The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.

This book reviews the phenomenology displayed by relativistic jets as well as the most recent theoretical efforts to understand the physical mechanisms at their origin. Relativistic jets have been observed and studied in Active Galactic Nuclei (AGN) for about half a century and are believed to be fueled by accretion onto a supermassive black hole at the center of the host galaxy. Since the first discovery of relativistic jets associated with so-called "micro-quasars" much more recently, it has seemed clear that much of the physics governing the relativistic outflows in stellar X-ray binaries harboring black holes and in AGN must be common, but acting on very different spatial and temporal scales. With new observational and theoretical results piling up every day, this book attempts to synthesize a consistent, unified physical picture of the formation and disruption of jets in accreting black-hole systems. The chapters in this book offer overviews accessible not only to specialists but also to graduate students and astrophysicists working in other areas. Covered topics comprise Relativistic jets in stellar systems Launching of AGN jets Parsec-scale AGN jets Kiloparsec-scale AGN jets Black hole magnetospheres Theory of relativistic jets The structure and dynamics of the inner accretion disk The origin of the jet magnetic field X-ray observations, phenomenology, and connection with theory

This volume provides a comprehensive selection of recent studies addressing insect hearing and acoustic communication. The variety of signalling behaviours and hearing organs makes insects highly suitable animals for exploring and analysing signal generation and hearing in the context of neural processing, ecology, evolution and genetics. Across a variety of hearing species like moths, crickets, bush-crickets, grasshoppers, cicadas and flies, the leading researchers in the field cover recent scientific progress and address key points in current research, such as:

. How can we approach the evolution of hearing in insects and what is the developmental and neural origin of the auditory organs?

. How are hearing and sound production embedded in the natural lifestyle of the animals, allowing intraspecific communication but also predator avoidance and even predation?

. What are the functional properties of hearing organs and how are they achieved at the molecular, biophysical and neural levels?

. What are the neural mechanisms of central auditory processing and signal generation?

The book is intended for students and researchers both inside and outside of the fascinating field of bioacoustics and aims to foster understanding of hearing and acoustic communication in insects."

This book presents a systematic attempt to generalize several fundamental physical laws related to subsurface fluid flow that are important for a number of contemporary applications in the areas of hydrogeology, reservoir engineering and rock mechanics. It also covers the history of discovering these physical laws, their respective scope of validity, and their generalizations or extensions. The physical laws discussed include Darcy's law, Darcy-Buckingham law and Hooke's law. Darcy's law is the fundamental law for subsurface fluid flow. For low-permeability media, it is not always adequate because of the strong fluid-solid interaction. Though the Darcy-Buckingham law is often used for modeling subsurface multiphase flow, it is only valid under the local equilibrium condition. This condition does not hold in many cases, especially when fingering flow occurs. It is well known that subsurface fluid flow is coupled with mechanical deformation of subsurface media; in some applications, this coupling can play a dominant role. The continuum-scale elastic deformation of natural rock, however, does not always follow the traditional form of Hooke's law. The book also presents applications of the proposed generalizations of the physical laws to several important engineering projects.

Understanding the stars is the bedrock of modern astrophysics. Stars are the source of life. The chemical enrichment of our Milky Way and of the Universe withallelementsheavierthanlithiumoriginatesintheinteriorsofstars.Stars arethe tracersofthe dynamics ofthe Universe,gravitationallyimplying much more than meets the eye. Stars ionize the interstellar medium and re-ionized the early intergalactic medium. Understanding stellar structure and evolution is fundamental. While stellar structure and evolution are understood in general terms, we lack important physical ingredients, despite extensive research during recent decades.Classicalspectroscopy,photometry,astrometryandinterferometryof stars have traditionally been used as observational constraints to deduce the internal stellar physics. Unfortunately, these types of observations only allow the tuning of the basic common physics laws under stellar conditions with relatively poor precision. The situation is even more worrisome for unknown aspects of the physics and dynamics in stars. These are usually dealt with by using parameterised descriptions of, e.g., the treatments of convection, rotation,angularmomentumtransport,theequationofstate,atomicdi?usion andsettlingofelements,magneto-hydrodynamicalprocesses,andmore.There is a dearth of observational constraints on these processes, thus solar values areoftenassignedtothem.Yetitishardtoimaginethatonesetofparameters is appropriate for the vast range of stars.

