The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.

Disulfide-containing proteins belong to a unique class of proteins for studying the mechanism of protein folding. Their folding mechanism can be analyzed by three distinct techniques: (1) The conventional denaturation-renaturation method (disulfide intact); (2) The disulfide oxidation method (oxidative folding); and (3) The emerging disulfide scrambling method. Each technique provides specific information as to how an unfolded disulfide protein refolds to form the native structure. This book is intended to highlight the knowledge of several important proteins (BPTI, RNase A, beta-Lactalbumin and Lysozyme etc.) that have been characterized in depth by these methodologies. The book will also devote sections to comparing these methodologies and chaperones (PDI and Dsb machineries) that facilitate folding of disulfide proteins. Folding of Disulfide Proteins aims to cover the knowledge of protein folding accumulated from studies of disulfide-containing proteins, including methodologies, folding pathways, and folding mechanism of numerous extensively characterized disulfide proteins. This book will be of interest to those interested in problems related to protein folding, and anyone who is interested in understanding the mechanism of protein misfolding and protein misfolding-related diseases. Folding of Disulfide Proteins aims to cover the knowledge of protein folding accumulated from studies of disulfide-containing proteins, including methodologies, folding pathways, and folding mechanism of numerous extensively characterized disulfide proteins. This book will be of interest to those interested in problems related to protein folding, and anyone who is interested in understanding the mechanism of protein misfolding and protein misfolding-related diseases.

This book concisely expounds the fundamental concepts, phenomena, theories and procedures in a complete and systematic sense. In this book, not only almost all the important achievements from predecessors but also the contributions from the author himself have been summed up profoundly. Starting from the derivation of fundamental equations, various classical acoustical phenomena such as reflection, refraction, scattering diffraction and absorption in atmosphere, as well as the influences of gravitation and rotation of the earth on the behaviors of different atmospheric waves including acoustic waves, have been discussed in viewpoints of wave acoustics and geometrical acoustics respectively. The recent developments of several computation methods in the field of atmospheric acoustics have been introduced in some detail. As for the application aspects, atmospheric remote sensing has been discussed from the angle of inverse problems.

This book reviews the phenomenology displayed by relativistic jets as well as the most recent theoretical efforts to understand the physical mechanisms at their origin. Relativistic jets have been observed and studied in Active Galactic Nuclei (AGN) for about half a century and are believed to be fueled by accretion onto a supermassive black hole at the center of the host galaxy. Since the first discovery of relativistic jets associated with so-called "micro-quasars" much more recently, it has seemed clear that much of the physics governing the relativistic outflows in stellar X-ray binaries harboring black holes and in AGN must be common, but acting on very different spatial and temporal scales. With new observational and theoretical results piling up every day, this book attempts to synthesize a consistent, unified physical picture of the formation and disruption of jets in accreting black-hole systems. The chapters in this book offer overviews accessible not only to specialists but also to graduate students and astrophysicists working in other areas. Covered topics comprise Relativistic jets in stellar systems Launching of AGN jets Parsec-scale AGN jets Kiloparsec-scale AGN jets Black hole magnetospheres Theory of relativistic jets The structure and dynamics of the inner accretion disk The origin of the jet magnetic field X-ray observations, phenomenology, and connection with theory

This volume provides a comprehensive selection of recent studies addressing insect hearing and acoustic communication. The variety of signalling behaviours and hearing organs makes insects highly suitable animals for exploring and analysing signal generation and hearing in the context of neural processing, ecology, evolution and genetics. Across a variety of hearing species like moths, crickets, bush-crickets, grasshoppers, cicadas and flies, the leading researchers in the field cover recent scientific progress and address key points in current research, such as:

. How can we approach the evolution of hearing in insects and what is the developmental and neural origin of the auditory organs?

. How are hearing and sound production embedded in the natural lifestyle of the animals, allowing intraspecific communication but also predator avoidance and even predation?

. What are the functional properties of hearing organs and how are they achieved at the molecular, biophysical and neural levels?

