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Books > Science & Mathematics > Physics > Applied physics & special topics

Exciton Polaritons in Microcavities - New Frontiers (Hardcover, 2012): Daniele Sanvitto, Vladislav Timofeev Exciton Polaritons in Microcavities - New Frontiers (Hardcover, 2012)
Daniele Sanvitto, Vladislav Timofeev
R5,420 Discovery Miles 54 200 Ships in 10 - 15 working days

In the past decade, there has been a burst of new and fascinating physics associated to the unique properties of two-dimensional exciton polaritons, their recent demonstration of condensation under non-equilibrium conditions and all the related quantum phenomena, which have stimulated extensive research work. This monograph summarizes the current state of the art of research on exciton polaritons in microcavities: their interactions, fast dynamics, spin-dependent phenomena, temporal and spatial coherence, condensation under non-equilibrium conditions, related collective quantum phenomena and most advanced applications. The monograph is written by the most active authors who have strongly contributed to the advances in this area. It is of great interests to both physicists approaching this subject for the first time, as well as a wide audience of experts in other disciplines who want to be updated on this fast moving field.

The Cluster Active Archive - Studying the Earth's Space Plasma Environment (Hardcover, 2010 ed.): Harri Laakso, Matthew... The Cluster Active Archive - Studying the Earth's Space Plasma Environment (Hardcover, 2010 ed.)
Harri Laakso, Matthew Taylor, C. Philippe Escoubet
R8,830 Discovery Miles 88 300 Ships in 10 - 15 working days

Since the year 2000 the ESA Cluster mission has been investigating the small-scale structures and processes of the Earth's plasma environment, such as those involved in the interaction between the solar wind and the magnetospheric plasma, in global magnetotail dynamics, in cross-tail currents, and in the formation and dynamics of the neutral line and of plasmoids.

This book contains presentations made at the 15th Cluster workshop held in March 2008. It also presents several articles about the Cluster Active Archive and its datasets, a few overview papers on the Cluster mission, and articles reporting on scientific findings on the solar wind, the magnetosheath, the magnetopause and the magnetotail.

Advances in Bio-Mechanical Systems and Materials (Hardcover, 2013 ed.): Andreas Ochsner, Holm Altenbach Advances in Bio-Mechanical Systems and Materials (Hardcover, 2013 ed.)
Andreas Ochsner, Holm Altenbach
R4,099 R3,516 Discovery Miles 35 160 Save R583 (14%) Ships in 12 - 17 working days

This monograph presents the latest results related to bio-mechanical systems and materials. The bio-mechanical systems with which his book is concerned are prostheses, implants, medical operation robots and muscular re-training systems. To characterize and design such systems, a multi-disciplinary approach is required which involves the classical disciplines of mechanical/materials engineering and biology and medicine. The challenge in such an approach is that views, concepts or even language are sometimes different from discipline to discipline and the interaction and communication of the scientists must be first developed and adjusted. Within the context of materials' science, the book covers the interaction of materials with mechanical systems, their description as a mechanical system or their mechanical properties.

Microseismic Monitoring and Geomechanical Modelling of CO2 Storage in Subsurface Reservoirs (Hardcover, 2012 ed.): James P.... Microseismic Monitoring and Geomechanical Modelling of CO2 Storage in Subsurface Reservoirs (Hardcover, 2012 ed.)
James P. Verdon
R4,578 Discovery Miles 45 780 Ships in 10 - 15 working days

This thesis presents an impressive summary of the potential to use passive seismic methods to monitor the sequestration of anthropogenic CO2 in geologic reservoirs. It brings together innovative research in two distinct areas - seismology and geomechanics - and involves both data analysis and numerical modelling. The data come from the Weyburn-Midale project, which is currently the largest Carbon Capture and Storage (CCS) project in the world. James Verdon's results show how passive seismic monitoring can be used as an early warning system for fault reactivation and top seal failure, which may lead to the escape of CO2 at the surface.

Electro-Chemo-Mechanics of Anodic Porous Alumina Nano-Honeycombs: Self-Ordered Growth and Actuation (Hardcover, 2015 ed.):... Electro-Chemo-Mechanics of Anodic Porous Alumina Nano-Honeycombs: Self-Ordered Growth and Actuation (Hardcover, 2015 ed.)
Chuan Cheng
R4,598 R3,722 Discovery Miles 37 220 Save R876 (19%) Ships in 12 - 17 working days

In this thesis, real-time evolution of the nanopore channel growth and self-ordering process in anodic nanoporous alumina are simulated on the basis of an established kinetics model. The simulation results were in accordance with the experiments on the (i) growth sustainability of pore channels guided by pre-patterns; and (ii) substrate grain orientation dependence on self-ordering. In addition, a new fabrication method for the rapid synthesis of highly self-ordered nanoporous alumina is established, based on a systematic search for the self-ordering conditions in experiments. Lastly, it reports on a novel surface-charge induced strain in nanoporous alumina-aluminium foils, which indicates that nanoporous alumina can be used as a new type of actuating material in micro-actuator applications.