Working in mathematical oncology is a slow and difficult process, requiring the acquisition of a special mindset that goes well beyond the usual applications of mathematics and physics. "Mathematical Oncology 2013" presents the most significant recent results in the field of mathematical oncology, highlighting the work of world-class research teams. This innovative volume emphasizes the way different researchers see and approach problems, not just technical results. It covers many of the most important topics related to the mathematical modeling of tumors, including: Free boundaries. Tumors are growing entities, as such their spatial mean field description involves free boundary problems.Constitutive equations. Tumors should be described as nontrivial porous media.Stochastic dynamics. At the end of anti-cancer therapy, a small number of cells remain, whose dynamics is thus inherently stochastic.Noise-induced state transitions. The growth parameters of macroscopic tumors are non-constant, as are the parameters of anti-tumor therapies. This may induce phenomena that are mathematically equivalent to phase transitions.Stochastic and fractal geometry. Tumor vascular growth is self-similar.

The intended audience consists of graduate students and researchers in the fields biomathematics, computational and theoretical biology, biophysics and bioengineering, where the phenomenon tumor is acquiring the same relevance as in modern molecular biology."

DNA (sometimes referred to as the molecule of life), is the most interesting and most important of all molecules. Electrochemistry of Nucleic Acids and Proteins: Towards Electrochemical Sensors for Genomics and Proteomics is devoted to the electrochemistry of DNA and RNA and to the development of sensors for detecting DNA damage and DNA hybridization. Volume 1, in the brand new series Perspectives in Bioanalysis, looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century.
* Covers highly sophisticated methods of electrochemical analysis of nucleic acids and proteins
* Summarises the present state of electrochemical analysis of nucleic acids and proteins
* Includes future trends in the electrochemical analysis in genomics and proteomics

This book presents the concepts and tools of ice mechanics, together with examples of their application in the fields of glaciology, climate research and civil engineering in cold regions. It starts with an account of the most important physical properties of sea and polar ice treated as an anisotropic polycrystalline material, and reviews relevant field observations and experimental measurements. The book focuses on theoretical descriptions of the material behaviour of ice in different stress, deformation and deformation-rate regimes on spatial scales ranging from single ice crystals, those typical in civil engineering applications, up to scales of thousands of kilometres, characteristic of large, grounded polar ice caps in Antarctica and Greenland. In addition, it offers a range of numerical formulations based on either discrete (finite-element, finite-difference and smoothed particle hydrodynamics) methods or asymptotic expansion methods, which have been used by geophysicists, theoretical glaciologists and civil engineers to simulate the behaviour of ice in a number of problems of importance to glaciology and civil engineering, and discusses the results of these simulations. The book is intended for scientists, engineers and graduate students interested in mathematical and numerical modelling of a wide variety of geophysical and civil engineering problems involving natural ice.

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

Mars, the most habitable of our sister planets, holds a special place in our imaginations and in our space exploration program. Fully half of NASA's planetary exploration effort is now devoted to Mars. Key questions include: Has Mars ever harbored life? Is there life on Mars now? Will humans be able to survive on the Martian surface? Answers to these questions lie in determining the present location of water on Mars and its likely inventory in the past, and in determining the present radiation environment of Mars. The 2001 Mars Odyssey Mission contributes greatly these answers by detecting near-surface water through measurements of neutron flux, from the detection of carbonates, and the quantification of its radiation environment. This book captures the objectives, the design of the mission and the details of the instruments carried to Mars. It should be of interest to every scientist interested in participating in the on-going exploration of Mars from graduate students to senior scientists as it provides the background information essential to interpret the many exciting results now appearing from the mission.

