This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course - grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.

This book provides a coherent and comprehensive overview of the generation and application of mono-energetic positron beams. It has been written by acknowledged experts, at a level accessible to graduate students working, or planning to work, with positron beams, and to scientists in other areas who want to know something about the field.

The book begins with a brief historical introduction and an overview of how positron beams are generated and transported. A description of the fate of slow positrons in gaseous and condensed matter, with reference to many of the fundamental measurements made possible by the advent of positron beams, is followed by a discussion on applications in the study of solid surfaces, defect profiling in subsurface regions, interfaces and thin films, and the probing of bulk properties in novel ways. The book ends with a look at the future, considering the prospects for intense positron beams and their potential for further research.

This handbook is a compendium giving a comprehensive description of the basics of semiconductor physics relevant to the design and analysis of thin film solar cell materials. It starts from the basics of material science, describing the material and its growth, defect and electrical properties, the basics of its interaction with photons and the involved statistics, proceeding to space charge effects in semiconductors and pn-junctions. Most attention is given to analyze homo- and hetero-junction solar cells using various models and applying the field-of-direction analysis for discussing current voltage characteristics, and helping to discover the involvement of high-field effects in solar cells. The comprehensive coverage of the main topics of - and relating to - solar cells with extensive reference to literature helps scientists and engineers at all levels to reach a better understanding and improvement of solar cell properties and their production. The author is one of the founders of thin film solar cell research.

The articles included in this Volume represent a broad and highly qualified view on the present state of general relativity, quantum gravity, and their cosmological and astrophysical implications. As such, it may serve as a valuable source of knowledge and inspiration for experts in these fields, as well as an advanced source of information for young researchers.
The occasion to gather together so many leading experts in the field was to celebrate the centenary of Einstein's stay in Prague in 1911-1912. It was in fact during his stay in Prague that Einstein started in earnest to develop his ideas about general relativity that fully developed in his paper in 1915.
Approaching soon the centenary of his famous paper, this volume offers a precious overview of the path done by the scientific community in this intriguing and vibrant field in the last century, defining the challenges of the next 100 years.
The content is divided into four broad parts: (i) Gravity and Prague, (ii) Classical General Relativity, (iii) Cosmology and Quantum Gravity, and (iv) Numerical Relativity and Relativistic Astrophysics.

In this thesis, the author investigates the biophysical basis of the local field potential (LFP) as a way of gaining a better understanding of its underlying physiological mechanisms. The results represent major advances in our understanding and interpretation of LFPs and brain oscillations. They highlight the importance of using suitable experimental and analytical methods to explore the activity of brain circuits and point to the LFP as a useful, but complex variable for this purpose.

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.
Key Features
* Summarizes current state of amiloride-sensitive sodium channel field
* Analyzes structure-function of epithelial sodium channels
* Discusses immunolocalization of epithelial sodium channels
* Examines hormonal regulation of sodium channels
* Discusses sodium channels in lymphocytes, kidney, and lung
* Considers mechanosensitivity of sodium channels
* Provides ideas on sodium channels and disease

This 6th edition of "Tools of Radio Astronomy", the most used introductory text in radio astronomy, has been revised to reflect the current state of this important branch of astronomy. This includes the use of satellites, low radio frequencies, the millimeter/sub-mm universe, the Cosmic Microwave Background and the increased importance of mm/sub-mm dust emission. Several derivations and presentations of technical aspects of radio astronomy and receivers, such as receiver noise, the Hertz dipole and beam forming have been updated, expanded, re-worked or complemented by alternative derivations. These reflect advances in technology. The wider bandwidths of the Jansky-VLA and long wave arrays such as LOFAR and mm/sub-mm arrays such as ALMA required an expansion of the discussion of interferometers and aperture synthesis. Developments in data reduction algorithms have been included. As a result of the large amount of data collected in the past 20 years, the discussion of solar system radio astronomy, dust emission, and radio supernovae has been revisited. The chapters on spectral line emission have been updated to cover measurements of the neutral hydrogen radiation from the early universe as well as measurements with new facilities. Similarly the discussion of molecules in interstellar space has been expanded to include the molecular and dust emission from protostars and very cold regions. Several worked examples have been added in the areas of fundamental physics, such as pulsars. Both students and practicing astronomers will appreciate this new up-to-date edition of Tools of Radio Astronomy.

