The book is structured in nine sections, each containing several chapters. The volume starts with an overview of analytical techniques and progresses through purification of proteins; protein modification and inactivation; protein size, shape, and structure; enzyme kinetics; protein-ligand interactions; industrial enzymology; and laboratory quality control. The book is targeted at all scientists interested in protein research.

This two volume set introduces the up-to-date high-tech applications of Aggregation-Induced Emission (AIE) luminogens mainly in the areas of biosensing, bioimaging, and biomedicine. The 1st volume covers the applications of AIE materials in biosensing and bioimaging, including the technological utilizations in ionic/biomolecular sensing, bacterial imaging, cell imaging, intracellular microenvironment analysis, advanced optical imaging and multimodality, etc. It is an essential reference for materials scientists, chemists, physicists and biological chemists.

Gamma-ray astronomy began in the mid-1960s with balloon satellite, and, at very high photon energies, also with ground-based instruments. However, the most significant progress was made in the last decade of the 20th century, when the tree satellite missions SIGMA, Compton, and Beppo-Sax gave a completely new picture of our Universe and made gamma-ray astronomy an integral part of astronomical research. This book, written by well-known experts, gives the first comprehensive presentation of this field of research, addressing both graduate students and researchers. Gamma-ray astronomy helps us to understand the most energetic processes and the most violent events in the Universe. After describing cosmic gamma-ray production and absorption, the instrumentation used in gamma-ray astronomy is explained. The main part of the book deals with astronomical results, including the somewhat surprising result that the gamma-ray sky is continuously changing.

This volume opens up new perspectives on the physics of the Earth's interior for graduate students and researchers working in the fields of geophysics and geodesy. It looks at our planet in an integrated fashion, linking the physics of its interior to the geophysical and geodetic techniques that record, over a broad spectrum of spatial wavelengths, the ongoing modifications in the shape and gravity field of the planet. Basic issues related to the rheological properties of the Earth's mantle and to its slow deformation will be understood, in both mathematical and physical terms, within the framework of an analytical normal mode relaxation theory. Fundamentals of this theory are developed in the first, tutorial part. The second part deals with a wide range of applications, ranging from changes in the Earth's rotation to post-seismic deformation and sea-level variations induced by post-glacial rebound. In the study of the physics of the Earth's interior, the book bridges the gap between seismology and geodynamics.

This volume contains the Proceedings of the Fourth Scientific Meeting of the Spanish Astronomical Society (Sociedad Espanola de Astronomfa, SEA). The meeting was held at the Universidade de Santiago de Compostela in Galicia from September 11 to 14, 2000. The event brought together 156 participants who pre- sented their latest results in many different subjects. In comparison with the previous scientific meetings of the Society, the numbers of oral talks and poster contributions (95 and 51, respectively) are rapidly increasing, confirming that the SEA conferences are becoming a point of reference to assess the interests and achievements of astrophysical research in Spain. During the meeting, the SEA made public the granting of the Prize to the Best Spanish Ph. D. Thesis in As- tronomy and Astrophysics for the period 1998-1999 to Dr. H. Socas. This is the first time that the SEA is awarding this prize, which aim is to encourage young spanish astrophysicists to pursue a high level scientific career. The Society is indebted to the Universidade de Santiago de Compostela, and, in particular, to the Observatorio Astronomico Ramon Marfa Aller, for its hospi- tality. The Local Organizing Committee took care of all the logistics details to ensure a nice stay for all the participants. The effort of the Scientific Organizing Committee was decisive in determining the organizational and scientific success of the meeting.

Lasers are progressively more used as versatile tools for fabrication purposes. The wide range of available powers, wavelengths, operation modes, repetition rates etc. facilitate the processing of a large spectrum of materials at exceptional precision and quality. Hence, manifold methods were established in the past and novel methods are continuously under development. Biomimetics, the translation from nature-inspired principles to technical applications, is strongly multidisciplinary. This field offers intrinsically a wide scope of applications for laser based methods regarding structuring and modification of materials. This book is dedicated to laser fabrication methods in biomimetics. It introduces both, a laser technology as well as an application focused approach. The book covers the most important laser lithographic methods and various biomimetics application scenarios ranging from coatings and biotechnology to construction, medical applications and photonics.