. What are the neural mechanisms of central auditory processing and signal generation?

The book is intended for students and researchers both inside and outside of the fascinating field of bioacoustics and aims to foster understanding of hearing and acoustic communication in insects."

In early April 1911 Albert Einstein arrived in Prague to become full professor of theoretical physics at the German part of Charles University. It was there, for the first time, that he concentrated primarily on the problem of gravitation. Before he left Prague in July 1912 he had submitted the paper Relativitat und Gravitation: Erwiderung auf eine Bemerkung von M. Abraham in which he remarkably anticipated what a future theory of gravity should look like.

At the occasion of the Einstein-in-Prague centenary an international meeting was organized under a title inspired by Einstein's last paper from the Prague period: "Relativity and Gravitation, 100 Years after Einstein in Prague." The main topics of the conference included: classical relativity, numerical relativity, relativistic astrophysics and cosmology, quantum gravity, experimental aspects of gravitation and conceptual and historical issues.

The conference attracted over 200 scientists from 31 countries, among them a number of leading experts in the field of general relativity and its applications. This volume includes abstracts of the plenary talks and full texts of contributed talks and articles based on the posters presented at the conference. These describe primarily original results of the authors. Full texts of the plenary talks are included in the volume "General Relativity, Cosmology and Astrophysics--Perspectives 100 Years after Einstein in Prague," eds. J. Bi ak and T. Ledvinka, published also by Springer Verlag."

Understanding the stars is the bedrock of modern astrophysics. Stars are the source of life. The chemical enrichment of our Milky Way and of the Universe withallelementsheavierthanlithiumoriginatesintheinteriorsofstars.Stars arethe tracersofthe dynamics ofthe Universe,gravitationallyimplying much more than meets the eye. Stars ionize the interstellar medium and re-ionized the early intergalactic medium. Understanding stellar structure and evolution is fundamental. While stellar structure and evolution are understood in general terms, we lack important physical ingredients, despite extensive research during recent decades.Classicalspectroscopy,photometry,astrometryandinterferometryof stars have traditionally been used as observational constraints to deduce the internal stellar physics. Unfortunately, these types of observations only allow the tuning of the basic common physics laws under stellar conditions with relatively poor precision. The situation is even more worrisome for unknown aspects of the physics and dynamics in stars. These are usually dealt with by using parameterised descriptions of, e.g., the treatments of convection, rotation,angularmomentumtransport,theequationofstate,atomicdi?usion andsettlingofelements,magneto-hydrodynamicalprocesses,andmore.There is a dearth of observational constraints on these processes, thus solar values areoftenassignedtothem.Yetitishardtoimaginethatonesetofparameters is appropriate for the vast range of stars.

The years 2012/2013 mark the 50th anniversary of the theoretical prediction that Brown Dwarfs, i.e. degenerate objects which are just not massive enough to sustain stable hydrogen fusion, exist. Some 20 years after their discovery, how Brown Dwarfs form is still one of the main open questions in the theory of star formation. In this volume, the pioneers of Brown Dwarf research review the history of the theoretical prediction and the subsequent discovery of Brown Dwarfs. After an introduction, written by Viki Joergens, reviewing Shiv Kumar's theoretical prediction of the existence of brown dwarfs, Takenori Nakano reviews his and Hayashi's calculation of the Hydrogen Burning Minimum Mass. Both predictions happened in the early 1960s. Jill Tarter then writes on the introduction of the term 'Brown Dwarf', before Ben Oppenheimer, Rafael Rebolo and Gibor Basri describe their first discovery of Brown Dwarfs in the 1990s. Lastly, Michael Cushing and Isabelle Baraffe describe the development of the field to the current state of the art. While the book is mainly aimed at the Brown Dwarf research community, the description of the pioneering period in a scientific field will attract general readers interested in astronomy as well.

