This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.

If standard gravitational theory is correct, then most of the matter in the universe is in an unidentified form which does not emit enough light to have been detected by current instrumentation. This proceedings was devoted to a discussion of the so-called "missing matter" problem in the universe. The goal of the School was to make current research work on unseen matter accessible to students of faculties without prior experience in this area. Due to the pedagogical nature of the School and the strong interactions between students and the lectures, the written lectures included in this volume often contain techniques and explanations not found in more formal journal publications.

If standard gravitational theory is correct, then most of the matter in the universe is in an unidentified form which does not emit enough light to have been detected by current instrumentation. This proceedings was devoted to a discussion of the so-called "missing matter" problem in the universe. The goal of the School was to make current research work on unseen matter accessible to students of faculties without prior experience in this area. Due to the pedagogical nature of the School and the strong interactions between students and the lectures, the written lectures included in this volume often contain techniques and explanations not found in more formal journal publications.

This volume contains the lectures presented at the first course of the Inter national School of Space Chemistry held in Erice (Sicily) from May 10 to May 20 at the 'E. Majorana Centre for Scientific Culture'. The course was attended by 57 participants from 11 countries. The recognition by Professor A. Zichichi that space chemistry is one of the important and rapidly growing scientific disciplines with many and varied appli cations provided the stimulation to initiate this new school. Historically, the study of chemistry in space had its major origins in comets, the solar nebula and circumstellar envelopes before the interstellar medium achieved its current prominence. A remarkably rapid development in interstellar chemistry was precipitated by the discovery of formaldehyde in the late 1960's made possible by the new radio observational techniques. A four atom molecule in interstellar space was indeed a surprise considering that only a short time ear lier there were still arguments about the existence of the simplest of all molecules - the hydrogen molecule. The application of ion-molecule reactions to interstellar cloud chemistry provided a rich variety of new possibilities which were, however, continuously under pressure to keep pace with radio-astronomical discoveries of more and more complex molecules."

This volume focuses on latest research in therapeutic devices for cardiovascular, i.e. vascular and valvular and cardiac diseases. In the area of vascular therapies, aspects covered relate to latest research in small-diameter tissue-regenerative vascular grafts, one of the greatest persisting challenges in cardiovascular therapies, stent grafts and endovascular stents for percutaneous arterial interventions. Contributions on valvular therapies focus on tissue engineered and tissue regenerative prosthetic heart valves and valvular prostheses for trans-apical implantation including the challenges posed on the prosthesis design. The section on cardiac diseases aims at covering therapeutic advances for myocardial infarction and prevention of heart failure and on in vivo biomechanics of implantable cardiac pacemaker devices. A further section complements these three areas by presenting constitutive modelling of soft biological tissues of the cardiovascular system, an area imperative for advanced numerical and computational modelling in the development and optimisation of cardiovascular devices and therapies.

The study of orbits in dynamical systems and the theory of order and chaos has progressed enormously over the last few decades. It thus became an essential tool in dynamical astronomy. The book is the first to provide a general overview of order and chaos in dynamical astronomy. The progress of the theory of chaos has a profound impact on galactic dynamics. It has even invaded celestial mechanics, since chaos was found in the solar system which in the past was considered as a prototype of order. The book provides a unifying approach to these topics from an author who has spent more than 50 years of research in the field. The first part treats order and chaos in general. The other two parts deal with order and chaos in galaxies and with other applications in dynamical astronomy, ranging from celestial mechanics to general relativity and cosmology. This book, addressing especially the astrophysics, is also written as a textbook on dynamical systems for students in physics.

This book provides an overview of recent research highlights in the main areas of application of magnetic reconnection (MR), including planetary, solar and magnetospheric physics and astrophysics. It describes how research on magnetic reconnection, especially concerning the Earth's magnetosphere, has grown extensively due to dedicated observations from major satellite missions such as Cluster, Double Star and Themis. The accumulated observations from these missions are being supplemented by many theoretical and modelling efforts, for which large scale computer facilities are successfully being used, and the theoretical advances are also covered in detail. Opening with an introductory discussion of some fundamental issues related to magnetic reconnection, subsequent chapters address topics including collisionless magnetic reconnection, MHD structures in 3D reconnection, energy conversion processes, fast reconnection mediated by plasmoids, rapid reconnection and magnetic field topology. Further chapters consider specific areas of application such as magnetospheric dayside and tail reconnection, comparative reconnection in planetary systems and reconnection in astrophysical systems. The book offers insight into discussions about fundamental concepts and key aspects of MR, access to the full set of applications of MR as presently known in space physics and in astrophysics, and an introduction to a new related area of study dealing with the annihilation of quantum magnetic fluxes and its implications in the study on neutron star activity. The book is aimed primarily at students entering the field, but will also serve as a useful reference text for established scientists and senior researchers.

