context of ultraviolet completion such as string theory. In the second area, the author provides a new answer to the naturalness problem, of why the cosmological constant and the Higgs mass are extremely small compared with the Planck scale. Based on the baby universe theory originally proposed by Coleman, the smallness of those quantities is successfully explained without introducing any additional new particles relevant at the TeV energy scale.

Ever since their discovery in 1967, pulsars and neutron stars have provided an unprecedented opportunity to study the extremes of physics. This started with the very rapid identification of pulsars as rotating neutron stars with extremely strong magnetic fields and, selecting just a few highlights from the following decades, was followed by the discovery of the Hulse-Taylor binary, millisecond pulsars, the first pulsars in globular clusters, the pulsar planets and the double pulsar. In the last decade alone, we have made some amazing discoveries and observations with an impact across all areas of astronomy. With these proceedings of IAU Symposium 337, the 50th anniversary of the discovery of pulsars is celebrated by reflecting on what we have learned from these remarkable physical laboratories and by casting our eyes forward to the exciting opportunities they will provide for physical and astrophysical studies in the coming decades.

This timely book presents an overview of the galaxies within the Local Volume, including the Local Group and our closest neighbours, the Andromeda Galaxy and the Magellanic Clouds. Presented here are the latest results from radio, infrared and optical surveys as well as detailed multi-wavelength studies of individual galaxies. The book aims to provide a vibrant forum for presentations and discussions across a broad range of astrophysical topics.

In Bilayer Lipid Membranes. Structure and Mechanical Properties the authors use new methods of measurement, which they have themselves developed, to present an analysis of the relation between membrane structure and viscoelastic properties, in particular in the transversal direction. Hianik and Passechnik's approach is fundamentally different from the usual one, in that they analyze lipid bilayer dynamics during various modes of deformation, arriving at a new, three-layer' model that accounts for the great heterogeneity of biomembranes. The macroscopic parameters of membranes have been measured using a wide variety of methods, leading to a discussion of the correlations between the parameters. There is also an extensive discussion of the dynamic changes in mechanical properties of lipid bilayers in the course of conformational transition of integral proteins. During the conformational changes of proteins, the structure of a bilayer undergoes a transition, reaching a new, stable membrane state. The book is the first to present a comprehensive analysis of long-distance interaction in lipid bilayers and of molecular mechanisms of mechanoreception. Audience: Scientists and graduate students working in biophysics, membranology, physiology, medicine, pharmacology, bioelectronics, electrochemistry, and colloid chemistry.

The discovery of the earth's radiation belts in 1957 marked the beginning of what is now known as magnetospheric physics. The field has evolved normally from an early discovery phase through a period of exploration and into an era of quantitative studies of the dynamics of magnetized plasmas as they occur in nature. Such environments are common throughout the universe and have been studied in varying detail at the sun, the planets, pulsars, and certain radio galaxies. The purpose of this book is to describe basic quantitative aspects of magnetospheric physics. We use selected examples from the earth's magnetosphere to show how theory and data together form a quantitative framework for magnetospheric research. We have tried to organize the material along the philosophy of starting simply and adding com plexity only as necessary. We have avoided controversial and relatively new research topics and have tried to use as examples physical processes generally accepted as important within the earth's magnetospheric system. However, even in some of our examples, the question of whether the physical process applied to a particular problem is the dominant process, has yet to be answered."

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.

Audouin Dollfus Observatoire de Paris, Section de Meudon, 92195 Meudon, FRfu CE The North Atlantic Treaty Organization (NATO) and, in particular, its Department of Scientific Affairs headed by Dr. C. Sinclair, actively supports new fields of science. The recent exploration of the outer parts of the Solar System by spacecraft focused the attention of a large community of scientists on the problem of ices, which playa major role in the accretionary processes in space except for the close neighborhood of the Sun and of other stars. NATO responded to this new interest by agreeing to sponsor an Advanced Research Workshop "Ices in the Solar System," provided a proper organizing body could be set up. It was a pleasure to organize such a workshop jointly with Profes sor Roman Smoluchowski who had earlier organized similar conferences. I knew from the experience of others who managed such meetings in the past that there would be much work, but the opportunity of cooperating with Smoluchowski was very attractive and convinced me to agree. If well organized, the whole project promised to be more than rewarding for a large community of scientists, both in the short run and in the long run, by clarifying certain outstanding questions in astrophysics. It became clear that a well-organized international conference would attract top scientists and help unravel many fundamental problems."

The Andromeda Galaxy, or M31, is an attractive galaxy for astronomers. It is close to us, it is of about the size of our galaxy, it provides some intriguing observational puzzles because the galaxy is nearly edge-on, and many objects can be studied in detail, because they are still sufficiently bright. With the current developments in instrumentation with which increasingly detailed studies of the Andromeda Galaxy can be made, this book provides a solid foundation for the start of new observations. This book is a mine of information about M31. It can be used as a reference by insiders, and at the same time it provides easy access for newcomers to the field.