Morphology Genetic Materials Templated from Nature Species (Hardcover, 2012): Di Zhang Morphology Genetic Materials Templated from Nature Species (Hardcover, 2012)
Di Zhang
R4,592 Discovery Miles 45 920 Ships in 10 - 15 working days

"Morphology Genetic Materials Templated from Nature Species" provides a comprehensive and up-to-date coverage of research on bio-inspired functional materials including materials science and engineering aspects of the fabrication, properties, and applications. The book discusses bio-inspired strategies integrating biotemplate, biomineralization, and biomimesis in nature, which are adopted to fabricate functional materials with hierarchical bio-architectures and interrelated outstanding performances, as well as valuable applications in photoelectricity, photonics, photocatalysis, chemical detection, bio-imaging, and photoelectron transfer components/devices.

The book is intended for researchers and graduate students in the fields of materials science, chemistry, nanotechnology, semiconductor, biotechnology, environmental engineering, etc.

Prof. Dr. Di Zhang is currently a professor at the School of Materials Science and Engineering, Shanghai Jiao Tong University, and the director of the State Key Laboratory of Metal Matrix Composites, China.

"

Dark Matter in Astro- and Particle Physics - Proceedings of the International Conference Dark 2002, Cape Town, South Africa,... Dark Matter in Astro- and Particle Physics - Proceedings of the International Conference Dark 2002, Cape Town, South Africa, 4-9 February 2002 (Hardcover)
H.V. Klapdor-Kleingrothaus, R.D. Viollier
R2,688 Discovery Miles 26 880 Ships in 12 - 17 working days

The search for Dark Matter in the Universe has established itself as one of the most exciting and central fields of astrophysics, particle physics and cosmology. The lectures and talks in this book emphasize the experimental and theoretical status and future perspectives, stressing in particular the interplay between astro- and particle physics.

Computational Molecular Magnetic Resonance Imaging for Neuro-oncology (Hardcover, 1st ed. 2021): Michael O. Dada, Bamidele O.... Computational Molecular Magnetic Resonance Imaging for Neuro-oncology (Hardcover, 1st ed. 2021)
Michael O. Dada, Bamidele O. Awojoyogbe
R4,343 Discovery Miles 43 430 Ships in 12 - 17 working days

Based on the analytical methods and the computer programs presented in this book, all that may be needed to perform MRI tissue diagnosis is the availability of relaxometric data and simple computer program proficiency. These programs are easy to use, highly interactive and the data processing is fast and unambiguous. Laboratories (with or without sophisticated facilities) can perform computational magnetic resonance diagnosis with only T1 and T2 relaxation data. The results have motivated the use of data to produce data-driven predictions required for machine learning, artificial intelligence (AI) and deep learning for multidisciplinary and interdisciplinary research. Consequently, this book is intended to be very useful for students, scientists, engineers, the medical personnel and researchers who are interested in developing new concepts for deeper appreciation of computational magnetic resonance imaging for medical diagnosis, prognosis, therapy and management of tissue diseases.

Background Processes in the Electrostatic Spectrometers of the KATRIN Experiment (Hardcover, 2014 ed.): Susanne Mertens Background Processes in the Electrostatic Spectrometers of the KATRIN Experiment (Hardcover, 2014 ed.)
Susanne Mertens
R3,581 Discovery Miles 35 810 Ships in 12 - 17 working days

Neutrinos continue to be the most mysterious and, arguably, the most fascinating particles of the Standard Model as their intrinsic properties such as absolute mass scale and CP properties are unknown. The open question of the absolute neutrino mass scale will be addressed with unprecedented accuracy by the Karlsruhe Tritium Neutrino (KATRIN) experiment, currently under construction. This thesis focusses on the spectrometer part of KATRIN and background processes therein. Various background sources such as small Penning traps, as well as nuclear decays from single radon atoms are fully characterized here for the first time. Most importantly, however, it was possible to reduce the background in the spectrometer by more than five orders of magnitude by eliminating Penning traps and by developing a completely new background reduction method by stochastically heating trapped electrons using electron cyclotron resonance (ECR). The work beautifully demonstrates that the obstacles and challenges in measuring the absolute mass scale of neutrinos can be met successfully if novel experimental tools (ECR) and novel computing methods (KASSIOPEIA) are combined to allow almost background-free tritium ss-spectroscopy.