A reissue of a classic book, intended for undergraduate courses in biophysics, biological physics, physiology, medical physics, and biomedical engineering. This is an introduction to mechanics, with examples and problems from the medical and biological sciences, covering standard topics of kinematics, dynamics, statics, momentum, and feedback, control and stability but with the emphasis on physical and biological systems. The book can be used as a supplement to standard introductory physics courses, as well as for medical schools, medical physics courses, and biology departments. The three volumes combined present all the major topics in physics. Originally published in 1974 from the authors typescript, this reissue will be edited, corrected, typeset, the art redrawn, and an index added, plus a solutions manual will also be available.

The present 15th volume of the ISSI Space Science Series is devoted to Auroral Plasma Physics. The aurora is arguably the most intriguing phenomenon in space plasma physics. Not only is it the most spectacular manifestation of the Sun-Earth connection chain, but the underlying plasma processes are expected to be ubiqui- tous in the plasma universe. Recognizing the enormous progress made over the last decade in the understanding of the physics of the auroral acceleration processes, it seemed timely to write a comprehensive and integrated book on the subject. Re- cent advances concern the clarification of the nature of the acceleration process of the electrons that are responsible for the visible aurora, the recognition of the fundamental role of the large-scale current systems in organizing the auroral mor- phology, and of the interplay between particles and electromagnetic fields. The project began in March 1999, as a natural follow-up of the project on Magnetospheric Plasma Sources and Losses that resulted in volume 6 of this se- ries, with a planning meeting by a core-group that coordinated the project. The group consisted of J. E. Borovsky, Los Alamos National Laboratory; C. W. Carl- son, University of California, Berkeley; G. Haerendel, Max-Planck-Institut fur ex- traterrestrische Physik, Garching; B. Hultqvist, Swedish Intitute ofSpace Physics, H. E. J. Koskinen, Finnish Meteorological Institute, Helsinki; W. Lotko, Kiruna; Dartmouth College, Hanover, New Hampshire; K. A. Lynch, University of New Hampshire, Durham and G. Marklund, Royal Institute ofTechnology, Stockholm. G. Paschmann, ISSI, Bern, was the project leader.

An up-to-date account on the advancement in science and technology and the most recent developments on materials used for solar energy devices is presented with detailed description in the following areas: selective coating for heating and cooling; photovoltaic conversion and comparison among single crystalline silicon, concentrating cells and amorphous silicon and advance tendum coating for selective spectrum which can be used for greenhouse, homes and in energy conservation.

An up-to-date account on the advancement in science and technology and the most recent developments on materials used for solar energy devices is presented with detailed description in the following areas: selective coating for heating and cooling; photovoltaic conversion and comparison among single crystalline silicon, concentrating cells and amorphous silicon and advance tendum coating for selective spectrum which can be used for greenhouse, homes and in energy conservation.

Infrared astronomy has undergone an enormous revolution during the last decade. Despite the great technical difficulties of building detectors in a cryogenic environment, the scientific advances in infrared astronomy have been astounding. In the near future many more advances can be expected from still newer developments in telescope and detector designs. High quality detector arrays and passively cooled telescopes are very promising techniques for achieving considerably larger apertures. This volume contains the refereed papers from the workshop on 'Next Generation Infrared Observatory', dealing with all new aspects of future infrared telescopes.

The workshop "From Dust to Terrestrial Planets" was initiated by a working group of planetary scientists invited to ISSI by Johannes Geiss in November 1997. The group split to focus on three topics, one of which was the history of the early solar system, including the formation of the terrestrial planets in the inner solar system. Willy Benz, Gunter Lugmair, and Frank Podosek were invited to convene planetary scientists, astrophysicists, and cosmochemists to synthesize the current knowledge on the origin and evolution of our inner planetary system. The convenors raised the interest of scientists from all over the world in the detailed assessment of the available astronomical, chronological, geochemical and dynamical constraints of the first period of inner solar system evolution. In partic ular, this included appraisal of the newest results from astronomical observations by the Hubble Space Telescope, the Infrared Space Observatory, and other space and ground-based facilities of solar-like systems and nebular disks, possibly repre senting early stages of the solar accretion disk and planet formation. At the same time, the current models of the origin, evolution, transport, and accretion processes of circum stellar disks were presented. This included the new insights provided by the recent discovery of extrasolar giant planets, which were considered insofar as they are relevant to the overall dynamics of the inner part of the solar system.