Remote Sensing from a New Perspective The idea for this book began many years ago, when I was asked to teach a course on remote sensing. Not long before that time, I had been part of the effort to develop the first database for planetary data with a common digital array format and interactive processing capabilities to correlate those data easily: the lunar consortium. All the available lunar remote sensing data were included, orbital and ground-based, ranging across the entire electromagnetic spectrum. I had used this powerful tool extensively, and, in that spirit, I was determined to create a course which covered the entire spectrum and a variety of targets. As I looked around for the equivalent of a textbook, which I was willing to pull together from several sources, I realized that available material was very heavily focused on the visual and near visual spectrum and on the Earth as a target. Even The Surveillant Science, edited by Edward Holz and published in 1973, which broke new ground in having diverse articles on most of the spectrum when it was created, focused entirely on the Earth. My personal favorite, the exceedingly well written book on remote sensing by Floyd Sabins first published in 1978, covered the visual, infrared, and microwave portions of the spectrum beautifully but focused on the Earth as well. Unhindered, I developed what I called 'packets' of material for each part of the spectrum.

This book provides a comprehensive presentation of Earth s energy flows and their consequences for the climate. The Earth s climate as well as planetary climates in general, are broadly controlled by three fundamental parameters: the solar irradiance, the planetary albedo and the planetary emissivity. Space measurements indicate that these three quantities are remarkably stable. A minor decrease inplanetary emissivity is consistent with theoretical calculations. This is due to the ongoing increase of atmospheric greenhouse gases making the atmosphere more opaque to long wave terrestrial radiation. As a consequence radiation processes are slightly out of balance as less heat is leaving the Earth in the form of thermal radiation than the incoming amount of heat from the sun. Present space-based systems cannot yet satisfactorily measure this imbalance, but the effect can be inferred from the measurements of the increase of heat in the oceans. Minor amounts of heat are also used to melt ice and to warm the atmosphere and the surface of the Earth.
The book brings to fore the complexity of feedback processes of the Earth s climate system and in particular the way clouds and aerosols affect the energy balance both directly and indirectly through feed-back loops driven by the dynamics of atmospheric, ocean and land surface processes. The book highlights recent scientific progress as well as remaining challenges.
Previously published in Surveys in Geophysics, Volume 33, Nos. 3-4, 2012"

"Dynamics of Soft Matter: Neutron Applications" provides an overview of neutron scattering techniques that measure temporal and spatial correlations simultaneously, at the microscopic and/or mesoscopic scale. These techniques offer answers to new questions arising at the interface of physics, chemistry, and biology. Knowledge of the dynamics at these levels is crucial to understanding the soft matter field, which includes colloids, polymers, membranes, biological macromolecules, foams, emulsions towards biological & biomimetic systems, and phenomena involving wetting, friction, adhesion, or microfluidics.

Emphasizing the complementarities of scattering techniques with other spectroscopic ones, this volume also highlights the potential gain in combining techniques such as rheology, NMR, light scattering, dielectric spectroscopy, as well as synchrotron radiation experiments. Key areas covered include polymer science, biological materials, complex fluids and surface science.

IAU Symposium No. 134 on Active Galactic Nuclei was hosted by the Lick Observatory, as part of the celebration of its centennial, for the Observatory went into operation as part of the University of California on June 1, 1888. Twenty years later, in 1908, Lick Observatory graduate student Edward A. Fath recognized the unusual emission-line character of the spectrum of the nucleus of the spiral "nebula" NGC 1068, an object now well-known as one of the nearest and brightest Seyfert galaxies and active galactic nuclei. Ten years after that, and seventy years before this Symposium, Lick Observatory faculty member Heber D. Curtis published his description of the "curious straight ray" in M 87, "apparently connected with the nucleus by a thin line of matter," which we now recognize as an example of one of the jets which are the subject of so much current AGN research. The symposium was held at Kresge College on the campus of the University of California, Santa Cruz, only a short walk through the redwood groves to the Lick Observatory offices. A total of 232 astronomers and astrophysicists from 24 countries attended and took part in the Symposium. About 200 more had applied to come, but could not be accepted in order to keep the meeting at a reasonable size. Most of the participants lived in the Kresge College apartments immediately adjacent to the Kresge Town Hall in which the oral sessions took place.

The high accuracy of modern astronomical spatial-temporal reference systems has made them considerably complex. This book offers a comprehensive overview of such systems. It begins with a discussion of 'The Problem of Time', including recent developments in the art of clock making (e.g., optical clocks) and various time scales. The authors address the definitions and realization of spatial coordinates by reference to remote celestial objects such as quasars. After an extensive treatment of classical equinox-based coordinates, new paradigms for setting up a celestial reference system are introduced that no longer refer to the translational and rotational motion of the Earth. The role of relativity in the definition and realization of such systems is clarified. The topics presented in this book are complemented by exercises (with solutions). The authors offer a series of files, written in Maple, a standard computer algebra system, to help readers get a feel for the various models and orders of magnitude. Beyond astrometry, the main fields of application of high-precision astronomical spatial-temporal reference systems and frames are navigation (GPS, interplanetary spacecraft navigation) and global geodynamics, which provide a high-precision Celestial Reference System and its link to any terrestrial spatial-temporal reference system. Mankind's urgent environmental questions can only be answered in the context of appropriate reference systems in which both aspects, space and time, are realized with a sufficiently high level of accuracy. This book addresses all those interested in high-precision reference systems and the various techniques (GPS, Very Long Baseline Interferometry, Satellite Laser Ranging, Lunar Laser Ranging) necessary for their realization, including the production and dissemination of time signals.