DNA (sometimes referred to as the molecule of life), is the most interesting and most important of all molecules. Electrochemistry of Nucleic Acids and Proteins: Towards Electrochemical Sensors for Genomics and Proteomics is devoted to the electrochemistry of DNA and RNA and to the development of sensors for detecting DNA damage and DNA hybridization. Volume 1, in the brand new series Perspectives in Bioanalysis, looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century.
* Covers highly sophisticated methods of electrochemical analysis of nucleic acids and proteins
* Summarises the present state of electrochemical analysis of nucleic acids and proteins
* Includes future trends in the electrochemical analysis in genomics and proteomics

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

This book contains a collection of papers that were presented at the IUTAM Symposium on "Computer Models in Biomechanics: From Nano to Macro" held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+-regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

This book provides a challenging and stimulating introduction to the contemporary topics of complexity and criticality, and explores their common basis of scale invariance, a central unifying theme of the book.Criticality refers to the behaviour of extended systems at a phase transition where scale invariance prevails. The many constituent microscopic parts bring about macroscopic phenomena that cannot be understood by considering a single part alone. The phenomenology of phase transitions is introduced by considering percolation, a simple model with a purely geometrical phase transition, thus enabling the reader to become intuitively familiar with concepts such as scale invariance and renormalisation. The Ising model is then introduced, which captures a thermodynamic phase transition from a disordered to an ordered system as the temperature is lowered in zero external field. By emphasising analogies between percolation and the Ising model, the reader's intuition of phase transitions is developed so that the underlying theoretical formalism may be appreciated fully. These equilibrium systems undergo a phase transition only if an external agent finely tunes certain external parameters to particular values.Besides fractals and phase transitions, there are many examples in Nature of the emergence of such complex behaviour in slowly driven non-equilibrium systems: earthquakes in seismic systems, avalanches in granular media and rainfall in the atmosphere. A class of non-equilibrium systems, not constrained by having to tune external parameters to obtain critical behaviour, is addressed in the framework of simple models, revealing that the repeated application of simple rules may spontaneously give rise to emergent complex behaviour not encoded in the rules themselves. The common basis of complexity and criticality is identified and applied to a range of non-equilibrium systems. Finally, the reader is invited to speculate whether self-organisation in non-equilibrium systems might be a unifying concept for disparate fields such as statistical mechanics, geophysics and atmospheric physics.Visit for animations for the models in the book (available for Windows and Linux), solutions to exercises, as well as a list with corrections.

It is over a quarter of a century since the discovery of out?ows from young stars. The intervening years have led to remarkable advances in our understanding of this phenomenon. Much of the progress can be attributed to advances in facilities and technologies, including not only larger telescopes but also improved instrument and detector performance. In addition protostellar out?ows have now been imaged from the ground and space at high spatial resolution, e. g. with HST, and at a wide - riety of wavelengths from X-rays to radio waves, revealing more and more about their physics. This veritable revolution in observation has been accompanied by an exponential growth in our ability to numerically simulate the launching and pro- gation of jets. Codes continue to improve: they now incorporate more physics and are increasingly ef?cient through, for example, techniques such as adaptive mesh re?nement and the use of parallel processing in cluster environments. Simulating the launching and propagation of a jet all the way from the vicinity of the star up to 4 several thousand AU (a size range of10 ) is now much closer. In more recent times, developments in observation, theory and numerical s- ulation have been joined by laboratory jet experiments reproducing, on centimetre scales, that which is seen in astrophysics to stretch for several parsecs.

Lightning represents a natural phenomenon of substantial interest. Due to its complex nature, research continues in many countries and reveals amazing results. Lightning is actively observed because of its relevance to Earth climate and air composition in addition to the classical aspects of related human fatalities and damage to forests, buildings, power lines, aircraft, structures and electronic devices. In this volume, the most important contemporary questions on lightning are addressed and analyzed under many experimental and theoretical aspects. Lightning detection techniques using ground-based and space-borne methods are described, along with network engineering and statistical analysis. Contributions detail research on atmospheric electricity, cloud physics, lightning physics, modeling of electrical storms and middle atmospheric events. Special phenomena such as triggered lightning and sprite observations are examined. Lightning-induced nitrogen oxides and their effects on atmospheric chemistry and climate are discussed. Each topic is presented by international experts in the field. Topics include: * air chemistry * convective storms * infrasound from lightning * lightning and climate change * lightning and precipitation * lightning and radiation * lightning and supercells * lightning and thunderstorms * lightning detection * lightning from space * lighting protection * lightning return strokes * observations and interpretations * spatial distribution and frequency * triggered lightning * weather extremes