Geospatial Algebraic Computations - Theory and Applications (Hardcover, 3rd ed. 2016): Joseph Awange, Bela Palancz Geospatial Algebraic Computations - Theory and Applications (Hardcover, 3rd ed. 2016)
Joseph Awange, Bela Palancz
R4,575 R3,993 Discovery Miles 39 930 Save R582 (13%) Ships in 12 - 17 working days

Improved geospatial instrumentation and technology such as in laser scanning has now resulted in millions of data being collected, e.g., point clouds. It is in realization that such huge amount of data requires efficient and robust mathematical solutions that this third edition of the book extends the second edition by introducing three new chapters: Robust parameter estimation, Multiobjective optimization and Symbolic regression. Furthermore, the linear homotopy chapter is expanded to include nonlinear homotopy. These disciplines are discussed first in the theoretical part of the book before illustrating their geospatial applications in the applications chapters where numerous numerical examples are presented. The renewed electronic supplement contains these new theoretical and practical topics, with the corresponding Mathematica statements and functions supporting their computations introduced and applied. This third edition is renamed in light of these technological advancements.

Laser-Driven Particle Acceleration Towards Radiobiology and Medicine (Hardcover, 1st ed. 2016): Antonio Giulietti Laser-Driven Particle Acceleration Towards Radiobiology and Medicine (Hardcover, 1st ed. 2016)
Antonio Giulietti
R4,900 R3,731 Discovery Miles 37 310 Save R1,169 (24%) Ships in 12 - 17 working days

This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.

Evolutionary Biomechanics (Hardcover, New): Graham Taylor, Adrian Thomas Evolutionary Biomechanics (Hardcover, New)
Graham Taylor, Adrian Thomas
R3,873 R3,103 Discovery Miles 31 030 Save R770 (20%) Ships in 12 - 17 working days

Evolutionary biomechanics is the study of evolution through the analysis of biomechanical systems. Its unique advantage is the precision with which physical constraints and performance can be predicted from first principles. Instead of reviewing the entire breadth of the biomechanical literature, a few key examples are explored in depth as vehicles for discussing fundamental concepts, analytical techniques, and evolutionary theory. Each chapter develops a conceptual theme, developing the underlying theory and techniques required for analyses in evolutionary biomechanics. Examples from terrestrial biomechanics, metabolic scaling, and bird flight are used to analyse how physics constrains the design space that natural selection is free to explore, and how adaptive evolution finds solutions to the trade-offs between multiple complex conflicting performance objectives. Evolutionary Biomechanics is suitable for graduate level students and professional researchers in the fields of biomechanics, physiology, evolutionary biology and palaeontology. It will also be of relevance and use to researchers in the physical sciences and engineering.

X-Ray Phase-Contrast Tomography - Underlying Physics and Developments for Breast Imaging (Hardcover, 1st ed. 2020): Luca Brombal X-Ray Phase-Contrast Tomography - Underlying Physics and Developments for Breast Imaging (Hardcover, 1st ed. 2020)
Luca Brombal
R3,020 Discovery Miles 30 200 Ships in 10 - 15 working days

X-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis. This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences. Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals.

Kundalini Awakening - 5 Books in 1: Expand Mind Power through Chakra Meditation, Psychic Awareness, Enhance Psychic Abilities,... Kundalini Awakening - 5 Books in 1: Expand Mind Power through Chakra Meditation, Psychic Awareness, Enhance Psychic Abilities, Intuition, and Astral Travel (Hardcover)
Jenifer Williams
R1,411 R1,204 Discovery Miles 12 040 Save R207 (15%) Ships in 10 - 15 working days
Earliest Life on Earth: Habitats, Environments and Methods of Detection (Hardcover, 2011 Ed.): Suzanne D. Golding, Miryam... Earliest Life on Earth: Habitats, Environments and Methods of Detection (Hardcover, 2011 Ed.)
Suzanne D. Golding, Miryam Glikson
R4,630 Discovery Miles 46 300 Ships in 10 - 15 working days

This volume integrates the latest findings on earliest life forms, identified and characterised in some of the oldest rocks on Earth. New material from prominent researchers in the field is presented and evaluated in the context of previous work. Emphasis is placed on the integration of analytical methods with observational techniques and experimental simulations. The opening section focuses on submarine hot springs that the majority of researchers postulates served as the cradle of life on Earth. In subsequent sections, evidence for life in strongly metamorphosed rocks such as those in Greenland is evaluated and early ecosystems identified in the well preserved Barberton and Pilbara successions in Southern Africa and Western Australia. The final section includes a number of contributions from authors with alternate perspectives on the evidence and record of early life on Earth. Audience This volume will be valuable to researchers and graduate students in biogeosciences, geochemistry, paleontology and geology interested in the origin of life on earth.