Interesting and often unexpected achievements of the mechanics of space flight throw a new light onto several classical problems. The book 's emphasis is on analysis carried out on the level of graphs and drawings, and sometimes numbers, revealing the beauty of the research process leading to the results.

The Swiss Society for Astrophysics and Astronomy organizes each year in the late winter or early spring an advanced course. The format of the school is always iden tical: three leading lecturers are invited to cover the subject in nine or ten lectures each and to deliver a written version of their lecture notes. Lectures are held in the morning and late afternoon, thus leaving ample time for discussion and skiing. These arrangements prove very convivial and lead to an excellent atmosphere in which to learn exciting new subjects and establish contacts with colleagues. A wide variety of people attend the school, including many young students, mostly from Europe, and some experienced researchers. The 20th Advanced Course of the Swiss Society for Astrophysics and Astronomy took place in Les Diablerets from 1 to 6 April 1990. It was devoted to observational and theoretical aspects of active galactic nuclei. The previous advanced courses of the Swiss Society for Astrophysics and Astronomy have regularly taken place in Saas-Fee, a small resort in the Swiss Alps, hence the name "Saas-Fee" used to de scribe the courses and lecture notes. In the last three years, however, the course was organized in Leysin and in Les Diablerets, both also situated in the Swiss Alps."

Laser measurement technology has evolved in the last years in a versatile and reflationary way. Today, its methods are indispensable for research and development activities as well as for production technology. Every physicist and engineer should therefore gain a working knowledge of laser measurement technology.

This book closes the gap of existing textbooks. It introduces in a comprehensible presentation laser measurement technology in all its aspects. Numerous figures, graphs and tables allow for a fast access into the matter. In the first part of the book the important physical and optical basics are described being necessary to understand laser measurement technology. In the second part technically significant measuring methods are explained and application examples are presented.

Target groups of this textbook are students of natural and engineering sciences as well as working physicists and engineers, who are interested to make themselves familiar with laser measurement technology and its fascinating potentials.

Geometrical Physics in Minkowski Spacetime is an overview and description of the geometry in spacetime, and aids in the creation and development of intuition in four-dimensional Minkowski space. The deepest understanding of relativity and spacetime is in terms of the geometrical absolutes, and this is what the book seeks to develop. The most interesting topics requiring special relativity are covered, including:SpacetimeVectors in SpacetimeElectromagnetismAsymptotic Momentum ConservationCovectors and Dyadics in SpacetimeEnergy Tensor Although the book is not meant for the complete beginner in special relativity, the mathematical prerequisites for the early chapters of the book are very few - linear algebra and elementary geometry (done using vectors and a scalar product). For the later chapters, multivariable calculus and ordinary differential equations are often needed.

At the opening of the "Third Meeting on Celestial Mechanics - CELMEC III", strong sensations hit our minds. The conference (18-22 June 2001) was being held in Villa Mondragone, a beautiful complex of buildings and gardens located within the township of Monte Porzio Catone, on the hills surrounding Rome. A former papal residence, the building has been recently restored by the University of Rome "Tor Vergata" to host academic activities and events. The conference room is called "Salone degli Svizzeri": here, Gregory XIII, on February 24, 1582, gave its sanction to the reform of the Julian calendar and declared officially in use the calendar still adopted nowadays. The magnificent high walls and tall ceiling strongly resounded, giving to our voice a peculiar Vatican sound, which took us by surprise. May be - we thought - a distant echo of the very words of Gregory XIII proclaiming the modem calendar was still haunting the room. Around us, in the audience, many countries were represented, thus indicating that the idea of putting together the three "souls" of modem Celestial Mechanics - perturbation theories, solar and stellar system studies, spaceflight dynamic- had been successful. CELMEC III is in fact the latest of a series of meetings (the first two editions took place in 1993 and 1997 in L' Aquila, Italy) whose aim is to establish a common ground among people working in Celestial Mechanics, yet belonging to different institutions such as universities, astronomical observatories, research institutes, space agencies and industries.

Rotation is ubiquitous at each step of stellar evolution, from star formation to the final stages, and it affects the course of evolution, the timescales and nucleosynthesis. Stellar rotation is also an essential prerequisite for the occurrence of Gamma-Ray Bursts.