Les deuxiernes "Rencontres de l'Observatoire", qui ont eu lieu a l'Observatoire de Paris a Meudon du 10 au 14 Janvier 2000, ont reuni autour du theme "Problernes ernergents en physique de I'espace" 120 physiciens et astrophysiciens venus d'une vingtaine de pays differents. Nous avons voulu honorer a cette occasion Jean-Louis Steinberg pour ses con- tributions majeures a la recherche spatiale, ala radioastronomie et a la physique de I'espace. L'approche explicitement pluridisciplinaire de ce colloque, qui ne s'est pas laisse confiner dans les limites etroites de la physique spatiale ni dans celles imposees par certains programmes officiels, suit l'esprit de sa carriere scientifique: sortir des limites des sujets deja etudies ou sur Ie point de l'etre, et appliquer les connaissances acquises pour explorer de nouveaux domaines. Ce dernier quart de siecle a vu une croissance vertigineuse des performances spatiales. La technologie moderne ne perrnet pas encore de jongler avec les univers comme Ie prestidigitateur de Grandville (Grandville, Un autre monde, ed. H. Four- nier, Paris, 1844); mais quelques decades ont suffi pour voir des instruments soph- istiques explorer les frontieres du systerne solaire, et la cornmunaute de la recher- che spatiale a depasse rapidement Ie sujet etroit de I'environnement soleil-terre pour s'interesser a I'ensemble de l'heliosphere, OU les memes processus physiques sont a I'ceuvre.

Rationality - as opposed to 'ad-hoc' - and asymptotics - to emphasize the fact that perturbative methods are at the core of the theory - are the two main concepts associated with the Rational Asymptotic Modeling (RAM) approach in fluid dynamics when the goal is to specifically provide useful models accessible to numerical simulation via high-speed computing. This approach has contributed to a fresh understanding of Newtonian fluid flow problems and has opened up new avenues for tackling real fluid flow phenomena, which are known to lead to very difficult mathematical and numerical problems irrespective of turbulence. With the present scientific autobiography the author guides the reader through his somewhat non-traditional career; first discovering fluid mechanics, and then devoting more than fifty years to intense work in the field. Using both personal and general historical contexts, this account will be of benefit to anyone interested in the early and contemporary developments of an important branch of theoretical and computational fluid mechanics.

This text records the recent events in the development of astrometry. The results of space missions in astrometry, Hipparcos and some results from the Hubble Space telescope are presented. Combined with ground-based results, this provides astrometry results at milliarcsecond resolution. At the same time, the extragalactic reference frame, based on very long baseline interferometry radio positions, is being introduced as the fundamental reference frame. It is now also evident that future optical interferometry space missions can provide an additional improvement in future of orders of magnitude. In addition to presenting the results, the text also discusses different applications based on such accurate astrometric positions.

Black hole gravitohydromagnetics (GHM) is developed from the rudiments to the frontiers of research in this book. GHM describes plasma interactions that combine the effects of gravity and a strong magnetic field, in the vicinity (ergosphere) of a rapidly rotating black hole. This topic was created in response to the astrophysical quest to understand the central engines of radio loud extragalactic radio sources. The theory describes a "torsional tug of war" between rotating ergospheric plasma and the distant asymptotic plasma that extracts the rotational inertia of the black hole. The recoil from the struggle between electromagnetic and gravitational forces near the event horizon is manifested as a powerful pair of magnetized particle beams (jets) that are ejected at nearly the speed of light.

This second edition of the book is updated throughout and contains a completely new chapter discussing state of the art and results of numerical simulations of ergospheric disk jets occurring in magnetohydrodynamic accretion flows.