The study of planet formation has been revolutionized by recent observational breakthroughs, which have allowed the detection and characterization of extrasolar planets, the imaging of protoplanetary disks, and the discovery of the Solar System's Kuiper Belt. Written for beginning graduate students, this textbook provides a basic understanding of the astrophysical processes that shape the formation of planetary systems. It begins by describing the structure and evolution of protoplanetary disks, moves on to the formation of planetesimals, terrestrial and gas giant planets, and concludes by surveying new theoretical ideas for the early evolution of planetary systems. Covering all phases of planet formation - from protoplanetary disks to the dynamical evolution of planetary systems - this introduction can be understood by readers with backgrounds in planetary science, and observational and theoretical astronomy. It highlights the physical principles underlying planet formation and the areas where more research and new observations are needed.

This book describes origin and characteristics of the Earth's thermal field, thermal flow propagation and some thermal phenomena in the Earth. Description of thermal properties of rocks and methods of thermal field measurements in boreholes, underground, at near-surface conditions enables to understand the principles of temperature field acquisition and geothermal model development. Processing and interpretation of geothermal data are shown on numerous field examples from different regions of the world. The book warps, for instance, such fields as analysis of thermal regime of the Earth's crust, evolution and thermodynamic conditions of the magma-ocean and early Earth atmosphere, thermal properties of permafrost, thermal waters, geysers and mud volcanoes, methods of Curie discontinuity construction, quantitative interpretation of thermal anomalies, examination of some nonlinear effects, and integration of geothermal data with other geophysical methods. This book is intended for students and researchers in the field of Earth Sciences and Environment studying thermal processes in the Earth and in the subsurface. It will be useful for specialists applying thermal field analysis in petroleum, water and ore geophysics, environmental and ecological studies, archaeological prospection and climate of the past.

Most of the specialists working in this interdisciplinary field of physics, biology, biophysics and medicine are associated with "The International Institute of Biophysics" (IIB), in Neuss, Germany, where basic research and possibilities for applications are coordinated. The growth in this field is indicated by the increase in financial support, interest from the scientific community and frequency of publications.

Audience: The scientists of IIB have presented the most essential background and applications of biophotonics in these lecture notes in biophysics, based on the summer school lectures by this group. This book is devoted to questions of elementary biophysics, as well as current developments and applications. It will be of interest to graduate and postgraduate students, life scientists, and the responsible officials of industries and governments looking for non-invasive methods of investigating biological tissues.

This thesis explores the possibility of searching for new effects of dark matter that are linear in g, an approach that offers enormous advantages over conventional schemes, since the interaction constant g is very small, g<<1. Further, the thesis employs an investigation of linear effects to derive new limits on certain interactions of dark matter with ordinary matter that improve on previous limits by up to 15 orders of magnitude. The first-ever limits on several other interactions are also derived. Astrophysical observations indicate that there is five times more dark matter-an 'invisible' form of matter, the identity and properties of which still remain shrouded in mystery-in the Universe than the ordinary 'visible' matter that makes up stars, planets, dust and interstellar gases. Conventional schemes for the direct detection of dark matter involve processes (such as collisions with, absorption by or inter-conversion with ordinary matter) that are either quartic (g4) or quadratic (g2) in an underlying interaction constant g.

Proceedings of the 128th Symposium of the International Astronomical Union, held in Coolfont, West Virginia, USA, October 20-24, 1986.

The determination of when, how, how often and with whom an animal breeds is moving rapidly away from evolutionary pressures and towards human purposes: these include the breeding of around 50 billion mammals and birds for food production annually, the breeding of pedigree dogs and cats, racing dogs and horses, specialised laboratory animal strains and the use of reproductive science to conserve endangered species or breeds and to limit unwanted populations of pests and non-native species. But the ethics and sustainability of this takeover of animals' reproductive lives have been insufficiently examined by either professionals or the public. This book discusses the methods, the motivations and the consequences of human intervention in animal breeding in terms of animal health, behaviour and well-being. It explores where we are now and the choices ahead, and looks to a future where we have more respect for animals as sentient beings and where we could loosen the reins of reproductive control.

This book offers an overview of state-of-the-art in non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specific detection tools. Advanced materials play multiple roles in ultrasensitive detection. Optical and electrochemical detection tools are among the most widely investigated to analyze non amplified nucleic acids. Biosensors based on piezoelectric crystal have been also used to detect unamplified genomic DNA. The main scientific topics related to DNA diagnostics are discussed by an outstanding set of authors with proven experience in this field.