In this book the author thoroughly examines the basic mechanical and thermal effects of rotation, their influence on mass loss by stellar winds, the effects of differential rotation and its associated instabilities, the relation with magnetic fields and the evolution of the internal and surface rotation. Further, he discusses the numerous observational signatures of rotational effects obtained from spectroscopy and interferometric observations, as well as from chemical abundance determinations, helioseismology and asteroseismology, etc.

On an introductory level, this book presents in a didactical way the basic concepts of stellar structure and evolution in "track 1" chapters. The other more specialized chapters form an advanced course on the graduate level and will further serve as a valuable reference work for professional astrophysicists.

There comes a time in the affairs of every organization when we have to sit down and take stock of where we are and where we want to go. When the International Heat Flow Committee (as it was first called), IHFC, was formed in 1963 at the San Francisco International Union of Geodesy and Geophysics with Francis Birch as its first Chairman, the principal purpose was to stimulate work in the basic aspects of geothermics, particularly the measurement of terrestrial heat-flow density (HFD) in what were then the 'geothermally underdeveloped' areas of the world. In this, the IHFC was remarkably successful. By the beginning of the second decade of our existence, interest in the economic aspects of geothermics was increasing at a rapid pace and the IHFC served as a conduit for all aspects of geothermics and, moreover, became the group responsi ble for collecting data on all types of HFD measurements. In all the tasks that are undertaken, the IHFC relies on the enthusiasm of its members and colleagues who devote much of their time to the important but unglamorous and personally unrewarding tasks that were asked of them, and we arc fortunate that our parent institutions are usually quite tolerant of the time spent by their employees on IHFC work."

This book brings together an emerging consensus on our understanding of the complex functional materials including ferroics, perovskites, multiferroics, CMR and high-temperature superconductors. The common theme is the existence of many competing ground states and frustration as a collusion of spin, charge, orbital and lattice degrees of freedom in the presence of disorder and (both dipolar and elastic) long-range forces. An important consequence of the complex unit cell and the competing interactions is that the emergent materials properties are very sensitive to external fields thus rendering these materials with highly desirable, technologically important applications enabled by cross-response.

A "brain defibrillator" may be closer than we think. An epileptic seizure involves a paroxysmal change in the activity of millions of neurons. Feedback control of seizures would require an implantable device that could predict seizure occurrence and then deliver a stimulus to abort it. To examine the feasibility of building such a device, this text brings together experts in epilepsy, bio-engineering, and dynamical systems theory. Topics include the development of epileptic systems, seizure prediction, neural synchronization, wave phenomena in excitable media, and the control of complex neural dynamics using brief electrical stimuli.

consequences of broken symmetry -here parity-is studied. In this model, turbulence is dominated by a hierarchy of helical (corkscrew) structures. The authors stress the unique features of such pseudo-scalar cascades as well as the extreme nature of the resulting (intermittent) fluctuations. Intermittent turbulent cascades was also the theme of a paper by us in which we show that universality classes exist for continuous cascades (in which an infinite number of cascade steps occur over a finite range of scales). This result is the multiplicative analogue of the familiar central limit theorem for the addition of random variables. Finally, an interesting paper by Pasmanter investigates the scaling associated with anomolous diffusion in a chaotic tidal basin model involving a small number of degrees of freedom. Although the statistical literature is replete with techniques for dealing with those random processes characterized by both exponentially decaying (non-scaling) autocorrelations and exponentially decaying probability distributions, there is a real paucity of literature appropriate for geophysical fields exhibiting either scaling over wide ranges (e. g. algebraic autocorrelations) or extreme fluctuations (e. g. algebraic probabilities, divergence of high order statistical moments). In fact, about the only relevant technique that is regularly used -fourier analysis (energy spectra) -permits only an estimate of a single (power law) exponent. If the fields were mono-fractal (characterized by a single fractal dimension) this would be sufficient, however their generally multifractal character calls for the development of new techniques.

This book gives an historical perspective of Plate Tectonics. Furthermore, it discusses the foundations of rigid plate tectonics and the limitations of this approach. This classic approach can explain the data to a level of 95 % precision. Some anomalies subsit which must be explained by a more general model. The authors refer to these anomalies: for example discrepancies between spatial geodetical data and rigid kinematics in oceans or rheology significance of fractal dimensions in seismicity and faulting, etc. In this unique book the reader has access to data as well as to interpretations from a broad spectrum of disciplines. Great emphasis is placed on the limitations of the rigid plate tectonics theory of the earth.