Quantum Measurement of Gravity for Geodesists and Geophysicists (Hardcover, 1st ed. 2020): Fernando Sanso, Federica Migliaccio Quantum Measurement of Gravity for Geodesists and Geophysicists (Hardcover, 1st ed. 2020)
Fernando Sanso, Federica Migliaccio
R3,797 Discovery Miles 37 970 Ships in 10 - 15 working days

During the last thirty years a great advancement in low energy physics, particularly interactions of atoms with the electromagnetic field, has been achieved and the development of electronics and laser techniques has allowed to implement a fine manipulation of atoms with photons. A wealth of important applications has sprung out from the ability of manipulating large samples of cold atoms. Among them, the improvement of atomic clocks and the creation of atomic gyroscopes and of atomic gravity meters, which is obviously of great interest for geodesists and geophysicists, particularly for potential applications in satellite geodesy. This book explains the fundamental concepts necessary to understand atom manipulation by photons, including the principles of quantum mechanics. It is conceived as a road that leads the reader from classical physics (mechanics and electromagnetism, considered as a common scientific background of geodesists and geophysicists), to the basics of quantum mechanics in order to understand the dynamics of atoms falling in the gravity field, while interacting with suitably resonant laser beams. There are different types of measurements of gravity based on the manipulation of ultra-cold atoms; the book presents the principles of the instruments based on stimulated Raman transition, which can be easily worked out analytically. However, the concepts explained in the text can provide a good starting point to understand also the applications based on the so-called Block oscillations or on the Bose-Einstein condensation.

Ultrafast Dynamics of Phospholipid-Water Interfaces - Studied by Nonlinear Time-Resolved Vibrational Spectroscopy (Hardcover,... Ultrafast Dynamics of Phospholipid-Water Interfaces - Studied by Nonlinear Time-Resolved Vibrational Spectroscopy (Hardcover, 1st ed. 2015)
Rene Costard
R3,020 Discovery Miles 30 200 Ships in 10 - 15 working days

This thesis presents a highly innovative study of the ultrafast structural and vibrational dynamics of hydrated phospholipids, the basic constituents of cell membranes. As a novel approach to the water-phospholipid interface, the author studies phosphate vibrations using the most advanced methods of nonlinear vibrational spectroscopy, including femtosecond two-dimensional infrared spectroscopy. He shows for the first time that the structure of interfacial water undergoes very limited fluctuations on a 300 fs time scale and that the lifetimes of hydrogen bonds with the phospholipid are typically longer than 10 ps. Such properties originate from the steric hindrance of water fluctuations at the interface and the orienting action of strong electric fields from the phospholipid head group dipoles. In an extensive series of additional experiments, the vibrational lifetimes of the different vibrations and the processes of energy dissipation are elucidated in detail.

Plasma Astrophysics, Part I - Fundamentals and Practice (Hardcover, 2nd ed. 2012): Boris V. Somov Plasma Astrophysics, Part I - Fundamentals and Practice (Hardcover, 2nd ed. 2012)
Boris V. Somov
R5,968 Discovery Miles 59 680 Ships in 10 - 15 working days

This two-part book is devoted to classic fundamentals and current practices and perspectives of modern plasma astrophysics. This first part uniquely covers all the basic principles and practical tools required for understanding and work in plasma astrophysics. More than 25% of the text is updated from the first edition, including new figures, equations and entire sections on topics such as magnetic reconnection and the Grad-Shafranov equation. The book is aimed at professional researchers in astrophysics, but it will also be useful to graduate students in space sciences, geophysics, applied physics and mathematics, especially those seeking a unified view of plasma physics and fluid mechanics.