This book provides an in-depth treatment of both linear fiber-optic systems and their key enabling devices. It presents a concise but rigorous treatment of the theory and practice of analog (linear) fiber-optics links and systems that constitute the foundation of Hybrid Fiber Coax infrastructure in present-day CATV distribution and cable modem Internet access. Emerging applications in remote fiber-optic feed for free-space millimeter wave enterprise campus networks are also described. Issues such as dispersion and interferometric noise are treated quantitatively, and means for mitigating them are explained. This broad but concise text will thus be invaluable not only to students of fiber-optics communication but also to practicing engineers. To the second edition of this book important new aspects of linear fiber-optic transmission technologies are added, such as high level system architectural issues, algorithms for deriving the optimal frequency assignment, directly modulated or externally modulated laser transmitters and the use of Erbium-doped fiber amplifier (EDFA) in linear fiber optic systems. Significant examples of field deployed military systems enabled by linear fiber optic links are described in an appendix.

This book presents new mathematics for the description of structure and dynamics in molecular and cellular biology. On an exponential scale it is possible to combine functions describing inner organisation, including finite periodicity, with functions for outside morphology into a complete definition of structure. This mathematics is particularly fruitful to apply at molecular and atomic distances. The structure descriptions can then be related to atomic and molecular forces and provide information on structural mechanisms. The calculations have been focussed on lipid membranes forming the surface layers of cell organelles. Calculated surfaces represent the mid-surface of the lipid bilayer. Membrane dynamics such as vesicle transport are described in this new language. Periodic membrane assemblies exhibit conformations based on the standing wave oscillations of the bilayer, considered to reflect the true dynamic nature of periodic membrane structures. As an illustration the structure of an endoplasmatic reticulum has been calculated. The transformation of such cell membrane assemblies into cubosomes seems to reflect a transition into vegetative states. The organisation of the lipid bilayer of nerve cells is analyzed, taking into account an earlier observed lipid bilayer phase transition associated with the depolarisation of the membrane. Evidence is given for a new structure of the alveolar surface, relating the mathematical surface defining the bilayer organisation to new experimental data. The surface layer is proposed to consist of a coherent phase, consisting of a lipid-protein bilayer curved according to a classical surface - the CLP surface. Without employing this new mathematics it would not be possible to give an analytical description of this structure and its deformation during the respiration cycle. In more general terms this mathematics is applied to the description of the structure and dynamic properties of motor proteins, cytoskeleton proteins, and RNA/DNA. On a macroscopic scale the motions of cilia, sperm and flagella are modelled.
This mathematical description of biological structure and dynamics, biomathematics, also provides significant new information in order to understand the mechanisms governing shape of living organisms.

In seismology an earthquake source is described in terms of a fault with a particular rupture size. The faulting process of large earthquakes has been investigated in the last two decades through analyses of long-period seismo grams produced by advanced digital seismometry. By long-period far-field approximation, the earthquake source has been represented by physical parameters such as s ismic moment, fault dimension and earthquake mag nitude. Meanwhile, destruction often results from strong ground motion due to large earthquakes at short distances. Since periods of strong ground motion are far shorter than those of seismic waves at teleseismic distances, the theory of long-period source process of earthquakes cannot be applied directly to strong ground motion at short distances. The excitation and propagation of high-frequency seismic waves are of special interest in recent earthquake seismology. In particular, the descrip tion and simulation of strong ground motion are very important not only for problems directly relevant to earthquake engineering, but also to the frac ture mechanics of earthquake faulting. Understanding of earthquake sources has been developed by investigating the complexity of faulting processes for the case of large earthquakes. Laboratory results on rock failures have also advanced the understanding of faulting mechanisms. Various attempts have been made to simulate, theoretically and empirically, the propagation of short-period seismic waves in the heterogeneous real earth."