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

This book contains a collection of papers that were presented at the IUTAM Symposium on "Computer Models in Biomechanics: From Nano to Macro" held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+-regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

This book provides a challenging and stimulating introduction to the contemporary topics of complexity and criticality, and explores their common basis of scale invariance, a central unifying theme of the book.Criticality refers to the behaviour of extended systems at a phase transition where scale invariance prevails. The many constituent microscopic parts bring about macroscopic phenomena that cannot be understood by considering a single part alone. The phenomenology of phase transitions is introduced by considering percolation, a simple model with a purely geometrical phase transition, thus enabling the reader to become intuitively familiar with concepts such as scale invariance and renormalisation. The Ising model is then introduced, which captures a thermodynamic phase transition from a disordered to an ordered system as the temperature is lowered in zero external field. By emphasising analogies between percolation and the Ising model, the reader's intuition of phase transitions is developed so that the underlying theoretical formalism may be appreciated fully. These equilibrium systems undergo a phase transition only if an external agent finely tunes certain external parameters to particular values.Besides fractals and phase transitions, there are many examples in Nature of the emergence of such complex behaviour in slowly driven non-equilibrium systems: earthquakes in seismic systems, avalanches in granular media and rainfall in the atmosphere. A class of non-equilibrium systems, not constrained by having to tune external parameters to obtain critical behaviour, is addressed in the framework of simple models, revealing that the repeated application of simple rules may spontaneously give rise to emergent complex behaviour not encoded in the rules themselves. The common basis of complexity and criticality is identified and applied to a range of non-equilibrium systems. Finally, the reader is invited to speculate whether self-organisation in non-equilibrium systems might be a unifying concept for disparate fields such as statistical mechanics, geophysics and atmospheric physics.Visit for animations for the models in the book (available for Windows and Linux), solutions to exercises, as well as a list with corrections.

This book provides an introduction to the mathematical aspects of Euler's elastic theory and its application. The approach is rigorous, as well as visually depicted, and can be easily digested. The first few chapters introduce the needed mathematical concepts from geometry and variational calculus. The formal definitions and proofs are always illustrated through complete derivations and concrete examples. In this way, the reader becomes acquainted with Cassinian ovals, Sturmian spirals, co-Lemniscates, the nodary and the undulary, Delaunay surfaces, and their generalizations. The remaining chapters discuss the modeling of membranes, mylar balloons, rotating liquid drops, Hele-Shaw cells, nerve fibers, Cole's experiments, and membrane fusion. The book is geared towards applied mathematicians, physicists and engineers interested in Elastica Theory and its applications.

This short monograph presents the theory of electromagnetic pulses in a simple and physical way. All pulses discussed are exact solutions of the Maxwell equations, and have finite energy, momentum and angular momentum. There are five chapters: on Fundamentals, Solutions of the Wave Equation, Electromagnetic Pulses, Angular Momentum, and Lorentz Transformations. Nine Appendices cover mathematical or associated aspects, such as chiral measures of electromagnetic fields. The subject matter is restricted to free-space classical electrodynamics, but contact is made with quantum theory in proofs that causal pulses are equivalent to superpositions of photons.

This book focuses on the application of fluorescence to study motor proteins (myosins, kinesins, DNA helicases and RNA polymerases). It is intended for a large community of biochemists, biophysicists and cell biologists who study a diverse collection of motor proteins. It can be used by researchers to gain an insight into their first experiments, or by experienced researchers who are looking to expand their research to new areas. Each chapter provides valuable advice for executing the experiments, along with detailed background knowledge in order to develop own experiments.