This short monograph presents the theory of electromagnetic pulses in a simple and physical way. All pulses discussed are exact solutions of the Maxwell equations, and have finite energy, momentum and angular momentum. There are five chapters: on Fundamentals, Solutions of the Wave Equation, Electromagnetic Pulses, Angular Momentum, and Lorentz Transformations. Nine Appendices cover mathematical or associated aspects, such as chiral measures of electromagnetic fields. The subject matter is restricted to free-space classical electrodynamics, but contact is made with quantum theory in proofs that causal pulses are equivalent to superpositions of photons.

This book focuses on the application of fluorescence to study motor proteins (myosins, kinesins, DNA helicases and RNA polymerases). It is intended for a large community of biochemists, biophysicists and cell biologists who study a diverse collection of motor proteins. It can be used by researchers to gain an insight into their first experiments, or by experienced researchers who are looking to expand their research to new areas. Each chapter provides valuable advice for executing the experiments, along with detailed background knowledge in order to develop own experiments.

Mars, the most habitable of our sister planets, holds a special place in our imaginations and in our space exploration program. Fully half of NASA's planetary exploration effort is now devoted to Mars. Key questions include: Has Mars ever harbored life? Is there life on Mars now? Will humans be able to survive on the Martian surface? Answers to these questions lie in determining the present location of water on Mars and its likely inventory in the past, and in determining the present radiation environment of Mars. The 2001 Mars Odyssey Mission contributes greatly these answers by detecting near-surface water through measurements of neutron flux, from the detection of carbonates, and the quantification of its radiation environment. This book captures the objectives, the design of the mission and the details of the instruments carried to Mars. It should be of interest to every scientist interested in participating in the on-going exploration of Mars from graduate students to senior scientists as it provides the background information essential to interpret the many exciting results now appearing from the mission.

This is the first book that is not exclusively focused on ion channels functioning in sensory mechanisms that are characteristic of animals and humans, but also describes the role of ion channels in signal transduction mechanisms found in microbial cells and plants. It summarizes comprehensively the progress that has been made in studies of ion channels and their role in sensory physiology.

The book provides an elaborate treatment of groundwater prospecting and management covering remote sensing, geological-geophysical cum hydrogeological studies, exploration (geological and geophysical), development (well logging techniques, pump test, its analysis and applications in well design), contamination (pollution of groundwater) and regulatory legislations regarding groundwater utilization under one cover. The book presents an elucidation of fundamental and theoretical background of each technique supported by necessary illustrative examples and exclusive case studies. It is a text-cum-reference book not only for students, research scholars and practicing earth scientists but also for practicing civil and agricultural engineers working in the application of groundwater resources, engaged in its exploration, development, contamination, legislation and management. The general readers can also refer the book for understanding the groundwater domain for adequate knowledge, as groundwater resources are essential life support commodity which is replenishable but not inexhaustible.

This book provides an introduction to the mathematical aspects of Euler's elastic theory and its application. The approach is rigorous, as well as visually depicted, and can be easily digested. The first few chapters introduce the needed mathematical concepts from geometry and variational calculus. The formal definitions and proofs are always illustrated through complete derivations and concrete examples. In this way, the reader becomes acquainted with Cassinian ovals, Sturmian spirals, co-Lemniscates, the nodary and the undulary, Delaunay surfaces, and their generalizations. The remaining chapters discuss the modeling of membranes, mylar balloons, rotating liquid drops, Hele-Shaw cells, nerve fibers, Cole's experiments, and membrane fusion. The book is geared towards applied mathematicians, physicists and engineers interested in Elastica Theory and its applications.