The PUILS series delivers up-to-date reviews of progress in Ultrafast Intense Laser Science, a newly emerging interdisciplinary research field spanning atomic and molecular physics, molecular science, and optical science, which has been stimulated by the recent developments in ultrafast laser technologies. Each volume compiles peer-reviewed articles authored by researchers at the forefront of each their own subfields of UILS. Every chapter opens with an overview of the topics to be discussed, so that researchers unfamiliar to the subfield, as well as graduate students, can grasp the importance and attractions of the research topic at hand; these are followed by reports of cutting-edge discoveries. This ninth volume covers a broad range of topics from this interdisciplinary research field, focusing on ultrafast molecular responses to an intense laser field, advanced techniques for attosecond pulse generation, atomic and molecular responses to attosecond pulses, photoelectron spectroscopy of atoms and molecules interacting with intense light fields, and attosecond pulse interaction with solid materials.

This book delves into the recent developments in the microscale and microfluidic technologies that allow manipulation at the single and cell aggregate level. Expert authors review the dominant mechanisms that manipulate and sort biological structures, making this a state-of-the-art overview of conventional cell sorting techniques, the principles of microfluidics, and of microfluidic devices. All chapters highlight the benefits and drawbacks of each technique they discuss, which include magnetic, electrical, optical, acoustic, gravity/sedimentation, inertial, deformability, and aqueous two-phase systems as the dominant mechanisms utilized by microfluidic devices to handle biological samples. Each chapter explains the physics of the mechanism at work, and reviews common geometries and devices to help readers decide the type of style of device required for various applications. This book is appropriate for graduate-level biomedical engineering and analytical chemistry students, as well as engineers and scientists working in the biotechnology industry.

This book describes the operation of a particular technique for the production of compound semiconductor materials. It describes how the technique works, how it can be used for the growth of particular materials and structures, and the application of these materials for specific devices. It contains not only a fundamental description of the operation of the technique but also contains lists of data useful for the everyday operation of OMVPE reactors. It also offers specific recipes that can be used to produce a wide range of specific materials, structures, and devices.
Key Features
* Updated with new emphasis on the semiconducting nitride materials-GaN and its alloys with In and Al
* Emphasizes the newly understood aspects of surface processes
* Contains a new chapter, as well as several new sections in chapters on thermodynamics and kinetics

Acoustics of Layered Media II presents the theory of sound propagation and reflection of spherical waves and bounded beams in layered media. It is mathematically rigorous but at the same time care is taken that the physical usefulness in applications and the logic of the theory are not hidden. Both moving and stationary media, discretely and continuously layered, including a range-dependent environment, are treated for various types of acoustic wave sources. Detailed appendices provide further background on the mathematical methods.This second edition reflects the notable recent progress in the field of acoustic wave propagation in inhomogeneous media.

As the first comprehensive and authoritative review of intra-seasonal variability (ISV), this multi-author work balances coverage of observation, theory and modeling and provides a single source of reference for all those interested in this important, multi-faceted natural phenomenon and its relation to major short-term climatic variations. Commencing with an overview of ISV and observations from an historical perspective, the book offers successive chapters that deal with the role of ISV in monsoon variability on the monsoon regions of South Asia, East Asia and South America, in North America, and in the oceans. The coupling between ocean and atmosphere is considered, together with the function of angular momentum and Earth rotation. Later chapters deal with modeling ISV in the atmosphere and oceans, and the connection between the Madden and Julian Oscillations, and El Nino/Southern Oscillation with short-term climate are considered.