Fast Solar Wind Driven by Parametric Decay Instability and Alfven Wave Turbulence (Hardcover, 1st ed. 2021): Munehito Shoda Fast Solar Wind Driven by Parametric Decay Instability and Alfven Wave Turbulence (Hardcover, 1st ed. 2021)
Munehito Shoda
R3,020 Discovery Miles 30 200 Ships in 10 - 15 working days

This book discusses key theoretical aspects concerning the formation of the solar wind: the most essential building block in the heliosphere, in which planets orbit. To understand the influence of solar activity on planetary magnetospheres and atmospheres, we need to first understand the origin of the solar wind, which is still under debate. This book presents the outcomes of state-of-the-art numerical simulations of solar wind acceleration, including the first three-dimensional simulation of the turbulence-driven solar wind model. One of the book's goals is to include compressional effects in the dynamics of solar wind turbulence; accordingly, it discusses parametric decay instability in detail. Several key aspects that are relevant to the Parker Solar Probe observations are also discussed. Given its scope, the book plays a key role in bridging the gap between the theory of magnetohydrodynamic turbulence and current/future in-situ observations of the solar wind. This book is based on the Ph.D. thesis by the author, which won the 2019 International Astronomical Union Division E Ph.D. prize.

Eclipsing Binary Stars: Modeling and Analysis (Hardcover, 2nd ed. 2009): Josef Kallrath, Eugene F. Milone Eclipsing Binary Stars: Modeling and Analysis (Hardcover, 2nd ed. 2009)
Josef Kallrath, Eugene F. Milone
R4,775 Discovery Miles 47 750 Ships in 12 - 17 working days

Astronomers learn much of what they know about the mass, brightness, and size of stars by observing binary systems, in which two stars orbit each other, periodically cutting off the others light. This book provides astronomers with a guide to specifying an astrophysical model for a set of observations, selecting an algorithm to determine the parameters of the model, and estimating the errors of the parameters.

Stellar Magnetism (Hardcover): Leon Mestel Stellar Magnetism (Hardcover)
Leon Mestel
R8,150 R7,177 Discovery Miles 71 770 Save R973 (12%) Ships in 12 - 17 working days

Most stars appear to show some degree of magnetic activity. Varying magnetic fields show up in the familiar sun-spot cycle and in similar activity in other cool stars. Many hot stars carry steady magnetic fields stronger than the average solar field and are well described as oblique rotators. A similar model is applicable to the rapidly rotating, enormously dense neutron stars with their far stronger fields, observed as radio and X-ray pulsars. Galactic magnetic fields may play a crucial role in star formation, and in the spectacular behaviour in galactic nuclei. Cosmical magnetism in general is a rapidly developing field, and this book has grown out of the lifelong work of an outstanding researcher in the area. An authoritative account with broad astronomical scope, its thorough, careful and well-argued approach makes it a fine addition to the professional literature. Most of the important topics are treated in mathematical depth with references to other relevant literature. Some of the studies, especially those on accretion discs, dynamos, and winds, are applicable to galaxies and galactic nuclei. This book is sure to become an invaluable professional reference and guide to current thinking in the field. It will be of particular interest to graduate students, for whom it shows how the area has developed and indicates the many challenging research problems, some of which may soon yield their secrets to the emerging supercomputers.

How to Understand the True Cosmos - New Gravity at Cosmic Distances (Hardcover): Sol Aisenberg How to Understand the True Cosmos - New Gravity at Cosmic Distances (Hardcover)
Sol Aisenberg
R914 Discovery Miles 9 140 Ships in 12 - 17 working days
Biophysics of the Failing Heart - Physics and Biology of Heart Muscle (Hardcover, 2013 ed.): R. John Solaro, Jil C. Tardiff Biophysics of the Failing Heart - Physics and Biology of Heart Muscle (Hardcover, 2013 ed.)
R. John Solaro, Jil C. Tardiff
R3,927 R3,638 Discovery Miles 36 380 Save R289 (7%) Ships in 12 - 17 working days

Subjects in the monograph "Biophysics of the Failing Heart" include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.

Atmospheric Physics - Background - Methods - Trends (Hardcover, 2012 ed.): Ulrich Schumann Atmospheric Physics - Background - Methods - Trends (Hardcover, 2012 ed.)
Ulrich Schumann
R6,091 Discovery Miles 60 910 Ships in 10 - 15 working days

On the occasion of the 50th anniversary of the Institute of Atmospheric Physics of the German Aerospace Center (DLR), this book presents more than 50 chapters highlighting results of the institute s research.

The book provides an up-to-date, in-depth survey across the entire field of atmospheric science, including atmospheric dynamics, radiation, cloud physics, chemistry, climate, numerical simulation, remote sensing, instruments and measurements, as well as atmospheric acoustics.

The authors have provided a readily comprehensible and self-contained presentation of the complex field of atmospheric science. The topics are of direct relevance for aerospace science and technology. Future research challenges are identified."

Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane (Hardcover, 2012 ed.): Ksenia Guseva Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane (Hardcover, 2012 ed.)
Ksenia Guseva
R1,568 Discovery Miles 15 680 Ships in 10 - 15 working days

With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.

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