This book focuses on essential theories, methods and techniques in the field of environmental and engineering geophysics that can contribute to resource detection and environmental protection. Geophysics has been playing an important role in exploring the earth, locating vital resources and promoting the development of society. This book covers a range of topics including the exploration of modern resources, such as ore deposits, coal mines, shale gas and geothermal power, and the monitoring of geological disasters, including the rock-soil body, ground deformation, mines, specific rock-soil engineering disasters, desertification of land and environmental abnormalities. This book not only offers a valuable resource for geophysical researchers; it also demonstrates how geophysics theories and methods can be practically implemented to protect our environment and promote the development of human society.

This book offers a collection of papers presented in the International Conference on Geomagnetism, Paleomagnetism and Rock Magnetism held in Kazan (Russia) in October 2017. Papers in this book are dedicated to the study of the geomagnetic field through most of the Earth's history as well as planetary and meteorite magnetism, and magnetic signatures of terrestrial impact craters. Recent studies, summaries, and reviews include: 1 - theory of the geomagnetic field, its generation and variations; 2 - experimental data on the geomagnetic field changes; 3 - studies of rock magnetism; 4 - paleotectonic reconstructions and paleoceanography; 5 - magnetostratigraphy; 6 - extraterrestrial magnetism. Summary reports and reviews will be presented by the world's leading experts in the field of geomagnetic studies. Such workshops held by Academic Council have become traditional. They are always attended by leading professionals from Russia, CIS and non-CIS countries. In addition to discussion sessions focused on recent studies and findings, lectures on some basic concepts of geomagnetism will be delivered by leading Russian and foreign scientists

This is the first book that is not exclusively focused on ion channels functioning in sensory mechanisms that are characteristic of animals and humans, but also describes the role of ion channels in signal transduction mechanisms found in microbial cells and plants. It summarizes comprehensively the progress that has been made in studies of ion channels and their role in sensory physiology.

The book provides an elaborate treatment of groundwater prospecting and management covering remote sensing, geological-geophysical cum hydrogeological studies, exploration (geological and geophysical), development (well logging techniques, pump test, its analysis and applications in well design), contamination (pollution of groundwater) and regulatory legislations regarding groundwater utilization under one cover. The book presents an elucidation of fundamental and theoretical background of each technique supported by necessary illustrative examples and exclusive case studies. It is a text-cum-reference book not only for students, research scholars and practicing earth scientists but also for practicing civil and agricultural engineers working in the application of groundwater resources, engaged in its exploration, development, contamination, legislation and management. The general readers can also refer the book for understanding the groundwater domain for adequate knowledge, as groundwater resources are essential life support commodity which is replenishable but not inexhaustible.

Impact cratering is an important geological process on all solid planetary bodies, and, in the case of Earth, may have had major climatic and biological effects. Most terrestrial impact craters have been erased or modified beyond recognition. However, major impacts throw ejecta over large areas of the Earth's surface. Recognition of these impact ejecta layers can help fill in the gaps in the terrestrial cratering record and at the same time provide direct correlation between major impacts and other geological events, such as climatic changes and mass extinctions. This book provides the first summary of known distal impact ejecta layers

It is over a quarter of a century since the discovery of out?ows from young stars. The intervening years have led to remarkable advances in our understanding of this phenomenon. Much of the progress can be attributed to advances in facilities and technologies, including not only larger telescopes but also improved instrument and detector performance. In addition protostellar out?ows have now been imaged from the ground and space at high spatial resolution, e. g. with HST, and at a wide - riety of wavelengths from X-rays to radio waves, revealing more and more about their physics. This veritable revolution in observation has been accompanied by an exponential growth in our ability to numerically simulate the launching and pro- gation of jets. Codes continue to improve: they now incorporate more physics and are increasingly ef?cient through, for example, techniques such as adaptive mesh re?nement and the use of parallel processing in cluster environments. Simulating the launching and propagation of a jet all the way from the vicinity of the star up to 4 several thousand AU (a size range of10 ) is now much closer. In more recent times, developments in observation, theory and numerical s- ulation have been joined by laboratory jet experiments reproducing, on centimetre scales, that which is seen in astrophysics to stretch for several parsecs.