Many large-scale projects for detecting gravitational radiation are currently being developed, all with the aim of opening a new window onto the observable Universe. As a result, numerical relativity has recently become a major field of research, and Elements of Numerical Relativity and Relativistic Hydrodynamics is a valuable primer for both graduate students and non-specialist researchers wishing to enter the field.

A revised and significantly enlarged edition of LNP 673 Elements of Numerical Relativity, this book starts with the most basic insights and aspects of numerical relativity before it develops coherent guidelines for the reliable and convenient selection of each of the following key aspects: evolution formalism; gauge, initial, and boundary conditions; and various numerical algorithms. And in addition to many revisions, it includes new, convenient damping terms for numerical implementations, a presentation of the recently-developed harmonic formalism, and an extensive, new chapter on matter space-times, containing a thorough introduction to relativistic hydrodynamics.

While proper reference is given to advanced applications requiring large computational resources, most tests and applications in this book can be performed on a standard PC.

This volume contains the proceedings of The Second Polish-US Conf- ence on High Temperature Superconductivity which was held August 18-21, 1998 in Karpacz, Poland. The conference followed The First Polish-US C- ference on High Temperature Superconductivity organized in 1995, proce- ings of which were published by Springer-Verlag in 1996 (Recent Devel- ments in High Temperature Superconductivity, Lecture Notes in Physics 475). High Temperature Superconductivity (HTSC) in complex copper oxides has become a household name after twelve years of intense research following its discovery in 1986 by J. G. Bednorz and K. A. Miiller. Because of the rapid growth of the HTSC field, there is a need for periodic summary and conden- tion both for scientists working in the field and, especially, for young resear- ers entering the field of oxide materials. Following the First Conference, it was recognized that an extended format of lectures perfectly satisfied that need, providing adequate time for experts from the international community to fully introduce and develop complex ideas. Thus, the format of the Second Conference brought together by cooperating scientists from the Institute of Low Temperature and Structure Research of the Polish Academy of Science at Wroctaw, Northern Illinois University, and Argonne National Laboratory remained mostly unchanged. Again, we were delighted to receive enthusiastic responses from distinguished US and Polish scientists who were invited to p- ticipate.

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchersin all fields of life sciences.
Key Features
* Prokaryotic ABC Transporters
* Eukaryotic ABC Transporters
* Nonmammalian ABC Transport Systems
* Mammalian P-Glycoproteins
* Multidrug Resistance Associated Protein
* Cystic Fibrosis Transmembrane Conductance Regulator
* Sulfonylurea Receptor
* Intracellular ABC Transporters

Scope and ideas of the workshop The workshop which took place at the University of Giessen from Oct. 3 to Oct. 7, 2002 and whose proceedings are collected in this volume started from the idea to convene a number of scientists with the aim to outline their "visions" for the future of radiation research on the basis of their expertise. As radiation research is a very wide field restrictions were unavoidable. It was decided to concentrate this time mainly on molecular and cellular biology because it was felt that here action is par-ticularly needed. This did not exclude contributions from neighbouring fields as may be seen from the table of contents. It was clearly not planned to have a c- prehensive account of the present scientif fic achievements but the results presented should only serve as a starting point for the discussion of future lines of research, with the emphasis on the "outreach" to other parts of life sciences. If you are interested in the future ask the young - we attempted, therefore, to invite mainly younger colleagues (with a few exceptions) who had, however, already left their marks in the field. They were asked to describe what they felt is important in radiation research and may have significant influences on other branches of life sciences. They were given the task to demonstrate what is lost for science "if we do no longer exist".