The SECCHI A and B instrument suites (Howard et al. , 2006) onboard the two STEREO mission spacecraft (Kaiser, 2005) are each composed of: one Extreme Ultra-Violet Imager (EUVI), two white-light coronagraphs (COR1 and COR2), and two wide-angle heliospheric imagers (HI1 and HI2). Technical descriptions of EUVI, COR1 and the HIs can be found in Wuelser et al. (2004), Thompson et al. (2003), and De?se et al. (2003), respectively. The images produced by SECCHI represent a data visualization challenge: i) the images are 2048x2048 pixels (except for the HIs, which are usually binned onboard 2x2), thus the vast majority of computer displays are not able to display them at full frame and full r- olution, and ii) more importantly, the ?ve instruments of SECCHI A and B were designed to be able to track Coronal Mass Ejections from their onset (with EUVI) to their pro- gation in the heliosphere (with the HIs), which implies that a set of SECCHI images that covers the propagation of a CME from its initiation site to the Earth is composed of im- ?1 ages with very different spatial resolutions - from 1. 7 arcsecondspixel for EUVI to 2. 15 ?1 arcminutespixel for HI2, i. e. 75 times larger. A similar situation exists with the angular scales of the physical objects, since the size of a CME varies by orders of magnitude as it expands in the heliosphere.

This book is the proceedings of the 7th International Summer School on Biophysics: Supramolecular Structure and Function, held September 14-26, 2000, in Rovinj, Croatia. An enormous amount of new knowledge on the molecular basis of biological phenomena has emerged in the rapidly expanding field of biophysics. The principles and methods of modern biophysics now provide a strong foundation for all of the biosciences, and serve as a rational common language for scientists from various disciplines. The series of books on Supramolecular Structure and Function was inspired by the International Summer School on Biophysics, established under the sponsorship of IUPAB, UNESCO, and ICGEB, held in Rovinj, in 2001, and follows the successful interdisciplinary approach. This volume covers some powerful methods, such as analytical centrifugation, mass spectrometry, fluorescence spectroscopy, infrared spectroscopy, electron spin resonance and nuclear magnetic resonance, for the study of complex biological structures, and discusses useful physical concepts as applied to biological and biochemical systems. Case-orientated studies concentrating on particular methodologies are presented and examples are given, addressing some of the most important aspects of structure-function relationship in biological assemblies. Biophysics nowadays collaborates closely with molecular biology and bioinformatics as well as with neurosciences, and this is also demonstrated in this book. The book should be of interest both to experienced researchers wishing to widen their insight into molecular structure and function, and to younger scientists at the doctoral and postdoctoral level interested in the molecular nature offundamental biological entities and phenomena.

Mechanics plays a fundamental role in aeolian processes and other environmental studies. This proposed book systematically presents the new progress in the research of aeolian processes, especially in the research on mechanism, theoretical modelling and computational simulation of aeolian processes from the viewpoint of mechanics. Nowadays, environmental and aeolian process related problems are attracting more and more attention. We hope this proposed book will provide scientists and graduate students in aeolian research and other environmental research some mechanical methods and principles and introduce aeolian related problems of environment to mathematical and mechanical scientists.

This volume addresses the physical foundation of remote sensing. The basic grounds are presented in close association with the kinds of environmental targets to monitor and with the observing techniques. The book aims at plugging the quite large gap between the thorough and quantitative description of electromagnetic waves interacting with the Earth's environment and the user applications of Earth observation. It is intended for scientifically literate students and professionals who plan to gain a first understanding of remote sensing data and of their information content.

This book presents a collection of reviews prepared for the conference "Atmosphere, Ionosphere, Safety," held in Kaliningrad, Russia, in July 2012. It provides the reader insight into the current developments in the following fields: physics of elementary processes; ionosphere dynamics; ball lightning and aerosol structures; as well as remote detection of the radioactive and highly toxic substances. The diversity of scope presented offers readers an up-to-date overview of trends, questions and their solutions.

This unique volume contains the proceedings of two "Non-Sleeping Universe" conferences: "Stars and the ISM" and "From Galaxies to the Horizon." The book provides an overview of recent developments in a variety of areas, covering a very wide range of spatial and temporal scales.

Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties. The benefits of medical image synthesis have sparked growing interest in a number of advanced clinical applications, such as magnetic resonance imaging (MRI)-only radiation therapy treatment planning and positron emission tomography (PET)/MRI scanning. This book will be a comprehensive and exciting resource for undergraduates, graduates, researchers, and practitioners.

This interdisciplinary meeting has brought together a group of astrophysicists with hands-on experience in the numerical computation of astrophysical fluid dynamics, in particular nonlinear stellar pulsations, and a group of applied mathematicians who are actively engaged with the development of novel and improved numerical methods. The goal of the workshop has been for the astrophysicists to discuss in detail the numerical problems encountered in the modelling of stellar pulsations and for the mathematicians to present a survey of recent developments in numerical techniques. This astrophysical-mathematical intercourse will help the astrophysicists in the future development of more reliable and efficient codes, on the one hand, and it has introduced the mathematicians to an unfamiliar area which is a tough testing ground for their techniques. Since the difficulties encountered are common to other fluid dynamics problems, and are in fact perhaps more severe, fluid dynamicists in other research areas may fmd the results of this workshop of interest as well. Much of our theoretical understanding of the intricate and interesting behavior of variable stars rests on our ability to perform accurate numerical hydrodynamical computations of stellar models. Extensive calculations of nonlinear radial stellar pulsations with the use of increasingly powerful computers are showing more and more clearly that the numerical codes in current use have serious deficiencies.

The book's principal aim is to clarify fundamental concepts, decipher mathematical structures used to model space-time and relativistic worlds, and to disclose their physical meaning. After each chapter, philosophical implications of the presented material are commented upon.Both special and general theories of relativity are presented in the book with the stress on their global aspects. Although global mathematical methods are extensively used throughout the book, the definitions of new concepts, short comments and examples make reading smooth without the need to consult other textbooks or review papers.

Cognition and artificial intelligence are entering a new era in which the aspects of symbolic manipulation and of connectionism begin to come together. This leads to a dialog of truly interdisciplinary character. The book covers aspects of fuzzy logic, case based reasoning, learning as well as meaning, language, and consciousness. The authors of this topical volume have their background in logic, computer science, physics and mathematics, philosophy, psychology and neurobiology.

Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant systems.

Maverick's Earth and Universe is about the true nature of Earth and Universe, and the way science should work, including a methodology more fundamental than the so-called scientific method.

Periodic magnetic structures (undulators) are widely used in accelerators to generate monochromatic undulator radiation (UR) in the range from far infrared to the hard X-ray region. Another periodic crystalline structure is used to produce quasimonochromatic polarized photon beams via the coherent bremsstrahlung mechanism (CBS). Due to such characteristics as monochromaticity, polarization and adjustability, these types of radiation is of large interest for applied and basic research of accelerator-emitted radiation. The book provides a detailed overview of the fundamental principles behind electromagnetic radiation emitted from accelerated charged particles (e.g. UR, CBS, radiation of fast electrons in Laser flash fields) as well as a unified description of relatively new radiation mechanisms which attracted great interest in recent years. This are the so-called polarization radiation excited by the Coulomb field of incident particles in periodic structures, parametric X-rays, resonant transition radiation and the Smith-Purcell effect. Characteristics of such radiation sources and perspectives of their usage are discussed. The recent experimental results as well as their interpretation are presented.

IAU Symposium 172 Dynamics, Ephemerides and Astrometry of the Solar System was held in Paris in July, 1995. 250 scientists from 33 countries attended the symposium; 24 invited lectures and 165 contributed papers were presented (117 of which were posters). The papers covered topics on celestial mechanics (chaos and evolution of the solar system, asteroids, theories of the motion of the planets, the moon and the natural satellites), methods (symplectic mappings and elliptic functions), astrometry (CCD observations, VLBI and radar observations), ephemerides (representation and numerical integration) and on the history of celestial mechanics.