Lithium niobate, LiNbO , is an oxide ferroelectric with various kinds of pro- 3 nouncedphysicalproperties. Thisversatilityhaspromoteditscareerinscience anddevices. Ithasbeenparticularlyfruitfulintheopticalregime,wheremany e?ects have been found in LiNbO and devices introduced using it as a host. 3 One of the few big drawbacks, namely the low level laser damage threshold based on photorefraction due to extrinsic defects was discovered very early. A relatively new topic, not involved so far in any general description, is a fundamental dependence of the optical properties of LiNbO on intrinsic de- 3 fects. Their importance has been realised out due to the development of varies growthtechniquesintherecentpast. Theprogressinthegrowthandstudiesof LiNbO crystals with di?erent composition, particularly almost stoichiomet- 3 ric ones, has revealed a signi?cant and sometimes decisive role of the intrinsic defects. For example, the photoinduced charge transport, and therefore the photorefractive properties governing the recording of the phase gratings in LiNbO , are strongly controlled by the content of intrinsic defects. The re- 3 cently found impact of intrinsic defects on the coercive ?eld in LiNbO is 3 of fundamental importance for the creation of periodically poled structures (PPLN) aimed at the optical-frequency conversion in the quasi-phase mat- ing (QPM) mode of operation. As a consequence of these results, an idea of the intrinsic defects in LiNbO has been developed during the last decade 3 and involves microscopic studies on defects, photorefraction and ferroelectric switching using spectroscopic and structure methods.

Intended for undergraduate non-science majors, satisfying a general education requirement or seeking an elective in natural science, this is a physics text, but with the emphasis on topics and applications in astronomy. The perspective is thus different from most undergraduate astronomy courses: rather than discussing what is known about the heavens, this text develops the principles of physics so as to illuminate what we see in the heavens. The fundamental principles governing the behaviour of matter and energy are thus used to study the solar system, the structure and evolution of stars, and the early universe. The first part of the book develops Newtonian mechanics towards an understanding of celestial mechanics, while chapters on electromagnetism and elementary quantum theory lay the foundation of the modern theory of the structure of matter and the role of radiation in the constitution of stars. Kinetic theory and nuclear physics provide the basis for a discussion of stellar structure and evolution, and an examination of red shifts and other observational data provide a basis for discussions of cosmology and cosmogony.

The first section of this volume corresponds to courses on the cytoskeleton, its various structures and its dynamics, especially during the cell cycle. The reductionist approach is favoured in this field and considerable effort is spent on finding out how these structures are built up from their component molecules, how they grow or decrease in size, how they interact with each other and with other cell components. The second section describes the endo membrane system of a eukaryotic cell and the regulated protein traffic that flows through it. Part III deals with the onset of higher levels of organization. Topics covered include the development of the central nervous system, the role of time in biology and theoretical models to describe biochemical and cellular oscillations. The volume concludes with a reflection on physics and biology and the author shares some of his thoughts on the different ways in which physicists and biologists tackle problems in their respective fields.

This textbook on the nature of space and time explains the new theory of Space Dynamics, which describes the dynamics of gravity as the evolution of conformal 3-dimensional geometry. Shape Dynamics is equivalent to Einstein's General Relativity in those situations in which the latter has been tested experimentally, but the theory is based on different first principles. It differs from General Relativity in certain extreme conditions. Shape Dynamics allows us to describe situations in which the spacetime picture is no longer adequate, such as in the presence of singularities, when the idealization of infinitesimal rods measuring scales and infinitesimal clocks measuring proper time fails. This tutorial book contains both a quick introduction for readers curious about Shape Dynamics, and a detailed walk-through of the historical and conceptual motivations for the theory, its logical development from first principles and a description of its present status. It includes an explanation of the origin of the theory, starting from problems posed first by Newton more than 300 years ago. The book will interest scientists from a large community including all foundational fields of physics, from quantum gravity to cosmology and quantum foundations, as well as researchers interested in foundations. The tutorial is sufficiently self-contained for students with some basic background in Lagrangian/Hamiltonian mechanics and General Relativity.

Learn about the many biological and medical applications of ultrashort laser pulses. The authors highlight and explain how the briefness of these laser pulses permits the tracing of even the fastest processes in photo-active bio-systems. They also present a variety of applications that rely on the high peak intensity of ultrashort laser pulses. Easy-to-follow examples cover non-linear imaging techniques, optical tomography, and laser surgery.